Current Hepatology Reports
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Recent Advances in Systemic Therapies for Advanced Hepatocellular Carcinoma
Current Hepatology Reports - - 2021
This paper aims to summarize the data of recently completed and key ongoing clinical trials of systemic agents for advanced hepatocellular carcinoma (aHCC). In particular, the review focuses on ongoing checkpoint inhibitor combination trials and promising studies combining tyrosine kinase inhibitors with checkpoint inhibitors. The recently approved combination of atezolizumab and bevacizumab based...... hiện toàn bộ
Nonalcoholic Steatohepatitis and Liver Transplantation
Current Hepatology Reports - Tập 15 - Trang 113-116 - 2016
The growing epidemic of obesity has led to an increase in the number of patients developing end-stage liver disease related to nonalcoholic steatohepatitis (NASH). In fact, NASH is now the second-leading etiology for liver transplantation in the USA. In this context, interest is growing in understanding the outcomes of liver transplantation in patients with NASH. Current data suggest that the shor...... hiện toàn bộ
Strategies for the Elimination of Hepatitis C Virus Infection as a Public Health Threat in the United States
Current Hepatology Reports - Tập 17 - Trang 111-120 - 2018
Direct-acting antiviral regimens for chronic hepatitis C virus (HCV) infection became available in 2014, and these highly curative therapies have the potential to reduce HCV-associated morbidity and mortality, decrease HCV transmission, and eliminate HCV infection as a public health problem. This review summarizes the recommendations by the National Academies of Sciences, Engineering, and Medicine...... hiện toàn bộ
Liệu có thể ngừng điều trị bằng Nucleos(t)ide Analog (NA) ở bệnh nhân Viêm gan B mãn tính HBeAg âm tính? Dịch bởi AI
Current Hepatology Reports - Tập 13 - Trang 256-263 - 2014
Trong bài tổng quan này, chúng tôi trình bày những bằng chứng cho thấy phần lớn bệnh nhân viêm gan B mãn tính HBeAg âm tính, người đã từng được điều trị bằng lamivudine và sau đó là adefovir và entecavir, sẽ gặp phải tái phát vi sinh cũng như lâm sàng nếu các liệu pháp này bị ngừng. Do đó, các hướng dẫn điều trị hiện tại của AASLD và EASL khuyến nghị thời gian điều trị bằng thuốc kháng vi-rút (NA)...... hiện toàn bộ
Splanchnic and Extrasplanchnic Thrombosis in Cirrhosis: Prophylaxis vs Treatment
Current Hepatology Reports - Tập 13 - Trang 224-234 - 2014
Venous thromboembolism (deep vein thrombosis and pulmonary embolism) and portal vein thrombosis (PVT) occur in up to 6.3 % and 15.9 % of patients with cirrhosis, respectively. There is recent evidence that a procoagulable prothrombotic state is related to cirrhosis despite the reduced levels of many coagulation factors, and decreased platelet counts. Indeed, (i) the combination of high levels of f...... hiện toàn bộ
Hepatotoxicity in Patients with Metabolic Syndrome: Causes and Consequences
Current Hepatology Reports - Tập 16 - Trang 286-292 - 2017
The purpose of this review was to analyze the current evidence regarding the incidence, mechanisms, and outcomes of drug-induced liver injury (DILI) and hepatotoxicity in patients with metabolic syndrome and nonalcoholic fatty liver disease. DILI is a complex clinical entity. Although uncommon, its incidence and diagnosis have been rising in recent years as basic research and clinical databases pr...... hiện toàn bộ
Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatocellular Carcinoma: How Common?
Current Hepatology Reports - Tập 14 - Trang 87-98 - 2015
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common cause of chronic liver disease in Western countries. NAFLD can progress to cirrhosis and its related complications, including hepatocellular carcinoma (HCC). Review of available evidence suggests an increased risk of HCC among patients with NAFLD-related cirrhosis, although this risk is smaller than risk of HCC among patients ...... hiện toàn bộ
Management of Immune-Tolerant Patients with Chronic HBV Infection
Current Hepatology Reports - Tập 22 - Trang 130-137 - 2023
Hepatitis B virus (HBV) is a leading cause of hepatocellular carcinoma (HCC). Patients in the early phase of chronic HBV infection are designated “immune-tolerant” due to highly active viral replication without significant liver damage. Although these individuals are believed to have a low HCC risk, recent data showed conflicting results, which are summarized in this review. Clonally expanded hepa...... hiện toàn bộ
Acute Kidney Injury in Acute on Chronic Liver Failure Versus Decompensated Cirrhosis—What Is the Difference?
Current Hepatology Reports -
Correction to: Hepatitis B Core Antibody: Role in Clinical Practice in 2020The article “Hepatitis B Core Antibody: Role in Clinical Practice in 2020,” written by Robert G. Gish, Syed Abdul Basit, John Ryan, Altaf Dawood, and Ulrike Protzer, was originally published Online First without Open Access. After publication in volume 19, issue 3, pages 254–265, the author decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the co... ... hiện toàn bộ
Current Hepatology Reports - - 2020
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