Current Protocols in Human Genetics

Sound and reproducible laboratory methods are the foundation of scientific discovery. Yet, all too often, nuances that are critical for an experiment’s success are not captured in the primary literature but exist only as part of a lab’s oral tradition. The aim of each Current Protocols title is to provide the clearest, most detailed and reliable step-by-step instructions for all protocols relevant to a given subject area. Written by experts in the field and extensively edited to our exacting standards, the protocols include all of the information necessary to complete an experiment in the laboratory—introduction, materials lists with supplier information, detailed step-by-step procedures with helpful annotations, recipes for reagents and solutions, illustrative figures and information-packed tables. Each article also provides invaluable discussions of background information, applications of the methods, important assumptions, key parameters, time considerations, and tips to help avoid common pitfalls and troubleshoot experiments. Furthermore, Current Protocols content is thoughtfully organized by topic for optimal usage and to maximize contextual knowledge. Quarterly issues allow Current Protocols to constantly evolve to keep pace with the newest discoveries and developments. Current Protocols in Human Genetics is the comprehensive resource for all types of research and clinical laboratory approaches pertaining to human genetics. Current Protocols in Human Genetics brings together hundreds of core and cutting edge techniques in all branches of genetics including: Genetic Mapping Genotyping Cytogenetics Identifying Candidate Genes Identifying Sequence Variants Clinical Cytogenetics Clinical Molecular Genetics Cancer Genetics Transcriptional Profiling Gene Therapy Forensic Genetics Model Systems for the Analysis of Human Disease Biochemical Genetics High‐Throughput Sequencing Mitochondrial Genetics Epigenetics iPS Cell Models.