miR-183-3p suppresses proliferation and migration of keratinocyte in psoriasis by inhibiting GAB1Hereditas - Tập 157 Số 1 - 2020
Ting Liu, Xiaoyan Zhang, Yujuan Wang
Abstract Background MicroRNAs (miRNAs) target genes involved in the
hyperproliferation of keratinocytes or immune dysfunction of psoriasis. This
study prospectively determined the involvement of miR-183-3p in the pathogenesis
of psoriasis. Methods Differentially expressed miR-183-3p between psoriatic
lesional and non-lesional skin were determined by quantitative RT-PCR and in
situ hybridization (I... hiện toàn bộ
Mutations in the gene of the Gα subunit of the heterotrimeric G protein are the cause for the brachytic1 semi-dwarf phenotype in barley and applicable for practical breedingHereditas - Tập 155 - Trang 1-13 - 2017
Ilka Braumann, Christoph Dockter, Sebastian Beier, Axel Himmelbach, Finn Lok, Udda Lundqvist, Birgitte Skadhauge, Nils Stein, Shakhira Zakhrabekova, Ruonan Zhou, Mats Hansson
Short-culm mutants have been widely used in breeding programs to increase
lodging resistance. In barley (Hordeum vulgare L.), several hundreds of
short-culm mutants have been isolated over the years. The objective of the
present study was to identify the Brachytic1 (Brh1) semi-dwarfing gene and to
test its effect on yield and malting quality. Double-haploid lines generated
through a cross between ... hiện toàn bộ
Identification of potential crucial genes and key pathways in osteosarcomaHereditas - Tập 157 - Trang 1-13 - 2020
Junwei Liu, Siyu Wu, Xiaoyu Xie, Ziming Wang, Qianqian Lei
The aim of this study is to identify the potential pathogenic and
metastasis-related differentially expressed genes (DEGs) in osteosarcoma through
bioinformatic analysis of Gene Expression Omnibus (GEO) database. Gene
expression profiles of GSE14359, GSE16088, and GSE33383, in total 112
osteosarcoma tissue samples and 7 osteoblasts, were analyzed. Seventy-four
normal-primary DEGs (NPDEGs) and 764 ... hiện toàn bộ
Characterization and functional analysis of SIAH1 during skin and hair follicle development in the angora rabbit (Oryctolagus cuniculus)Hereditas - Tập 157 - Trang 1-9 - 2020
Tong Zhou, Yang Chen, Bohao Zhao, Shuaishuai Hu, Jiali Li, Ming Liu, Shuang Liang, Zhiyuan Bao, Xinsheng Wu
Seven in absentia homolog 1 (SIAH1) is an E3 ubiquitin ligase containing a
RING-finger domain and a key regulator of normal development. Skin and hair
follicle development is a complex and special process of morphogenesis involving
multiple signaling pathways. SIAH1 is enriched in the Wnt signaling pathway and
potentially related to hair follicle cycle and skin development. This study aims
to prov... hiện toàn bộ