Diabetes Care

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The Hyperglycemia and Adverse Pregnancy Outcome Study
Diabetes Care - Tập 35 Số 4 - Trang 780-786 - 2012
Patrick M. Catalano, David McIntyre, J. CRUICKSHANK, David R. McCance, Alan Dyer, Boyd E. Metzger, Lynn P. Lowe, Elisabeth R. Trimble, Donald R. Coustan, Bengt Persson, Moshe Hod, Jeremy Oats
OBJECTIVE To determine associations of gestational diabetes mellitus (GDM) and obesity with adverse pregnancy outcomes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. RESEARCH DESIGN AND METHODS Participants underwent a 75-g oral glucose tolerance test (OGTT) between 24 and 32 weeks. GDM was diagnosed post hoc using International Association of Diabetes and Pregnancy Study Groups ... hiện toàn bộ
Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy.
Diabetes Care - Tập 22 Số 8 - Trang 1296-1301 - 1999
Dan Ziegler, M Hanefeld, K. J. Ruhnau, H Hasche, M Lobisch, Klemens Schütte, Gorazd Kerum, R. Maleßa
OBJECTIVE: To evaluate the efficacy and safety of alpha-lipoic acid given intravenously, followed by oral treatment in type 2 diabetic patients with symptomatic polyneuropathy. RESEARCH DESIGN AND METHODS: In a multicenter randomized double-blind placebo-controlled trial (Alpha-Lipoic Acid in Diabetic Neuropathy [ALADIN] III Study), 509 outpatients were randomly assigned to sequential treatment wi... hiện toàn bộ
Clinical, Autoimmune, and Genetic Characteristics of Adult-Onset Diabetic Patients With GAD Autoantibodies in Japan (Ehime Study)
Diabetes Care - Tập 25 Số 6 - Trang 995-1001 - 2002
Haruyo Takeda, Eiji Kawasaki, Ikki Shimizu, Etsushi Konoue, Masao Fujiyama, Satoshi Murao, Kiyonobu TANAKA, Kennichi Mori, Yoshinao Tarumi, Isamu Seto, Yasuhisa Fujii, Kenichi Kato, Shiori Kondo, Yasuharu Takada, Nobuaki Kitsuki, Yukikazu Kaino, Kaichi Kida, Naotake Hashimoto, Yukio Yamane, Takashi Yamawaki, Hiroshi Onuma, Tatsuya Nishimiya, Haruhiko Osawa, Yasushi Saitō, Hideichi Makino
OBJECTIVE—To characterize the clinical, autoimmune, and genetic features in Japanese adult-onset diabetic patients with GAD autoantibodies. RESEARCH DESIGN AND METHODS—GAD autoantibodies (GADab) were screened in 4,980 diabetic patients with age of onset >20 years in the hospital-based Ehime Study, and the GADab-positive (GADab+) patients were then divided into two groups according to their insu... hiện toàn bộ
Immunogenetic and Clinical Characterization of Slowly Progressive IDDM
Diabetes Care - Tập 16 Số 5 - Trang 780-788 - 1993
Tetsuro Kobayashi, Koji Tamemoto, Kōji Nakanishi, Norihiro Kato, Minoru Okubo, Hiroshi Kajio, Tadao Sugimoto, Toshio Murase, Kinori Kosáka
OBJECTIVE To examine the clinical and immunogenetic heterogeneity of IDDM. RESEARCH DESIGN AND METHODS We divided 207 IDDM patients into groups based on the interval from clinical onset to initiation of insulin therapy: group A (<3 mo, acute clinical-onset group, n = 134), group B (3–12 mo, intermediate group, n = 31), and group C (>13 mo, slowly progressive group, n = 42). Immunogenetic and... hiện toàn bộ
Distinct Genetic and Immunological Features in Patients With Onset of IDDM Before and After Age 40
Diabetes Care - Tập 20 Số 4 - Trang 524-529 - 1997
Tobias Lohmann, Jochen Sessler, Hans-Joachim Verlohren, Sabine Schröder, Julia Rötger, Karsten Dãhn, Nils G. Morgenthaler, Werner A. Scherbaum
OBJECTIVE Young age at onset is a relevant parameter associated with a rapid progression of IDDM. Our major aim was to define differences between IDDM patients with age at diagnosis > 40 years and adult IDDM with onset at a younger age. RESEARCH DESIGN AND METHODS The correlation between islet-related antibodies (islet cell antibodies [ICAs] and antibodies [Abs] to GAD and the tyrosine phosphat... hiện toàn bộ
Autoantibody Against ICA512 Did Not Improve Test Sensitivity for Slowly Progressive IDDM in Adults
Diabetes Care - Tập 20 Số 4 - Trang 679-680 - 1997
Akira Kasuga, Yukako Ozawa, Taro Maruyama, Toshihide Ishihara, Shin Amemiya, Takao Saruta
GAD Antibodies in NIDDM: Ten-year follow-up from the diagnosis
Diabetes Care - Tập 18 Số 12 - Trang 1557-1565 - 1995
Leo Niskanen, Jaakko Tuomilehto, Jukka Karjalainen, Leif Groop, Matti Uusitupa
OBJECTIVE To study the frequency of antibodies to glutamic acid decarboxylase (GAD) and islet cell antibodies (ICAs) and their predictive value with respect to the development of insulin deficiency in 133 newly diagnosed middle-aged patients with non-insulin-dependent diabetes mellitus (NIDDM) and in 126 control subjects and to study the persistence of GAD antibodies in diabetic patients during th... hiện toàn bộ
Predictive Value of Autoantibodies to IA-2 for Insulin Requirements in Japanese Subjects With Type 1 Diabetes
Diabetes Care - Tập 26 Số 11 - Trang 3188-3189 - 2003
Tsuguhito Ota, Toshinari Takamura, Yoshiyuki Bando, Rika Usuda, Yukihiro Nagai
Matrix Metalloproteinase 2 May Be a Marker of Microangiopathy in Children and Adolescents With Type 1 Diabetes
Diabetes Care - Tập 27 Số 1 - Trang 273-274 - 2004
Giuseppe Derosa, Maria Antonietta Avanzini, Diego Geroldi, Roberto Fogari, Renata Lorini, Annalisa De Silvestri, Carmine Tinelli, G Rondini, Giuseppe d’Annunzio
Variation of Interstitial Glucose Measurements Assessed by Continuous Glucose Monitors in Healthy, Nondiabetic Individuals
Diabetes Care - Tập 33 Số 6 - Trang 1297-1299 - 2010
OBJECTIVE To characterize glucose levels during daily living using continuous glucose monitors (CGMs) in nondiabetic individuals. RESEARCH DESIGN AND METHODS Seventy-four healthy children, adolescents, and adults aged 9–65 years with normal glucose tolerance used a blinded CGM device for 3 to 7 days. RESULTS Sensor glucose concentrations were 71–120 mg/dl for 91% of the day. Sensor values were ≤60... hiện toàn bộ
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