Drugs in R & D

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Pharmacokinetics of a New Oral Vitamin D Receptor Activator (2-Methylene-19-Nor-(20S)-1α,25-Dihydroxyvitamin D3) in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism on Hemodialysis
Drugs in R & D - Tập 17 - Trang 597-605 - 2017
Richa Pandey, Julia B. Zella, Jinge G. Zhu, Lori A. Plum, Margaret Clagett-Dame, William J. Blaser, Wendy Bedale, Hector F. DeLuca, Daniel W. Coyne
2-Methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (DP001 or 2MD) is a novel, potent 1α-hydroxylated vitamin D analog that binds to the vitamin D receptor and suppresses parathyroid hormone synthesis and secretion with potential for an improved safety profile compared to existing active vitamin D analogs. The purpose of this study was to evaluate the pharmacokinetics of DP001 given orally after he...... hiện toàn bộ
Population Pharmacokinetics and Pharmacodynamics of GSK961081 (Batefenterol), a Muscarinic Antagonist and β2-Agonist, in Moderate-to-Severe COPD Patients: Substudy of a Randomized Trial
Drugs in R & D - Tập 15 - Trang 281-291 - 2015
Claire L. Ambery, Pascal Wielders, Andrea Ludwig-Sengpiel, Robert Chan, John H. Riley
GSK961081 (batefenterol) is a novel bifunctional molecule composed of a muscarinic antagonist and a β2‐agonist. The aims of this substudy were (1) to characterize the population pharmacokinetics (PK) and pharmacodynamics (PD) of GSK961081 in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD); and (2) to investigate the relationship between systemic exposure to GSK961081...... hiện toàn bộ
Six-Month Toxicity Study of Oral Administration of D-003 in Sprague Dawley Rats
Drugs in R & D - Tập 3 - Trang 375-386 - 2012
Rafael Gámez, Rosa Más, Miriam Noa, Roberto Menéndez, Haydee García, Jorge González, Yohany Pérez, Eddy Goicochea
Background: D-003 is a mixture of high molecular weight aliphatic primary acids purified from sugarcane wax (Saccharum officinarum) having cholesterol-lowering and antiplatelet effects. Aim: This study was undertaken to investigate the toxicity induced by long-term oral administration of D-003 for 6 months to Sprague Dawley rats of both sexes. Met...... hiện toàn bộ
Transmucosal Delivery of Nicotine in Combination with Tincture of Benzoin Inhibits Apoptosis
Drugs in R & D - Tập 17 - Trang 615-621 - 2017
Alex Battaglia, Thanh Nguyen
The aim of this study was to test the hypothesis that tincture of benzoin (TOB) facilitates immediate transmucosal nicotine absorption while simultaneously promoting a safe and sustained delivery of the nicotine. In combination with TOB, nicotine toxicity and diffusion across human mucosal cells were measured using a 3-D human mucosal tissue model. Nicotine was delivered 2.1 times more quickly in ...... hiện toàn bộ
WF 10
Drugs in R & D - Tập 5 - Trang 242-244 - 2012
WF 10 [TCDO, Oxoferin®, Immunokine™, Macrokine™] is a 1 : 10 dilution of tetrachlorodecaoxide formulated for IV delivery. It was developed by Oxo Chemie in Switzerland as an adjunctive therapy to combination antiretroviral and opportunistic infection prophylaxis regimens in AIDS patients. WF 10 specifically targets macrophages. Oxo Chemie has worldwide patent rights to WF 10 and Dimethaid Research...... hiện toàn bộ
Novel Genetic Techniques and Approaches in the Microbial Genomics Era
Drugs in R & D - Tập 8 - Trang 201-212 - 2012
Michael J. Pucci
The availability of microbial genome sequences has ushered in the genomics era and has led to numerous technical advancements over the past decade. These advances have been both in the bioinformatics field that has integrated computer-based approaches with biology and in research methods in the laboratory. The advances have assisted scientists in their study of bacterial gene complements and the r...... hiện toàn bộ
Novel Strategies for the Treatment of COVID-19
Drugs in R & D - - 2022
Matthew W McCarthy
Rimonabant
Drugs in R & D - Tập 3 - Trang 65-66 - 2012
Author’s Reply to Srinivas: “A Single Dose-Escalation Study to Evaluate the Safety and Pharmacokinetics of Orally Administered Des-Aspartate Angiotensin I in Healthy Subjects”
Drugs in R & D - Tập 17 - Trang 243-244 - 2016
Meng-Kwoon Sim, Kok-Onn Lee
Prediction of Clearance in Children from Adults Following Drug–Drug Interaction Studies: Application of Age-Dependent Exponent Model
Drugs in R & D - Tập 20 - Trang 47-54 - 2020
Iftekhar Mahmood
Pharmacokinetic drug–drug interaction (DDI) studies are conducted in adult subjects during drug development but there are limited studies that have characterized pharmacokinetic DDI studies in children. The objective of this study was to evaluate if the DDI clearance values from adults can be allometrically extrapolated from adults to children. Fifteen drugs were included in this study and the age...... hiện toàn bộ
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