Current Molecular Biology Reports
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Recent Advances in the Inference of Gene Flow from Population Genomic Data
Current Molecular Biology Reports - Tập 5 - Trang 107-115 - 2019
Detecting gene flow between populations or species is a fundamental goal of
population genetics and speciation research and is also central for a thorough
understanding of the demographic history of lineages. While population genomic
data offer an unparalleled opportunity to study gene flow and other evolutionary
processes at high resolution, extracting meaningful patterns from such large and
comp...
Phenotype of Bone Marrow Adipose Tissue: Specificities of the Anatomical Distribution, Secretory Profile, Lipid Content, and Response to Nutritional Status
Current Molecular Biology Reports - Tập 4 - Trang 8-15 - 2018
Bone marrow adipose tissue (BMAT) is currently considered as a unique and
typical fat depot, able to modulate the metabolism of bone cells that share the
same microenvironment, with putative subsequent impact on skeletal health. The
aim of the present review is to update knowledge related to the molecular
phenotype of the BMAT adipocytes. Although sharing white and brown adipose
tissue-like featur...
Biomimicking of the Breast Tumor Microenvironment
Current Molecular Biology Reports - Tập 1 - Trang 71-76 - 2015
The tumor microenvironment is well known to play a role in sustaining malignant
transformation of tissue, tumor progression, and in drug responsiveness;
however, much remains unclear about the interplay between tumor cells, the
extracellular matrix, and stroma cells. The extracellular matrix has been shown
to elicit both biochemical and biophysical signaling, and matrix rigidity is an
important mi...
Molluscan Genomics: Implications for Biology and Aquaculture
Current Molecular Biology Reports - Tập 3 - Trang 297-305 - 2017
As a result of advances in DNA sequencing technology, molluscan genome research,
which initially lagged behind that of many other animal groups, has recently
seen a rapid succession of decoded genomes. Since molluscs are highly divergent,
the subjects of genome projects have been highly variable, including evolution,
neuroscience, and ecology. In this review, recent findings of molluscan genome
pr...
Tumor Microenvironment Heterogeneity: Challenges and Opportunities
Current Molecular Biology Reports - - 2017
New PTH Signals Mediating Bone Anabolism
Current Molecular Biology Reports - Tập 3 - Trang 133-141 - 2017
Because of its clinical relevance, extensive work has been performed to uncover
the signaling pathways modulated by parathyroid hormone (PTH). This review
focuses on the recent identification of novel effectors of the anabolic effect
of PTH in bone. PTH-induced activation of PKA leads to inactivation of SIK2 and
nuclear translocation of HDAC4/5. This inhibits MEF2C-dependent Sost expression.
Howev...
Cell Mechanosensitivity Is Enabled by the LINC Nuclear Complex
Current Molecular Biology Reports - Tập 2 - Trang 36-47 - 2016
Mechanoresponses in mesenchymal stem cells (MSCs) guide both differentiation and
function. In this review, we focus on advances in our understanding of how the
cytoplasmic cytoskeleton, nuclear envelope, and nucleoskeleton, which are
connected via linker of nucleoskeleton and cytoskeleton (LINC) complexes, are
emerging as an integrated dynamic signaling platform to regulate MSC
mechanobiology. Thi...
Progenitor Cells of the Mandibular Condylar Cartilage
Current Molecular Biology Reports - Tập 1 - Trang 110-114 - 2015
The secondary cartilage of the mandibular condyle is unique as it undergoes
endochondral ossification during growth and robustly remodels in response to
changes in its mechanical loading environment. This cartilage is derived from
mesenchymal progenitor cells that express markers of early osteoblast
differentiation, namely alkaline phosphatase (ALP) and runt-related
transcription factor 2 (Runx2)....
Novel Drug Treatments for Ewing Sarcoma
Current Molecular Biology Reports - Tập 5 - Trang 153-166 - 2019
Ewing sarcoma is the second most common bone cancer seen in children and
adolescents. Previous reports have demonstrated that the main driver of
malignancy in this disease is an aberrant transcription factor that is expressed
by gene fusions between the EWSR1 gene and an ETS family transcription factor
such as FLI1 or ERG. Here we review recent preclinical and clinical advances in
drug development...
Epigenetic Control of Osteoblast Differentiation by Enhancer of Zeste Homolog 2 (EZH2)
Current Molecular Biology Reports - Tập 3 - Trang 94-106 - 2017
Because epigenetic processes are critical during development, there is
considerable interest in understanding how epigenetic enzymes control lineage
commitment and progression. We review recent studies indicating that methylation
of histone 3 at lysine 27 (H3K27), which is a major epigenetic modification that
promotes gene silencing by reducing chromatin accessibility, is a principal
regulatory me...
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