Current Hepatology Reports

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New Tools for the Noninvasive Assessment of Cirrhosis
Current Hepatology Reports - Tập 13 - Trang 14-23 - 2014
Bogdan Procopet, Annalisa Berzigotti
The diagnosis of cirrhosis and portal hypertension is critical for the correct management and follow-up of patients with chronic liver disease. Non-invasive methods to safely replace liver biopsy and hepatic venous pressure gradient measurement have been increasingly studied in the last 20 years. This review summarizes the available data regarding validated non-invasive methods to diagnose cirrhos...... hiện toàn bộ
Implications of Circulating Hepatitis B Virus RNA Levels in Assessment of Response to Antiviral Therapy
Current Hepatology Reports - Tập 17 - Trang 451-458 - 2018
Tianlun Zhou, Chuanmin Wang, Aejaz Sayeed, Timothy Block
Treatment of chronic hepatitis B infection with nucleos(t)ide analogues induces a significant inhibition of HBV DNA titer. However, reduction of viral DNA load is not an ideal marker to predict sustainable antiviral effect. Circulating HBV RNA has been, recently, explored as a novel biomarker for monitoring viral persistence and the progression of liver disease. This review aims to discuss the cha...... hiện toàn bộ
Optimal Management of HIV-HCV Coinfection
Current Hepatology Reports - Tập 13 - Trang 295-303 - 2014
Stanislas Pol, Anais Vallet-Pichard
Around 25 % of HIV-positive individuals are HCV coinfected. HIV infection clearly worsened the natural history of chronic HCV infection, and despite the improved cares of comorbidities (chronic alcohol intake, metabolic syndrome, poor immune status by an earlier and better immune restoration with antiretrovirals (ARV), and finally by a decreasing hepatotoxicity of ARV), liver-related mortality rem...... hiện toàn bộ
Assessment of HCC Risk in Patients with Chronic HBV (REACH, PAGE-B, and Beyond)
Current Hepatology Reports - Tập 19 - Trang 285-292 - 2020
Terry Cheuk-Fung Yip, Lilian Yan Liang, Grace Lai-Hung Wong
To provide an updated overview on the current status of risk prediction scores for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus infection. More HCC risk scores have been developed, validated, and optimized (e.g., with liver stiffness measurement) in different patient and ethnic groups. Risk scores for treated patients with high negative predictive values would be able ...... hiện toàn bộ
Selection for Liver Transplantation: Indications and Evaluation
Current Hepatology Reports - Tập 19 - Trang 203-212 - 2020
Nadim Mahmud
Liver transplantation is an important therapeutic option for patients with life-limiting liver disease, which may present in the form of acute liver failure, end-stage chronic liver disease, primary hepatic cancers, or inborn metabolic disorders. While significant strides have been made with respect to liver transplantation outcomes, the practice is constrained by an organ supply/demand mismatch. ...... hiện toàn bộ
Addressing Chronic HCV in People Who Inject Drugs and Inmates Is Necessary to Achieve HCV Elimination
Current Hepatology Reports - Tập 21 - Trang 1-7 - 2022
Nikhilesh R. Mazumder, Steven L. Flamm
Direct-acting antivirals (DAA) have revolutionized the field of hepatitis C in the last decade; however, significant challenges remain in eliminating the disease specifically among difficult-to-reach populations. This paper reviews the barriers to viral elimination with a specific emphasis on people who inject drugs and incarcerated patients. People who inject drugs face challenges at every stage ...... hiện toàn bộ
Tailored Algorithms for Hepatocellular Carcinoma Surveillance: Is One-Size-Fits-All Strategy Outdated?
Current Hepatology Reports - Tập 16 - Trang 64-71 - 2017
Nicolas Goossens, C. Billie Bian, Yujin Hoshida
Current clinical practice guidelines recommend regular hepatocellular carcinoma (HCC) surveillance with biannual ultrasound with or without serum alpha-fetoprotein uniformly applied to all patients with cirrhosis. However, clinical implementation of this one-size-fits-all strategy has been challenging as evidenced by very low application rate below 20% due to various reasons, including suboptimal ...... hiện toàn bộ
Diagnosis and Management of Noncirrhotic Portal Hypertension
Current Hepatology Reports - Tập 22 - Trang 252-262 - 2023
Jaclyn E. Kagihara, Daniela Goyes, Atoosa Rabiee
Porto-sinusoidal vascular disease (PSVD) refers to a group of vascular diseases of the liver with lesions encompassing the portal venules and sinusoids, irrespective of portal pressure measurements and the presence or absence of cirrhosis. This article aims to provide an update on the pathologic, clinical, diagnostic, and therapeutic aspects of this underrecognized disease. The diagnosis of PSVD r...... hiện toàn bộ
HCV and Liver Transplantation
Current Hepatology Reports - Tập 20 - Trang 191-197 - 2021
Alyson Kaplan, Robert S. Brown
This review presents the epidemiology, diagnosis, and treatment of HCV in those with cirrhosis, with a particular focus on unique challenges surrounding liver transplantation in the post-DAA era. Rates of hepatitis C virus (HCV) infection have been rising over the past several years, largely attributable to the opioid epidemic in the USA. Fortunately, despite this increase, the advent of direct-ac...... hiện toàn bộ
Nutrition in Viral Hepatitis
Current Hepatology Reports - Tập 22 - Trang 9-23 - 2023
Dibya L. Praharaj, Anil C. Anand
Viral hepatitis caused by various hepatotropic viruses (Hepatitis A, B, C, and E) is common in developing countries and continues to cause significant morbidity and mortality. The liver is the largest organ of the body with various metabolic functions. Patients with acute and chronic viral hepatitis often have altered metabolism leading to decreased food intake and malnutrition. The presence of pr...... hiện toàn bộ
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