European Journal of Clinical Pharmacology

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Pharmacokinetics and dialysability of isradipine in chronic haemodialysis patients
European Journal of Clinical Pharmacology - Tập 42 - Trang 231-233 - 1992
K. Schönholzer, C. Marone
The pharmacokinetics of isradipine, a calcium-channel blocker, have been studied in eight patients on chronic haemodialysis. A single oral dose of 5 mg was administered on both a non-haemodialysis and a haemodialysis day and the plasma concentrations of isradipine were analyzed. The mean cmax, tmax, AUC, and t1/2 in plasma on the non-haemodialysis day were 5.2 ng·ml−1, 1.4 h, 23.8 ng·h·ml−1, and 3...... hiện toàn bộ
Recommended drug use after acute myocardial infarction by migration status and education level
European Journal of Clinical Pharmacology - - 2015
Dashti Ali Mustafa Dzayee, Tahereh Moradi, Omid Beiki, Lars Alfredsson, Rickard Ljung
The purpose of this study is to investigate the association between migration status and education level and the use of recommended drugs after first acute myocardial infarction (MI). A nationwide cohort study performed in Sweden from January 1, 2006 to August 1, 2008. The cohort consisted of 49,037 incident cases of first acute MI. In total, 37,570 individuals survived 180 days after MI, of whom ...... hiện toàn bộ
Converting cyclosporine A from intravenous to oral administration in hematopoietic stem cell transplant recipients and the role of azole antifungals
European Journal of Clinical Pharmacology - - 2018
Ferdows Atiq, Edon Hameli, Annoek E.C. Broers, Jeanette K. Doorduijn, Teun van Gelder, Louise M. Andrews, Birgit C. P. Koch, Jorie Versmissen, Brenda C M de Winter
Individual variation in the response to phenprocoumon
European Journal of Clinical Pharmacology - Tập 11 - Trang 351-358 - 1977
S. Husted, F. Andreasen
In nine patients, the synthesis rate Rsyn of the vitamin K-dependent clotting factors was calculated from changes in prothrombin-complex activity after intravenous administration of a synthesis-blocking dose of phenprocoumon (PPC). The biological half-life of PPC was between 2.70 and 7.01 days. No correlation was found between the level of the free fraction of this strongly protein-bound drug and ...... hiện toàn bộ
Population pharmacokinetics of bisoprolol in patients with chronic heart failure
European Journal of Clinical Pharmacology - Tập 69 - Trang 859-865 - 2012
Valentina N. Nikolic, Tatjana Jevtovic-Stoimenov, Radmila Velickovic-Radovanović, Stevan Ilic, Marina Deljanin-Ilic, Dragan Marinkovic, Svetlana Apostolović, Dragana Stanojevic, Slavoljub Zivanovic, Nikola Stefanovic, Srdjan Pesic, Dejana Ruzic Zecevic, Jasmina R. Milovanovic, Slobodan M. Jankovic
The aim of the study was to develop a population pharmacokinetic (PK) model for clearance of bisoprolol in patients with congestive heart failure (CHF). Parameters associated with the plasma concentrations of bisoprolol at steady-state were analyzed in 61 patients (mean age 66.21 ± 9.49 years; mean total body weight 8.90 ± 12.26 kg) with CHF using non-linear mixed-effect modeling (NONMEM). A valid...... hiện toàn bộ
Paracetamol versus placebo: Effects on post-operative course
European Journal of Clinical Pharmacology - Tập 15 Số 1 - Trang 27-33 - 1979
Per Skjelbred, P Løkken
Announcements
European Journal of Clinical Pharmacology - Tập 28 - Trang 108-108 - 1985
Comparative evaluation of intravenous phenytoin, procainamide and practolol in the acute treatment of ventricular arrhythmias
European Journal of Clinical Pharmacology - Tập 11 - Trang 1-6 - 1977
E. Karlsson, A. Kinman, C. Sonnhag
Ten patients with a persistent ventricular arrhythmia, but no other sign of heart disease, were studied by means of an exercise test performed 4 times with a fixed work load, over 30–40 min. No drug was given in the first exercise test and in the others phenytoin, procainamide or practolol were chosen at random for i. v. administration. Blood samples for determination of plasma concentration were ...... hiện toàn bộ
CYP1A2 genotype affects carbamazepine pharmacokinetics in children with epilepsy
European Journal of Clinical Pharmacology - Tập 72 - Trang 439-445 - 2016
Natasa Djordjevic, Dragana Dragas Milovanovic, Marija Radovanovic, Ivan Radosavljevic, Slobodan Obradovic, Mihajlo Jakovljevic, Dragan Milovanovic, Jasmina R. Milovanovic, Slobodan Jankovic
The purpose of this study is to investigate the effect of two of the most important functional CYP1A2 variations −3860G > A and −163C > A on carbamazepine pharmacokinetics in Serbian pediatric epileptic patients. The study involved 40 Serbian pediatric epileptic patients on steady-state carbamazepine treatment. Genotyping for −3860G > A and −163C > A was carried out using PCR-RFLP method, and carb...... hiện toàn bộ
A clinically relevant pharmacokinetic interaction between cyclosporine and imatinib
European Journal of Clinical Pharmacology - - 2016
Ferdows Atiq, Annoek E C Broers, Louise M Andrews, Jeanette K Doorduijn, Birgit C P Koch, Teun Van Gelder, Jorie Versmissen
Cyclosporine A (CsA) and imatinib are both CYP3A4 and P-glycoprotein substrates. Concomitant use after hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML) or Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (ALL) may therefore result in a pharmacokinetic interaction. Although case reports and a recent small study in children indeed suggested there is a ...... hiện toàn bộ
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