Human Psychopharmacology

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The effects of caffeine and automaticity on a visual information processing task
Human Psychopharmacology - Tập 7 Số 6 - Trang 379-388 - 1992
Wing Hong Loke
AbstractThe present study examined caffeine's effect on mental performance in contrast to a recent study (Loke and Goh, 1992) which examined the effects of caffeine user‐effect on mental performance. Taken together, the studies would provide a detailed understanding of the effects of caffeine and automaticity on the visual search/detection domain of information pro...... hiện toàn bộ
Nicotine improves antisaccade task performance without affecting prosaccades
Human Psychopharmacology - Tập 19 Số 6 - Trang 409-419 - 2004
Abigail L. Larrison, Kevin A. Briand, Anne B. Sereno
AbstractAlthough there is ample evidence for a cognitive‐attentional benefit of the stimulant nicotine, the source of this benefit is not as well understood. One approach is to address what aspects of performance nicotine affects at a functional systems level. It is currently debated whether the benefits produced by nicotine are the effect of enhanced higher cognit...... hiện toàn bộ
Development of a statistical approach to classifying treatment response in individual children with ADHD
Human Psychopharmacology - Tập 19 Số 7 - Trang 445-456 - 2004
C Mollica, Paul Maruff, Alasdair Vance
AbstractThe use of cognitive tests as measures of treatment response in individual children with ADHD has not been adequately evaluated or commonly applied by clinicians. This is most likely due to a lack of suitable assessment tasks as well as clinicians' limited awareness of the appropriate statistical techniques for analysing cognitive change in individuals. Thi...... hiện toàn bộ
Ethanol‐Induced CNS depression and divided attention
Human Psychopharmacology - Tập 10 Số 4 - Trang 327-331 - 1995
S Millar, L J Duncan, B. Tiplady
AbstractSubject performed a divided attention task in which they detected occurrences of a target letter in a stimulus figure which was a large letter made up of an array of small letters. Subjects pressed one button if the large letter was the target, another if the small letters were the target.Performance on this task was compared to other atten...... hiện toàn bộ
A comparative study of on‐the‐road and simulated driving performance after nocturnal treatment with lormetazepam 1 mg and oxazepam 50 mg
Human Psychopharmacology - Tập 7 Số 5 - Trang 297-309 - 1992
Edmund R. Volkerts, Margriet van Laar, A. P. P. van Willigenburg, T. A. Plomp, R. A. A. Maes
AbstractThe main purpose of this study was to compare the sensitivity of a driving simulator test model (TS2) with a standard on‐the‐road driving test, after one night treatment with lormetazepam 1 mg, oxazepam 50 mg (as a verum) and placebo. The secondary purpose was to measure the effects of the intended drugs and placebo in the same subject sample, after two tre...... hiện toàn bộ
Dose‐response effects of zaleplon as compared with triazolam (0·25 mg) and placebo in chronic primary insomnia
Human Psychopharmacology - Tập 15 Số 8 - Trang 595-604 - 2000
Christopher L. Drake, Timothy Roehrs, Richard M. Mangano, Thomas Roth
AbstractThe effects of two nights of treatment with the short‐acting benzodiazepine receptor agonist zaleplon, triazolam, or placebo was assessed in chronic primary insomniacs using two concurrent, multi‐center, randomized, double‐blind, Latin Square crossover studies. Study 1 (n = 47) compared zaleplon (10 and 40 mg) to triazolam (0·25 m...... hiện toàn bộ
A method for determining the magnitude of change across different cognitive functions in clinical trials: the effects of acute administration of two different doses alprazolam
Human Psychopharmacology - Tập 20 Số 4 - Trang 263-273 - 2005
Peter J. Snyder, John L. Werth, Bruno Giordani, Angela F. Caveney, Douglas E. Feltner, Paul Maruff
AbstractWhile there is no doubt that benzodiazepine administration leads to transient cognitive impairment in healthy adults, the nature and magnitude of such impairment has not been well described. The cognitive effects of a single dose of alprazolam 0.5 and 1 mg were therefore assessed in 36 healthy adults on measures of psychomotor function, visual attention, wo...... hiện toàn bộ
Stability of cognitive impairment in chronic schizophrenia over brief and intermediate re‐test intervals
Human Psychopharmacology - Tập 24 Số 2 - Trang 113-121 - 2009
Robert H. Pietrzak, Peter J. Snyder, Colleen E. Jackson, James Olver, Trevor R. Norman, Danijela Piškulić, Paul Maruff
AbstractObjectiveThis study examined between‐ and within‐subject stability of cognitive performance in individuals with chronic schizophrenia.MethodsThirty individuals with schizophrenia and 20 healthy controls matched by age, sex, education, and estimated IQ underwent...... hiện toàn bộ
An investigation of the range of cognitive impairments induced by scopolamine 0·6 mg s.c
Human Psychopharmacology - Tập 3 Số 1 - Trang 27-41 - 1988
Keith Wesnes, Paul Simpson, A.G. Kidd
AbstractThe present study was conducted to determine the degree to which impairments in attention accompany the memory deficits produced by scopolamine. Eighteen healthy young volunteers received scopolamine 0·6 mg subcutaneously on three experimental sessions and placebo on three others. On each session, prior to, and 60 min after injection, the subjects underwent...... hiện toàn bộ
Cognitive testing in early phase clinical trials: outcome according to adverse event profile in a Phase I study
Human Psychopharmacology - Tập 21 Số 7 - Trang 481-488 - 2006
Alex Collie, Paul Maruff, Peter J. Snyder, Miss Amanda Darekar, John P. Huggins
AbstractBackgroundIt has been proposed that objective cognitive testing provides additional information to that collected via adverse event (AE) recordings. However, in clinical trials of compounds with potentially negative effects on cognition, the results of cognitive testing may overlap with AE recordings.... hiện toàn bộ
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