Drug Delivery and Translational Research
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
An updated review on application of 3D printing in fabricating pharmaceutical dosage forms
Drug Delivery and Translational Research - Tập 12 - Trang 2428-2462 - 2021
The concept of “one size fits all” followed by the conventional healthcare system has drawbacks in providing precise pharmacotherapy due to variation in the pharmacokinetics of different patients leading to serious consequences such as side effects. In this regard, digital-based three-dimensional printing (3DP), which refers to fabricating 3D printed pharmaceutical dosage forms with variable geome...... hiện toàn bộ
Ameliorative effect of rubiadin-loaded nanocarriers in STZ-NA-induced diabetic nephropathy in rats: formulation optimization, molecular docking, and in vivo biological evaluation
Drug Delivery and Translational Research - Tập 12 - Trang 615-628 - 2021
Diabetic nephropathy (DN) is a significant source of end-stage renal illness all over the world in both developed and developing countries. The aim of the study was to optimize rubiadin-loaded niosomes (RLN) using Box-Behnken design for the management of streptozotocin-nicotinamide (STZ-NA)-induced DN in Wistar rats. The RLN were formulated by a “thin-layer hydration technique.” The optimization o...... hiện toàn bộ
Improving the biopharmaceutical attributes of mangiferin using vitamin E-TPGS co-loaded self-assembled phosholipidic nano-mixed micellar systems
Drug Delivery and Translational Research - Tập 8 - Trang 617-632 - 2018
The current research work encompasses the development, characterization, and evaluation of self-assembled phospholipidic nano-mixed miceller system (SPNMS) of a poorly soluble BCS Class IV xanthone bioactive, mangiferin (Mgf) functionalized with co-delivery of vitamin E TPGS. Systematic optimization using I-optimal design yielded self-assembled phospholipidic nano-micelles with a particle size of ...... hiện toàn bộ
Lack of in vitro–in vivo correlation for a UC781-releasing vaginal ring in macaques
Drug Delivery and Translational Research - Tập 5 - Trang 27-37 - 2015
This study describes the preclinical development of a matrix-type silicone elastomer vaginal ring device designed to provide controlled release of UC781, a non-nucleoside reverse transcriptase inhibitor. Testing of both human- and macaque-sized rings in a sink condition in vitro release model demonstrated continuous UC781 release in quantities considered sufficient to maintain vaginal fluid concen...... hiện toàn bộ
Stem cells technology: a powerful tool behind new brain treatments
Drug Delivery and Translational Research - Tập 8 - Trang 1564-1591 - 2018
Stem cell research has recently become a hot research topic in biomedical research due to the foreseen unlimited potential of stem cells in tissue engineering and regenerative medicine. For many years, medicine has been facing intense challenges, such as an insufficient number of organ donations that is preventing clinicians to fulfill the increasing needs. To try and overcome this regrettable mat...... hiện toàn bộ
Biological characterization of a novel hybrid copolymer carrier system based on glycogen
Drug Delivery and Translational Research - Tập 8 - Trang 73-82 - 2017
The effective drug delivery systems for cancer treatment are currently on high demand. In this paper, biological behavior of the novel hybrid copolymers based on polysaccharide glycogen were characterized. The copolymers were modified by fluorescent dyes for flow cytometry, confocal microscopy, and in vivo fluorescence imaging. Moreover, the effect of oxazoline grafts on degradation rate was exami...... hiện toàn bộ
A novel scalable fabrication process for the production of dissolving microneedle arrays
Drug Delivery and Translational Research - Tập 9 - Trang 240-248 - 2018
Microneedle arrays have emerged as an alternative method for transdermal drug delivery. Although micromolding using a centrifugation method is widely used to prepare microneedles in laboratory, few researchers were focused on manufacturing processes capable of facile scale-up. A novel female mold was initially designed in this study, namely double-penetration female mold (DPFM) with the pinpoints ...... hiện toàn bộ
Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model
Drug Delivery and Translational Research - Tập 4 Số 2 - Trang 203-209 - 2014
Phospholipid–polyethylenimine conjugate-based micelle-like nanoparticles for siRNA delivery
Drug Delivery and Translational Research - Tập 1 - Trang 25-33 - 2010
Gene silencing using small interfering RNA (siRNA) is a promising therapeutic strategy for the treatment of various diseases, in particular, cancer. Recently, our group reported on a novel gene carrier, the micelle-like nanoparticle (MNP), based on the combination of a covalent conjugate of phospholipid and polyethylenimine (PLPEI) with polyethylene glycol (PEG) and lipids. These long-circulating ...... hiện toàn bộ
Ion-pair formation combined with a penetration enhancer as a dual strategy to improve the transdermal delivery of meloxicam
Drug Delivery and Translational Research - Tập 8 - Trang 64-72 - 2017
The aim of the study was to develop a novel drug-in-adhesive patch for transdermal delivery of meloxicam (MLX). The formulation involved a strategy to combine a chemical enhancer with an ion-pair agent. Diethylamine (DETA) was selected as the counter ion to form the ion-pair agent MLX-DETA. MLX-DETA was characterized by nuclear magnetic resonance spectroscopy (NMR) and Fourier transform infrared s...... hiện toàn bộ
Tổng số: 1,048
- 1
- 2
- 3
- 4
- 5
- 6
- 10