EMBO Journal
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A systematic survey of in vivo obligate chaperonin-dependent substrates
EMBO Journal - Tập 29 Số 9 - Trang 1552-1564 - 2010
Mechanism of chaperonin action: GroES binding and release can drive GroEL-mediated protein folding in the absence of ATP hydrolysis.
EMBO Journal - Tập 15 Số 22 - Trang 6111-6121 - 1996
Activation of sarcoplasmic reticular Ca2+ transport ATPase by phosphorylation of an associated phosphatidylinositol.
EMBO Journal - Tập 2 Số 9 - Trang 1543-1548 - 1983
p21 maintains senescent cell viability under persistent <scp>DNA</scp> damage response by restraining <scp>JNK</scp> and caspase signaling Abstract Cellular senescence is a permanent state of cell cycle arrest that protects the organism from tumorigenesis and regulates tissue integrity upon damage and during tissue remodeling. However, accumulation of senescent cells in tissues during aging contributes to age‐related pathologies. A deeper understanding of the mechanisms regulating the viability of senescent cells is therefore required. Here, we show that the CDK inhibitor p21 (CDKN 1A) maintains the viability of DNA damage‐induced senescent cells. Upon p21 knockdown, senescent cells acquired multiple DNA lesions that activated ataxia telangiectasia mutated (ATM ) and nuclear factor (NF )‐κB kinase, leading to decreased cell survival. NF ‐κB activation induced TNF ‐α secretion and JNK activation to mediate death of senescent cells in a caspase‐ and JNK ‐dependent manner. Notably, p21 knockout in mice eliminated liver senescent stellate cells and alleviated liver fibrosis and collagen production. These findings define a novel pathway that regulates senescent cell viability and fibrosis.
EMBO Journal - Tập 36 Số 15 - Trang 2280-2295 - 2017
Editing of the HLA-DR-peptide repertoire by HLA-DM.
EMBO Journal - Tập 15 Số 22 - Trang 6144-6154 - 1996
T4 polynucleotide kinase; cloning of the gene (pseT) and amplification of its product.
EMBO Journal - Tập 4 Số 10 - Trang 2695-2703 - 1985
The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.
EMBO Journal - Tập 11 Số 5 - Trang 1733-1742 - 1992
Dysregulated mi <scp>RNA</scp> biogenesis downstream of cellular stress and <scp>ALS</scp> ‐causing mutations: a new mechanism for <scp>ALS</scp>
EMBO Journal - Tập 34 Số 21 - Trang 2633-2651 - 2015
FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment
EMBO Journal - Tập 31 Số 24 - Trang 4502-4510 - 2012
Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.
EMBO Journal - Tập 12 Số 5 - Trang 1969-1978 - 1993
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