Dermatology and Therapy
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Real-World Experience of Methotrexate in the Treatment of Skin Diseases: an Italian Delphi Consensus
Dermatology and Therapy - Tập 13 - Trang 1219-1241 - 2023
After decades of use, methotrexate displays an established safety and efficacy profile in both in-hospital and outpatient settings. Despite its widespread use, there is surprisingly little clinical evidence to guide daily practice with methotrexate in dermatology. To provide guidance for clinicians in daily practice for areas in which there is limited guidance. A Delphi consensus exercise on 23 s......
Crisaborole Ointment Improves Quality of Life of Patients with Mild to Moderate Atopic Dermatitis and Their Families
Dermatology and Therapy - Tập 8 - Trang 605-619 - 2018
The impact of crisaborole ointment, a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis (AD), on quality of life (QoL) was assessed in two identically designed phase 3 studies (AD-301: NCT02118766; AD-302: NCT02118792, both at
http://www.clinicaltrials.gov
). In both studies, patients aged ≥ 2 years with mild to moderate AD per the Investigator’s Static Global Assessment were randomly assigned 2:1 to receive crisaborole or vehicle twice daily for 28 days. QoL was assessed using the Children’s Dermatology Life Quality Index (CDLQI) (2–15 years), the Dermatology Life Quality Index (DLQI) (≥ 16 years), and the Dermatitis Family Impact Questionnaire (DFI) (parents/caregivers/family of patients aged 2–17 years). Established QoL score severity bands provided clinical context. Greater mean improvement in QoL was observed in crisaborole-treated patients than in vehicle-treated patients at day 29 [mean change from baseline (∆BL), CDLQI: − 4.6 vs. − 3.0; P < 0.001; DLQI: − 5.2 vs. − 3.5; P = 0.015]. At baseline, more than half the patients had a “moderate effect” or higher of AD on QoL. At day 29, there was a trend toward more crisaborole- than vehicle-treated patients having “small effect” to “no effect”, The QoL of parents/caregivers/family improved more for crisaborole-treated than for vehicle-treated patients (∆BL, DFI: − 3.7 vs. − 2.7; P = 0.003). Crisaborole treatment results in clinically meaningful improvement in QoL for patients and their parents/caregivers/families. AD-301:
http://www.clinicaltrials.gov...
Botulinum Toxin A Alleviates Persistent Erythema and Flushing in Patients with Erythema Telangiectasia Rosacea
Dermatology and Therapy - Tập 12 - Trang 2285-2294 - 2022
The persistent erythema and flushing seen in some cases of rosacea do not respond effectively to, or may easily relapse after, oral medication or light-based therapies (laser or intense pulsed light). Intradermal botulinum toxin A (BTX-A) injection can be used to treat intractable erythema and flushing, but studies with large samples and long-term observation have not been conducted to determine i......
Patients with Chronic Urticaria Remain Largely Undertreated: Results from the DERMLINE Online Survey
Dermatology and Therapy - Tập 11 - Trang 1027-1039 - 2021
Chronic urticaria (CU) is an unpredictable disease, with high disease burden and a significant negative impact on quality of life, especially in patients of working age. Many patients are undertreated, and there is poor awareness of strategies to manage patients with CU in the real-world setting. The current study aimed to gain a better understanding of CU from the patients’ perspective, including......
Pooled Safety Analysis of Baricitinib in Adult Participants with Atopic Dermatitis in the Japanese Subpopulation from Six Randomized Clinical Trials
Dermatology and Therapy - Tập 12 - Trang 2765-2779 - 2022
Baricitinib is an oral selective Janus kinase (JAK)1/JAK2 inhibitor approved in Japan and the European Union for the treatment of atopic dermatitis (AD). The aim of this study is to report pooled safety data for baricitinib in the Japanese subpopulation of the clinical development program in moderate-to-severe AD. This analysis included participant-level safety data from five double-blind, randomi......
A Real-World, Non-interventional Indian Study Evaluating Intensive Plant-Based Butter Moisturizing Cream in Psoriasis
Dermatology and Therapy - Tập 9 - Trang 537-546 - 2019
Psoriasis is estimated to affect 0.44–2.8% of the Indian population. Moisturizers are a key adjuvant psoriasis treatment strategy, but data regarding their effectiveness, safety and compliance pattern in an Indian context are lacking. Hence, this real-world study on an intensive plant-based butter moisturizing cream (Venusia ® Max) was conducted among Indian patients with psoriasis. This was an ob......
Evaluation of Psychological Wellbeing and Social Impact of Combined Facial and Truncal Acne: a Multi-national, Mixed-Methods Study
Dermatology and Therapy - Tập 12 - Trang 1847-1858 - 2022
Half of the individuals with facial acne develop truncal acne, but the impact of combined facial and truncal acne (CA) on patients’ quality of life is poorly researched. A 60-min interview of 30 participants with CA was conducted that formed the basis for a cross-sectional survey of 694 adolescents and adults with CA. The main themes identified from the qualitative interviews among CA subjects inc......
Impact and Management of Loss of Eyebrows and Eyelashes
Dermatology and Therapy - Tập 13 - Trang 1243-1253 - 2023
Eyelashes and eyebrows have different functions, ranging from practical purposes such as protecting the eye apparatus from external hazards to the definition of our facial expression. For this reason, their loss could have both functional and psychological impact on patients’ quality of life. Complete or partial loss can occur any time during life, and identifying the cause is mandatory to establi......
So sánh Công cụ Đánh giá Tác động Chất lượng Cuộc sống của Bệnh nhân Ung thư Da và Bảng hỏi Chỉ số Ung thư Da trong việc Đo lường Chất lượng Cuộc sống Liên quan đến Sức khỏe và Tác động của Tài liệu Giáo dục Bệnh nhân ở Bệnh nhân mắc Bệnh Bạch biến, Ung thư Da không phải Melanoma và Melanoma Da Dịch bởi AI
Dermatology and Therapy - Tập 11 - Trang 929-940 - 2021
Ít nghiên cứu đánh giá các biện pháp kết quả do bệnh nhân báo cáo và tác động của tài liệu giáo dục bệnh nhân ở những bệnh nhân Đức mắc bệnh ung thư da. Chúng tôi thực hiện một nghiên cứu theo chiều dọc để đo lường tác động của điều trị đến chất lượng cuộc sống liên quan đến sức khỏe ở bệnh nhân Đức mắc ung thư da, xác định các biến có thể góp phần vào sự thay đổi chất lượng cuộc sống liên quan đế......
#ung thư da #chất lượng cuộc sống #tài liệu giáo dục bệnh nhân #trị liệu #tác động sức khỏe
Tổng số: 754
- 1
- 2
- 3
- 4
- 5
- 6
- 10