Current Allergy and Asthma Reports
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Immune dysregulation in atopic dermatitis
Current Allergy and Asthma Reports - Tập 6 - Trang 384-389 - 2006
Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in affected individuals. It is characterized by dysregulated immune responses that consist of an increased systemic Th2 response and a combination of Th2 and Th1 responses in the skin lesions. In this article, we review factors that contribute to these abnormal responses, including key effector cells of the ......
The Relationship Between Advances in Understanding the Microbiome and the Maturing Hygiene Hypothesis
Current Allergy and Asthma Reports - Tập 13 - Trang 487-494 - 2013
Expanding knowledge about an interaction of the bacterial colonization with pathogenic and non-pathogenic bacteria and the human immune system leads to speculation on potential effects on health and disease. Recent advances in sequencing technologies and new bioinformatic possibilities now allow investigating the microbes that colonize the human gut, skin and airways in more detail. In light of th......
Primary ciliary dyskinesia and upper airway diseases
Current Allergy and Asthma Reports - Tập 6 - Trang 513-517 - 2006
Primary ciliary dyskinesia (PCD) is a rare and difficultto-diagnose disease with morbidity related to infections of the upper and lower respiratory tract. The disease is caused by mutations in genes that are required for proper ciliary function. The defect in ciliary function results in reduced or absent mucociliary clearance, thereby predisposing the affected individual to repeated bacterial infe......
Conjunctival allergen challenge: Models in the investigation of ocular allergy
Current Allergy and Asthma Reports - - 2003
The Dietary Fiber Pectin: Health Benefits and Potential for the Treatment of Allergies by Modulation of Gut Microbiota
Current Allergy and Asthma Reports - Tập 21 - Trang 1-19 - 2021
The incidence of allergies is increasing and has been associated with several environmental factors including westernized diets. Changes in environment and nutrition can result in dysbiosis of the skin, gut, and lung microbiota altering the production of microbial metabolites, which may in turn generate epigenetic modifications. The present review addresses studies on pectin-mediated effects on al......
Emerging Therapies in Anaphylaxis: Alternatives to Intramuscular Administration of Epinephrine
Current Allergy and Asthma Reports - Tập 21 - Trang 1-9 - 2021
Anaphylaxis is a severe, life-threatening, systemic allergic reaction that should be recognized and treated promptly. Intramuscular (IM) epinephrine is the first-line treatment for anaphylaxis and there are no absolute contraindications to its use. Despite its established track record of efficacy and safety, physicians and patients face barriers in the recognition and treatment of anaphylaxis, inc......
Otitis Media and Inborn Errors of Immunity
Current Allergy and Asthma Reports - Tập 20 - Trang 1-5 - 2020
The aim of this review is as follows: (1) to present the role of otitis as a warning sign for inborn errors of immunity (IEI), (2) to establish which patients presenting otitis should be investigated for IEI, (3) to review data about main IEI associated with otitis-prone patients. Otitis media is a very common infection in general population. The concept of otitis-prone children established a cert......
Allergen-specific Immunotherapy in Atopic Eczema
Current Allergy and Asthma Reports - Tập 11 - Trang 277-283 - 2011
Aeroallergens are relevant eliciting factors of allergic rhinoconjunctivitis and bronchial asthma but also of atopic eczema. The use of allergen-specific immunotherapy as in respiratory atopic diseases is controversial in patients with atopic eczema, but refined diagnostic methods to characterize subgroups of patients with relevant allergies and the results of smaller controlled studies give rise ......
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