Drug Delivery and Translational Research

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Zein nanoparticles as low-cost, safe, and effective carriers to improve the oral bioavailability of resveratrol
Drug Delivery and Translational Research - Tập 10 - Trang 826-837 - 2020
Rute Nunes, Ana Baião, Diana Monteiro, José das Neves, Bruno Sarmento
The clinical translation of the multiple pharmacological effects of resveratrol (RSV) found in preclinical studies has been impaired by its poor bioavailability, due to poor solubility and rapid metabolism and elimination. The inclusion of this molecule in medicines or functional food products will be ineffective unless suitable systems are developed. Zein protein may constitute an inexpensive, sa...... hiện toàn bộ
Advanced harmonization techniques result in accurate establishment of in vitro–in vivo correlations for oxybenzone from four complex dermal formulations with reapplication
Drug Delivery and Translational Research - Tập 13 - Trang 275-291 - 2022
Paige N. Zambrana, Dana C. Hammell, Audra L. Stinchcomb
Due to high variability during clinical pharmacokinetic (PK) evaluation, the prediction of in vivo exposure from in vitro absorption testing of topical semisolid and liquid dermal products has historically proven difficult. Since absorption from unoccluded formulations can be influenced by environmental factors such as temperature and humidity, maximal effort must be placed on the harmonization of...... hiện toàn bộ
Sirolimus-loaded exosomes as a promising vascular delivery system for the prevention of post-angioplasty restenosis
Drug Delivery and Translational Research - - Trang 1-19 - 2023
Fatemeh Mehryab, Shahram Rabbani, Faezeh Shekari, Abdoreza Nazari, Nazanin Goshtasbi, Azadeh Haeri
Restenosis remains the main reason for treatment failure of arterial disease. Sirolimus (SIR) as a potent anti-proliferative agent is believed to prevent the phenomenon. The application of exosomes provides an extended-release delivery platform for SIR intramural administration. Herein, SIR was loaded into fibroblast-derived exosomes isolated by ultracentrifugation. Different parameters affecting ...... hiện toàn bộ
Formulation and evaluation of proniosomes containing lornoxicam
Drug Delivery and Translational Research - Tập 6 - Trang 511-518 - 2016
Jyotsana R. Madan, Nitesh P. Ghuge, Kamal Dua
Proniosomes are the new generation provesicular drug delivery system of non-ionic surfactant, lecithin and cholesterol which upon reconstitution get converted into niosomes. The objective of current study was to develop stable and sustain transdermal delivery system for lornoxicam. Lornoxicam-loaded topically applied proniosomal gel was formulated, optimized, and evaluated with the aim to deliver ...... hiện toàn bộ
Wound healing applications of sericin/chitosan-capped silver nanoparticles incorporated hydrogel
Drug Delivery and Translational Research - - 2017
Jyoti Verma, Jovita Kanoujia, Poonam Parashar, Chandra Bhushan Tripathi, Shubhini A. Saraf
Cytosine arabinoside prodrug designed to bind plasma serum albumin for drug delivery
Drug Delivery and Translational Research - Tập 8 - Trang 1162-1170 - 2018
Wei Wei, Zhonggui He, Jincheng Yang, Mengchi Sun, Jin Sun
Rational design of anticancer prodrugs for efficient albumin binding can show distinct advantages in drug delivery in terms of high drug availability, long systemic circulation, potential targeting effect, and enhanced chemotherapy effect. In the present study, we reported a cytosine arabinoside (Ara-C) prodrug which could well formulate in solution and instantly transform into long-circulating na...... hiện toàn bộ
Vaginal deployment and tenofovir delivery by microbicide gels
Drug Delivery and Translational Research - - 2015
Yajing Gao, Andrew Yuan, Oranat Chuchuen, Anthony S. Ham, Kuo-Hsiung Yang, David F. Katz
Assessment of mechanical stability of rapidly separating microneedles for transdermal drug delivery
Drug Delivery and Translational Research - Tập 8 - Trang 1034-1042 - 2018
Meng Chan He, Bo Zhi Chen, Mohammad Ashfaq, Xin Dong Guo
The rapidly separating microneedles (RS-PP-MNs), composed of PVA (separable arrow head) MNs and a poly(L-lactide-co-D, L-lactide) (PLA) supporting array, are used for transdermal delivery system at high humidity. The fabricated RS-PP-MNs should have sufficient mechanical strength at different humidity. In general, the water adsorption rate was increased with increasing humidity; by contrast, stora...... hiện toàn bộ
Medium-chain triglyceride-stabilized docetaxel-loaded HSA nanoparticles effectively inhibited metastatic non-small cell lung cancer
Drug Delivery and Translational Research - Tập 13 - Trang 2869-2884 - 2023
Yunlong Cheng, Xiaoying Pang, Jing Wu, Lingling Zhou, Jinxu Cao, Liuchang Wang, Kang Qian, Peng Yang, Minjun Xu, Dongyu Sheng, Ran Meng, Pengzhen Wang, Qian Guo, Shuting Xu, Yan Wei, Qizhi Zhang
Metastatic non-small cell lung cancer (NSCLC) is refractory with a very poor prognosis. Docetaxel (DTX) injection (Taxotere®) has been approved for the treatment of locally advanced or metastatic NSCLC. However, its clinical application is restricted by severe adverse effects and non-selective tissue distribution. In this study, we successfully developed DTX-loaded human serum albumin (HSA) nanopa...... hiện toàn bộ
The intracellular visualization of exogenous DNA in fluorescence microscopy
Drug Delivery and Translational Research - - 2024
Christina Greitens, Jean-Christophe Leroux, Michael Burger
In the development of non-viral gene delivery vectors, it is essential to reliably localize and quantify transfected DNA inside the cell. To track DNA, fluorescence microscopy methods are commonly applied. These mostly rely on fluorescently labeled DNA, DNA binding proteins fused to a fluorescent protein, or fluorescence in situ hybridization (FISH). In addition, co-stainings are often used to det...... hiện toàn bộ
Tổng số: 1,048   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10