Apoptosis Is the Mode of β-Cell Death Responsible for the Development of IDDM in the Nonobese Diabetic (NOD) MouseDiabetes - Tập 46 Số 5 - Trang 750-757 - 1997
Bronwyn A. O’Brien, Brian Harmon, Donald P. Cameron, David J. Allan
The NOD/Lt mouse, a widely used model of human autoimmune IDDM, was used to establish the mode of β-cell death responsible for the development of IDDM. Apoptotic cells were present within the islets of Langerhans in hematoxylin and eosin–stained sections of pancreases harvested from 3- to 18-week-old female NOD/Lt mice (a range of 11–50 apoptotic cells per 100 islets). Immunohistochemical ...... hiện toàn bộ
Association of Variants in RETN With Plasma Resistin Levels and Diabetes-Related Traits in the Framingham Offspring StudyDiabetes - Tập 58 Số 3 - Trang 750-756 - 2009
Marie‐France Hivert, Man Li, Jarred B. McAteer, Josée Dupuis, Caroline S. Fox, L. Adrienne Cupples, James B. Meigs, Jose C. Florez
OBJECTIVE— The RETN gene encodes the adipokine resistin. Associations of RETN with plasma resistin levels, type 2 diabetes, and related metabolic traits have been inconsistent. Using comprehensive linkage disequilibrium mapping, we genotyped tag single nucleotide polymorphisms (SNPs) in RETN and tested associations with plasma resistin levels, risk of diabetes, and glycemic traits.... hiện toàn bộ
Diabetes Antibody Standardization Program: First Assay Proficiency EvaluationDiabetes - Tập 52 Số 5 - Trang 1128-1136 - 2003
Polly J. Bingley, Ezio Bonifacio, Patricia W. Mueller
The aims of the first proficiency evaluation of the Diabetes Antibody Standardization Program (DASP) were to assess general implementation of assay methods and to evaluate the new World Health Organization (WHO) reference reagent for autoantibodies to GAD and IA-2. Forty-six laboratories in 13 countries received coded sera from 50 patients with newly diagnosed type 1 diabetes and 50 blood ...... hiện toàn bộ