Current Treatment Options in Rheumatology

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Idiopathic Inflammatory Myopathies and Malignancy
Current Treatment Options in Rheumatology - Tập 3 - Trang 299-307 - 2017
Elizabeth Hendren, Ophir Vinik
Purpose of review This review highlights concepts in diagnosis and management of patients with cancer-associated myositis (CAM). Recent findings Recent systematic reviews and large cohort studies have identified various characteristics associated with malignancy in patients with idiopathic inflammatory myopathy (IIM), including the utility of myosi...... hiện toàn bộ
Past, Present, and Future in Dermatomyositis Therapeutics
Current Treatment Options in Rheumatology - Tập 8 Số 4 - Trang 71-90
Mo Chung, Julie J Paik
A Promising Target in Rheumatoid Arthritis Treatment: Granulocyte-Macrophage Colony-Stimulating Factor
Current Treatment Options in Rheumatology - Tập 1 - Trang 320-333 - 2015
A. Berkant Avci, Eugen Feist, Gerd-R. Burmester
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is more familiar to clinicians as a hemopoietic growth factor. However, it also modulates functions of myeloid cells such as macrophages. Experimental work has demonstrated its significant contribution to the pathogenesis of rheumatoid arthritis (RA). It was a long-time concern that targeted therapies against this cytokine could cause sever...... hiện toàn bộ
Risks and Benefits of Glucocorticoids in ANCA-Associated Vasculitis
Current Treatment Options in Rheumatology - Tập 3 - Trang 244-253 - 2017
Jennifer C. Rodrigues, Michael Walsh
Purpose of Review Glucocorticoids are a cornerstone in the treatment of ANCA-associated vasculitis. However, the role of long-term, low-dose glucocorticoids for the prevention of relapses is uncertain and substantial practice pattern variation exists. In this review, we will explore evidence supporting or refuting the position that low-dose glucocorticoids modify the risk ...... hiện toàn bộ
Weathering the Storm: Improving Therapeutic Interventions for Cytokine Storm Syndromes by Targeting Disease Pathogenesis
Current Treatment Options in Rheumatology - Tập 3 - Trang 33-48 - 2017
Lehn K. Weaver, Edward M. Behrens
Cytokine storm syndromes require rapid diagnosis and treatment to limit the morbidity and mortality caused by the hyperinflammatory state that characterizes these devastating conditions. Herein, we discuss the current knowledge that guides our therapeutic decision-making and personalization of treatment for patients with cytokine storm syndromes. Firstly, ICU-level supportive care is often require...... hiện toàn bộ
Management of Salivary Hypofunction in Sjögren’s Syndrome
Current Treatment Options in Rheumatology - - 2015
Ava J. Wu
Insights Into Systemic Sclerosis from Gene Expression Profiling
Current Treatment Options in Rheumatology - Tập 7 - Trang 208-221 - 2021
Jennifer M. Franks, Michael L. Whitfield
The emergence of genomic data science stands poised to revolutionize our molecular understanding of the heterogeneity of complex diseases including systemic autoimmune diseases. In systemic sclerosis (SSc), bulk and single-cell transcriptomics have provided a new lens into the heterogeneity of this complex condition, both in terms of molecular heterogeneity, treatment response, and cell types impo...... hiện toàn bộ
Rheumatoid Arthritis–Associated Interstitial Lung Disease: Current Update on Prevalence, Risk Factors, and Pharmacologic Treatment
Current Treatment Options in Rheumatology - Tập 6 - Trang 337-353 - 2020
Sicong Huang, Vanessa L. Kronzer, Paul F. Dellaripa, Kevin D. Deane, Marcy B. Bolster, Vivek Nagaraja, Dinesh Khanna, Tracy J. Doyle, Jeffrey A. Sparks
Rheumatoid arthritis–associated interstitial lung disease (RA-ILD) is one of the most serious extraarticular RA manifestations. RA-ILD is associated with worse physical function, lower quality of life, and increased mortality. RA-ILD is comprised of heterogeneous subtypes characterized by inflammation and fibrosis. Diagnosis can be difficult since the presentation of RA-ILD is characterized by non...... hiện toàn bộ
Whiplash Injuries
Current Treatment Options in Rheumatology - Tập 6 - Trang 394-405 - 2020
Robert Teasell, Swati Mehta, Eldon Loh
Whiplash injuries, also known as whiplash-associated disorders, are commonly seen after motor vehicle accidents and are challenging to manage as a large number of individuals go on to chronicity and are resistant or only partially responsive to current treatments. Although the pathophysiology remains uncertain, there is compelling evidence that a significant number of chronic whiplash injuries are...... hiện toàn bộ
Mechanisms and Mediators of Pain in Chronic Inflammatory Arthritis
Current Treatment Options in Rheumatology - Tập 7 - Trang 194-207 - 2021
Marco Di Carlo, Gianluca Smerilli, Fausto Salaffi
Pain in chronic inflammatory joint diseases is a common symptom reported by patients. Pain becomes of absolute clinical relevance especially when it becomes chronic, i.e., when it persists beyond normal healing times. As an operational definition, pain is defined chronic when it lasts for more than 3 months. This article aims to provide a review of the main mechanisms underlying pain in patients w...... hiện toàn bộ
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