European Journal of Clinical Pharmacology
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Pharmacokinetics and dialysability of isradipine in chronic haemodialysis patients
European Journal of Clinical Pharmacology - Tập 42 - Trang 231-233 - 1992
The pharmacokinetics of isradipine, a calcium-channel blocker, have been studied in eight patients on chronic haemodialysis. A single oral dose of 5 mg was administered on both a non-haemodialysis and a haemodialysis day and the plasma concentrations of isradipine were analyzed. The mean cmax, tmax, AUC, and t1/2 in plasma on the non-haemodialysis day were 5.2 ng·ml−1, 1.4 h, 23.8 ng·h·ml−1, and 3......
Converting cyclosporine A from intravenous to oral administration in hematopoietic stem cell transplant recipients and the role of azole antifungals
European Journal of Clinical Pharmacology - - 2018
Population pharmacokinetics of bisoprolol in patients with chronic heart failure
European Journal of Clinical Pharmacology - Tập 69 - Trang 859-865 - 2012
The aim of the study was to develop a population pharmacokinetic (PK) model for clearance of bisoprolol in patients with congestive heart failure (CHF). Parameters associated with the plasma concentrations of bisoprolol at steady-state were analyzed in 61 patients (mean age 66.21 ± 9.49 years; mean total body weight 8.90 ± 12.26 kg) with CHF using non-linear mixed-effect modeling (NONMEM). A valid......
Paracetamol versus placebo: Effects on post-operative course
European Journal of Clinical Pharmacology - Tập 15 Số 1 - Trang 27-33 - 1979
Comparative evaluation of intravenous phenytoin, procainamide and practolol in the acute treatment of ventricular arrhythmias
European Journal of Clinical Pharmacology - Tập 11 - Trang 1-6 - 1977
Ten patients with a persistent ventricular arrhythmia, but no other sign of heart disease, were studied by means of an exercise test performed 4 times with a fixed work load, over 30–40 min. No drug was given in the first exercise test and in the others phenytoin, procainamide or practolol were chosen at random for i. v. administration. Blood samples for determination of plasma concentration were ......
A clinically relevant pharmacokinetic interaction between cyclosporine and imatinib
European Journal of Clinical Pharmacology - - 2016
Cyclosporine A (CsA) and imatinib are both CYP3A4 and P-glycoprotein substrates. Concomitant use after hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML) or Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (ALL) may therefore result in a pharmacokinetic interaction. Although case reports and a recent small study in children indeed suggested there is a ......
Components of variability in serum theophylline concentrations during maintenance therapy with a sustained release formulation
European Journal of Clinical Pharmacology - Tập 23 - Trang 225-228 - 1982
Fifteen adult chronic asthmatic patients were studied on 6 consecutive days of the second week of treatment with a new sustained release theophylline formulation, and 8 were again studied after three months on the same dosing regimen (375 mg b.i.d.). Serum theophylline concentrations were maintained in the therapeutic range (peak −19.7±5.0 µg/ml; through −13.0±3.2 µg/ml) throughout the 12 hour dos......
Relationship between hemoglobin levels and vancomycin clearance in patients with sepsis
European Journal of Clinical Pharmacology - Tập 75 Số 7 - Trang 929-937 - 2019
Tổng số: 7,012
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