DISEASES
SCOPUS (2020-2025)ESCI-ISI
2079-9721
Cơ quản chủ quản: MDPI
Lĩnh vực:
Research & Experimental
Các bài báo tiêu biểu
Viral Vectors in Gene Therapy
Tập 6 Số 2 - Trang 42
Applications of viral vectors have found an encouraging new beginning in gene
therapy in recent years. Significant improvements in vector engineering,
delivery, and safety have placed viral vector-based therapy at the forefront of
modern medicine. Viral vectors have been employed for the treatment of various
diseases such as metabolic, cardiovascular, muscular, hematologic,
ophthalmologic, and inf...
Milk’s Role as an Epigenetic Regulator in Health and Disease
Tập 5 Số 1 - Trang 12
It is the intention of this review to characterize milk’s role as an epigenetic
regulator in health and disease. Based on translational research, we identify
milk as a major epigenetic modulator of gene expression of the milk recipient.
Milk is presented as an epigenetic “doping system” of mammalian development.
Milk exosome-derived micro-ribonucleic acids (miRNAs) that target DNA
methyltransferas...
Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response
Tập 11 Số 1 - Trang 30
Proteins are central to life functions. Alterations in the structure of proteins
are reflected in their function. Misfolded proteins and their aggregates present
a significant risk to the cell. Cells have a diverse but integrated network of
protection mechanisms. Streams of misfolded proteins that cells are continuously
exposed to must be continually monitored by an elaborated network of molecular...
Progressive Immunodeficiency with Gradual Depletion of B and CD4+ T Cells in Immunodeficiency, Centromeric Instability and Facial Anomalies Syndrome 2 (ICF2)
Tập 7 Số 2 - Trang 34
Immunodeficiency, centromeric instability and facial anomalies syndrome 2 (ICF2)
is a rare autosomal recessive primary immunodeficiency disorder. So far, 27
patients have been reported. Here, we present three siblings with ICF2 due to a
homozygous ZBTB24 gene mutation (c.1222 T>G, p. (Cys408Gly)). Immune deficiency
in these patients ranged from late-onset combined immunodeficiency (CID) with
sever...
Chaperones and Proteostasis: Role in Parkinson’s Disease
Tập 8 Số 2 - Trang 24
Proper folding to attain a defined three-dimensional structure is a prerequisite
for the functionality of a protein. Improper folding that eventually leads to
formation of protein aggregates is a hallmark of several neurodegenerative
disorders. Loss of protein homeostasis triggered by cellular stress conditions
is a major contributing factor for the formation of these toxic aggregates. A
conserved...