Current Hepatology Reports

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The Assessment and Management of Pain in Cirrhosis
Current Hepatology Reports - Tập 17 - Trang 42-51 - 2018
Matthew Klinge, Tami Coppler, Jane M. Liebschutz, Mohannad Dugum, Ajay Wassan, Andrea DiMartini, Shari Rogal
The treatment of pain in patients with cirrhosis is complicated by unpredictable hepatic drug metabolism and a higher risk of adverse drug reactions. We aimed to conduct a scoping review regarding pain management in cirrhosis. Despite the high prevalence of pain in patients with cirrhosis, there is little literature to guide the management of pain in this population. Complex pain syndromes and dis... hiện toàn bộ
Evidence-Based Approach to Stopping Oral Antiviral Therapy in Chronic HBV
Current Hepatology Reports - Tập 18 - Trang 512-521 - 2019
Maximilian Wübbolding, Markus Cornberg, Christoph Höner zu Siederdissen
To review the evidence for stopping antiviral therapy with nucleos(t)ide analogues (NA) in patients with chronic hepatitis B. HBsAg loss is usually stable even without anti-HBs seroconversion after stopping NA therapy. About 50% of HBeAg-positive patients who have achieved anti-HBe seroconversion and have stopped NA therapy remain in virological remission. Consolidation therapy increases the respo... hiện toàn bộ
Management of Direct-Acting Antiviral Failures in Chronic Hepatitis C Infection
Current Hepatology Reports - Tập 15 - Trang 296-306 - 2016
Kevin Tin, Eiei Soe, James Park
Direct-acting antiviral agents have revolutionized the treatment for chronic hepatitis C infection with very high cure rates. Treatment failures are commonly due to non-adherence and relapse but less often to viral breakthrough while on therapy. Resistance-associated variants have also emerged to be a culprit for treatment failures. Optimal retreatment regimens in patients who fail direct-acting a... hiện toàn bộ
Exercise as Medicine: The Impact of Exercise Training on Nonalcoholic Fatty Liver Disease
Current Hepatology Reports - Tập 19 - Trang 402-411 - 2020
Audrey Thorp, Jonathan G. Stine
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of global liver disease. Because current pharmacologic treatments are ineffective, lifestyle change centered on exercise remains the most effective NAFLD treatment. The aim of this systematic review is to summarize and evaluate the current evidence supporting the use of exercise training as a medical treatment for adult patients with NAFL... hiện toàn bộ
Care After Cure: Long-term Follow-up in Hepatitis C
Current Hepatology Reports - Tập 20 Số 4 - Trang 183-190
Kostantinos Morris, Andrew J. Muir
Impact of Non-alcoholic Fatty Liver Disease on Chronic Hepatitis B Infection
Current Hepatology Reports - Tập 16 - Trang 97-104 - 2017
Anthony W.H. Chan, Grace L.H. Wong, Vincent W.S. Wong
Both chronic hepatitis B (CHB) and non-alcoholic fatty liver disease (NAFLD) are frequent liver diseases with substantial morbidity and mortality. How often do these two diseases occur together? Does hepatitis B virus protect or promote concurrent fatty liver? How does concurrent fatty liver influence the clinical outcomes of CHB? We summarized the latest evidence to tackle all these clinically si... hiện toàn bộ
New Tools for the Noninvasive Assessment of Cirrhosis
Current Hepatology Reports - Tập 13 - Trang 14-23 - 2014
Bogdan Procopet, Annalisa Berzigotti
The diagnosis of cirrhosis and portal hypertension is critical for the correct management and follow-up of patients with chronic liver disease. Non-invasive methods to safely replace liver biopsy and hepatic venous pressure gradient measurement have been increasingly studied in the last 20 years. This review summarizes the available data regarding validated non-invasive methods to diagnose cirrhos... hiện toàn bộ
Recent Advances in the Pathogenesis of Hepatitis C Virus-Related Non-Alcoholic Fatty Liver Disease and Its Impact on Patients Cured of Hepatitis C
Current Hepatology Reports - Tập 16 - Trang 317-325 - 2017
Takumi Kawaguchi, Hironori Koga, Takuji Torimura
Patients with chronic hepatitis C infection frequently develop non-alcoholic fatty liver disease (NAFLD), which confers a risk of hepatocellular carcinoma (HCC). Although direct-acting antivirals allow the majority of patients to achieve a sustained virologic response (SVR), post-SVR patients still carry a non-negligible risk of HCC. This review summarizes recent findings regarding the pathogenesi... hiện toàn bộ
Innovative Care Models in Liver Disease: the Role of Multidisciplinary Teams
Current Hepatology Reports - Tập 17 - Trang 193-199 - 2018
Avegail Flores, Chanda K. Ho, Sumeet K. Asrani
Patients with chronic liver disease have diverse healthcare and psychosocial needs across a multitude of care domains. Incorporation of multidisciplinary teams (MDT) enhances care coordination between physician, patient, and other healthcare providers. A MDT approach may be beneficial to provide comprehensive care for all cirrhotics. MDT are successfully used for management of hepatocellular carci... hiện toàn bộ
Hepatitis C and Hepatocellular Carcinoma
Current Hepatology Reports - Tập 15 - Trang 291-295 - 2016
Janice Jou, Willscott E. Naugler
With the significant burden of hepatocellular carcinoma (HCC) attributable to hepatitis C (HCV), prevention of HCC should first and foremost include treatment of hepatitis C. At the very least, any patient who is at risk for liver disease progression to advanced fibrosis should have HCV treated. This is potentially one of the single most important interventions that can be employed long-term to de... hiện toàn bộ
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