Systemic Administration of C-Type Natriuretic Peptide as a Novel Therapeutic Strategy for Skeletal DysplasiasEndocrinology - Tập 150 Số 7 - Trang 3138-3144 - 2009
Akihiro Yasoda, Hidetomo Kitamura, Toshihito Fujii, Eri Kondo, Naoaki Murao, Masako Miura, Naotetsu Kanamoto, Yasato Komatsu, Hiroshi Arai, Kazuwa Nakao
Skeletal dysplasias are a group of genetic disorders characterized by severe impairment of bone growth. Various forms of them add to produce a significant morbidity and mortality, yet no efficient drug therapy has been developed to date. We previously demonstrated that C-type natriuretic peptide (CNP), a member of the natriuretic peptide family, is a potent stimulator of endochondral bone ...... hiện toàn bộ