Current Breast Cancer Reports
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Breast Cancer Heterogeneity: Roles in Tumorigenesis and Therapeutic Implications
Current Breast Cancer Reports - Tập 9 Số 1 - Trang 34-44 - 2017
Nipple-Sparing Mastectomy in Patients with Germline BRCA Mutations: Is it Safe?
Current Breast Cancer Reports - Tập 8 - Trang 90-94 - 2016
Through most of recorded medical history, there has been debate about how much healthy tissue should be removed in order to effectively treat breast cancer. The prevailing opinion at the start of the twentieth century was “a lot.” The trend has been reversed in recent decades as advances in systemic treatments and radiation therapy have pushed local recurrence rates down even as breast surgery has......
Update on the Role of Epothilones in Metastatic Breast Cancer
Current Breast Cancer Reports - Tập 5 - Trang 51-56 - 2012
The role of epothilones in the treatment of locally advanced and metastatic breast cancer remains unclear. While the pivotal studies for ixabepilone were published between 2005 and 2010, and the agent received approval in 2007 from the U.S. Food and Drug Administration, its uptake in routine treatment of breast cancer that is resistant to anthracyclines and taxanes remains inconsistent. The other ......
Sentinel Lymph Node Biopsy After Chemotherapy
Current Breast Cancer Reports - Tập 3 - Trang 97-103 - 2011
The timing of sentinel lymph node (SLN) biopsy in patients receiving neoadjuvant chemotherapy remains a debated topic, despite increasing literature supporting use of SLN biopsy after chemotherapy. This article outlines the arguments for SLN biopsy prior to initiation of systemic therapy versus after neoadjuvant chemotherapy and the literature surrounding this debate. Additionally, special patient......
Biomarkers in Breast Cancer and the Implications of Their Discordance
Current Breast Cancer Reports - Tập 5 - Trang 266-274 - 2013
The analysis of biomarkers in breast cancer has made a large impact in treatment decisions and determining prognosis. Information gained from the phenotypic and molecular profile helps both in prognostic stratification as well as treatment selection. With the advent of newer more efficacious chemotherapeutic and biological agents in the management of metastatic breast cancer, most women with this ......
Cognition After Breast Cancer
Current Breast Cancer Reports - Tập 6 - Trang 205-210 - 2014
Diagnosis and adjuvant treatment of women with breast cancer has been associated with cognitive impairments assessed by neuropsychological tests and in self-reported cognitive changes. The mechanisms by which cognitive impairments occur are not well understood, but studies assessing neuropsychological performance, self-report, biomarkers, and imaging are increasing our knowledge of causative mecha......
Correction to: A Radiation Oncologist’s Guide to Axillary Management in Breast Cancer: a Walk Through the Trials
Current Breast Cancer Reports - Tập 12 - Trang 44-44 - 2020
The original version of this article unfortunately contained a mistake.
Treatment of Metastatic Triple-Negative Breast Cancer
Current Breast Cancer Reports - Tập 4 - Trang 10-21 - 2012
The triple-negative breast cancer (TNBC) phenotype, defined as the lack of estrogen and progesterone hormone receptors and the HER2 receptor, represents approximately 15% to 20% of all breast cancer cases. Challenges faced in management of these patients arise from the heterogeneity of TNBC and the absence of well-defined molecular targets. Subgroups derive significant benefit from cytotoxics howe......
The Role of Capecitabine in Early Stage Breast Cancer
Current Breast Cancer Reports - Tập 4 - Trang 22-29 - 2012
Adjuvant systemic therapy is partly responsible for the decrease in breast cancer mortality we have seen over the past two decades. Hormonal therapy and combination chemotherapy based on anthracyclines and taxanes represent the best current approach for early breast cancer patients. Primary as well as secondary development of resistance represents the major challenges to improve our results. Major......
Impact of Systemic Therapy on Fertility in Women with Early-Stage Breast Cancer
Current Breast Cancer Reports - Tập 16 - Trang 61-68 - 2024
Fertility concerns are common among young women diagnosed with breast cancer, as systemic therapy increases the risk of premature ovarian insufficiency and delays family planning. Here, we review the impact of systemic therapies, including chemotherapy, endocrine therapy, HER-2 directed therapy, PARP inhibitors, and immunotherapy, on ovarian reserve. With an improved understanding of disease biolo......
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