European Journal of Drug Metabolism and Pharmacokinetics

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Microbial Metabolism of Atovaquone and Cytotoxicity of the Produced Phase I Metabolite
European Journal of Drug Metabolism and Pharmacokinetics - Tập 41 Số 5 - Trang 645-650 - 2016
Eliane de Oliveira Silva, Natália dos Santos Gonçalves, Raquel Santos, Niege Araçari Jacometti Cardoso Furtado
An attempt to predict daily erythrocyte lithium fluctuations
European Journal of Drug Metabolism and Pharmacokinetics - - 1995
Ö. Sögüt, C. Yalçinkaya, R. Saygili, I. Tuglular, A. Kayali
Erythrocyte lithium concentration, which is a better predictor of brain lithium levels than plasma lithium concentrations, possesses the disadvantage of precise hourly determination following the last intake. The variability in RBC lithium accumulation increases as the extracellular lithium concentration increases. This increase is also time dependent and it would be very useful if the pharmacokin...... hiện toàn bộ
Pharmacokinetics and hepatic uptake of gliquidone affected by Huangqi injection
European Journal of Drug Metabolism and Pharmacokinetics - Tập 39 - Trang 255-261 - 2013
Fan Zhang, Yuhui Wei, Yan Zhou, Dan Wang, Liting Zhou, Jianping Zhang, Xinan Wu
The root of Astragalus membranaceus also known as Huang Qi in China is a common traditional Chinese herb with extensive pharmacological activities. Huangqi injection (HI), a common preparation of Huang Qi, was wildly co-administered with gliquidone to treat diabetes mellitus and diabetic nephropathy in clinic of China. The aim of the study was to investigate the effect of HI on the pharmacokineti...... hiện toàn bộ
Single- and multiple-dose pharmacokinetics of inhaled indacaterol in healthy Chinese volunteers
European Journal of Drug Metabolism and Pharmacokinetics - Tập 40 - Trang 203-208 - 2014
Ji Jiang, Lilly Li, Hequn Yin, Ralph Woessner, Corinne Emotte, Ruobing Li, Sanjeev Khindri, Hu Pei
Indacaterol is an inhaled, ultra–long-acting β2-agonist that provides 24-h bronchodilation with once-daily dosing in patients with chronic obstructive pulmonary disorder. This study evaluated the pharmacokinetics, safety, and tolerability of multiple daily inhaled doses of indacaterol 150 or 300 μg once daily in healthy Chinese volunteers. This was a single-center, randomized, double-blind, multip...... hiện toàn bộ
Clinical study on the bioequivalence of two tablet formulations of flurbiprofen
European Journal of Drug Metabolism and Pharmacokinetics - Tập 34 - Trang 1-5 - 2009
Latif Ozbay, Durisehvar Ozer Unal, Iclal Cakici, Ayşen Fenercioglu, Dilek Erol
Flurbiprofen (CAS 5104-49-4) is a member of phenylaikanoic acid derivative group of nonsteroid anti-inflammatory drugs. It exhibits anti-inflammatory, analgesic and antipyretic activities. Two different tablets containing flurbiprofen (FLU) were investipted in 24 healthy volunteers to prove the bioequivalence between both treatments after single oral dose administrations. Fluroben® 100 mg tablet a...... hiện toàn bộ
Comparison of the rapidity of onset of the therapeutic effect between nateglinide and mitiglinide by PK/PD analysis in rats
European Journal of Drug Metabolism and Pharmacokinetics - Tập 37 - Trang 9-15 - 2011
Toshiyuki Takanohashi, Harumi Arisaka, Kazuyuki Ubukata, Masahiro Hayashi, Yasuhiko Yamada
Nateglinide and mitiglinide are immediate short-acting insulinotropic agents. Both are administered preprandially to control postprandial hyperglycemia. Glinide drugs are characterized by immediate onset as well as rapid disappearance of effect as compared with sulfonylurea drugs. We examined the rapidity of onset of the therapeutic effect between nateglinide and mitiglinide by pharmacokinetic/pha...... hiện toàn bộ
Effect of Curcuma longa on CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects
European Journal of Drug Metabolism and Pharmacokinetics - Tập 40 - Trang 61-66 - 2014
Fahad Ibrahim Al-Jenoobi, Areej A. Al-Thukair, Mohd Aftab Alam, Fawkeya A. Abbas, Abdullah M. Al-Mohizea, Khalid M. Alkharfy, Saleh A. Al-Suwayeh
Effect of Curcuma longa rhizome powder and its ethanolic extract on CYP2D6 and CYP3A4 metabolic activity was investigated in vitro using human liver microsomes and clinically in healthy human subjects. Dextromethorphan (DEX) was used as common probe for CYP2D6 and CYP3A4 enzymes. Metabolic activity of CYP2D6 and CYP3A4 was evaluated through in vitro study; where microsomes were incubated with NAD...... hiện toàn bộ
Rapid Brain Distribution of Subcutaneously Administered Methamphetamine in Mice
European Journal of Drug Metabolism and Pharmacokinetics - Tập 48 - Trang 115-118 - 2022
Greg Gorman, Lori Coward, Michael D. Hambuchen
Pharmacokinetics and metabolism of [3H]-pipethiaden in healthy volunteers
European Journal of Drug Metabolism and Pharmacokinetics - Tập 17 - Trang 89-92 - 1992
Z. Plecitá, M. Španěl, I. ULČ, V. Rejholec, R. Lapka
Six healthy volunteers participated in a single-dose study of pharmacokinetics and metabolism of oral administration of [3H]-pipethiaden (1 mg). Plasma levels of total radioactivity, urinary excretion and metabolism were analyzed by liquid scintillation counting and radio-TLC. The mean peak plasma concentration of radioactive metabolites was 4.9 ng eq/ml, and the mean elimination half life was 11....... hiện toàn bộ
Herb-drug interaction between irinotecan and psoralidin-containing herbs
European Journal of Drug Metabolism and Pharmacokinetics - Tập 40 - Trang 481-484 - 2014
Xi-Shan Zhang, Zhi-Qiang Zhao, Zhen-Sheng Qin, Kun Wu, Tian-Fang Xia, Li-Qun Pang
Herb-drug interaction strongly limits the clinical utilization of herbs and drugs. Irinotecan-induced diarrhea is closely related with the UDP-glucuronosyltransferase 1A1-catalyzed glucuronidation of SN-38 which has been widely regarded to be the toxic substance basis of irinotecan. The present study aims to determine the influence of herbal component psoralidin toward the toxicity of irinotecan. ...... hiện toàn bộ
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