Current Atherosclerosis Reports
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Evidence for Aggressive Blood Pressure–Lowering Goals in Patients with Coronary Artery Disease
Current Atherosclerosis Reports - Tập 12 - Trang 134-139 - 2010
Lowering blood pressure (BP) reduces the risk of major cardiovascular mortality and morbidity. Current consensus targets for BP reduction are less than 140/90 mm Hg in uncomplicated hypertension and less than 130/80 mm Hg in those patients with diabetes, chronic kidney disease, and coronary artery disease or in those who are at high risk for developing coronary artery disease (defined as a Framing...... hiện toàn bộ
Oxidative stress, alpha-tocopherol therapy, and atherosclerosis
Current Atherosclerosis Reports - Tập 4 - Trang 373-380 - 2002
Atherosclerosis is the leading cause of morbidity and mortality in the United States. Evidence suggests that antioxidants, especially α-tocopherol (AT), have potential benefits with respect to cardiovascular disease. AT has been shown to decrease lipid peroxidation, to inhibit platelet adhesion, aggregation, and smooth muscle cell proliferation, to exert anti-inflammatory effects on monocytes, and...... hiện toàn bộ
Statin Use and Coronary Artery Calcification: a Systematic Review and Meta-analysis of Observational Studies and Randomized Controlled Trials
Current Atherosclerosis Reports - - 2023
This review aimed to determine the association between statin use and coronary artery calcification (CAC), as detected by computed tomography in the general population, in previously published observational studies (OSs) and randomized controlled trials (RCTs). A systematic search until February 2022 identified 41 relevant studies, comprising 29 OSs and 12 RCTs. We employed six meta-analysis model...... hiện toàn bộ
PCSK9 Inhibition: Current Concepts and Lessons from Human Genetics
Current Atherosclerosis Reports - Tập 17 - Trang 1-10 - 2015
Low-density lipoprotein cholesterol (LDL-C) plays a central role in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Statins are the cornerstone of therapy for the treatment of elevated LDL-C and for the primary and secondary prevention of ASCVD. However, some patients are intolerant of statins or are unable to achieve acceptable lipid levels on statin-based regimens alone. Prop...... hiện toàn bộ
The Spectrum of Atherosclerotic Coronary Artery Disease in HIV Patients
Current Atherosclerosis Reports - - 2010
Pharmacogenetics of Antiplatelet Therapy
Current Atherosclerosis Reports - Tập 16 - Trang 1-8 - 2014
There has been substantial progress toward understanding and investigating the specific genetic factors that influence interindividual variations in platelet-directed therapy. There has also been substantial progress toward better understanding of the pharmacogenetics of drug metabolism and phamacodynamic response to platelet antagonists. We summarize the relationship between genetic polymorphisms...... hiện toàn bộ
Revisiting Dietary Cholesterol Recommendations: Does the Evidence Support a Limit of 300 mg/d?
Current Atherosclerosis Reports - Tập 12 - Trang 377-383 - 2010
The perceived association between dietary cholesterol (DC) and risk for coronary heart disease (CHD) has resulted in recommendations of no more than 300 mg/d for healthy persons in the United States. These dietary recommendations proposed in the 1960s had little scientific evidence other than the known association between saturated fat and cholesterol and animal studies where cholesterol was fed i...... hiện toàn bộ
MicroRNAs as Biomarkers for Myocardial Infarction
Current Atherosclerosis Reports - Tập 14 - Trang 193-200 - 2012
MicroRNAs (miRs) are short non-coding RNA molecules involved in post-transcriptional gene regulation by binding to the 3′ untranslated region of a messenger RNA (mRNA), thereby inhibiting the translation or inducing mRNA destabilization. MiRs are generally considered to act as intracellular mediators essential for normal cardiac function, and their deregulated expression profiles have been associa...... hiện toàn bộ
Moving the Paradigm Forward for Prediction and Risk-Based Primary Prevention of Heart Failure in Special Populations
Current Atherosclerosis Reports - Tập 24 - Trang 343-356 - 2022
Heart failure (HF) treatment paradigms increasingly recognize the importance of primary prevention. This review explores factors that enhance HF risk, summarizes evidence supporting the pharmacologic primary prevention of HF, and notes barriers to the implementation of primary prevention of HF with a focus on female and sexual and gender minority patients. HF has pathophysiologic sex-specific dist...... hiện toàn bộ
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