Elsevier BV
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Sắp xếp:
Targeting Neuroprotection as an Alternative Approach to Preventing and Treating Neuropathic Pain
Elsevier BV - Tập 6 - Trang 648-662 - 2009
Therapeutic Antibodies in Neurological Diseases: Witnessing the Continuation of the Impressive Success in Neuro-Immunotherapies
Elsevier BV - Tập 19 - Trang 687-690 - 2022
Cognitive Training in Parkinson’s Disease Induces Local, Not Global, Changes in White Matter Microstructure
Elsevier BV - - 2021
Previous studies showed that cognitive training can improve cognitive performance in various neurodegenerative diseases but little is known about the effects of cognitive training on the brain. Here, we investigated the effects of our cognitive training paradigm, COGTIPS, on regional white matter microstructure and structural network topology. We previously showed that COGTIPS has small, positive ...... hiện toàn bộ
Pharmacological BACE Inhibition Improves Axonal Regeneration in Nerve Injury and Disease Models
Elsevier BV - Tập 17 - Trang 973-988 - 2020
While the peripheral nervous system is able to repair itself following injury and disease, recovery is often slow and incomplete, with no available treatments to enhance the effectiveness of regeneration. Using knock-out and transgenic overexpressor mice, we previously reported that BACE1, an aspartyl protease, as reported by Hemming et al. (PLoS One 4:12, 2009), negatively regulates peripheral ne...... hiện toàn bộ
Long Noncoding RNA POU3F3 and α-Synuclein in Plasma L1CAM Exosomes Combined with β-Glucocerebrosidase Activity: Potential Predictors of Parkinson’s Disease
Elsevier BV - Tập 17 - Trang 1104-1119 - 2020
Long noncoding RNAs (lncRNAs) are implicated in the autophagic-lysosomal pathway (ALP) and are closely linked to Parkinson’s disease (PD) pathology. β-Glucocerebrosidase (GCase) has also been reported to be correlated with α-synuclein (α-syn) proteostasis. However, lncRNAs and α-syn in neural-derived L1CAM exosomes and GCase activity in the plasma of PD patients have not been studied. This study u...... hiện toàn bộ
The physician—patient relationship in dementia care
Elsevier BV - Tập 4 - Trang 545-548 - 2007
Medical care of patients with dementia often occurs within a physician—patient relationship whose features differ from relationships with patients without dementia. Many basic assumptions of the physician—patient relationship may not completely hold true, and certain aspects of the patient role may be shared by others besides the patient. For example, the entire premise of consent to the patient r...... hiện toàn bộ
A Novel Second-Generation EP2 Receptor Antagonist Reduces Neuroinflammation and Gliosis After Status Epilepticus in Rats
Elsevier BV - Tập 18 - Trang 1207-1225 - 2021
Prostaglandin-E2 (PGE2), an important mediator of inflammation, achieves its functions via four different G protein–coupled receptors (EP1, EP2, EP3, and EP4). We previously demonstrated that the EP2 receptor plays a proinflammatory and neurodegenerative role after status epilepticus (SE). We recently developed TG8-260 as a second-generation highly potent and selective EP2 antagonist. Here, we inv...... hiện toàn bộ
DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases
Elsevier BV - Tập 18 - Trang 1710-1728 - 2021
CAG repeat expansion is the genetic cause of nine incurable polyglutamine (polyQ) diseases with neurodegenerative features. Silencing repeat RNA holds great therapeutic value. Here, we developed a repeat-based RNA-cleaving DNAzyme that catalyzes the destruction of expanded CAG repeat RNA of six polyQ diseases with high potency. DNAzyme preferentially cleaved the expanded allele in spinocerebellar ...... hiện toàn bộ
Platform Presentation—Longitudinal Structural MRI Data from PREDICT-HD: Striatal and Cortical Changes in Pre-Clinical HD
Elsevier BV - Tập 6 Số 1 - Trang 202-203 - 2009
Ketone bodies as a therapeutic for Alzheimer’s disease
Elsevier BV - Tập 5 - Trang 470-480 - 2008
An early feature of Alzheimer’s disease (AD) is region-specific declines in brain glucose metabolism. Unlike other tissues in the body, the brain does not efficiently metabolize fats; hence the adult human brain relies almost exclusively on glucose as an energy substrate. Therefore, inhibition of glucose metabolism can have profound effects on brain function. The hypometabolism seen in AD has rece...... hiện toàn bộ
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