Hepatology Research
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Expressions of transforming growth factor (TGF)-β1 and TGF-β type II receptor and their relationship with apoptosis during chemical hepatocarcinogenesis in rats
Hepatology Research - Tập 27 - Trang 205-213 - 2003
NASH: A global health problem Non‐alcoholic fatty liver disease (NAFLD) is a major public health problem both in the Western world and in the East. This is mainly due to the high prevalence of the disease and its effects on the individual with NAFLD. In the USA, it is estimated that approximately a third of the general population has NAFLD. Increasing age, obesity and the presence of multiple features of metabolic syndrome, especially diabetes, are associated with a higher probability of having non‐alcoholic steatohepatitis (NASH). In the individual with NAFLD, excess hepatic fat is associated with an increased risk of developing diabetes, hypertension, cardiovascular events, abnormal resting electrocardiography and endothelial dysfunction. These findings have been corroborated in studies in teenagers as well as adults. There is also an increase in cardiovascular mortality, especially in those with NASH. In addition, there is an increased risk of death from a variety of non‐hepatocellular cancers. From a liver perspective, NAFLD is associated with a 15–20% risk of progression to cirrhosis. The disease progresses more rapidly in those with diabetes, increasing age and obesity. The PNPLA3 gene mutation at position 148 is associated with not only steatosis, but with the likelihood of having steatohepatitis and increased inflammation and fibrosis. Once cirrhosis develops, the liver disease decompensates at the rate of 3–4% per year. NASH‐related cirrhosis is a risk factor for hepatocellular cancer. All of these factors indicate that NAFLD is a common condition that has significant adverse health consequences for those who are afflicted. It is therefore a major public health hazard throughout the world
Hepatology Research - Tập 41 Số 7 - Trang 670-674 - 2011
Microbubble-induced increase in ablation of liver tumors by high-intensity focused ultrasound
Hepatology Research - Tập 36 - Trang 308-314 - 2006
Exploratory study on telaprevir given every 8 h at 500 mg or 750 mg with peginterferon‐alpha‐2b and ribavirin in hepatitis <scp>C</scp> patients Aim The aims of this study are to assess the antiviral effects, safety and telaprevir (TVR ) pharmacokinetics in two cohorts given TVR every 8 h (q8h) at doses of 500 mg and 750 mg with peginterferon‐α‐2b and ribavirin in chronic hepatitis C patients. Methods Twenty chronic hepatitis C (HCV ) patients with genotype 1b in high viral loads were randomly assigned to two TVR ‐based regimens of 750 mg q8h (group A ) and 500 mg q8h (group B ) in combination with peginterferon‐α‐2b and ribavirin for 12 weeks. Results Although the difference was not statistically significant other than trough concentration (C trough ) at week 4, the parameters of maximum concentration (C max ), the area under the concentration time curve (AUC 0–∞ ) and C trough tended to be higher in group A than those in group B . The antiviral effects were similar in the two groups (sustained virological response rates [SVR ], 40% in group A , 50% in group B ). The discontinuation rates by anemia were 30% in group A and 20% in group B . Serum creatinine concentrations were lower in group B than those in group A. Conclusion Although the exposure to TVR tended to be lower in 500 mg q8h than that in 750 mg q8h, the SVR rates in both groups were similar. The result suggests that the 500 mg q8h dose may be one option for treatment. In addition, the present findings indicate that the development of adverse events which increase with a TVR ‐based regimen, specifically anemia and creatinine, could be avoided by dose adjustment of TVR .
Hepatology Research - Tập 43 Số 7 - Trang 691-701 - 2013
Impact of tumor size, number of tumors and neutrophil‐to‐lymphocyte ratio in liver transplantation for recurrent hepatocellular carcinoma Aim Hepatocellular carcinoma (HCC ) is primarily treated with hepatic resection and/or locoregional therapy. When HCC recurs and further treatment is no longer possible owing to poor liver function, liver transplantation (LT ) or living‐donor LT (LDLT ) is considered. The aim of this study was to clarify risk factors for tumor recurrence after LDLT in patients with recurrent HCC . Methods The study comprised 104 patients who had undergone LDLT because of end‐stage liver disease with recurrent HCC . The recurrence‐free survival rates after the LDLT were calculated. Risk factors for tumor recurrence were identified. Results The 1‐, 3‐ and 5‐year recurrence‐free survival rates were 89.6%, 80.3% and 78.4%, respectively. By univariate analysis, the factors affecting recurrence‐free survival were the sum of the largest tumor size and number of tumors of 8 or more (P < 0.0001), des‐γ‐carboxy prothrombin of more than 300 mAU /mL (P = 0.0001), and a neutrophil‐to‐lymphocyte ratio (NLR ) of 4 or more (P = 0.0002), α‐fetoprotein of more than 400 ng/mL (P = 0.0001) and bilobar tumor distribution (P = 0.046). A multivariate analysis identified independent risk factors for post‐LDLT tumor recurrence including the sum of tumor size and number of tumors of 8 or more (P = 0.0004) and an NLR of 4 or more (P = 0.01). The 1‐ and 3‐ year recurrence‐free survival rates in the recipients who had both risk factors were 30.0% and 15.0%, respectively. Conclusion LDLT should not be performed for patients who have both independent risk factors after any treatments for HCC .
Hepatology Research - Tập 43 Số 7 - Trang 709-716 - 2013
Temporal changes in the stiffness of the remnant liver and spleen after donor hepatectomy as assessed by acoustic radiation force impulse: A preliminary study Aim: Virtual touch tissue quantification (VTTQ) is an implementation of ultrasound acoustic radiation force impulse imaging that provides numerical measurements of tissue stiffness. We have evaluated the temporal changes of the remnant liver and spleen after living donor hepatectomy with special reference to the differences between right and left liver donation.Methods: Nineteen living donors who received right lobectomy (small remnant liver [SRL] group; n = 7) or extended left and caudate lobectomy (large remnant liver [LRL] group; n = 12) were enrolled. They underwent measurement of liver and spleen VTTQ before and after donor surgery.Results: Virtual touch tissue quantification of the remnant liver increased postoperatively until postoperative day (POD) 3–5, and the values in the SRL group were significantly higher than those in the LRL group at POD 3–9. The values of the spleen also increased after donor surgery and the values in the SRL group were significantly higher than those in the LRL group at POD 3–14. A significant positive correlation between postoperative maximum value of VTTQ and postoperative maximum total bilirubin levels was observed. In liver transplant recipients, there was a significant positive correlation between preoperative spleen VTTQ and the corresponding actual portal venous pressure that was measured at the time of transplant surgery.Conclusion: Stiffness of the remaining liver and spleen in the smaller remnant liver group became harder than that in the larger remnant liver group. Perioperative measurement of liver and spleen VTTQ seems to be a useful means for assessing the physiology of liver regeneration.
Hepatology Research - Tập 41 Số 6 - Trang 579-586 - 2011
Infection with GB virus C in the patients with primary hepatocellular carcinoma in Japan
Hepatology Research - Tập 8 - Trang 37-43 - 1997
Elevation of serum riboflavin carrier protein in hepatocellular carcinoma
Hepatology Research - Tập 35 - Trang 83-87 - 2006
High incidence of extrahepatic manifestations in an HCV hyperendemic area
Hepatology Research - Tập 22 - Trang 27-36 - 2002
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