Current Treatment Options in Rheumatology
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How Can We Manipulate the IL-23/IL-17 Axis?
Current Treatment Options in Rheumatology - Tập 1 - Trang 182-196 - 2015
There is compelling evidence that interleukin (IL)-23/IL-17 axis plays a
critical role in the pathogenesis of inflammatory spondyloarthritides including
ankylosing spondylitis, reactive arthritis, psoriatic arthritis, and
inflammatory bowel disease-associated arthritis. IL-17 is a family of cytokines.
Of the six members of IL-17, IL-17A and IL-17F are the most closely related
proinflammatory cytok...
Disease Modification in Psoriatic Arthritis
Current Treatment Options in Rheumatology - Tập 4 - Trang 197-213 - 2018
To provide clinicians evidence-based strategies to diagnose and treat psoriatic
arthritis (PsA) patients based on involvement of the key domains peripheral
arthritis, psoriasis and nails, axial involvement, dactylitis, and enthesitis,
with the goal of improving outcomes for PsA patients by lessening joint pain and
swelling and the degree of inflammation in the other key domains. It is also
imperat...
Gout và Tăng Uric: Một Góc Nhìn Lịch Sử Dịch bởi AI
Current Treatment Options in Rheumatology - Tập 1 - Trang 119-130 - 2015
Gout là một rối loạn phổ biến về chuyển hóa axit uric. Là một căn bệnh đã có từ
lâu đời, những biểu hiện ấn tượng và đặc trưng của nó đã được các bác sĩ lâm
sàng và những người mắc bệnh quen thuộc từ nhiều thế kỷ. Những liệu pháp hiện
đại hiệu quả có thể đã làm giảm bớt tầm quan trọng của nó, nhưng lịch sử dài và
phong phú của nó vẫn là nguồn cảm hứng, thực sự là một hình thức giải trí cho
những a...
#Gout #Tăng Uric #Lịch sử bệnh học #Sinh lý bệnh #Y học
Idiopathic Inflammatory Myopathies and Malignancy
Current Treatment Options in Rheumatology - Tập 3 - Trang 299-307 - 2017
Purpose of review This review highlights concepts in diagnosis and management of
patients with cancer-associated myositis (CAM). Recent findings Recent
systematic reviews and large cohort studies have identified various
characteristics associated with malignancy in patients with idiopathic
inflammatory myopathy (IIM), including the utility of myositis-specific
antibodies (MSA) associated with high...
Using the Concept of Frailty to Understand Variability in Health Outcomes Among Individuals with Systemic Lupus Erythematosus
Current Treatment Options in Rheumatology - Tập 6 - Trang 268-281 - 2020
Some individuals experience greater susceptibility to adverse health outcomes
than others, which is known as frailty. There are two main approaches to
operationalizing frailty—the phenotypic approach and the deficit accumulation
approach. We review these approaches and discuss their respective strengths and
limitations. Both approaches can advance our understanding of the unexplained
heterogeneity...
Autoimmune Necrotizing Myopathies: Subtypes and Advances in Treatment
Current Treatment Options in Rheumatology - Tập 3 - Trang 267-274 - 2017
Purpose of Review Necrotizing autoimmune myopathies (NAM), or immune-mediated
necrotizing myopathies (IMNM), are considered as a unique category of autoimmune
myopathy given their distinctive histologic, serologic, and clinical features.
The goals of this article are to review the subtypes of IMNM and to discuss
treatment options that apply to these conditions. Recent findings Two thirds of
cases ...
The Greater Trochanteric Pain Syndrome: Clinical Presentation, Diagnosis, and Management
Current Treatment Options in Rheumatology - Tập 9 - Trang 192-203 - 2023
This review describes the greater trochanteric pain syndrome in terms of its
clinical presentation, diagnosis, and management. We emphasized recent studies
including emerging therapies such as radiofrequency ablation of the trochanteric
branches of the femoral nerve and new surgical therapies such as minimal
invasive surgery and gluteal reconstruction. We describe conservative therapies,
such as l...
Insight into the Contrasting Findings of Therapeutic Trials of Digital Ischaemic Manifestations of Systemic Sclerosis
Current Treatment Options in Rheumatology - Tập 5 - Trang 85-103 - 2019
Digital vascular complications are a major cause of disease-related morbidity in
systemic sclerosis (SSc). Demonstrating treatment efficacy in the management of
cutaneous vascular manifestations of SSc has been challenging. The contrasting
findings of clinical trials of Raynaud’s phenomenon (RP) and digital ulcers (DU)
for within-class medications have led to doubt on likely efficacy; with
geograp...
Personalized Axial Spondyloarthritis Care
Current Treatment Options in Rheumatology - Tập 4 - Trang 158-173 - 2018
To discuss the personalized care of patients with axial spondyloarthritis.
Secukinumab, an IL-17A inhibitor, has recently been proven to be effective in
treating signs and symptoms of ankylosing spondylitis. The latest update of
ASAS/EULAR management recommendations include secukinumab and recommend a
personalized medicine approach for the treatment of patients with axial
spondyloarthritis. Nonste...
Management of Dry Eye in Sjögren’s Syndrome
Current Treatment Options in Rheumatology - Tập 1 - Trang 292-304 - 2015
The treatment of dry eye in Sjögren’s syndrome varies based on the severity of
the disease. First-line therapy usually includes environmental changes and
lubrication of the ocular surface with the use of artificial tears and/or
ointments. Punctal occlusion may also help by extending available lubrication
via natural or artificial tears. However, the occlusion of the puncta is usually
recommended a...
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