European Journal of Endocrinology

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Low beta-arrestin expression correlates with the responsiveness to long-term somatostatin analog treatment in acromegaly
European Journal of Endocrinology - Tập 174 Số 5 - Trang 651-662 - 2016
Federico Gatto, Nienke R. Biermasz, Richard A. Feelders, Johan M. Kros, Fadime Dogan, A. J. van der Lely, Sebastian Neggers, Steven W. J. Lamberts, Alberto M. Pereira, Diego Ferone, Leo J. Hofland
AbstractObjectiveThe high expression of somatostatin receptor subtype 2 (SSTR2 also known as sst2) usually present in growth hormone (GH)-secreting adenomas is the rationale for therapy with somatostatin analogs (SSAs) in acromegaly. Although SSTR2 expression is a good predictor for biochemical response to SSA treatment, we still face tumors resistant to SSAs despite high SSTR2 expression. Recentl... hiện toàn bộ
Quantitative analysis of somatostatin receptor subtype (SSTR1–5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas
European Journal of Endocrinology - Tập 156 Số 1 - Trang 65-74 - 2007
Giselle Fernandes Taboada, Raúl M. Luque, Wildebranham Bastos, Renata F.C. Guimarães, Jorge B Marcondes, Leila Chimelli, Rosita Fontes, Paulo J P Mata, Paulo Niemeyer Filho, Denise Pires de Carvalho, Rhonda D. Kineman, Mônica R. Gadelha
Objective: It is believed that the variable effectiveness of somatostatin analogs in post-surgical management of somatotropinomas and non-functioning pituitary adenomas (NFPA) may be due in part to variable expression of somatostatin receptor isoforms (SSTR1–5), within and between pituitary tumor types. Design and methods: Quantitative real-time RT-PCR was used to compare absolute mRNA copy number... hiện toàn bộ
STUDIES ON THE METABOLISM OF C-21 STEROIDS IN THE HUMAN FOETO-PLACENTAL UNIT
European Journal of Endocrinology - Tập 52 Số 4 - Trang 598-606 - 1966
R. Palmera, G. Eriksson, N. Wiqvist, E. Diczfalusy
ABSTRACT Two midterm human placentas were perfused in situ with pregnenolone-7α-3H sulphate and the unconjugated metabolites present in the placentas and perfusates were analyzed. Eighty-five and 54% of the radioactive material recovered from the placentas was in an unconjugated form, whereas only 1 and 3% of that found in the perfusates was unconjugated. Eighty-one and 76% of the unconjugated mat... hiện toàn bộ
METABOLISM OF DEHYDROEPIANDROSTERONE AND DEHYDROEPIANDROSTERONE SULPHATE BY THE HUMAN FOETUS AT MIDPREGNANCY
European Journal of Endocrinology - Tập 52 Số 4 - Trang 583-597 - 1966
E. Bolté, N. Wiqvist, E. Diczfalusy
ABSTRACT Four previable foetuses (18th to 20th week of gestation) were perfused with a combination of 14C-labelled dehydroepiandrosterone (DHA) and 3H-labelled dehydroepiandrosterone sulphate (DHAS). Approximately 80% of the radioactive material administered was recovered from the various foetal tissues and perfusates. With the exception of the liver, which exhibited an approximately equal concent... hiện toàn bộ
STUDIES ON THE AROMATISATION OF NEUTRAL STEROIDS IN PREGNANT WOMEN
European Journal of Endocrinology - Tập 45 Số 4 - Trang 535-559 - 1964
E. Bolté, S Mancuso, G. Eriksson, N. Wiqvist, E. Diczfalusy
ABSTRACT In 15 cases of therapeutic abortion by laparotomy the placenta was disconnected from the foetus and perfused in situ with tracer amounts of radioactive dehydroepiandrosterone (DHA), dehydroepiandrosterone sulphate (DHAS), androst-4-ene-3,17-dione (A), testosterone (T) and 17β-oestradiol (OE2). Analysis of the placentas, perfusates and urine samples revealed an extensive aromatisation of D... hiện toàn bộ
STUDIES ON THE METABOLISM OF C-21 STEROIDS IN THE HUMAN FOETO-PLACENTAL UNIT
European Journal of Endocrinology - Tập 48 Số 2 - Trang 234-248 - 1965
R. PION, Randal C. Jaffe, G. Eriksson, N. Wiqvist, E. Diczfalusy
ABSTRACT In situ perfusion of human midterm placentas with labelled pregnenolone and 17α-hydroxypregnenolone was carried out. Following perfusion with pregnenolone in two experiments, 80 and 90 per cent of the radioactive material recovered from the placenta and 25 and 29 per cent of that recovered from the perfusate was progesterone. These figures accounted for 17 and 13 per cent of the perfused ... hiện toàn bộ
METABOLISM OF OESTRONE AND OESTRADIOL IN THE HUMAN FOETO-PLACENTAL UNIT AT MIDPREGNANCY
European Journal of Endocrinology - Tập 49 Số 1 - Trang 65-82 - 1965
J Schwers, G. Eriksson, E. Diczfalusy
ABSTRACT In four cases of therapeutic abortion by laparotomy, tracer amounts of oestrone-6,7-3H and 17β-oestradiol-16-14C were injected into the umbilical vein 20 minutes prior to the interruption of gestation, and the radioactive material recovered from the placenta and various foetal tissues was analysed. More than 92 per cent of the radioactive material recovered from the foetus, but less than ... hiện toàn bộ
THE DEVELOPMENT OF THE MOUSE OVARY FROM BIRTH TO MATURITY
European Journal of Endocrinology - Tập 62 Số 1 - Trang 98-116 - 1969
Hannah Peters
ABSTRACT Changes occur in the infant ovary which develop the structurally simple organ at birth to a highly complex one in the maturing animal. The ovary in the immature mouse is not a dormant organ but one that is characterized by a continuous growth and development and a concurrent continuous degeneration of oocytes and follicles. The stroma cells which are present in the ovary at birth are appa... hiện toàn bộ
EFFECT OF MUSCULAR EXERCISE ON THE PLASMA LEVEL OF CORTISOL IN MAN
European Journal of Endocrinology - Tập 48 Số 1 - Trang 163-168 - 1965
A Cornil, A. De Coster, Georges Copinschi, J. R. M. Franckson
ABSTRACT Intense muscular exercise performed on a bicycle ergometer by untrained normal men is accompanied by a significant fall in the plasma cortisol level. This observation suggests an increased utilization or diffusion of cortisol during exercise.
Heritability of pubertal timing: detailed evaluation of specific milestones in healthy boys and girls
European Journal of Endocrinology - Tập 183 Số 1 - Trang 13-20 - 2020
Alexander S. Busch, Casper P. Hagen, Anders Juul
Objective Pubertal timing is highly heritable. Observational studies were inconclusive concerning a potential sex-specific difference in the parental contribution, while genome-wide association studies highlighted a heterogeneity in the genetic architecture of pubertal timing between sexes. Our objectives were to evaluate the association of timing of pubertal milestones in offspring with parental ... hiện toàn bộ
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