Diabetes, Obesity and Metabolism

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Effect of caloric restriction with and without exercise training on oxidative stress and endothelial function in obese subjects with type 2 diabetes
Diabetes, Obesity and Metabolism - Tập 10 Số 11 - Trang 1062-1073 - 2008
Thomas P. Wycherley, Grant D. Brinkworth, M. Noakes, Jonathan D. Buckley, Peter Clifton
Aim:  Effects of dietary weight loss on endothelial function, particularly when combined with exercise training, is largely unknown in type 2 diabetes. We sought to determine whether aerobic exercise training provided any additional improvements in endothelial function, oxidative stress or other established markers of cardiovascular risk when combined with an energy‐...... hiện toàn bộ
Effects of an energy‐restricted low‐carbohydrate, high unsaturated fat/low saturated fat diet versus a high‐carbohydrate, low‐fat diet in type 2 diabetes: A 2‐year randomized clinical trial
Diabetes, Obesity and Metabolism - Tập 20 Số 4 - Trang 858-871 - 2018
Jeannie Tay, Campbell H. Thompson, Natalie D. Luscombe‐Marsh, Thomas P. Wycherley, Manny Noakes, Jonathan D. Buckley, Gary Wittert, William S. Yancy, Grant D. Brinkworth
AimTo examine whether a low‐carbohydrate, high‐unsaturated/low‐saturated fat diet (LC) improves glycaemic control and cardiovascular disease (CVD) risk factors in overweight and obese patients with type 2 diabetes (T2D).MethodsA total of 115 adults with T2D (mean [SD]; BMI, 34.6 [4.3] kg/m... hiện toàn bộ
Pharmacogenomic association between a variant in SLC47A1 gene and therapeutic response to metformin in type 2 diabetes
Diabetes, Obesity and Metabolism - Tập 15 Số 2 - Trang 189-191 - 2013
Ivan Tkáč, Lucia Klimčáková, Martin Javorský, M. Fabianová, Zbyněk Schroner, Hana Hermanová, Eva Babjaková, Ružena Tkáčová
Pharmacogenetic studies revealed that variants in genes related to the pharmacokinetics of metformin were associated with glucose‐lowering effect of metformin. The aim of this study was to investigate possible associations of the variants in genes encoding organic cationic transporters–solute carrier family 22, members A1, A2 (SLC22A1... hiện toàn bộ
Metabolic effects of Lactobacillus reuteriDSM 17938 in people with type 2 diabetes: A randomized controlled trial
Diabetes, Obesity and Metabolism - Tập 19 Số 4 - Trang 579-589 - 2017
Reza Mobini, Valentina Tremaroli, Marcus Ståhlman, Fredrik Karlsson, Max Levin, Maria Ljungberg, Maja Sohlin, Heléne Bertéus Forslund, Rosie Perkins, Fredrik Bäckhed, Per‐Anders Jansson
AimsTo investigate the metabolic effects of 12‐week oral supplementation with Lactobacillus reuteri DSM 17938 in patients with type 2 diabetes on insulin therapy.M...... hiện toàn bộ
Metformin targets brown adipose tissue in vivo and reduces oxygen consumption in vitro
Diabetes, Obesity and Metabolism - Tập 20 Số 9 - Trang 2264-2273 - 2018
Peter Breining, Jonas Jensen, Elias Sundelin, Lars Christian Gormsen, Steen Jakobsen, Morten Busk, Lars Rolighed, Peter Bross, Paula Fernández‐Guerra, Lasse K. Markussen, Nanna E. Rasmussen, Jacob B. Hansen, Steen B. Pedersen, Bjørn Richelsen, Niels Jessen
AimsTo test the hypothesis that brown adipose tissue (BAT) is a metformin target tissue by investigating in vivo uptake of [11C]‐metformin tracer in mice and studying in vitro effects of metformin on cultured human brown adipocytes.Materials and methodsTissue‐specific upta...... hiện toàn bộ
Treatment with LY2409021, a glucagon receptor antagonist, increases liver fat in patients with type 2 diabetes
Diabetes, Obesity and Metabolism - Tập 19 Số 11 - Trang 1521-1528 - 2017
Cristina B. Guzmán, Xiaotian Michelle Zhang, Rong Liu, Arie Regev, Sudha S. Shankar, Parag Garhyan, Sreekumar Pillai, C Kazda, Naga Chalasani, Thomas A. Hardy
AimsTo evaluate whether treatment with LY2409021, a novel, selective glucagon receptor antagonist, is associated with changes in hepatic fat and other safety variables related to the benefit–risk profile for chronic use in patients with type 2 diabetes (T...... hiện toàn bộ
Physiologic action of glucagon on liver glucose metabolism
Diabetes, Obesity and Metabolism - Tập 13 Số s1 - Trang 118-125 - 2011
Christopher J. Ramnanan, Dale S. Edgerton, Guillaume Kraft, Alan D. Cherrington
Glucagon is a primary regulator of hepatic glucose production (HGP) in vivo during fasting, exercise and hypoglycaemia. Glucagon also plays a role in limiting hepatic glucose uptake and producing the hyperglycaemic phenotype associated with insulin deficiency and insulin resistance. In response to a physiological rise in glucagon, HGP is rapidly stimulated. This ...... hiện toàn bộ
High‐dose sodium‐glucose co‐transporter‐2 inhibitors are superior in type 2 diabetes: A meta‐analysis of randomized clinical trials
Diabetes, Obesity and Metabolism - Tập 23 Số 9 - Trang 2125-2136 - 2021
Fang‐Hong Shi, Hao Li, Long Shen, Jingjing Fu, Jing Ma, Zhi‐Chun Gu, Hou‐Wen Lin
AbstractAimTo determine the overall efficacy of high‐ versus low‐dose sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors in patients with type 2 diabetes (T2D).Material and MethodsA literature search using MEDLINE, EMBASE and the Cochrane Library was performed from 1 J...... hiện toàn bộ
Effects of once‐weekly dulaglutide on kidney function in patients with type 2 diabetes in phase II and III clinical trials
Diabetes, Obesity and Metabolism - Tập 19 Số 3 - Trang 436-441 - 2017
Katherine R. Tuttle, T. D. McKinney, Jaime A. Davidson, Greg Anglin, Kristine D. Harper, Fady T. Botros
Dulaglutide is a once‐weekly glucagon‐like peptide‐1 receptor agonist approved for the treatment of type 2 diabetes (T2D). Integrated data from 9 phase II and III trials in people with T2D (N = 6005) were u...... hiện toàn bộ
Do we know the true mechanism of action of the DPP‐4 inhibitors?
Diabetes, Obesity and Metabolism - Tập 20 Số 1 - Trang 34-41 - 2018
Emilie S. Andersen, Carolyn F. Deacon, Jens J. Holst
The prevalence of type 2 diabetes is increasing, which is alarming because of its serious complications. Anti‐diabetic treatment aims to control glucose homeostasis as tightly as possible in order to reduce these complications. Dipeptidyl peptidase‐4 (DPP‐4) inhibitors are a recent addition to the anti‐diabetic treatment modalit...... hiện toàn bộ
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