Genomic Medicine

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HGM2008 plenary abstracts: landscape of genomic variation
Genomic Medicine - Tập 2 Số 3-4 - Trang 133-133 - 2008
Evan E. Eichler, M Snyder
5α-androstane-3α,17β-diol selectively activates the canonical PI3K/AKT pathway: a bioinformatics-based evidence for androgen-activated cytoplasmic signaling
Genomic Medicine - Tập 1 - Trang 139-146 - 2008
Mikhail G. Dozmorov, Qing Yang, Adam Matwalli, Robert E. Hurst, Daniel J. Culkin, Bradley P. Kropp, Hsueh-Kung Lin
5α-Androstane-3α,17β-diol (3α-diol) is reduced from the potent androgen, 5α-dihydrotestosterone (5α-DHT), by reductive 3α-hydroxysteroid dehydrogenases (3α-HSDs) in the prostate. 3α-diol is recognized as a weak androgen with low affinity toward the androgen receptor (AR), but can be oxidized back to 5α-DHT. However, 3α-diol may have potent effects by activating cytoplasmic signaling pathways, stim...... hiện toàn bộ
The electronic health record as a primary source of clinical phenotype for genetic epidemiological studies
Genomic Medicine - Tập 2 - Trang 5-5 - 2008
Yoshiji Yamada
Genome variation, diversity and evolution
Genomic Medicine - Tập 2 - Trang 253-271 - 2009
Genomics of complex disorders II
Genomic Medicine - Tập 2 - Trang 201-203 - 2009
Disorders of the genome architecture: a review
Genomic Medicine - Tập 2 - Trang 69-76 - 2009
Dhavendra Kumar
Genetic diseases are recognized to be one of the major categories of human disease. Traditionally genetic diseases are subdivided into chromosomal (numerical or structural aberrations), monogenic or Mendelian diseases, multifactorial/polygenic complex diseases and mitochondrial genetic disorders. A large proportion of these conditions occur sporadically. With the advent of newer molecular techniqu...... hiện toàn bộ
Peripheral blood gene expression profiling for cardiovascular disease assessment
Genomic Medicine - Tập 1 - Trang 105-112 - 2008
Hamza Aziz, Aimee Zaas, Geoffrey S. Ginsburg
Whole blood gene expression profiling has the potential to be informative about dynamic changes in disease states and to provide information on underlying disease mechanisms. Having demonstrated proof of concept in animal models, a number of studies have now tried to tackle the complexity of cardiovascular disease in human hosts to develop better diagnostic and prognostic indicators. These studies...... hiện toàn bộ
Genomics of model organisms
Genomic Medicine - Tập 2 Số 3-4 - Trang 209-211 - 2008
Vani Brahmachari, Hina Sultana, Ram Parkisan, Rakesh K. Mishra, Hemant Bengani, Debbie K. Goode, Heather Callaway, Greg Elgar Queen
Why should genomic medicine become more evidence-based?
Genomic Medicine - Tập 1 - Trang 91-93 - 2007
Muin J. Khoury, Linda A. Bradley
HUGO 20th anniversary lecture
Genomic Medicine - Tập 2 - Trang 129-129 - 2009
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