Current Colorectal Cancer Reports

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Liver-Directed Therapy for Metastatic Colon Cancer: Update
Current Colorectal Cancer Reports - Tập 18 - Trang 18-25 - 2022
John J. Waddell, Patricia H. Townsend, Zachary S. Collins, Carissa Walter
To discuss the emerging technologies in the field of Interventional radiology (IR) for the management of metastatic colorectal cancer (mCRC). We review the field of selective internal radiation therapy (SIRT), and well-known IR treatments, with a more focused investigation of radioembolization with Yttrium-90 (Y-90). State-of-the-art treatment modalities for unresectable hepatic malignancies are c...... hiện toàn bộ
Progastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem Cells
Current Colorectal Cancer Reports - Tập 8 - Trang 277-289 - 2012
Pomila Singh, Shubhashish Sarkar, Carla Kantara, Carrie Maxwell
Preneoplastic lesions (aberrant crypt foci, hyperplastic/dysplastic polyps) are believed to be precursors of sporadic colorectal tumors (adenomas, adenocarcinomas). Aberrant crypt foci and hyperplastic/dysplastic polyps likely originate from abnormal growth of colonic crypts in response to aberrant queues in the microenvironment of colonic crypts. Thus, identifying factors which regulate homeostat...... hiện toàn bộ
Pelvic Reirradiation for the Treatment of Locally Recurrent Rectal Cancer
Current Colorectal Cancer Reports - Tập 13 - Trang 175-182 - 2017
Randa Tao, Shane Lloyd, Lindsay Burt, Jonathan Whisenant, Ignacio Garrido-Laguna, Prajnan Das
This study aims to summarize the literature on pelvic reirradiation for the treatment of locally recurrent rectal cancer. Symptom palliation, rates of local progression after reirradiation with or without surgery, overall survival, and toxicity outcomes are discussed. The majority of patients received total doses of 30–40 Gy given in 1.2 or 1.5 Gy twice-daily fractions. Treatment evolved over time...... hiện toàn bộ
Clinical Implications of Circulating Tumor Cells in Advanced Colorectal Cancer
Current Colorectal Cancer Reports - - 2012
Shahab Ahmed, Cathy Eng
Can We Reliably Predict a Clinical Complete Response in Rectal Cancer? Current Trends and Future Strategies
Current Colorectal Cancer Reports - Tập 14 - Trang 56-63 - 2018
Luis R. Taveras, Holly B. Cunningham, Jonathan B. Imran
Prediction of clinical complete response is pivotal in the management of patients with rectal cancer. The ability to determine tumor response to neoadjuvant therapy in rectal cancer might guide subsequent treatment modalities. We review the current literature on predictors of complete response after neoadjuvant for rectal cancer with an emphasis of clinical complete response rather than pathologic...... hiện toàn bộ
DRO1/CCDC80: a Novel Tumor Suppressor of Colorectal Carcinogenesis
Current Colorectal Cancer Reports - Tập 11 Số 4 - Trang 200-208 - 2015
Jessica I. Grill, Frank T. Kolligs
Colorectal Cancer Surveillance: What Is the Optimal Frequency of Follow-up and Which Tools Best Predict Recurrence?
Current Colorectal Cancer Reports - - 2017
Michele M. Gage, Matthew T. Hueman
Clinical Complete Response After Neoadjuvant Therapy in Rectal Cancer: Is Surgery Needed?
Current Colorectal Cancer Reports - Tập 11 - Trang 360-368 - 2015
Georgios Karagkounis, Matthew F. Kalady
Neoadjuvant chemoradiation followed by proctectomy is the recommended treatment plan for locally advanced rectal cancer in the USA. After chemoradiation, approximately 20 % of patients experience a complete pathologic response, which is associated with improved oncological outcomes. This observation prompted questions about the necessity of surgery if the tumor has completely regressed. Using clin...... hiện toàn bộ
Newer Agents in Colon Cancer: What’s Next?
Current Colorectal Cancer Reports - Tập 9 - Trang 74-84 - 2013
Belisario A. Arango, Ikechukwu Akunyili
Colorectal cancer (CRC) was the third leading cause of cancer deaths in the United States in 2012, and most patients eventually develop metastatic disease. The use of cytotoxic chemotherapy, the antiangiogenesis drug bevacizumab, and the anti-EGFR monoclonal antibodies cetuximab and panitumumab have led to an improvement in median OS for metastatic CRC. Despite this improvement in survival, few ag...... hiện toàn bộ
Quality of Life After Radiotherapy for Rectal and Anal Cancer
Current Colorectal Cancer Reports - Tập 16 - Trang 1-10 - 2020
Shane S. Neibart, Sharon L. Manne, Salma K. Jabbour
With advances in radiation therapy (RT) techniques for rectal and anal cancers allowing for the modulation of critical normal tissues, there has been an increased emphasis on improving the quality of life (QOL) for cancer survivors. Herein, we review the literature to examine the impact of RT on QOL and patient-reported outcomes (PROs) to better inform providers about the challenges of survivorshi...... hiện toàn bộ
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