Current Breast Cancer Reports

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Breast Cancer Heterogeneity: Roles in Tumorigenesis and Therapeutic Implications
Current Breast Cancer Reports - Tập 9 Số 1 - Trang 34-44 - 2017
Fresia Pareja, Caterina Marchiò, Felipe C. Geyer, Britta Weigelt, Jorge S. Reis‐Filho
Intraoperative Margin Trials in Breast Cancer
Current Breast Cancer Reports - Tập 14 Số 3 - Trang 65-74 - 2022
Ava Armani, Johanna M Borst, Sasha Douglas, Nicole Goldharber, Raeda Taj, Sarah L. Blair
Abstract Purpose of Review Obtaining negative margins in breast conservation surgery continues to be a challenge. Re-excisions are difficult for patients and expensive for the health systems. This paper reviews the literature on current strategies and intraoperative clinical trials to reduce positive margin rates. Recent Findings The best available data demonstrate that intraoperative imaging with... hiện toàn bộ
Nipple-Sparing Mastectomy in Patients with Germline BRCA Mutations: Is it Safe?
Current Breast Cancer Reports - Tập 8 - Trang 90-94 - 2016
Richard Gilmore, David M. Euhus
Through most of recorded medical history, there has been debate about how much healthy tissue should be removed in order to effectively treat breast cancer. The prevailing opinion at the start of the twentieth century was “a lot.” The trend has been reversed in recent decades as advances in systemic treatments and radiation therapy have pushed local recurrence rates down even as breast surgery has... hiện toàn bộ
Local-Regional Treatment of the Patient With Inflammatory Breast Cancer
Current Breast Cancer Reports - Tập 7 - Trang 37-42 - 2015
Michael C. Stauder, Wendy A. Woodward
Inflammatory breast cancer (IBC) is a diagnosis based on a constellation of clinical features including a rapid onset of breast erythema and edema (peau d’orange) of a third or more of the skin of the breast and with a palpable border to the edema. Incidence has increased although it makes up only 1–4 % of all breast cancer diagnoses. In spite of some encouraging recent clinical outcome data, publ... hiện toàn bộ
The Androgen Receptor in Breast Cancer: Biology and Treatment Considerations
Current Breast Cancer Reports - Tập 4 - Trang 56-65 - 2011
Ayca Gucalp, Tiffany A. Traina
The androgen receptor (AR) is expressed in 70–90% of invasive breast cancers. Despite the ubiquitous expression of AR in both primary and metastatic breast cancers, the clinical significance of this hormone receptor as a prognostic/predictive marker and its functional role in tumorigenesis remains poorly understood. This review summarizes the recent progress made in understanding the role of the A... hiện toàn bộ
Refining risk assessment in women with atypical hyperplasia
Current Breast Cancer Reports - Tập 1 - Trang 167-174 - 2009
Amy C. Degnim, Lynn C. Hartmann
Atypical hyperplasia (AH) is associated with an approximate fourfold increase in breast cancer risk. Although this increase in risk is significant, the majority of women with AH will not develop breast cancer. Current breast cancer risk prediction models are unable to provide accurate risk estimates for individuals with AH. Tamoxifen offers a substantive risk reduction for women with AH, but its p... hiện toàn bộ
Tamoxifen so với Raloxifene so với Exemestane cho Hóa dự phòng Dịch bởi AI
Current Breast Cancer Reports - Tập 4 - Trang 207-215 - 2012
Laura Reimers, Katherine D. Crew
Dữ liệu từ các thử nghiệm lâm sàng về các chất điều biến thụ thể estrogen chọn lọc (SERMs) và các chất ức chế aromatase (AIs) đã cho thấy tỷ lệ mắc ung thư vú giảm trong bối cảnh phòng ngừa ở những phụ nữ có nguy cơ cao. Chúng tôi đã tiến hành một cuộc tổng quan rộng rãi về các thử nghiệm lâm sàng và các báo cáo gần đây về những rào cản trong việc tiếp nhận hóa dự phòng ung thư vú, nhằm cung cấp t... hiện toàn bộ
#ung thư vú #hóa dự phòng #lựa chọn SERMs #chất ức chế aromatase #sức khỏe cộng đồng
A Multidisciplinary Approach to Managing Uncertainty
Current Breast Cancer Reports - Tập 13 - Trang 365-380 - 2021
Diana L. Lam, Elizabeth U. Parker, Janice N. Kim, Rachel L. Yung, Meghan R. Flanagan
Image-guided percutaneous breast biopsy of both palpable and non-palpable findings has become standard of care. These minimally invasive breast procedures can avoid a surgical procedure for patients who have benign findings and can also guide pre-surgical management for malignant pathology. Establishing radiology-pathologic concordance is critical to guide appropriate management and is often perfo... hiện toàn bộ
Male Breast Cancer
Current Breast Cancer Reports - Tập 14 - Trang 127-134 - 2022
Morgan Johnson, Kandice K. Ludwig
Male breast cancer (MBC) accounts fo r less than 1% of all breast cancers. Because of this rarity, treatment data is limited to retrospective analyses. The purpose of this paper is to improve awareness of risk factors and the presentation of MBC and to review current data regarding management. Risk factors for MBC include age, androgen-estrogen imbalance, family history, and genetic predisposition... hiện toàn bộ
Update on the Role of Epothilones in Metastatic Breast Cancer
Current Breast Cancer Reports - Tập 5 - Trang 51-56 - 2012
Bradford R. Hirsch, Shelby D. Reed, Gary H. Lyman
The role of epothilones in the treatment of locally advanced and metastatic breast cancer remains unclear. While the pivotal studies for ixabepilone were published between 2005 and 2010, and the agent received approval in 2007 from the U.S. Food and Drug Administration, its uptake in routine treatment of breast cancer that is resistant to anthracyclines and taxanes remains inconsistent. The other ... hiện toàn bộ
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