Diabetes

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HLA heterogeneity of insulin-dependent diabetes mellitus at diagnosis. The Pittsburgh IDDM study
Diabetes - Tập 34 Số 12 - Trang 1247-1252 - 1985
Mark S. Eberhardt, D. K. Wagener, T. J. Orchard, R. E. LaPorte, D. E. Cavender, B. S. Rabin, R. W. Atchison, L. H. Kuller, Allan Drash, D. J. Becker
Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers
Diabetes - Tập 46 Số 11 - Trang 1701-1710 - 1997
P. J. Bingley, Ezio Bonifacio, Alistair J.K. Williams, S. Genovese, G. F. Bottazzo, Elaine Gale
Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies
Diabetes - Tập 45 Số 7 - Trang 926-933 - 1996
C. F. Verge, R. Gianani, Eiji Kawasaki, L. Yu, M. Pietropaolo, R. A. Jackson, H. Peter Chase, George S. Eisenbarth
Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.
Diabetes - Tập 49 Số 12 - Trang 2142-2148 - 2000
Mauro Lepore, Simone Pampanelli, Carmine G. Fanelli, Francesca Porcellati, Luca Bartocci, Angelo Di Vincenzo, Cristina Cordoni, E Costa, P. Brunetti, Geremia B. Bolli
To compare the pharmacokinetics/dynamics of the long-acting insulin analog glargine with NPH, ultralente, and continuous subcutaneous (SC) infusion of insulin lispro (continuous subcutaneous insulin infusion [CSII]), 20 C-peptide-negative type 1 diabetic patients were studied on four occasions during an isoglycemic 24-h clamp. Patients received SC injection of either 0.3 U/kg glargine or N...... hiện toàn bộ
Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype
Diabetes - Tập 64 Số 1 - Trang 12-22 - 2015
Carlos Escande, Verónica Nin, Tamar Pirtskhalava, Claudia C.S. Chini, Tamar Tchkonia, James L. Kirkland, Eduardo N. Chini
Obesity is often regarded as the primary cause of metabolic syndrome. However, many lines of evidence suggest that obesity may develop as a protective mechanism against tissue damage during caloric surplus and that it is only when the maximum fat accumulation capacity is reached and fatty acid spillover occurs into to peripheral tissues that metabolic diseases develop. In this regard, iden...... hiện toàn bộ
Increase in [3H]PN 200-110 binding to cardiac muscle membrane in streptozocin-induced diabetic rats
Diabetes - Tập 39 Số 9 - Trang 1064-1069 - 1990
Y. Nishio, A. Kashiwagi, Tomohisa Ogawa, T. Asahina, M. Ikebuchi, M. Kodama, Ge Li
In vivo insulin resistance induced by amylin primarily through inhibition of insulin-stimulated glycogen synthesis in skeletal muscle
Diabetes - Tập 40 Số 5 - Trang 568-573 - 1991
S. Frontoni, S. B. Choi, D. Banduch, L. Rossetti
Effects of Diabetes and Insulin on the Expression of Galanin-Like Peptide in the Hypothalamus of the Rat
Diabetes - Tập 53 Số 5 - Trang 1237-1242 - 2004
Gregory S. Fraley, Jarrad M. Scarlett, Issei S. Shimada, Dawit N. Teklemichael, Blake V. Acohido, Donald K. Clifton, Robert A. Steiner
Galanin-like peptide (GALP) is produced in a small population of neurons in the arcuate nucleus of the hypothalamus, and leptin stimulates the hypothalamic expression of GALP mRNA. Because insulin and leptin share common signaling pathways in the brain, we reasoned that GALP neurons might also be responsive to changes in circulating concentrations of insulin. To test this hypothesis, we fi...... hiện toàn bộ
Influence of obesity, impaired glucose tolerance, and NIDDM on LDL structure and composition. Possible link between hyperinsulinemia and atherosclerosis
Diabetes - Tập 39 Số 12 - Trang 1527-1533 - 1990
Hisham A. Barakat, John W. Carpenter, Virginia D. McLendon, P. Khazanie, N. Leggett, Judy Heath, Richard H.L. Marks
Glycation, Oxidative Stress, and Scavenger Activity: Glucose Metabolism and Radical Scavenger Dysfunction in Endothelial Cells
Diabetes - Tập 45 Số Supplement_3 - Trang S84-S86 - 1996
Akiko Kashiwagi, Takayuki Asahina, Yoshihiko Nishio, Makoto Ikebuchi, Yasushi Tanaka, Ryuichi Kikkawa, Yukio Shigeta
It has been reported that oxidative stress is increased in vivo in the diabetic state. Increased oxidative stress is caused not only by accelerated production of oxygen-free radicals but also by decreased scavenging of those molecules. Endothelial cells are extremely sensitive to oxidative stress, resulting in impairments of various endothelial cell function. In this report, we studied the...... hiện toàn bộ
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