Current Molecular Biology Reports

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Recent Advances in the Inference of Gene Flow from Population Genomic Data
Current Molecular Biology Reports - Tập 5 - Trang 107-115 - 2019
Richard H. Adams, Drew R. Schield, Todd A. Castoe
Detecting gene flow between populations or species is a fundamental goal of population genetics and speciation research and is also central for a thorough understanding of the demographic history of lineages. While population genomic data offer an unparalleled opportunity to study gene flow and other evolutionary processes at high resolution, extracting meaningful patterns from such large and comp...... hiện toàn bộ
Phenotype of Bone Marrow Adipose Tissue: Specificities of the Anatomical Distribution, Secretory Profile, Lipid Content, and Response to Nutritional Status
Current Molecular Biology Reports - Tập 4 - Trang 8-15 - 2018
Céline Gillet, Joanne Rasschaert
Bone marrow adipose tissue (BMAT) is currently considered as a unique and typical fat depot, able to modulate the metabolism of bone cells that share the same microenvironment, with putative subsequent impact on skeletal health. The aim of the present review is to update knowledge related to the molecular phenotype of the BMAT adipocytes. Although sharing white and brown adipose tissue-like featur...... hiện toàn bộ
Biomimicking of the Breast Tumor Microenvironment
Current Molecular Biology Reports - Tập 1 - Trang 71-76 - 2015
Marta Giussani, Carmelo De Maria, Vasso Michele, Francesca Montemurro, Tiziana Triulzi, Elda Tagliabue, Cecilia Gelfi, Giovanni Vozzig
The tumor microenvironment is well known to play a role in sustaining malignant transformation of tissue, tumor progression, and in drug responsiveness; however, much remains unclear about the interplay between tumor cells, the extracellular matrix, and stroma cells. The extracellular matrix has been shown to elicit both biochemical and biophysical signaling, and matrix rigidity is an important mi...... hiện toàn bộ
Molluscan Genomics: Implications for Biology and Aquaculture
Current Molecular Biology Reports - Tập 3 - Trang 297-305 - 2017
Takeshi Takeuchi
As a result of advances in DNA sequencing technology, molluscan genome research, which initially lagged behind that of many other animal groups, has recently seen a rapid succession of decoded genomes. Since molluscs are highly divergent, the subjects of genome projects have been highly variable, including evolution, neuroscience, and ecology. In this review, recent findings of molluscan genome pr...... hiện toàn bộ
Tumor Microenvironment Heterogeneity: Challenges and Opportunities
Current Molecular Biology Reports - - 2017
Farhana Runa, Sarkis Hamalian, Kayla Meade, Preston Shisgal, Peter C. Gray, Jonathan A. Kelber
New PTH Signals Mediating Bone Anabolism
Current Molecular Biology Reports - Tập 3 - Trang 133-141 - 2017
Hadla Hariri, Martin Pellicelli, René St-Arnaud
Because of its clinical relevance, extensive work has been performed to uncover the signaling pathways modulated by parathyroid hormone (PTH). This review focuses on the recent identification of novel effectors of the anabolic effect of PTH in bone. PTH-induced activation of PKA leads to inactivation of SIK2 and nuclear translocation of HDAC4/5. This inhibits MEF2C-dependent Sost expression. Howev...... hiện toàn bộ
Cell Mechanosensitivity Is Enabled by the LINC Nuclear Complex
Current Molecular Biology Reports - Tập 2 - Trang 36-47 - 2016
Gunes Uzer, Clinton T. Rubin, Janet Rubin
Mechanoresponses in mesenchymal stem cells (MSCs) guide both differentiation and function. In this review, we focus on advances in our understanding of how the cytoplasmic cytoskeleton, nuclear envelope, and nucleoskeleton, which are connected via linker of nucleoskeleton and cytoskeleton (LINC) complexes, are emerging as an integrated dynamic signaling platform to regulate MSC mechanobiology. Thi...... hiện toàn bộ
Progenitor Cells of the Mandibular Condylar Cartilage
Current Molecular Biology Reports - Tập 1 - Trang 110-114 - 2015
Jennifer Robinson, Alina O’Brien, Jing Chen, Sunil Wadhwa
The secondary cartilage of the mandibular condyle is unique as it undergoes endochondral ossification during growth and robustly remodels in response to changes in its mechanical loading environment. This cartilage is derived from mesenchymal progenitor cells that express markers of early osteoblast differentiation, namely alkaline phosphatase (ALP) and runt-related transcription factor 2 (Runx2)....... hiện toàn bộ
Novel Drug Treatments for Ewing Sarcoma
Current Molecular Biology Reports - Tập 5 - Trang 153-166 - 2019
Reiya Hayden, Markos Leggas
Ewing sarcoma is the second most common bone cancer seen in children and adolescents. Previous reports have demonstrated that the main driver of malignancy in this disease is an aberrant transcription factor that is expressed by gene fusions between the EWSR1 gene and an ETS family transcription factor such as FLI1 or ERG. Here we review recent preclinical and clinical advances in drug development...... hiện toàn bộ
Epigenetic Control of Osteoblast Differentiation by Enhancer of Zeste Homolog 2 (EZH2)
Current Molecular Biology Reports - Tập 3 - Trang 94-106 - 2017
Amel Dudakovic, Andre J. van Wijnen
Because epigenetic processes are critical during development, there is considerable interest in understanding how epigenetic enzymes control lineage commitment and progression. We review recent studies indicating that methylation of histone 3 at lysine 27 (H3K27), which is a major epigenetic modification that promotes gene silencing by reducing chromatin accessibility, is a principal regulatory me...... hiện toàn bộ
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