Dermatology and Therapy
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Real-World Experience of Methotrexate in the Treatment of Skin Diseases: an Italian Delphi Consensus
Dermatology and Therapy - Tập 13 - Trang 1219-1241 - 2023
After decades of use, methotrexate displays an established safety and efficacy
profile in both in-hospital and outpatient settings. Despite its widespread use,
there is surprisingly little clinical evidence to guide daily practice with
methotrexate in dermatology. To provide guidance for clinicians in daily
practice for areas in which there is limited guidance. A Delphi consensus
exercise on 23 st...
Crisaborole Ointment Improves Quality of Life of Patients with Mild to Moderate Atopic Dermatitis and Their Families
Dermatology and Therapy - Tập 8 - Trang 605-619 - 2018
The impact of crisaborole ointment, a nonsteroidal phosphodiesterase 4 inhibitor
for the treatment of mild to moderate atopic dermatitis (AD), on quality of life
(QoL) was assessed in two identically designed phase 3 studies (AD-301:
NCT02118766; AD-302: NCT02118792, both at http://www.clinicaltrials.gov ). In
both studies, patients aged ≥ 2 years with mild to moderate AD per the
Investigator’s St...
Lichen Planopilaris Responsive to a Novel Phytoactive Botanical Treatment: A Case Series
Dermatology and Therapy - Tập 12 - Trang 1697-1710 - 2022
Lichen planopilaris (LPP) is characterized by chronic scarring alopecia that is
progressive and typically refractory to therapy. Current drug treatments are
suboptimal and not applicable for long-term use because of the high potential
for adverse effects, warranting safer and more effective treatment alternatives.
Based on our previous success in treating a patient with central centrifugal
cicatri...
Botulinum Toxin A Alleviates Persistent Erythema and Flushing in Patients with Erythema Telangiectasia Rosacea
Dermatology and Therapy - Tập 12 - Trang 2285-2294 - 2022
The persistent erythema and flushing seen in some cases of rosacea do not
respond effectively to, or may easily relapse after, oral medication or
light-based therapies (laser or intense pulsed light). Intradermal botulinum
toxin A (BTX-A) injection can be used to treat intractable erythema and
flushing, but studies with large samples and long-term observation have not been
conducted to determine i...
Patients with Chronic Urticaria Remain Largely Undertreated: Results from the DERMLINE Online Survey
Dermatology and Therapy - Tập 11 - Trang 1027-1039 - 2021
Chronic urticaria (CU) is an unpredictable disease, with high disease burden and
a significant negative impact on quality of life, especially in patients of
working age. Many patients are undertreated, and there is poor awareness of
strategies to manage patients with CU in the real-world setting. The current
study aimed to gain a better understanding of CU from the patients’ perspective,
including...
Pooled Safety Analysis of Baricitinib in Adult Participants with Atopic Dermatitis in the Japanese Subpopulation from Six Randomized Clinical Trials
Dermatology and Therapy - Tập 12 - Trang 2765-2779 - 2022
Baricitinib is an oral selective Janus kinase (JAK)1/JAK2 inhibitor approved in
Japan and the European Union for the treatment of atopic dermatitis (AD). The
aim of this study is to report pooled safety data for baricitinib in the
Japanese subpopulation of the clinical development program in moderate-to-severe
AD. This analysis included participant-level safety data from five double-blind,
randomi...
A Real-World, Non-interventional Indian Study Evaluating Intensive Plant-Based Butter Moisturizing Cream in Psoriasis
Dermatology and Therapy - Tập 9 - Trang 537-546 - 2019
Psoriasis is estimated to affect 0.44–2.8% of the Indian population.
Moisturizers are a key adjuvant psoriasis treatment strategy, but data regarding
their effectiveness, safety and compliance pattern in an Indian context are
lacking. Hence, this real-world study on an intensive plant-based butter
moisturizing cream (Venusia ® Max) was conducted among Indian patients with
psoriasis. This was an ob...
Clinical and Biochemical Assessment of Maintenance Treatment in Chronic Recurrent Seborrheic Dermatitis: Randomized Controlled Study
Dermatology and Therapy - Tập 4 - Trang 43-59 - 2014
Few studies have investigated the long-term effects of a maintenance regimen in
the prevention of relapses in scalp seborrheic dermatitis (SD), in particular
following biomarker changes. A new shampoo containing beta-glycyrrhetinic acid
(18βGA) in addition to cyclopiroxolamine (CPO) and zinc pyrithione (ZP) was
tested in 67 subjects suffering from SD with moderate to severe erythema and
itching in...
Evaluation of Psychological Wellbeing and Social Impact of Combined Facial and Truncal Acne: a Multi-national, Mixed-Methods Study
Dermatology and Therapy - Tập 12 - Trang 1847-1858 - 2022
Half of the individuals with facial acne develop truncal acne, but the impact of
combined facial and truncal acne (CA) on patients’ quality of life is poorly
researched. A 60-min interview of 30 participants with CA was conducted that
formed the basis for a cross-sectional survey of 694 adolescents and adults with
CA. The main themes identified from the qualitative interviews among CA subjects
inc...
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