European Journal of Clinical Pharmacology

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Is cyclosporine A transport inhibited by pravastatin via multidrug resistant protein 2?
European Journal of Clinical Pharmacology - Tập 66 Số 2 - Trang 153-158 - 2010
Ryuichi Kato, Mami Nishide, Chihiro Kozu, Asuka Iwamoto, Kazuya Urashima, Kaoru Suzuki, Yoshio Ijiri, Toshio Hayashi, Kazuhiko Tanaka
Comparative bioavailability of two different rectal preparations of piroxicam in man
European Journal of Clinical Pharmacology - Tập 43 - Trang 315-317 - 1992
S. Benkö, G. Grézal, É. Nagy, I. Klebovich
A comparative pharmacokinetic study was performed with two types of suppository each containing 20 mg piroxicam. The bioavailability of piroxicam was studied in 24 healthy volunteers in a double blind, randomised, cross over study. No significant difference was found in the pharmacokinetic parameters [AUC(0–72 h), AUC, Cmax, t1/2β calculated from plasma concentration time curves, indicating that t...... hiện toàn bộ
Excretion of methylproscillaridin in patients with a biliary fistula
European Journal of Clinical Pharmacology - - 1975
R. Staud, N. Rietbrock, H. P. Fassbender
Four patients with a biliary fistula received 0.5 mg3H-methylproscillaridin as a single oral dose. 55% of the dose was excreted in bile, 16% in urine and 3% in faeces. More than 60% of the radioactivity excreted in bile and urine appeared within the first 24 hours. 78% of the radioactivity in bile consisted of CHCl3-insoluble metabolites of methylproscillaridin, incubation of which with β-glucuron...... hiện toàn bộ
The regulatory control of non-steroidal anti-inflammatory agents
European Journal of Clinical Pharmacology - - 1981
M. N. G. Dukes, I. Lunde
The number of marketed non-steroidal anti-inflammatory agents varies widely from one European country to another, partly as a consequence of differing regulatory policies. During a four-year period, nine of 18 applications to market such drugs in the Netherlands failed; the remaining nine compounds were all licenced; in all, 22 single drug entities of this type are currently on sale. In Norway dur...... hiện toàn bộ
Pharmacokinetics of oxypolygelatine in healthy volunteers
European Journal of Clinical Pharmacology - Tập 55 - Trang 49-51 - 1999
P. A. Thürmann, R. Lissner, W. G. Struff, S. Harder
Objective/methods: The pharmacokinetics of the plasma substitute oxypolygelatine (OPG) were studied in 12 healthy volunteers after single-dose administration of 27 ml · kg−1 body weight, with a maximum of 2000 ml. OPG was determined in plasma and urine over 48 h after the infusion. Peak plasma OPG concentrations at the end of the infusion were determined to 4.600 (623) μg...... hiện toàn bộ
Influences of ABC transporter and CYP3A4/5 genetic polymorphisms on the pharmacokinetics of lenvatinib in Chinese healthy subjects
European Journal of Clinical Pharmacology - Tập 76 - Trang 1125-1133 - 2020
Jiaming Li, Xiaoqian Wang, Chen Ning, Zhaoyu Wang, Yao Wang, Ming Zheng, Siliang Zhang, Yang Lu, Yongjie Zhang, Ning Li, Xijing Chen, Di Zhao
To investigate whether the CYP3A4/5 and ABC transporter genetic polymorphisms could affect the pharmacokinetics of lenvatinib in Chinese healthy subjects. Thirty-two healthy Chinese volunteers were enrolled and took oral administration of 8 mg lenvatinib. Plasma concentration of lenvatinib was determined by UPLC-MS/MS, the CYP3A4*1G, CYP3A5*3, ABCB1 (3435 C>T, 1236 C>T, 2677 G>T/A), ABCG2 (421 C>A...... hiện toàn bộ
Bile acid is important for gastrointestinal absorption of nilotinib
European Journal of Clinical Pharmacology - Tập 68 - Trang 1575-1576 - 2012
Akihito Fujimi, Naoto Takahashi, Masatomo Miura, Yuji Kanisawa, Kaoru Ono, Kenichi Sawada
Teaching clinical pharmacology and therapeutics with an emphasis on the therapeutic reasoning of undergraduate medical students
European Journal of Clinical Pharmacology - Tập 64 - Trang 217-224 - 2008
Milan C. Richir, Jelle Tichelaar, Eric C. T. Geijteman, Theo P. G. M. de Vries
The rational prescribing of drugs is an essential skill of medical doctors. Clinical pharmacologists play an important role in the development of these skills by teaching clinical pharmacology and therapeutics (CP&T) to undergraduate medical students. Although the approaches to teaching CP&T have undergone many changes over the last decennia, it is essential that the actual teaching of CP&T contin...... hiện toàn bộ
Cardiac arrhythmias as correlated with the circadian rhythm of arterial pressure in hypertensive subjects with and without left ventricular hypertrophy
European Journal of Clinical Pharmacology - Tập 39 - Trang S49-S51 - 1990
S. Novo, M. Barbagallo, M. G. Abrignani, G. Alaimo, E. Nardi, S. Corrao, C. Papadia, A. Strano
To evaluate the relationship among supraventricular and ventricular arrhythmias with blood pressure and heart rate (HR) values, we studied 2 groups of 20 hypertensive men with (group I) and without (group II) left ventricular hypertrophy. Ambulatory electrocardiographic tracings were recorded continuously, together with ambulatory arterial pressure. Systolic (SBP) and diastolic (DBP) blood pressur...... hiện toàn bộ
Pharmacokinetics of ketoprofen following oral and intramuscular administration in young children
European Journal of Clinical Pharmacology - Tập 57 - Trang 643-647 - 2014
Hannu Kokki, Henri Tuomilehto, Marko Karvinen
Objective: The pharmacokinetics of ketoprofen following intramuscular injection or oral tablet was determined in children aged 10–69 months. Methods: Ten children received a single intramuscular injection of 1 mg kg–1 ketoprofen. Six children, weight 12–17 kg, received a 12.5-mg ketoprofen tablet and four children, weight 18–23 kg, received a 25-mg tablet. Venous blood samples wer...... hiện toàn bộ
Tổng số: 7,014   
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