Endocrine-Related Cancer

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
The dual role of filamin A in cancer: can't live with (too much of) it, can't live without it
Endocrine-Related Cancer - Tập 20 Số 6 - Trang R341-R356 - 2013
Rosalinda M Savoy, P. Ghosh
Filamin A (FlnA) has been associated with actin as cytoskeleton regulator. Recently its role in the cell has come under scrutiny for FlnA's involvement in cancer development. FlnA was originally revealed as a cancer-promoting protein, involved in invasion and metastasis. However, recent studies have also found that under certain conditions, it prevented tumor formation or progression, conf...... hiện toàn bộ
Telotristat ethyl in carcinoid syndrome: safety and efficacy in the TELECAST phase 3 trial
Endocrine-Related Cancer - Tập 25 Số 3 - Trang 309-322 - 2018
Marianne Pavel, David J. Gross, Marta Benavent, Petros Perros, Rajaventhan Srirajaskanthan, Richard R.P. Warner, Matthew H. Kulke, Lowell Anthony, Pamela L. Kunz, Dieter Hörsch, Martin O. Weickert, Pablo Lapuerta, Wenjun Jiang, Kenneth Kassler-Taub, Suman Wason, Rosanna Fleming, Douglas Fleming, Rocio García‐Carbonero
Telotristat ethyl, a tryptophan hydroxylase inhibitor, was efficacious and well tolerated in the phase 3 TELESTAR study in patients with carcinoid syndrome (CS) experiencing ≥4 bowel movements per day (BMs/day) while on somatostatin analogs (SSAs). TELECAST, a phase 3 companion study, assessed the safety and efficacy of telotristat ethyl in patients with CS (diarrhea, flushing, abdominal p...... hiện toàn bộ
Phase II clinical trial of pasireotide long-acting repeatable in patients with metastatic neuroendocrine tumors
Endocrine-Related Cancer - Tập 22 Số 1 - Trang 1-9 - 2015
Mauro Cives, Pamela L. Kunz, Brian Morse, Domenico Coppola, Michael J. Schell, Tiffany Campos, Phuong Nguyen, Prachi Nandoskar, Vilay H. Khandelwal, Jonathan Strosberg
Pasireotide long-acting repeatable (LAR) is a novel somatostatin analog (SSA) with avid binding affinity to somatostatin receptor subtypes 1, 2, 3 (SSTR1,2,3) and 5 (SSTR5). Results from preclinical studies indicate that pasireotide can inhibit neuroendocrine tumor (NET) growth more robustly than octreotidein vitro. This ...... hiện toàn bộ
Blood and tissue neuroendocrine tumor gene cluster analysis correlate, define hallmarks and predict disease status
Endocrine-Related Cancer - Tập 22 Số 4 - Trang 561-575 - 2015
Mark Kidd, Ignat Drozdov, Irvin M. Modlin
A multianalyte algorithmic assay (MAAA) identifies circulating neuroendocrine tumor (NET) transcripts (n=51) with a sensitivity/specificity of 98%/97%. We evaluated whether blood measurements correlated with tumor tissue transcript analysis. The latter were segregated into gene clusters (GC) that defined clinical ‘hallmarks’ of neoplasia. A MAAA/cluster integrate...... hiện toàn bộ
Predictive factors of efficacy of the somatostatin analogue octreotide as first line therapy for advanced pancreatic endocrine carcinoma
Endocrine-Related Cancer - Tập 13 Số 4 - Trang 1213-1221 - 2006
Giovanni Capretti, Rossella Bettini, Edoardo Missiaglia, William Mantovani, Irene Dalai, P. Capelli, M Ferdeghini, P. Pederzoli, Aldo Scarpa, Massimo Falconi
About 40% of nonfunctioning pancreatic endocrine carcinomas (NF-PEC) cannot be cured by surgery due to advanced stage disease. Somatostatin analogues have been proposed as first line therapy in these cases. We performed a prospective phase IV study to assess the efficacy of octreotide in advanced NF-PEC and identify factors predictive of response to therapy. Twenty-one consecutive patients...... hiện toàn bộ
Status of aromatase inhibitors in relation to other breast cancer treatment modalities.
Endocrine-Related Cancer - - Trang 277-291 - 1999
Joseph Ragaz
Aromatase is one of the key enzymes possibly linked with the perpetuation or even initiation of breast cancer. Modulation of its activity by the new generation inhibitors has resulted in increased responses and improved therapeutic ratio compared with those of parent aromatase inhibitors. More recent trials have shown promising results with regard to improved therapeutic ratio compared wit...... hiện toàn bộ
Differentiated thyroid carcinoma: defining new paradigms for postoperative management
Endocrine-Related Cancer - Tập 20 Số 4 - Trang R141-R154 - 2013
Cosimo Durante, Giuseppe Costante, Sébastiano Filetti
The demography of differentiated thyroid cancers (DTCs) has changed considerably since the 1990s, when the vast majority of these tumors were clinically evident at the time of diagnosis, and many were associated with regional lymph node involvement. Today's DTCs are more likely to be small, localized, asymptomatic papillary forms that are discovered incidentally, during neck imaging proced...... hiện toàn bộ
Molecular pathways mediating the anti-inflammatory effects of calcitriol: implications for prostate cancer chemoprevention and treatment
Endocrine-Related Cancer - Tập 17 Số 1 - Trang R19-R38 - 2010
Aruna V. Krishnan, David Feldman
Calcitriol, the hormonally active form of vitamin D, exerts multiple anti-proliferative and pro-differentiating actions including cell cycle arrest and induction of apoptosis in many malignant cells, and the hormone is currently being evaluated in clinical trials as an anti-cancer agent. Recent research reveals that calcitriol also exhibits multiple anti-inflammatory effects. First, calcit...... hiện toàn bộ
Clinical outcome of 50 patients with malignant abdominal paragangliomas and malignant pheochromocytomas
Endocrine-Related Cancer - Tập 5 Số 1 - Trang 59-68 - 1998
Rena Vassilopoulou‐Sellin
Molecular changes associated with the agonist activity of hydroxy-tamoxifen and the hyper-response to estradiol in hydroxy-tamoxifen-resistant breast cancer cell lines
Endocrine-Related Cancer - Tập 12 Số 1 - Trang 75-92 - 2005
Julie A. Vendrell, Ivan Bièche, Catherine Desmetz, Éric Badia, Sengül Tozlu, Catherine Nguyen, W Rozenbaum, Rosette Lidereau, Pascale A. Cohen
The aim of this study was to explore the pharmacological response to 4-hydroxy-tamoxifen (OH-Tam) and to estradiol (E2) in three cell lines: MVLN, a human breast carcinoma cell line derived from MCF-7, and two MVLN-derived OH-Tam-resistant (OTR) cell lines, called CL6.8 and CL6.32. The OH-Tam response in the OTR cells was associated with the development of both an agon...... hiện toàn bộ
Tổng số: 65   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7