Genome Biology

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Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains
Genome Biology - Tập 21 - Trang 1-19 - 2020
Elissavet Kentepozidou, Sarah J. Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T. Odom, Maša Roller, Paul Flicek
CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation of TADs, the role of CTCF binding in their evolution and stability remains elusive. We carry out an experimental and computational study that exploits the natural genetic variation ac...... hiện toàn bộ
Predicting the sites of metastases
Genome Biology - Tập 6 - Trang 1-4 - 2005
Brian Z Ring, Douglas T Ross
Transplantation of human breast cancer cells into immunodeficient mice together with gene-expression microarray studies has recently identified genes implicated in the tissue tropism of breast-cancer metastasis. Such signatures of site-specific metastatic capabilities might allow the targeting of therapy to likely sites of metastasis.
Author Correction: Towards accurate and reliable resolution of structural variants for clinical diagnosis
Genome Biology - Tập 23 - Trang 1-2 - 2022
Zhichao Liu, Ruth Roberts, Timothy R. Mercer, Joshua Xu, Fritz J. Sedlazeck, Weida Tong
An interpretable bimodal neural network characterizes the sequence and preexisting chromatin predictors of induced transcription factor binding
Genome Biology - Tập 22 - Trang 1-25 - 2021
Divyanshi Srivastava, Begüm Aydin, Esteban O. Mazzoni, Shaun Mahony
Transcription factor (TF) binding specificity is determined via a complex interplay between the transcription factor’s DNA binding preference and cell type-specific chromatin environments. The chromatin features that correlate with transcription factor binding in a given cell type have been well characterized. For instance, the binding sites for a majority of transcription factors display concurre...... hiện toàn bộ
Integrating whole transcriptome sequence data and public databases for analysis of somatic mutations in tumors
Genome Biology - Tập 12 - Trang 1-27 - 2011
Amin A Momin, Brian P James, Thomas C Motter, Humam N Kadara, Garth Powis, Ignacio I Wistuba
Genome-wide mapping of the sixth base
Genome Biology - Tập 12 - Trang 1-3 - 2011
Dinh Diep, Kun Zhang
Mapping of 5-hydroxylmethylcytosine in mammalian genomes has unveiled its unique role in the epigenetic regulation of gene expression. See Research article: http://genomebiology.com/2011/12/6/R54
BRCA1 linked with Fanconi anemia
Genome Biology - Tập 2 - Trang 1-4 - 2001
Cathy Holding
Fanconi anemia and breast cancer have been shown to share a common DNA repair pathway.
All about abo
Genome Biology - Tập 2 - Trang 1-2 - 2001
Jonathan B Weitzman
France failing young scientists
Genome Biology - Tập 4 - Trang 1-3 - 2003
Jane Burgermeister
Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans
Genome Biology - - 2006
Helga David, Gerald Hofmann, Ana Paula Oliveira, Hanne Jarmer, Jens Nielsen
Aspergillus nidulans (the asexual form of Emericella nidulans) is a model organism for aspergilli, which are an important group of filamentous fungi that encompasses human and plant pathogens as well as industrial cell factories. Aspergilli have a highly diversified metabolism and, because of their medical, agricultural and biotechnological importance, it would be valuable to have an understanding...... hiện toàn bộ
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