Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domainsGenome Biology - Tập 21 - Trang 1-19 - 2020
Elissavet Kentepozidou, Sarah J. Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T. Odom, Maša Roller, Paul Flicek
CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation of TADs, the role of CTCF binding in their evolution and stability remains elusive. We carry out an experimental and computational study that exploits the natural genetic variation ac...... hiện toàn bộ
Predicting the sites of metastasesGenome Biology - Tập 6 - Trang 1-4 - 2005
Brian Z Ring, Douglas T Ross
Transplantation of human breast cancer cells into immunodeficient mice together with gene-expression microarray studies has recently identified genes implicated in the tissue tropism of breast-cancer metastasis. Such signatures of site-specific metastatic capabilities might allow the targeting of therapy to likely sites of metastasis.
Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulansGenome Biology - - 2006
Helga David, Gerald Hofmann, Ana Paula Oliveira, Hanne Jarmer, Jens Nielsen
Aspergillus nidulans (the asexual form of Emericella nidulans) is a model organism for aspergilli, which are an important group of filamentous fungi that encompasses human and plant pathogens as well as industrial cell factories. Aspergilli have a highly diversified metabolism and, because of their medical, agricultural and biotechnological importance, it would be valuable to have an understanding...... hiện toàn bộ
Insights from the 2018 Biology of Genomes meetingGenome Biology - Tập 19 Số 1 - Trang 1-3 - 2018
Oak, Ninad, Plon, Sharon E.
A report on the Cold Spring Harbor Laboratory 31st annual meeting on the Biology of Genomes, held at Cold Spring Harbor, New York, USA, 8–12 May, 2018. The 2018 Biology of Genomes meeting at Cold Spring Harbor Laboratories covered a wide range of topics with research relevant to many aspects of genomics. Here we highlight two areas of research where multiple talks provided new insights.
Systemic analysis of the response of Aspergillus nigerto ambient pHGenome Biology - Tập 10 - Trang 1-14 - 2009
Mikael R Andersen, Linda Lehmann, Jens Nielsen
The filamentous fungus Aspergillus niger is an exceptionally efficient producer of organic acids, which is one of the reasons for its relevance to industrial processes and commercial importance. While it is known that the mechanisms regulating this production are tied to the levels of ambient pH, the reasons and mechanisms for this are poorly understood. To cast light on the connection between ext...... hiện toàn bộ