Current Hepatology Reports

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Management of Direct-Acting Antiviral Failures in Chronic Hepatitis C Infection
Current Hepatology Reports - Tập 15 - Trang 296-306 - 2016
Kevin Tin, Eiei Soe, James Park
Direct-acting antiviral agents have revolutionized the treatment for chronic hepatitis C infection with very high cure rates. Treatment failures are commonly due to non-adherence and relapse but less often to viral breakthrough while on therapy. Resistance-associated variants have also emerged to be a culprit for treatment failures. Optimal retreatment regimens in patients who fail direct-acting a...... hiện toàn bộ
New Tools for the Noninvasive Assessment of Cirrhosis
Current Hepatology Reports - Tập 13 - Trang 14-23 - 2014
Bogdan Procopet, Annalisa Berzigotti
The diagnosis of cirrhosis and portal hypertension is critical for the correct management and follow-up of patients with chronic liver disease. Non-invasive methods to safely replace liver biopsy and hepatic venous pressure gradient measurement have been increasingly studied in the last 20 years. This review summarizes the available data regarding validated non-invasive methods to diagnose cirrhos...... hiện toàn bộ
Hepatitis C and Hepatocellular Carcinoma
Current Hepatology Reports - Tập 15 - Trang 291-295 - 2016
Janice Jou, Willscott E. Naugler
With the significant burden of hepatocellular carcinoma (HCC) attributable to hepatitis C (HCV), prevention of HCC should first and foremost include treatment of hepatitis C. At the very least, any patient who is at risk for liver disease progression to advanced fibrosis should have HCV treated. This is potentially one of the single most important interventions that can be employed long-term to de...... hiện toàn bộ
Chemoprevention in hepatocellular carcinoma
Current Hepatology Reports - Tập 22 - Trang 108-117 - 2023
Hiroyuki Suzuki, Cheng Han Ng, Darren Jun Hao Tan, Margaret Teng, Takumi Kawaguchi, Daniel Q. Huang
The number of deaths due to hepatocellular carcinoma (HCC) continues to rise. Chemoprevention may be a useful strategy to prevent HCC. We summarize recent clinical and translational studies on the chemoprevention of HCC from the aspects of etiology-specific and generic chemoprevention in the context of contemporary HCC etiologies. Use of safe and effective HCC chemopreventive agents may reduce the...... hiện toàn bộ
Multidisciplinary Team Management of Patients with Hepatocellular Carcinoma
Current Hepatology Reports - Tập 16 Số 2 - Trang 146-151 - 2017
Caitlin A. Hester, Ali Mokdad, Adam C. Yopp
Diagnosis and Management of Occult Hepatitis B Infection
Current Hepatology Reports - Tập 19 - Trang 354-361 - 2020
Brian T. Lee, Ponni V. Perumalswami
Occult hepatitis B infection refers to the presence of replication-competent hepatitis B virus despite the lack of hepatitis B surface antigen due to epigenetic or immune control. Risk factors for occult hepatitis B infection include sex work, blood transfusion, hemodialysis, and liver transplantation. Historically, the recognition of occult hepatitis B infection has been important in preventing r...... hiện toàn bộ
Burden, Quality of Life, and Palliative Care for Family Caregivers of Individuals with Advanced Liver Disease: a Systematic Literature Review
Current Hepatology Reports - Tập 20 - Trang 198-212 - 2021
Christopher D. Woodrell, Arnab Mitra, Andrew Hamilton, Lissi Hansen
Identify and describe prior studies of family caregiver quality of life, health, and burden experienced while caring for patients with advanced liver disease and the possible role of palliative care. Thirty-six articles were identified that met inclusion criteria. Studies identified included cross-sectional, longitudinal, and prospective intervention studies, with a high proportion of qualitative ...... hiện toàn bộ
Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management
Current Hepatology Reports - Tập 17 - Trang 235-244 - 2018
Ben L. Da, Gil Ben-Yakov, David Kleiner, Christopher Koh
The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications...... hiện toàn bộ
The Role of RNA Interference in Functional Cure Strategies for Chronic Hepatitis B
Current Hepatology Reports - - 2020
Jeremy S Nayagam, Zillah Cargill, Kosh Agarwal
Abstract Purpose of Review Current treatments for chronic hepatitis B (CHB) are associated with low rates of cure. Functional cure has been accepted as a viable treatment end point in CHB. There have been substantial advances in the field of RNA interference (RNAi) therapeutics across a wide range o...... hiện toàn bộ
Extrahepatic Malignancies in Nonalcoholic Fatty Liver Disease
Current Hepatology Reports - Tập 18 - Trang 455-472 - 2019
Omar T. Ahmed, Alina M. Allen
Malignancy is the second most common cause of death in individuals with nonalcoholic fatty liver disease (NAFLD). Understanding unique characteristics of malignancy risk beyond hepatocellular carcinoma in NAFLD has significant implications in counseling and personalized preventative measures in this high-risk population. Herein, we systematically review the literature reporting extra-hepatic malig...... hiện toàn bộ
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