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Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice
Elsevier BV - - 2018
Christian Griñán-Ferré, Foteini Vasilopoulou, Sònia Abás, Sergio Rodríguez-Arévalo, Andrea Bagán, Francesc X. Sureda, Belén Pérez, Luis F. Callado, Jesús A. García-Sevilla, M. Julia García-Fuster, Carmen Escolano, Mercè Pallàs
As populations increase their life expectancy, age-related neurodegenerative disorders such as Alzheimer’s disease have become more common. I2-Imidazoline receptors (I2-IR) are widely distributed in the central nervous system, and dysregulation of I2-IR in patients with neurodegenerative diseases has been reported, suggesting their implication in cognitive impairment. This evidence indicates that ... hiện toàn bộ
Issues in the Treatment of Neurological Conditions Caused by Reactivation of Varicella Zoster Virus (VZV)
Elsevier BV - Tập 13 - Trang 509-513 - 2016
Peter G. E. Kennedy
Varicella zoster virus (VZV) is a ubiquitous neurotropic human herpesvirus. Primary infection usually causes varicella (chicken pox), after which virus becomes latent in ganglia along the entire neuraxis. Decades later, virus reactivates to produce herpes zoster (shingles), a painful dermatomally distributed vesicular eruption. Zoster may be further complicated by postherpetic neuralgia, VZV vascu... hiện toàn bộ
Dravet Syndrome: Novel Approaches for the Most Common Genetic Epilepsy
Elsevier BV - - 2021
Lori L. Isom, Kelly G. Knupp
Pompe Disease: From Basic Science to Therapy
Elsevier BV - Tập 15 - Trang 928-942 - 2018
Lara Kohler, Rosa Puertollano, Nina Raben
Pompe disease is a rare and deadly muscle disorder. As a clinical entity, the disease has been known for over 75 years. While an optimist might be excited about the advances made during this time, a pessimist would note that we have yet to find a cure. However, both sides would agree that many findings in basic science—such as the Nobel prize-winning discoveries of glycogen metabolism, the lysosom... hiện toàn bộ
Treating Traumatic Brain Injury with Minocycline
Elsevier BV - Tập 20 - Trang 1546-1564 - 2023
Peter J. Bergold, Rachel Furhang, Siobhán Lawless
Traumatic brain injury (TBI) results in both rapid and delayed brain damage. The speed, complexity, and persistence of TBI present large obstacles to drug development. Preclinical studies from multiple laboratories have tested the FDA-approved anti-microbial drug minocycline (MINO) to treat traumatic brain injury. At concentrations greater than needed for anti-microbial action, MINO readily inhibi... hiện toàn bộ
Dual HDAC/BRD4 Inhibitors Relieves Neuropathic Pain by Attenuating Inflammatory Response in Microglia After Spared Nerve Injury
Elsevier BV - Tập 19 - Trang 1634-1648 - 2022
Vittoria Borgonetti, Elisabetta Meacci, Federica Pierucci, Maria Novella Romanelli, Nicoletta Galeotti
Despite the effort on developing new treatments, therapy for neuropathic pain is still a clinical challenge and combination therapy regimes of two or more drugs are often needed to improve efficacy. Accumulating evidence shows an altered expression and activity of histone acetylation enzymes in chronic pain conditions and restoration of these aberrant epigenetic modifications promotes pain-relievi... hiện toàn bộ
Correction to: Current Perspectives on Aerobic Exercise in People with Parkinson’s Disease
Elsevier BV - - 2022
Sabine Schootemeijer, Nicolien M. van der Kolk, Bastiaan R. Bloem, Nienke M. de Vries
The Use of Pharmacological Retromer Chaperones in Alzheimer’s Disease and other Endosomal-related Disorders
Elsevier BV - Tập 12 - Trang 12-18 - 2014
Diego E. Berman, Dagmar Ringe, Greg A. Petsko, Scott A. Small
The retromer is an evolutionary conserved multiprotein complex involved in the sorting and retrograde trafficking of cargo from endosomal compartments to the Golgi network and to the cell surface. The neuronal retromer traffics the amyloid precursor protein away from the endosomes, a site where amyloid precursor protein is enzymatically cleaved into pathogenic fragments in Alzheimer’s disease. In ... hiện toàn bộ
Betulinic Acid Hydroxamate is Neuroprotective and Induces Protein Phosphatase 2A-Dependent HIF-1α Stabilization and Post-transcriptional Dephosphorylation of Prolyl Hydrolase 2
Elsevier BV - Tập 18 - Trang 1849-1861 - 2021
María E. Prados, Alejandro Correa-Sáez, Juan D. Unciti-Broceta, Martín Garrido-Rodríguez, Carla Jimenez-Jimenez, Massimiliano Mazzone, Alberto Minassi, Giovanni Appendino, Marco A. Calzado, Eduardo Muñoz
Huntington’s disease (HD) is a neurodegenerative disorder characterized by unwanted choreatic movements, behavioral and psychiatric disturbances, and dementia. The activation of the hypoxic response pathway through the pharmacological inhibition of hypoxia-inducing factor (HIF) prolyl-hydroxylases (PHDs) is a promising approach for neurodegenerative diseases, including HD. Herein, we have studied ... hiện toàn bộ
Targeting Mitochondrial Function for the Treatment of Acute Spinal Cord Injury
Elsevier BV - Tập 8 - Trang 168-179 - 2011
Melanie L. McEwen, Patrick G. Sullivan, Alexander G. Rabchevsky, Joe E. Springer
Traumatic injury to the mammalian spinal cord is a highly dynamic process characterized by a complex pattern of pervasive and destructive biochemical and pathophysiological events that limit the potential for functional recovery. Currently, there are no effective therapies for the treatment of spinal cord injury (SCI) and this is due, in part, to the widespread impact of the secondary injury casca... hiện toàn bộ
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