Drugs in R & D
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A Randomised Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of Palovarotene Ophthalmic Solution
Drugs in R & D - Tập 23 - Trang 43-53 - 2022
Palovarotene, a selective retinoic acid receptor γ agonist, is under investigation for the treatment of dry eye disease. This study aimed to determine the ocular and systemic safety, tolerability and pharmacokinetics of palovarotene ophthalmic solution (PVO-OS) in healthy adults. This was a randomised, vehicle-controlled phase I study (NCT04762355; retrospectively registered). Participants receive...... hiện toàn bộ
Physicochemical and Functional Similarity Assessment Between Proposed Bevacizumab Biosimilar BAT1706 and Reference Bevacizumab
Drugs in R & D - Tập 23 - Trang 267-288 - 2023
BAT1706 is a proposed biosimilar of bevacizumab, a vascular endothelial growth factor A (VEGF-A)-targeting biologic used to treat several different cancers, including metastatic colorectal cancer. A comprehensive physicochemical and functional similarity assessment is a key component of demonstrating biosimilarity between a reference biologic and a proposed biosimilar. Here we report the physicoch...... hiện toàn bộ
Pharmacokinetic Effects of Antidrug Antibodies Occurring in Healthy Subjects After a Single Dose of Intravenous Infliximab
Drugs in R & D - Tập 17 - Trang 607-613 - 2017
Infliximab pharmacokinetic studies have been performed in patients receiving chronic infliximab therapy. In these patients, infliximab antidrug antibodies (ADAs) increase infliximab clearance and decrease serum levels and drug efficacy. This study analyzed the pharmacokinetic effect of infliximab ADAs in healthy subjects receiving a single dose of intravenous infliximab. Data were obtained from a ...... hiện toàn bộ
Effect of Food on the Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237) in Patients with Advanced Solid Tumors
Drugs in R & D - Tập 16 Số 1 - Trang 45-52 - 2016
Users?? Perspectives on Bleeding Patterns after Two Years of Levonorgestrel-Releasing Intrauterine System Use
Drugs in R & D - - 2002
Differential Effects of Commercial-Grade and Purified Poloxamer 188 on Renal Function
Drugs in R & D - Tập 14 - Trang 73-83 - 2014
Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer with hemorheologic, antithrombotic, anti-inflammatory, and cytoprotective properties. It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb ischemia, shock, acute stroke, heart failure, and sickle cell crisis. P188 is available as an excipient-grade product, manufactured to National Formula...... hiện toàn bộ
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