European Journal of Drug Metabolism and Pharmacokinetics

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Microbial Metabolism of Atovaquone and Cytotoxicity of the Produced Phase I Metabolite
European Journal of Drug Metabolism and Pharmacokinetics - Tập 41 Số 5 - Trang 645-650 - 2016
Eliane de Oliveira Silva, Natália dos Santos Gonçalves, Raquel Santos, Niege Araçari Jacometti Cardoso Furtado
Pharmacokinetics and hepatic uptake of gliquidone affected by Huangqi injection
European Journal of Drug Metabolism and Pharmacokinetics - Tập 39 - Trang 255-261 - 2013
Fan Zhang, Yuhui Wei, Yan Zhou, Dan Wang, Liting Zhou, Jianping Zhang, Xinan Wu
The root of Astragalus membranaceus also known as Huang Qi in China is a common traditional Chinese herb with extensive pharmacological activities. Huangqi injection (HI), a common preparation of Huang Qi, was wildly co-administered with gliquidone to treat diabetes mellitus and diabetic nephropathy in clinic of China. The aim of the study was to investigate the effect of HI on the pharmacokineti...... hiện toàn bộ
Clinical study on the bioequivalence of two tablet formulations of flurbiprofen
European Journal of Drug Metabolism and Pharmacokinetics - Tập 34 - Trang 1-5 - 2009
Latif Ozbay, Durisehvar Ozer Unal, Iclal Cakici, Ayşen Fenercioglu, Dilek Erol
Flurbiprofen (CAS 5104-49-4) is a member of phenylaikanoic acid derivative group of nonsteroid anti-inflammatory drugs. It exhibits anti-inflammatory, analgesic and antipyretic activities. Two different tablets containing flurbiprofen (FLU) were investipted in 24 healthy volunteers to prove the bioequivalence between both treatments after single oral dose administrations. Fluroben® 100 mg tablet a...... hiện toàn bộ
Effect of Curcuma longa on CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects
European Journal of Drug Metabolism and Pharmacokinetics - Tập 40 - Trang 61-66 - 2014
Fahad Ibrahim Al-Jenoobi, Areej A. Al-Thukair, Mohd Aftab Alam, Fawkeya A. Abbas, Abdullah M. Al-Mohizea, Khalid M. Alkharfy, Saleh A. Al-Suwayeh
Effect of Curcuma longa rhizome powder and its ethanolic extract on CYP2D6 and CYP3A4 metabolic activity was investigated in vitro using human liver microsomes and clinically in healthy human subjects. Dextromethorphan (DEX) was used as common probe for CYP2D6 and CYP3A4 enzymes. Metabolic activity of CYP2D6 and CYP3A4 was evaluated through in vitro study; where microsomes were incubated with NAD...... hiện toàn bộ
Pharmacokinetics and metabolism of [3H]-pipethiaden in healthy volunteers
European Journal of Drug Metabolism and Pharmacokinetics - Tập 17 - Trang 89-92 - 1992
Z. Plecitá, M. Španěl, I. ULČ, V. Rejholec, R. Lapka
Six healthy volunteers participated in a single-dose study of pharmacokinetics and metabolism of oral administration of [3H]-pipethiaden (1 mg). Plasma levels of total radioactivity, urinary excretion and metabolism were analyzed by liquid scintillation counting and radio-TLC. The mean peak plasma concentration of radioactive metabolites was 4.9 ng eq/ml, and the mean elimination half life was 11....... hiện toàn bộ
New books
European Journal of Drug Metabolism and Pharmacokinetics - Tập 27 - Trang 141-144 - 2002
Assessment of the sustained release properties of a new oral formulation of trimetazidine in pigs and dogs and confirmation in healthy human volunteers
European Journal of Drug Metabolism and Pharmacokinetics - Tập 29 - Trang 61-68 - 2004
P. Génissel, Y. Chodjania, J. L. Demolis, I. Ragueneau, P. Jaillon
The pharmacokinetics of immediate (IR) and modified release (MR) trimetazidine (TMZ) in dogs and pigs, have been compared under single dose conditions, then predicted at steady-state under conditions mimicking an actual human pharmacokinetics study. In both animal species, the MR tablet has demonstrated sustained release properties, as assessed by delayed time to peak and increased mean absorption...... hiện toàn bộ
Classical Michaelis-Menten and system theory approach to modeling metabolite formation kinetics
European Journal of Drug Metabolism and Pharmacokinetics - Tập 29 - Trang 205-214 - 2004
Jovan Popović
The two compartment open model with Michaelis-Menten elimination kinetics is theorethicaly basic when single doses of drug are administered. To simulate data or to fit real data using this model, one must resort to numerical integration. A biomathematical model for multiple dosage regimen calculations of nonlinear metabolic systems in steady-state and a working example with phenytoin are presented...... hiện toàn bộ
Population Pharmacokinetic Model for Unbound Concentrations of Daptomycin in Patients with MRSA Including Patients Undergoing Hemodialysis
European Journal of Drug Metabolism and Pharmacokinetics - - 2023
Saki Takahashi, Yasuhiro Tsuji, Nick Holford, Chika Ogami, Hidefumi Kasai, Hitoshi Kawasuji, Hideto To, Yoshihiro Yamamoto
Unbound daptomycin concentrations are responsible for pharmacologically beneficial and adverse effects, although most previous reports have been limited to the use of total concentrations. We developed a population pharmacokinetic model to predict both total and unbound daptomycin concentrations. Clinical data were collected from 58 patients with methicillin-resistant Staphylococcus aureus includi...... hiện toàn bộ
Correction to: Safety, Tolerability and Pharmacokinetics of Single Dose Polyethylene Glycolated Exenatide Injection (PB-119) in Healthy Volunteers
European Journal of Drug Metabolism and Pharmacokinetics - Tập 45 Số 3 - Trang 371-371 - 2020
Hong Cui, Caiyun Zhao, Yuan Lv, Min-Ji Wei, Yan Zhu, Yun Li, Yong‐Gang Xia, Yan Liang, Jihong Tian, Pu Zhang
Tổng số: 1,708   
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