Current Colorectal Cancer Reports
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Current Status of the Watch-and-Wait Policy for Patients with Complete Clinical Response Following Neoadjuvant Chemoradiation in Rectal Cancer
Current Colorectal Cancer Reports - Tập 13 - Trang 17-26 - 2017
Preoperative chemoradiation is the standard of care for patients with locally advanced rectal cancer to reduce the risk of local recurrence. Chemoradiation can achieve a pathological complete response (pCR) in 10–20% of patients when surgery is performed at 4–12 weeks following completion, and a clinical complete response (cCR) in 15–30% if surgery is withheld. The probability of pCR and cCR is pa......
Liver-Directed Therapy for Metastatic Colon Cancer: Update
Current Colorectal Cancer Reports - Tập 18 - Trang 18-25 - 2022
To discuss the emerging technologies in the field of Interventional radiology (IR) for the management of metastatic colorectal cancer (mCRC). We review the field of selective internal radiation therapy (SIRT), and well-known IR treatments, with a more focused investigation of radioembolization with Yttrium-90 (Y-90). State-of-the-art treatment modalities for unresectable hepatic malignancies are c......
Blood Tests for Colorectal Cancer Screening in the Standard Risk Population
Current Colorectal Cancer Reports - Tập 11 - Trang 397-407 - 2015
Barriers to screening for colorectal cancer (CRC) might be circumvented by using a blood test. New blood markers continue to be discovered, comprising RNA, DNA, and protein. On reviewing the literature on biomarkers in blood, many potentially valuable markers have been described. Those based on DNA have been the best evaluated to date and are not subject to the same specificity problems as fecal i......
Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention
Current Colorectal Cancer Reports - Tập 8 - Trang 316-324 - 2012
Colorectal cancer is one of the commonest malignancies in both men and women. In spite of significant progress in screening and in surgical and therapeutic interventions, colorectal cancer (CRC) is still a major public health problem. Accumulating evidence suggests that targeting inflammatory pathways may provide protection against the development of CRC. Eicosanoids derived from the enzymes cyclo......
Use of Bevacizumab in the Management of Potentially Resectable Colorectal Liver Metastases: Safety, Pathologic Assessment and Benefit
Current Colorectal Cancer Reports - Tập 12 - Trang 208-216 - 2016
Liver metastases are a frequent and commonly lethal complication of colorectal cancer. Surgical resection of limited liver disease offers currently the best chance of long-term survival, but surgery is not feasible for a rather significant proportion of patients with hepatic metastases. Despite the overall improvement in the medical management of patients with metastatic colorectal cancer, whose m......
Mechanisms Regulating Microtubule Binding, DNA Replication, and Apoptosis are Controlled by the Intestinal Tumor Suppressor APC
Current Colorectal Cancer Reports - Tập 7 - Trang 145-151 - 2011
Colorectal cancer (CRC) results from the progressive accumulation of both genetic and epigenetic alterations that lead to the transformation of normal colorectal epithelium to benign (adenoma) and invasive (carcinoma) disease. Since its discovery in mutated form as the causative gene for familial adenomatous polyposis coli (FAP), as well as in many sporadic CRCs, the APC tumor suppressor has been ......
CD133, Stem Cells, and Cancer Stem Cells: Myth or Reality?
Current Colorectal Cancer Reports - Tập 7 - Trang 253-259 - 2011
CD133, a member of the prominin family, is found in a variety of tissues with at least three variants. The function of CD133 is not well understood, but its expression is subject to changes in the microenvironment cues including bioenergetic stress. Knockout of CD133 does not affect renewal, but mammary gland branching. A point mutation of CD133 (R733C) leads to retinal disorder. CD133 is found in......
Gene Signatures in Stage II Colon Cancer: A Clinical Review
Current Colorectal Cancer Reports - Tập 8 - Trang 225-231 - 2012
Understanding the biology of cancer is the key to understanding its behavior. Stage II colon cancers represent a unique treatment challenge for medical oncologists because they contain a very heterogeneous group of tumors with a wide range of recurrence risks after resection. Defining these differences in biology can help to explain differences in disease behavior. To this end, gene signatures hav......
Adoptive Cell Therapy for Colon Cancer: the Right Choice?
Current Colorectal Cancer Reports - Tập 10 - Trang 463-469 - 2014
Despite significant advances in the treatment and prognosis of colorectal cancer (CRC), not all tumors respond to current treatment modalities and patients with advanced disease continue to have a poor prognosis. New treatment strategies are needed to improve long-term survival in colorectal cancer patients with metastatic disease. Adoptive cell therapy is a novel approach that uses one’s own immu......
Progastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem Cells
Current Colorectal Cancer Reports - Tập 8 - Trang 277-289 - 2012
Preneoplastic lesions (aberrant crypt foci, hyperplastic/dysplastic polyps) are believed to be precursors of sporadic colorectal tumors (adenomas, adenocarcinomas). Aberrant crypt foci and hyperplastic/dysplastic polyps likely originate from abnormal growth of colonic crypts in response to aberrant queues in the microenvironment of colonic crypts. Thus, identifying factors which regulate homeostat......
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