Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.Diabetes - Tập 49 Số 12 - Trang 2142-2148 - 2000
Mauro Lepore, Simone Pampanelli, Carmine G. Fanelli, Francesca Porcellati, Luca Bartocci, Angelo Di Vincenzo, Cristina Cordoni, E Costa, P. Brunetti, Geremia B. Bolli
To compare the pharmacokinetics/dynamics of the long-acting insulin analog glargine with NPH, ultralente, and continuous subcutaneous (SC) infusion of insulin lispro (continuous subcutaneous insulin infusion [CSII]), 20 C-peptide-negative type 1 diabetic patients were studied on four occasions during an isoglycemic 24-h clamp. Patients received SC injection of either 0.3 U/kg glargine or N...... hiện toàn bộ
Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome PhenotypeDiabetes - Tập 64 Số 1 - Trang 12-22 - 2015
Carlos Escande, Verónica Nin, Tamar Pirtskhalava, Claudia C.S. Chini, Tamar Tchkonia, James L. Kirkland, Eduardo N. Chini
Obesity is often regarded as the primary cause of metabolic syndrome. However, many lines of evidence suggest that obesity may develop as a protective mechanism against tissue damage during caloric surplus and that it is only when the maximum fat accumulation capacity is reached and fatty acid spillover occurs into to peripheral tissues that metabolic diseases develop. In this regard, iden...... hiện toàn bộ
Effects of Diabetes and Insulin on the Expression of Galanin-Like Peptide in the Hypothalamus of the RatDiabetes - Tập 53 Số 5 - Trang 1237-1242 - 2004
Gregory S. Fraley, Jarrad M. Scarlett, Issei S. Shimada, Dawit N. Teklemichael, Blake V. Acohido, Donald K. Clifton, Robert A. Steiner
Galanin-like peptide (GALP) is produced in a small population of neurons in the arcuate nucleus of the hypothalamus, and leptin stimulates the hypothalamic expression of GALP mRNA. Because insulin and leptin share common signaling pathways in the brain, we reasoned that GALP neurons might also be responsive to changes in circulating concentrations of insulin. To test this hypothesis, we fi...... hiện toàn bộ
Different Regulated Expression of the Tyrosine Phosphatase-Like Proteins IA-2 and Phogrin by Glucose and Insulin in Pancreatic IsletsDiabetes - Tập 51 Số 10 - Trang 2982-2988 - 2002
Kristian Löbner, Holger Steinbrenner, Graham Roberts, Zhidong Ling, Guo-Cai Huang, Sandra Piquer, Daniël Pipeleers, Jochen Seißler, Michael R. Christie
IA-2 and phogrin are tyrosine phosphatase-like proteins that may mediate interactions between secretory granules and cytoskeleton in islets and neuroendocrine tissues. We investigated factors that regulate IA-2 and phogrin expression and their relationship to maturation of insulin secretory responses that occur after birth. Islet content of IA-2, but not phogrin, increased during the first...... hiện toàn bộ
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.Diabetes - Tập 49 Số 7 - Trang 1137-1141 - 2000
Jochen Seißler, Thu Nguyen, Gabriela Aust, Holger Steinbrenner, F. Porzsolt
IA-2, a member of the protein tyrosine phosphatase family, represents a major target autoantigen in type 1 diabetes. To study the regulation of IA-2 gene expression, we used INS-1 insulinoma cells to analyze beta-cell signal transduction pathways as well as the effect of metabolic and hormonal factors involved in the regulation of the insulin secretory pathway. Quantitative competitive rev...... hiện toàn bộ