Drug Safety
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Benefits and Risks of Minocycline in Rheumatoid Arthritis
Drug Safety - Tập 22 - Trang 405-414 - 2012
Rheumatoid arthritis is a chronic inflammatory disease affecting about 1% of the adult population. The pathophysiology of rheumatoid arthritis remains incompletely understood. An infectious aetiology of the disease has long been postulated, but not proved. Despite insufficient evidence for the infectious nature of this disorder, several antibacterials, such as sulfa compounds, tetracyclines and ri......
Drug Interactions with Grapefruit Juice
Drug Safety - Tập 18 - Trang 251-272 - 2012
Concomitant intake with grapefruit juice increases the concentrations of many drugs in humans. The effect seems to be mediated mainly by suppression of the cytochrome P450 enzyme CYP3A4 in the small intestine wall. This results in a diminished first pass metabolism with higher bioavailability and increased maximal plasma concentrations of substrates of this enzyme. The effect was most pronounced i......
A Scoping Review of Non-Medical and Extra-Medical Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Drug Safety - Tập 44 - Trang 917-928 - 2021
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used medications worldwide and have analgesic, antipyretic and anti-inflammatory properties. Although NSAIDs are recognised as generally safe and effective, non-medical and extra-medical use of these products can occur. Unlike the use of illegal and many prescription drugs, which are subject to extensive research attention,......
Fatal Venous Thromboembolism Associated with Different Combined Oral Contraceptives
Drug Safety - Tập 28 - Trang 907-916 - 2012
Background: Fatal venous thromboembolism (VTE) is a rare complication of combined oral contraceptive (COC) treatment. This study aims to determine incidences of fatal VTE in relation to the type of COC and the percentage of cases reported to the Swedish Adverse Drug Reactions Advisory Committee (SADRAC). A further aim is to compare the characteristics of reported and not reported ......
Face Oedema Induced by Intranasal Administration of Tixocortol
Drug Safety - Tập 29 Số 10 - Trang 911-1010 - 2006
Impact of Safety-Related Regulatory Action on Clinical Practice
Drug Safety - Tập 35 - Trang 373-385 - 2012
Background: After market approval, new serious safety issues are regularly identified for drugs that lead to regulatory action to inform healthcare professionals. However, the effectiveness of these safety-related regulatory actions is under question. We currently lack a comprehensive overview of the effects of these drug safety warnings on clinical practice to resolve the debate ......
Managing Antipsychotic-Induced Tardive Dyskinesia
Drug Safety - Tập 20 - Trang 187-193 - 2012
Antipsychotic-induced tardive dyskinesia is a common and clinically significant hazard of long term antipsychotic therapy. The arrival of atypical antipsy-chotics has markedly improved the outlook: atypical antipsychotics are emerging as effective treatments and may also reduce the prevalence and incidence of tardive dyskinesia. In mild cases, careful monitoring of tardive dyskinesia by serial Abn......
Authors’ Reply to Cotton and Nicol’s Comment on “Adverse Drug Reactions and Clinical Outcomes in Patients Initiated on Antiretroviral Therapy: A Prospective Cohort Study from Ethiopia”
Drug Safety - Tập 38 - Trang 933-933 - 2015
Anti-tumor Necrosis Factor-Alpha Therapy and Hypoglycemia: A Real-World Pharmacovigilance Analysis
Drug Safety - - 2022
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