Characterization of neuronal migration disorders in neocortical structures: extracellular in vitro recordingsEuropean Journal of Neuroscience - Tập 10 Số 10 - Trang 3085-3094 - 1998
Heiko J. Luhmann, Kristin Raabe, M Qü, Karl Zilles
AbstractThe majority of patients showing neuronal migration disorders in cortical structures suffer from pharmaco‐resistant epilepsy. In order to study the molecular and cellular mechanisms underlying this pronounced hyperexcitability, we used an animal model of focal cortical dysplasia demonstrating structural malformations which resemble the human pathology of mi...... hiện toàn bộ
Pyruvate and lactate protect striatal neurons against N‐methyl‐d‐aspartate‐induced neurotoxicityEuropean Journal of Neuroscience - Tập 11 Số 9 - Trang 3215-3224 - 1999
M. Maus, Philippe Marin, Maurice Israël, J. Głowiński, Joël Prémont
AbstractA sustained release of glutamate contributes to neuronal loss during cerebral ischaemia. Using cultured mouse striatal neurons, we observed that glucose deprivation, which occurs in this pathological process, enhanced the N‐Methyl‐d‐aspartate (NMDA)‐ or α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate (AMPA)‐induced neurotoxicity. The end...... hiện toàn bộ
Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy facesEuropean Journal of Neuroscience - Tập 23 Số 7 - Trang 1944-1948 - 2006
Bhismadev Chakrabarti, Lindsey Kent, John Suckling, Edward T. Bullmore, Simon Baron‐Cohen
AbstractHappy facial expressions are innate social rewards and evoke a response in the striatum, a region known for its role in reward processing in rats, primates and humans. The cannabinoid receptor 1 (CNR1) is the best‐characterized molecule of the endocannabinoid system, involved in processing rewards. We hypothesized that genetic variation in human ... hiện toàn bộ
Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminalsEuropean Journal of Neuroscience - Tập 29 Số 7 - Trang 1348-1356 - 2009
Marco Feligioni, Atsushi Nishimune, Jeremy M. Henley
AbstractPosttranslational modification by small ubiquitin‐like modifier (SUMO) proteins is emerging as an important regulatory mechanism for neuronal function and dysfunction. Although multiple potential presynaptic SUMOylation substrate proteins have been proposed from sequence analysis the functional consequences of presynaptic SUMOylation have not been determine...... hiện toàn bộ