Current Treatment Options in Rheumatology

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How Can We Manipulate the IL-23/IL-17 Axis?
Current Treatment Options in Rheumatology - Tập 1 - Trang 182-196 - 2015
Ling Zhao, Daniela Ghetie, Zhenyu Jiang, Cong-Qiu Chu
There is compelling evidence that interleukin (IL)-23/IL-17 axis plays a critical role in the pathogenesis of inflammatory spondyloarthritides including ankylosing spondylitis, reactive arthritis, psoriatic arthritis, and inflammatory bowel disease-associated arthritis. IL-17 is a family of cytokines. Of the six members of IL-17, IL-17A and IL-17F are the most closely related proinflammatory cytok...... hiện toàn bộ
Disease Modification in Psoriatic Arthritis
Current Treatment Options in Rheumatology - Tập 4 - Trang 197-213 - 2018
Alicia Lieberman, Christopher Ritchlin
To provide clinicians evidence-based strategies to diagnose and treat psoriatic arthritis (PsA) patients based on involvement of the key domains peripheral arthritis, psoriasis and nails, axial involvement, dactylitis, and enthesitis, with the goal of improving outcomes for PsA patients by lessening joint pain and swelling and the degree of inflammation in the other key domains. It is also imperat...... hiện toàn bộ
Gout và Tăng Uric: Một Góc Nhìn Lịch Sử Dịch bởi AI
Current Treatment Options in Rheumatology - Tập 1 - Trang 119-130 - 2015
C. Ronald MacKenzie
Gout là một rối loạn phổ biến về chuyển hóa axit uric. Là một căn bệnh đã có từ lâu đời, những biểu hiện ấn tượng và đặc trưng của nó đã được các bác sĩ lâm sàng và những người mắc bệnh quen thuộc từ nhiều thế kỷ. Những liệu pháp hiện đại hiệu quả có thể đã làm giảm bớt tầm quan trọng của nó, nhưng lịch sử dài và phong phú của nó vẫn là nguồn cảm hứng, thực sự là một hình thức giải trí cho những a...... hiện toàn bộ
#Gout #Tăng Uric #Lịch sử bệnh học #Sinh lý bệnh #Y học
Idiopathic Inflammatory Myopathies and Malignancy
Current Treatment Options in Rheumatology - Tập 3 - Trang 299-307 - 2017
Elizabeth Hendren, Ophir Vinik
Purpose of review This review highlights concepts in diagnosis and management of patients with cancer-associated myositis (CAM). Recent findings Recent systematic reviews and large cohort studies have identified various characteristics associated with malignancy in patients with idiopathic inflammatory myopathy (IIM), including the utility of myosi...... hiện toàn bộ
Using the Concept of Frailty to Understand Variability in Health Outcomes Among Individuals with Systemic Lupus Erythematosus
Current Treatment Options in Rheumatology - Tập 6 - Trang 268-281 - 2020
Alexandra Legge, John G. Hanly
Some individuals experience greater susceptibility to adverse health outcomes than others, which is known as frailty. There are two main approaches to operationalizing frailty—the phenotypic approach and the deficit accumulation approach. We review these approaches and discuss their respective strengths and limitations. Both approaches can advance our understanding of the unexplained heterogeneity...... hiện toàn bộ
Autoimmune Necrotizing Myopathies: Subtypes and Advances in Treatment
Current Treatment Options in Rheumatology - Tập 3 - Trang 267-274 - 2017
Jason Liebowitz, Lisa Christopher-Stine
Purpose of Review Necrotizing autoimmune myopathies (NAM), or immune-mediated necrotizing myopathies (IMNM), are considered as a unique category of autoimmune myopathy given their distinctive histologic, serologic, and clinical features. The goals of this article are to review the subtypes of IMNM and to discuss treatment options that apply to these conditions. ...... hiện toàn bộ
The Greater Trochanteric Pain Syndrome: Clinical Presentation, Diagnosis, and Management
Current Treatment Options in Rheumatology - Tập 9 - Trang 192-203 - 2023
Romain Guemara, Michael John Nissen
This review describes the greater trochanteric pain syndrome in terms of its clinical presentation, diagnosis, and management. We emphasized recent studies including emerging therapies such as radiofrequency ablation of the trochanteric branches of the femoral nerve and new surgical therapies such as minimal invasive surgery and gluteal reconstruction. We describe conservative therapies, such as l...... hiện toàn bộ
Insight into the Contrasting Findings of Therapeutic Trials of Digital Ischaemic Manifestations of Systemic Sclerosis
Current Treatment Options in Rheumatology - Tập 5 - Trang 85-103 - 2019
John D. Pauling, Vivek Nagaraja, Dinesh Khanna
Digital vascular complications are a major cause of disease-related morbidity in systemic sclerosis (SSc). Demonstrating treatment efficacy in the management of cutaneous vascular manifestations of SSc has been challenging. The contrasting findings of clinical trials of Raynaud’s phenomenon (RP) and digital ulcers (DU) for within-class medications have led to doubt on likely efficacy; with geograp...... hiện toàn bộ
Personalized Axial Spondyloarthritis Care
Current Treatment Options in Rheumatology - Tập 4 - Trang 158-173 - 2018
Nurullah Akkoc
To discuss the personalized care of patients with axial spondyloarthritis. Secukinumab, an IL-17A inhibitor, has recently been proven to be effective in treating signs and symptoms of ankylosing spondylitis. The latest update of ASAS/EULAR management recommendations include secukinumab and recommend a personalized medicine approach for the treatment of patients with axial spondyloarthritis. Nonste...... hiện toàn bộ
Management of Dry Eye in Sjögren’s Syndrome
Current Treatment Options in Rheumatology - Tập 1 - Trang 292-304 - 2015
Michelle Hessen, Sezen Karakus, Esen Karamursel Akpek
The treatment of dry eye in Sjögren’s syndrome varies based on the severity of the disease. First-line therapy usually includes environmental changes and lubrication of the ocular surface with the use of artificial tears and/or ointments. Punctal occlusion may also help by extending available lubrication via natural or artificial tears. However, the occlusion of the puncta is usually recommended a...... hiện toàn bộ
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