Human Psychopharmacology
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Significantly increased urinary free cortisol excretion in melancholic depressed females during L‐tryptophan loadingAbstract To assess the status of serotonergic neurotransmission in depressed females, the authors examined the excretion of free cortisol in 24 h urine both before and after administering 5 g L ‐tryptophan (L‐TRP) orally. The depressed patients were classified according to the DSM‐III into minor, simple major and major depression with melancholia. ... ... hiện toàn bộ
Human Psychopharmacology - Tập 5 Số 3 - Trang 239-244 - 1990
Pharmacological management of behavioural and psychological disturbance in dementiaAbstract Behavioural and psychological symptoms in patients with dementia are common, distressing and often difficult to manage. This review evaluates a range of drugs commonly used to manage these symptoms including antipsychotics, anticonvulsants, antidementia drugs and antidepressants. The risks and benefits of individual treatments are discussed ... ... hiện toàn bộ
Human Psychopharmacology - Tập 21 Số 1 - Trang 1-12 - 2006
Dose‐response effects of zaleplon as compared with triazolam (0·25 mg) and placebo in chronic primary insomniaAbstract The effects of two nights of treatment with the short‐acting benzodiazepine receptor agonist zaleplon, triazolam, or placebo was assessed in chronic primary insomniacs using two concurrent, multi‐center, randomized, double‐blind, Latin Square crossover studies. Study 1 (n = 47) compared zaleplon (10 and 40 mg) to triazolam (0·25 m... ... hiện toàn bộ
Human Psychopharmacology - Tập 15 Số 8 - Trang 595-604 - 2000
Nicotine improves antisaccade task performance without affecting prosaccadesAbstract Although there is ample evidence for a cognitive‐attentional benefit of the stimulant nicotine, the source of this benefit is not as well understood. One approach is to address what aspects of performance nicotine affects at a functional systems level. It is currently debated whether the benefits produced by nicotine are the effect of enhanced higher cognit... ... hiện toàn bộ
Human Psychopharmacology - Tập 19 Số 6 - Trang 409-419 - 2004
Circadian rhythm disturbances in depressionAbstract Objective The aim of this article is to review progress in understanding the mechanisms that underlie circadian and sleep rhythms, and their role in the pathogenesis and treatment of depression. Methods Literature was selected principally by Medline searches, and ...
Human Psychopharmacology - Tập 23 Số 7 - Trang 571-585 - 2008
Preliminary investigation of the association between psychotropic medication use and accidents, minor injuries and cognitive failuresAbstract Rationale Psychotropic medication may impair psychomotor and cognitive function, and so increase accident susceptibility. However, few studies examine any association in the framework of other demographic, health and occupational factors. Objectives To examine the...
Human Psychopharmacology - Tập 18 Số 7 - Trang 535-540 - 2003
Development of a statistical approach to classifying treatment response in individual children with ADHDAbstract The use of cognitive tests as measures of treatment response in individual children with ADHD has not been adequately evaluated or commonly applied by clinicians. This is most likely due to a lack of suitable assessment tasks as well as clinicians' limited awareness of the appropriate statistical techniques for analysing cognitive change in individuals. Thi... ... hiện toàn bộ
Human Psychopharmacology - Tập 19 Số 7 - Trang 445-456 - 2004
A method for determining the magnitude of change across different cognitive functions in clinical trials: the effects of acute administration of two different doses alprazolamAbstract While there is no doubt that benzodiazepine administration leads to transient cognitive impairment in healthy adults, the nature and magnitude of such impairment has not been well described. The cognitive effects of a single dose of alprazolam 0.5 and 1 mg were therefore assessed in 36 healthy adults on measures of psychomotor function, visual attention, wo... ... hiện toàn bộ
Human Psychopharmacology - Tập 20 Số 4 - Trang 263-273 - 2005
Stability of cognitive impairment in chronic schizophrenia over brief and intermediate re‐test intervalsAbstract Objective This study examined between‐ and within‐subject stability of cognitive performance in individuals with chronic schizophrenia. Methods Thirty individuals with schizophrenia and 20 healthy controls matched by age, sex, education, and estimated IQ underwent...
Human Psychopharmacology - Tập 24 Số 2 - Trang 113-121 - 2009
Cognitive testing in early phase clinical trials: outcome according to adverse event profile in a Phase I studyAbstract Background It has been proposed that objective cognitive testing provides additional information to that collected via adverse event (AE) recordings. However, in clinical trials of compounds with potentially negative effects on cognition, the results of cognitive testing may overlap with AE recordings. ... hiện toàn bộ
Human Psychopharmacology - Tập 21 Số 7 - Trang 481-488 - 2006
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