A clinically relevant pharmacokinetic interaction between cyclosporine and imatinibEuropean Journal of Clinical Pharmacology - - 2016
Ferdows Atiq, Annoek E C Broers, Louise M Andrews, Jeanette K Doorduijn, Birgit C P Koch, Teun Van Gelder, Jorie Versmissen
Cyclosporine A (CsA) and imatinib are both CYP3A4 and P-glycoprotein substrates. Concomitant use after hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML) or Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (ALL) may therefore result in a pharmacokinetic interaction. Although case reports and a recent small study in children indeed suggested there is a ...... hiện toàn bộ
Relationship between hemoglobin levels and vancomycin clearance in patients with sepsisEuropean Journal of Clinical Pharmacology - Tập 75 Số 7 - Trang 929-937 - 2019
Masayuki Chuma, Makoto Makishima, Toru Imai, Naohiro Tochikura, Shinichiro Suzuki, Tsukasa Kuwana, Nami Sawada, So Iwabuchi, Masao Sekimoto, Takahiro Nakayama, Takako Sakaue, Norikazu Kikuchi, Yoshikazu Yoshida, Kosaku Kinoshita
AnnouncementsEuropean Journal of Clinical Pharmacology - Tập 38 - Trang 212-212 - 1990
Lack of effect of cimetidine on the pharmacokinetics and metabolism of a single oral dose of metronidazoleEuropean Journal of Clinical Pharmacology - Tập 35 - Trang 65-68 - 1988
S. Loft, M. Døssing, J. Sonne, K. Dalhof, K. Bjerrum, H. E. Poulsen
The time course of the effect of cimetidine on the pharmacokinetics of metronidazole was investigated in 6 healthy volunteers. Cimetidine 1.0 g/day was administered for 9-days and metronidazole 500 mg was administered orally on the second and eighth days, and in a control experiment. During cimetidine treatment the plasma kinetics of metronidazole and its partial clearance by renal excretion of th...... hiện toàn bộ
Drug safety of macrolide and quinolone antibiotics in a tertiary care hospital: administration of interacting co-medication and QT prolongationEuropean Journal of Clinical Pharmacology - Tập 72 - Trang 859-867 - 2016
David Niedrig, Sarah Maechler, Liesa Hoppe, Natascia Corti, Helen Kovari, Stefan Russmann
Some macrolide and quinolone antibiotics (MQABs) are associated with QT prolongation and life-threatening torsade de pointes (TdP) arrhythmia. MQAB may also inhibit cytochrome P450 isoenzymes and thereby cause pharmacokinetic drug interactions (DDIs). There is limited data on the frequency and management of such risks in clinical practice. We aimed to quantify co-administration of MQAB with intera...... hiện toàn bộ