Current Colorectal Cancer Reports

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Current Status of the Watch-and-Wait Policy for Patients with Complete Clinical Response Following Neoadjuvant Chemoradiation in Rectal Cancer
Current Colorectal Cancer Reports - Tập 13 - Trang 17-26 - 2017
Rob Glynne-Jones, Rob Hughes
Preoperative chemoradiation is the standard of care for patients with locally advanced rectal cancer to reduce the risk of local recurrence. Chemoradiation can achieve a pathological complete response (pCR) in 10–20% of patients when surgery is performed at 4–12 weeks following completion, and a clinical complete response (cCR) in 15–30% if surgery is withheld. The probability of pCR and cCR is pa...... hiện toàn bộ
Liver-Directed Therapy for Metastatic Colon Cancer: Update
Current Colorectal Cancer Reports - Tập 18 - Trang 18-25 - 2022
John J. Waddell, Patricia H. Townsend, Zachary S. Collins, Carissa Walter
To discuss the emerging technologies in the field of Interventional radiology (IR) for the management of metastatic colorectal cancer (mCRC). We review the field of selective internal radiation therapy (SIRT), and well-known IR treatments, with a more focused investigation of radioembolization with Yttrium-90 (Y-90). State-of-the-art treatment modalities for unresectable hepatic malignancies are c...... hiện toàn bộ
Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention
Current Colorectal Cancer Reports - Tập 8 - Trang 316-324 - 2012
Chinthalapally V. Rao, Naveena B. Janakiram, Altaf Mohammed
Colorectal cancer is one of the commonest malignancies in both men and women. In spite of significant progress in screening and in surgical and therapeutic interventions, colorectal cancer (CRC) is still a major public health problem. Accumulating evidence suggests that targeting inflammatory pathways may provide protection against the development of CRC. Eicosanoids derived from the enzymes cyclo...... hiện toàn bộ
Gene Signatures in Stage II Colon Cancer: A Clinical Review
Current Colorectal Cancer Reports - Tập 8 - Trang 225-231 - 2012
Saima Sharif, Michael J. O’Connell
Understanding the biology of cancer is the key to understanding its behavior. Stage II colon cancers represent a unique treatment challenge for medical oncologists because they contain a very heterogeneous group of tumors with a wide range of recurrence risks after resection. Defining these differences in biology can help to explain differences in disease behavior. To this end, gene signatures hav...... hiện toàn bộ
Progastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem Cells
Current Colorectal Cancer Reports - Tập 8 - Trang 277-289 - 2012
Pomila Singh, Shubhashish Sarkar, Carla Kantara, Carrie Maxwell
Preneoplastic lesions (aberrant crypt foci, hyperplastic/dysplastic polyps) are believed to be precursors of sporadic colorectal tumors (adenomas, adenocarcinomas). Aberrant crypt foci and hyperplastic/dysplastic polyps likely originate from abnormal growth of colonic crypts in response to aberrant queues in the microenvironment of colonic crypts. Thus, identifying factors which regulate homeostat...... hiện toàn bộ
Pelvic Reirradiation for the Treatment of Locally Recurrent Rectal Cancer
Current Colorectal Cancer Reports - Tập 13 - Trang 175-182 - 2017
Randa Tao, Shane Lloyd, Lindsay Burt, Jonathan Whisenant, Ignacio Garrido-Laguna, Prajnan Das
This study aims to summarize the literature on pelvic reirradiation for the treatment of locally recurrent rectal cancer. Symptom palliation, rates of local progression after reirradiation with or without surgery, overall survival, and toxicity outcomes are discussed. The majority of patients received total doses of 30–40 Gy given in 1.2 or 1.5 Gy twice-daily fractions. Treatment evolved over time...... hiện toàn bộ
Clinical Implications of Circulating Tumor Cells in Advanced Colorectal Cancer
Current Colorectal Cancer Reports - - 2012
Shahab Ahmed, Cathy Eng
Can We Reliably Predict a Clinical Complete Response in Rectal Cancer? Current Trends and Future Strategies
Current Colorectal Cancer Reports - Tập 14 - Trang 56-63 - 2018
Luis R. Taveras, Holly B. Cunningham, Jonathan B. Imran
Prediction of clinical complete response is pivotal in the management of patients with rectal cancer. The ability to determine tumor response to neoadjuvant therapy in rectal cancer might guide subsequent treatment modalities. We review the current literature on predictors of complete response after neoadjuvant for rectal cancer with an emphasis of clinical complete response rather than pathologic...... hiện toàn bộ
Colonoscopy and Flexible Sigmoidoscopy in Colorectal Cancer Screening and Surveillance
Current Colorectal Cancer Reports - Tập 13 - Trang 284-292 - 2017
Juliana Yang, John H. Kwon
Since the invention of endoscopy in the 1800s, colonoscopy and flexible sigmoidoscopy have evolved into important tools in the diagnosis and treatment of lower gastrointestinal luminal diseases. These two modalities along with biochemical markers and widespread implementation of colorectal cancer (CRC) screening are responsible for the overall downtrend of CRC. However, this downward trend is not ...... hiện toàn bộ
DRO1/CCDC80: a Novel Tumor Suppressor of Colorectal Carcinogenesis
Current Colorectal Cancer Reports - Tập 11 Số 4 - Trang 200-208 - 2015
Jessica I. Grill, Frank T. Kolligs
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