European Journal of Neuroscience

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A slowly developing dysfunction of dopaminergic nigrostriatal neurons induced by long‐term paraquat administration in rats: an animal model of preclinical stages of Parkinson's disease?
European Journal of Neuroscience - Tập 22 Số 6 - Trang 1294-1304 - 2005
K Ossowska, Jadwiga Wardas, Maria Śmiałowska, Katarzyna Kuter, Tomasz Lenda, Joanna M. Wierońska, Barbara Zięba, Przemysław Nowak, Jolanta Dąbrowska, Aleksandra Bortel, Adam Kwieciński, S Wolfarth
AbstractThe aim of the present study was to examine the influence of the long‐term paraquat administration on the dopaminergic nigrostriatal system in rats. Paraquat was injected at a dose of 10 mg/kg i.p. for 4–24 weeks. We found that this pesticide reduced the number of tyrosine hydroxylase‐immunoreactive neurons of the substantia nigra; after the 4‐week treatment the reduction (17%, nonsignific... hiện toàn bộ
Postnatal loss of Merkel cells, but not of slowly adapting mechanoreceptors in mice lacking the neurotrophin receptor p75
European Journal of Neuroscience - Tập 11 Số 11 - Trang 3963-3969 - 1999
Ilka Kinkelin, Cheryl L. Stucky, Martin Koltzenburg
AbstractMerkel cells are specialized epidermal cells which are abundantly found in touch‐sensitive areas and which are innervated by slowly adapting mechanosensitive afferent fibres with large myelinated (Aβ) axons. The role of Merkel cells in mechanosensation, their developmental regulation and their influence on sensory neuron function are, however, incompletely understood. Here, we used mice la... hiện toàn bộ
NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala
European Journal of Neuroscience - Tập 20 Số 2 - Trang 537-548 - 2004
Ki A. Goosens, Stephen Maren
AbstractWe examined the contribution ofN‐methyl‐D‐aspartate (NMDA) receptors (NMDARs) to the acquisition and expression of amygdaloid plasticity and Pavlovian fear conditioning using single‐unit recording techniques in behaving rats. We demonstrate that NMDARs are essential for the acquisition of both behavioral and neuronal correlates of conditional fear, but play a comparatively limited role in ... hiện toàn bộ
Dopamine D1‐like receptor antagonism in amygdala impairs the acquisition of glucose‐conditioned flavor preference in rats
European Journal of Neuroscience - Tập 30 Số 2 - Trang 289-298 - 2009
Khalid Touzani, Richard J. Bodnar, Anthony Sclafani
AbstractThis study examined the role of dopamine within the amygdala (AMY) in flavor preference learning induced by post‐oral glucose. In Experiment 1, rats were trained with a flavor [conditioned stimulus (CS+)] paired with intragastric (IG) infusions of 8% glucose and a different flavor (CS−) paired with IG water infusions. The CS+ preference was evaluated in two‐bottle tests following bilateral... hiện toàn bộ
Activation of dopamine D1‐like receptors in nucleus accumbens is critical for the acquisition, but not the expression, of nutrient‐conditioned flavor preferences in rats
European Journal of Neuroscience - Tập 27 Số 6 - Trang 1525-1533 - 2008
Khalid Touzani, Richard J. Bodnar, Anthony Sclafani
AbstractThe present study investigated the role of dopamine neurotransmission within the nucleus accumbens (NAc) in flavor preference learning induced by the postoral consequences of carbohydrates. In Experiment 1, rats fitted with a gastric catheter were trained with a flavor (CS+) paired with intragastric (IG) infusions of 8% glucose and a different flavor (CS–) paired with IG water infusions. T... hiện toàn bộ
Effects of aspiration versus neurotoxic lesions of the amygdala on emotional responses in monkeys
European Journal of Neuroscience - Tập 11 Số 12 - Trang 4403-4418 - 1999
Martine Meunier, Jocelyne Bachevalier, Elisabeth A. Murray, Ludiše Málková, Mortimer Mishkin
AbstractAll previous reports describing alterations in emotional reactivity after amygdala damage in monkeys were based on aspiration or radiofrequency lesions which likely disrupted fibres of passage coursing to and from adjacent ventral and medial temporal cortical areas. To determine whether this associated indirect damage was responsible for some or all of the changes described earlier, we com... hiện toàn bộ
Longitudinal magnetic resonance imaging study of rhesus monkey brain development
European Journal of Neuroscience - Tập 24 Số 11 - Trang 3204-3212 - 2006
Ludiše Málková, Eric Heuer, Richard C. Saunders
AbstractTo examine early brain development, T1‐weighted structural MRI scans of seven rhesus monkeys (Macaca mulatta) were obtained longitudinally between the ages of 1 week and 4 years at 12 age points. Total brain volume, calculated at each age point, increased significantly, by 56%, between 1 week and 4 years. The greatest increase of 22% occurred between 1 week and 1 month, followed by further... hiện toàn bộ
Depression‐like behaviour in mice is associated with disrupted circadian rhythms in nucleus accumbens and periaqueductal grey
European Journal of Neuroscience - Tập 43 Số 10 - Trang 1309-1320 - 2016
Dominic Landgraf, Jaimie Long, David K. Welsh
AbstractAn association between circadian rhythms and mood regulation is well established, and disturbed circadian clocks are believed to contribute to the development of mood disorders, including major depressive disorder. The circadian system is coordinated by the suprachiasmatic nucleus (SCN), the master pacemaker in the hypothalamus that receives light input from the retina and synchronizes cir... hiện toàn bộ
Sprouting and Regeneration of Lesioned Corticospinal Tract Fibres in the Adult Rat Spinal Cord
European Journal of Neuroscience - Tập 5 Số 9 - Trang 1156-1171 - 1993
Lisa Schnell, Martin E. Schwab
AbstractWe have studied the effects of tissue transplants and antibodies (IN‐1) against the myelin‐associated neurite growth inhibitory proteins on sprouting and regeneration of the rat corticospinal tract (CST). Transplantation of embryonic spinal cord tissue into bilateral transection lesions of the lower thoracic spinal cord in young adult rats resulted in a marked increase of the sprouting of ... hiện toàn bộ
Single Channel Recording from Glial Cells on the Untreated Surface of the Frog Optic Nerve
European Journal of Neuroscience - Tập 3 Số 8 - Trang 813-819 - 1991
Héctor Marrero, Paula M. Orkand, Helmut Kettenmann, R. K. Orkand
AbstractThe patch clamp technique has been used to record single channel currents from the untreated surface of the intact frog optic nerve after the meninges and basal lamina have been mechanically removed. Cells filled via dialysis with Lucifer yellow (LY) from the patch pipette had a typical astrocyte morphology and were dye‐coupled to adjacent astrocytes. This is consistent with the electron‐m... hiện toàn bộ
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