Critical Care

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The association of time and medications with changes in bone mineral density in the 2 years after critical illness
Critical Care - Tập 21 - Trang 1-10 - 2017
Neil R. Orford, Michael Bailey, Rinaldo Bellomo, Julie A. Pasco, Claire Cattigan, Tania Elderkin, Sharon L. Brennan-Olsen, David J. Cooper, Mark A. Kotowicz
Critical illness is associated with increased risk of fragility fracture and loss of bone mineral density (BMD), although the impact of medication exposures (bone anti-fracture therapy or glucocorticoids) and time remain unexplored. The objective of this study was to describe the association of time after ICU admission, and post-ICU administration of bone anti-fracture therapy or glucocorticoids after critical illness, with change in BMD. In this prospective observational study, conducted in a tertiary hospital ICU, we studied adult patients requiring mechanical ventilation for at least 24 hours and measured BMD annually for 2 years after ICU discharge. We performed mixed linear modelling to describe the association of time, and post-ICU administration of anti-fracture therapy or glucocorticoids, with annualised change in BMD. Ninety-two participants with a mean age of 63 (±15) years had at least one BMD assessment after ICU discharge. In women, a greater loss of spine BMD occurred in the first year after critical illness (year 1: -1.1 ± 2.0% vs year 2: 3.0 ± 1.7%, p = 0.02), and anti-fracture therapy use was associated with reduced loss of BMD (femur 3.1 ± 2.4% vs -2.8 ± 1.7%, p = 0.04, spine 5.1 ± 2.5% vs -3.2 ± 1.8%, p = 0.01). In men anti-fracture and glucocorticoid use were not associated with change in BMD, and a greater decrease in BMD occurred in the second year after critical illness (year 1: -0.9 ± 2.1% vs year 2: -2.5 ± 2.1%, p = 0.03). In women a greater loss of spine BMD was observed in the first year after critical illness, and anti-fracture therapy use was associated with an increase in BMD. In men BMD loss increased in the second year after critical illness. Anti-fracture therapy may be an effective intervention to prevent bone loss in women after critical illness.
The significance of different formulations of aerosolized colistin
Critical Care - Tập 9 - Trang 1-2 - 2005
Argyris Michalopoulos, Sofia K Kasiakou, Matthew E Falagas
The process of teambuilding delays cardiopulmonary resuscitation
Critical Care - - 2004
S Marsch, P Hunziker, C Mueller, M Spychiger, M Breuer, N Semmer, F Tschan
Postconditioning effects following sevoflurane inhalational sedation in the ICU: a pilot study in cardiac surgery patients
Critical Care - - 2009
Kerstin D. Röhm, Jochen Mayer, Joachim Boldt, Stefan Suttner, Swen N. Piper
Study of procalcitonin as a marker of sepsis in patients of a general hospital during a 2-year period
Critical Care - Tập 11 - Trang 1-2 - 2007
Caterina Petrochilou, Myrianthi Pouyouka, Vasiliki Skandami, Charika Kontou, Melpomeni Kalderi, Alkipi Nitsa, Marina Toutouza
Urinary and plasma NGAL levels reflect the severity of acute kidney injury
Critical Care - Tập 14 - Trang 1-1 - 2010
K Bangert, LO Uttenthal
Levosimendan in trauma patients with acute cardiac failure
Critical Care - Tập 15 - Trang 1-190 - 2011
AN Afonin, N Karpun
Breathing variability—implications for anaesthesiology and intensive care
Critical Care - Tập 25 - Trang 1-13 - 2021
Oscar F. C. van den Bosch, Ricardo Alvarez-Jimenez, Harm-Jan de Grooth, Armand R. J. Girbes, Stephan A. Loer
The respiratory system reacts instantaneously to intrinsic and extrinsic inputs. This adaptability results in significant fluctuations in breathing parameters, such as respiratory rate, tidal volume, and inspiratory flow profiles. Breathing variability is influenced by several conditions, including sleep, various pulmonary diseases, hypoxia, and anxiety disorders. Recent studies have suggested that weaning failure during mechanical ventilation may be predicted by low respiratory variability. This review describes methods for quantifying breathing variability, summarises the conditions and comorbidities that affect breathing variability, and discusses the potential implications of breathing variability for anaesthesia and intensive care.
New markers of inflammation-induced renal injury subside when endotoxin tolerance develops in humans as measured by urine proteomics
Critical Care - Tập 14 Số 1 - Trang 1-1 - 2010
Heemskerk, S, Draisma, A, Laarakkers, C, Hoeven, J Vander, Masereeuw, R, Pickkers, P
Differential effect of alcohol on TNFα receptor II production in the presence of LPS challenge ex vivo
Critical Care - Tập 18 - Trang 1-182 - 2014
A Gavala, K Venetsanou, P Myrianthefs, E Manolis, C Kittas, G Baltopoulos
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