Human Psychopharmacology
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The effects of caffeine and automaticity on a visual information processing task
Human Psychopharmacology - Tập 7 Số 6 - Trang 379-388 - 1992
AbstractThe present study examined caffeine's effect on mental performance in
contrast to a recent study (Loke and Goh, 1992) which examined the effects of
caffeine user‐effect on mental performance. Taken together, the studies would
provide a detailed understanding of the effects of caffeine and automaticity on
the visual search/detection domain of information processing. Analyses of the
baseline...
Nicotine improves antisaccade task performance without affecting prosaccades
Human Psychopharmacology - Tập 19 Số 6 - Trang 409-419 - 2004
AbstractAlthough there is ample evidence for a cognitive‐attentional benefit of
the stimulant nicotine, the source of this benefit is not as well understood.
One approach is to address what aspects of performance nicotine affects at a
functional systems level. It is currently debated whether the benefits produced
by nicotine are the effect of enhanced higher cognitive function or reflect an
overal...
Development of a statistical approach to classifying treatment response in individual children with ADHD
Human Psychopharmacology - Tập 19 Số 7 - Trang 445-456 - 2004
AbstractThe use of cognitive tests as measures of treatment response in
individual children with ADHD has not been adequately evaluated or commonly
applied by clinicians. This is most likely due to a lack of suitable assessment
tasks as well as clinicians' limited awareness of the appropriate statistical
techniques for analysing cognitive change in individuals. This study
investigated the applicat...
Ethanol‐Induced CNS depression and divided attention
Human Psychopharmacology - Tập 10 Số 4 - Trang 327-331 - 1995
AbstractSubject performed a divided attention task in which they detected
occurrences of a target letter in a stimulus figure which was a large letter
made up of an array of small letters. Subjects pressed one button if the large
letter was the target, another if the small letters were the target.Performance
on this task was compared to other attention and psychomotor tasks in a
three‐way randomiz...
A comparative study of on‐the‐road and simulated driving performance after nocturnal treatment with lormetazepam 1 mg and oxazepam 50 mg
Human Psychopharmacology - Tập 7 Số 5 - Trang 297-309 - 1992
AbstractThe main purpose of this study was to compare the sensitivity of a
driving simulator test model (TS2) with a standard on‐the‐road driving test,
after one night treatment with lormetazepam 1 mg, oxazepam 50 mg (as a verum)
and placebo. The secondary purpose was to measure the effects of the intended
drugs and placebo in the same subject sample, after two treatment nights in the
morning and ...
Dose‐response effects of zaleplon as compared with triazolam (0·25 mg) and placebo in chronic primary insomnia
Human Psychopharmacology - Tập 15 Số 8 - Trang 595-604 - 2000
AbstractThe effects of two nights of treatment with the short‐acting
benzodiazepine receptor agonist zaleplon, triazolam, or placebo was assessed in
chronic primary insomniacs using two concurrent, multi‐center, randomized,
double‐blind, Latin Square crossover studies. Study 1 (n = 47) compared zaleplon
(10 and 40 mg) to triazolam (0·25 mg) and placebo. Study 2 (n = 36) compared
zaleplon (20 and 6...
A method for determining the magnitude of change across different cognitive functions in clinical trials: the effects of acute administration of two different doses alprazolam
Human Psychopharmacology - Tập 20 Số 4 - Trang 263-273 - 2005
AbstractWhile there is no doubt that benzodiazepine administration leads to
transient cognitive impairment in healthy adults, the nature and magnitude of
such impairment has not been well described. The cognitive effects of a single
dose of alprazolam 0.5 and 1 mg were therefore assessed in 36 healthy adults on
measures of psychomotor function, visual attention, working memory, planning and
learni...
Stability of cognitive impairment in chronic schizophrenia over brief and intermediate re‐test intervals
Human Psychopharmacology - Tập 24 Số 2 - Trang 113-121 - 2009
AbstractObjectiveThis study examined between‐ and within‐subject stability of
cognitive performance in individuals with chronic schizophrenia.MethodsThirty
individuals with schizophrenia and 20 healthy controls matched by age, sex,
education, and estimated IQ underwent repeated cognitive assessments at baseline
and 30 days using computerized tests of psychomotor function, visual
attention/informat...
An investigation of the range of cognitive impairments induced by scopolamine 0·6 mg s.c
Human Psychopharmacology - Tập 3 Số 1 - Trang 27-41 - 1988
AbstractThe present study was conducted to determine the degree to which
impairments in attention accompany the memory deficits produced by scopolamine.
Eighteen healthy young volunteers received scopolamine 0·6 mg subcutaneously on
three experimental sessions and placebo on three others. On each session, prior
to, and 60 min after injection, the subjects underwent an automated computerized
batter...
Cognitive testing in early phase clinical trials: outcome according to adverse event profile in a Phase I study
Human Psychopharmacology - Tập 21 Số 7 - Trang 481-488 - 2006
AbstractBackgroundIt has been proposed that objective cognitive testing provides
additional information to that collected via adverse event (AE) recordings.
However, in clinical trials of compounds with potentially negative effects on
cognition, the results of cognitive testing may overlap with AE
recordings.AimsTo examine cognitive function in subjects who do and do not
report sedation‐related AE...
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