Dermatology and Therapy

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Real-World Experience of Methotrexate in the Treatment of Skin Diseases: an Italian Delphi Consensus
Dermatology and Therapy - Tập 13 - Trang 1219-1241 - 2023
Giovanni Damiani, Paolo Amerio, Federico Bardazzi, Carlo G. Carrera, Andrea Conti, Francesco Cusano, Paolo Dapavo, Clara DeSimone, May El Hachem, Gabriella Fabbrocini, Paolo Gisondi, Francesco Loconsole, Giuseppe Micali, Iria Neri, Aurora Parodi, Stefano Piaserico, Marco Romanelli, Luca Stingeni, Paolo D. M. Pigatto
After decades of use, methotrexate displays an established safety and efficacy profile in both in-hospital and outpatient settings. Despite its widespread use, there is surprisingly little clinical evidence to guide daily practice with methotrexate in dermatology. To provide guidance for clinicians in daily practice for areas in which there is limited guidance. A Delphi consensus exercise on 23 s...... hiện toàn bộ
Crisaborole Ointment Improves Quality of Life of Patients with Mild to Moderate Atopic Dermatitis and Their Families
Dermatology and Therapy - Tập 8 - Trang 605-619 - 2018
Eric L. Simpson, Amy S. Paller, Mark Boguniewicz, Lawrence F. Eichenfield, Steven R. Feldman, Jonathan I. Silverberg, Sarah L. Chamlin, Lee T. Zane
The impact of crisaborole ointment, a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis (AD), on quality of life (QoL) was assessed in two identically designed phase 3 studies (AD-301: NCT02118766; AD-302: NCT02118792, both at http://www.clinicaltrials.gov ). In both studies, patients aged ≥ 2 years with mild to moderate AD per the Investigator’s Static Global Assessment were randomly assigned 2:1 to receive crisaborole or vehicle twice daily for 28 days. QoL was assessed using the Children’s Dermatology Life Quality Index (CDLQI) (2–15 years), the Dermatology Life Quality Index (DLQI) (≥ 16 years), and the Dermatitis Family Impact Questionnaire (DFI) (parents/caregivers/family of patients aged 2–17 years). Established QoL score severity bands provided clinical context. Greater mean improvement in QoL was observed in crisaborole-treated patients than in vehicle-treated patients at day 29 [mean change from baseline (∆BL), CDLQI: − 4.6 vs. − 3.0; P < 0.001; DLQI: − 5.2 vs. − 3.5; P = 0.015]. At baseline, more than half the patients had a “moderate effect” or higher of AD on QoL. At day 29, there was a trend toward more crisaborole- than vehicle-treated patients having “small effect” to “no effect”, The QoL of parents/caregivers/family improved more for crisaborole-treated than for vehicle-treated patients (∆BL, DFI: − 3.7 vs. − 2.7; P = 0.003). Crisaborole treatment results in clinically meaningful improvement in QoL for patients and their parents/caregivers/families. AD-301: http://www.clinicaltrials.gov... hiện toàn bộ
Impact and Management of Loss of Eyebrows and Eyelashes
Dermatology and Therapy - Tập 13 - Trang 1243-1253 - 2023
Michela Starace, Stephano Cedirian, Aurora M. Alessandrini, Francesca Bruni, Federico Quadrelli, Daniel F. Melo, Tatiana Silyuk, Andrei Doroshkevich, Bianca M. Piraccini, Matilde Iorizzo
Eyelashes and eyebrows have different functions, ranging from practical purposes such as protecting the eye apparatus from external hazards to the definition of our facial expression. For this reason, their loss could have both functional and psychological impact on patients’ quality of life. Complete or partial loss can occur any time during life, and identifying the cause is mandatory to establi...... hiện toàn bộ
Skin Bleaching and Dermatologic Health of African and Afro-Caribbean Populations in the US: New Directions for Methodologically Rigorous, Multidisciplinary, and Culturally Sensitive Research
Dermatology and Therapy - Tập 6 - Trang 453-459 - 2016
Emma K. T. Benn, Andrew Alexis, Nihal Mohamed, Yan-Hong Wang, Ikhlas A. Khan, Bian Liu
Skin-bleaching practices, such as using skin creams and soaps to achieve a lighter skin tone, are common throughout the world and are triggered by cosmetic reasons that oftentimes have deep historical, economic, sociocultural, and psychosocial roots. Exposure to chemicals in the bleaching products, notably, mercury (Hg), hydroquinone, and steroids, has been associated with a variety of adverse hea...... hiện toàn bộ
Efficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study
Dermatology and Therapy - - 2023
Lilia Ramos dos Santos Guadanhim, Hélio Amante Miot, Juliana L M Soares, Silas Arandas Monteiro e Silva, Gislaine Ricci Leonardi, Renato D. Lópes, Ediléia Bagatin
Review on Alopecia Areata in the Middle East and Africa: Landscape and Unmet Needs
Dermatology and Therapy - Tập 13 - Trang 1435-1464 - 2023
Anwar Al Hammadi, Nisha V. Parmar, Khadija Aljefri, Osama Al Sharif, Marwa Abdallah, Haytham Mohamed Ahmed, Alfred Ammoury
Alopecia areata (AA) is an autoimmune disease characterized by non-scarring hair loss in adults and children. Clinical manifestations range from hair loss in small, well-circumscribed patches to total hair loss on the scalp or any other hair-bearing areas. Although the exact pathogenesis of AA is not fully understood, it is thought that loss of immune privilege caused by immunological dysregulati...... hiện toàn bộ
A Survey of Community Dermatologists Reveals the Unnecessary Impact of Trial-and-Error Behavior on the Psoriasis Biologic Treatment Paradigm
Dermatology and Therapy - Tập 11 - Trang 1851-1860 - 2021
Bruce Strober, David Pariser, Ann Deren-Lewis, Tobin J. Dickerson, Mark Lebwohl, Alan Menter
In the USA, psoriasis affects approximately 3% of the population and costs more than $110 billion annually. The development of targeted biologics has revolutionized psoriasis management, but at an increasing cost. According to Joint AAD/NPF guidelines, an important need exists to identify biomarkers that can predict the appropriate biologic agent for patients. A survey of community dermatologists ...... hiện toàn bộ
Evaluation of a Novel Microfocused Ultrasound with Three‐Dimensional Digital Imaging for Facial Tightening: A Prospective, Randomized, Controlled Trial
Dermatology and Therapy - - Trang 1-17 - 2023
Jiafang Zhu, Yue Han, Ying Liu, Rui Chang, Wei Gao, Xia Gong, Yijia Zhu, Ying Shang, Lingyue Shen, Wenxin Yu, Dongze Lyu, Xiaoxi Lin
The excellent efficacy is mitigated by the limited safety profile of microfocused ultrasound procedures. We sought to assess the safety and tightening efficacy of a novel microfocused ultrasound. The randomized middle and lower face and submental region of the participants were treated with the novel device using the following transducers: M4.5, D4.5, M3.0, and D3.0. Improvement in paired comparis...... hiện toàn bộ
Scoping Review on Use of Drugs Targeting Interleukin 1 Pathway in DIRA and DITRA
Dermatology and Therapy - - 2018
Francisco Gómez-García, Juan Luis Sanz‐Cabanillas, Isabel Viguera-Guerra, Beatriz Isla-Tejera, Antonio Vélez-García Nieto, Juan Ruano
Real-World Recurrence Rates and Economic Burden in Patients with Resected Early-Stage Melanoma
Dermatology and Therapy - - 2020
Sekwon Jang, Tayla Poretta, Tarun Bhagnani, Qing Harshaw, Matthew Burke, Sumati Rao
Real-world data on recurrence and economic burden in patients with resected early-stage melanoma are limited. The objective of this study was to assess real-world recurrence rates, risk factors for recurrence, and costs of recurrence in patients with resected stage IIB, IIC, or IIIA melanoma in the USA. This retrospective analysis included patients with resected stage IIB, IIC, or IIIA melanoma (A...... hiện toàn bộ
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