Current Molecular Biology Reports

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Molluscan Genomics: Implications for Biology and Aquaculture
Current Molecular Biology Reports - Tập 3 - Trang 297-305 - 2017
Takeshi Takeuchi
As a result of advances in DNA sequencing technology, molluscan genome research, which initially lagged behind that of many other animal groups, has recently seen a rapid succession of decoded genomes. Since molluscs are highly divergent, the subjects of genome projects have been highly variable, including evolution, neuroscience, and ecology. In this review, recent findings of molluscan genome pr...... hiện toàn bộ
New PTH Signals Mediating Bone Anabolism
Current Molecular Biology Reports - Tập 3 - Trang 133-141 - 2017
Hadla Hariri, Martin Pellicelli, René St-Arnaud
Because of its clinical relevance, extensive work has been performed to uncover the signaling pathways modulated by parathyroid hormone (PTH). This review focuses on the recent identification of novel effectors of the anabolic effect of PTH in bone. PTH-induced activation of PKA leads to inactivation of SIK2 and nuclear translocation of HDAC4/5. This inhibits MEF2C-dependent Sost expression. Howev...... hiện toàn bộ
Cell Mechanosensitivity Is Enabled by the LINC Nuclear Complex
Current Molecular Biology Reports - Tập 2 - Trang 36-47 - 2016
Gunes Uzer, Clinton T. Rubin, Janet Rubin
Mechanoresponses in mesenchymal stem cells (MSCs) guide both differentiation and function. In this review, we focus on advances in our understanding of how the cytoplasmic cytoskeleton, nuclear envelope, and nucleoskeleton, which are connected via linker of nucleoskeleton and cytoskeleton (LINC) complexes, are emerging as an integrated dynamic signaling platform to regulate MSC mechanobiology. Thi...... hiện toàn bộ
Progenitor Cells of the Mandibular Condylar Cartilage
Current Molecular Biology Reports - Tập 1 - Trang 110-114 - 2015
Jennifer Robinson, Alina O’Brien, Jing Chen, Sunil Wadhwa
The secondary cartilage of the mandibular condyle is unique as it undergoes endochondral ossification during growth and robustly remodels in response to changes in its mechanical loading environment. This cartilage is derived from mesenchymal progenitor cells that express markers of early osteoblast differentiation, namely alkaline phosphatase (ALP) and runt-related transcription factor 2 (Runx2)....... hiện toàn bộ
Epigenetic Control of Osteoblast Differentiation by Enhancer of Zeste Homolog 2 (EZH2)
Current Molecular Biology Reports - Tập 3 - Trang 94-106 - 2017
Amel Dudakovic, Andre J. van Wijnen
Because epigenetic processes are critical during development, there is considerable interest in understanding how epigenetic enzymes control lineage commitment and progression. We review recent studies indicating that methylation of histone 3 at lysine 27 (H3K27), which is a major epigenetic modification that promotes gene silencing by reducing chromatin accessibility, is a principal regulatory me...... hiện toàn bộ
MicroRNA Applications in Marine Biology
Current Molecular Biology Reports - Tập 5 - Trang 167-175 - 2019
Carolina A. Bonin, Andre J. van Wijnen, Eric A. Lewallen
MicroRNAs (miRNAs) are single-stranded, short (~ 22 nt) non-coding RNAs that control gene expression in most metazoan taxa. These vital post-transcriptional regulators are emerging as a novel class of relatively well-conserved biomarkers useful to molecular ecologists working on non-model marine organisms. The purpose of this review is to provide researchers with a brief background on miRNAs and t...... hiện toàn bộ
Plant-Based Vaccine for Livestock: Key Points to Unleash Platform Translation in Developing Countries
Current Molecular Biology Reports - - 2016
María Sol Pérez Aguirreburualde, Silvana Petruccelli, Fernando Felix Bravo Almonacid, Andrés Wigdorovitz
Applications and Future Directions for Population Transcriptomics in Marine Invertebrates
Current Molecular Biology Reports - Tập 5 - Trang 116-127 - 2019
Lani U. Gleason
RNA-sequencing has provided a new way to study transcriptomic population differences of non-model organisms such as marine invertebrates. Importantly, population transcriptomics can provide insight regarding the genetic mechanisms that allow some populations to tolerate various environmental stressors in this era of climate change. Such studies can help us predict future population dynamics and sp...... hiện toàn bộ
Sclerostin and Adipose Tissue
Current Molecular Biology Reports - Tập 3 - Trang 71-78 - 2017
Keertik Fulzele, Paola Divieti Pajevic
Since its discovery 15 years ago, inhibition of sclerostin has come to be identified as a potent anabolic agent. The sclerostin neutralizing antibody, romosozumab, is a promising treatment for postmenopausal osteoporosis. Animal studies also show a role of sclerostin in regulating hematopoietic cells and, more recently, adipocytes. This review will summarize the newly discovered effects of scleros...... hiện toàn bộ
miRNA Regulation of Chondrogenesis
Current Molecular Biology Reports - Tập 4 - Trang 208-217 - 2018
Garyfallia Papaioannou, Anastasia Kozlova, Tatsuya Kobayashi
Knowledge of microRNAs (miRNAs) in cartilage biology is constantly expanding. The purpose of this review is to provide a global view on recent findings and to discuss the future direction of miRNA research in cartilage. Physiological roles and mechanisms of action of miRNAs in chondrogenesis have been investigated in animal and cell models. In addition to these efforts to understand basic biology,...... hiện toàn bộ
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