Postoperative Monitoring: Biomarkers and Alloimmune Responses and Their Relevance to Vascularized Composite AllotransplantationCurrent Transplantation Reports - Tập 1 - Trang 203-210 - 2014
Gavin Whitehouse, Alberto Sanchez-Fueyo
Vascularized composite allotransplantation (VCA) is an evolving area of transplantation. Postoperative monitoring and immunosuppression strategies draw experience from solid organ transplantation, but VCA provides unique challenges as grafts incorporate histologically heterogenous tissues with differing degrees of antigenicity. In addition, such procedures are often life-improving rather than life...... hiện toàn bộ
Vascularized Composite Allografts: Procurement, Allocation, and ImplementationCurrent Transplantation Reports - Tập 1 - Trang 173-182 - 2014
Axel Rahmel
Vascularized composite allotransplantation is a continuously evolving area of modern transplant medicine. Recently, vascularized composite allografts (VCAs) have been formally classified as ‘organs’. In this review, key aspects of VCA procurement are discussed, with a special focus on interaction with the procurement of classical solid organs. In addition, options for a matching and allocation sys...... hiện toàn bộ
Cognitive Function in Kidney TransplantationCurrent Transplantation Reports - Tập 7 - Trang 145-153 - 2020
Andrew Jurgensen, Abd Assalam Qannus, Aditi Gupta
Cognitive impairment is common in kidney transplant recipients and affects quality of life, graft survival, morbidity, and mortality. In this review article we discuss the epidemiology, diagnosis, pathophysiology, and future directions for cognitive impairment in kidney transplantation. We describe the potential role of pre-transplant cognition, immunosuppression, and peri-transplant factors in po...... hiện toàn bộ
What Is Direct Allorecognition?Current Transplantation Reports - Tập 3 - Trang 275-283 - 2016
Dominic A. Boardman, Jacinta Jacob, Lesley A. Smyth, Giovanna Lombardi, Robert I. Lechler
Direct allorecognition is the process by which donor-derived major histocompatibility complex (MHC)-peptide complexes, typically presented by donor-derived ‘passenger’ dendritic cells, are recognised directly by recipient T cells. In this review, we discuss the two principle theories which have been proposed to explain why individuals possess a high-precursor frequency of T cells with direct allos...... hiện toàn bộ
Platelets: Mechanistic and Diagnostic Significance in TransplantationCurrent Transplantation Reports - Tập 7 - Trang 124-130 - 2020
Raneem Khedraki, Jayeeta Dhar, William M. Baldwin
In addition to their function in coagulation, platelets recently have been recognized as an important component of innate immune responses. This review relates salient immune functions of platelets to transplants. Platelets are critical bridges between vascular endothelium and leukocytes. Real-time imaging of platelets has demonstrated that platelets rapidly adhere to vascular endothelium and form...... hiện toàn bộ
Review of Major Drug-Drug Interactions in Thoracic TransplantationCurrent Transplantation Reports - Tập 5 - Trang 220-230 - 2018
Yu Xie, Deanna Dilibero, David H. Chang
The first human lung transplant surgery in the world was done in 1963, followed by the first heart transplant in 1967, making this year its 50th anniversary. Since then, there has been great advancement in immunotherapy, with the adoption of calcineurin inhibitors (CNI), mycophenolate mofetil, and proliferation signal inhibitors (PSI). However, while these medications are crucial to maintenance of...... hiện toàn bộ
Managing the Costs of Routine Follow-up Care After Living Kidney Donation: a Review and Survey of Contemporary Experience, Practices, and ChallengesCurrent Transplantation Reports -
Krista L. Lentine, Nagaraju Sarabu, Gwen McNatt, Robert Howey, Rebecca Hays, Christie P. Thomas, Ursula Lebron-Banks, Linda Ohler, Cody Wooley, Addie Wisniewski, Huiling Xiao, Andrea L. Tietjen
Abstract
Purpose of Review
While living organ donor follow-up is mandated for 2 years in the USA, formal guidance on recovering associated costs of follow-up care is lacking. In this review, we discuss current billing practices of transplant programs for living kidney donor follow-up, and propose fu...... hiện toàn bộ
Informed Consent of Living Kidney Donors: Pitfalls and Best PracticeCurrent Transplantation Reports - Tập 2 - Trang 29-34 - 2015
Rebecca E. Hays
Informed consent is clearly considered the ethical bedrock fundamental to living organ donation, a procedure lacking medical benefits for its participants. Recent guidelines have focused on strengthening content components of living kidney donor informed consent, including Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) policies that prescribe key compo...... hiện toàn bộ