Clinical and Translational Oncology

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Durable clinical benefit with exemestane in leptomeningeal metastasis of breast cancer
Clinical and Translational Oncology - Tập 7 - Trang 358-360 - 2005
Luis Miguel Navarro Martín, Alberto Ocaña Fernández, Cesar Augusto Rodríguez Sánchez, Isabel Ruiz Martín, Juan Jesús Cruz Hernández
Since most chemotherapy agents do not cross the blood brain barrier, the classical approach for leptomeningeal metastasis (LM) of breast cancer is the administration of cranial intra-ventricular chemotherapy. The roles of hormonal agents like tamoxifen and aromatase inhibitors in LM treatment are not clear. We report the case of a patient with leptomeningeal metastasis from breast cancer with long...... hiện toàn bộ
Enhanced expression of IMPDH2 promotes metastasis and advanced tumor progression in patients with prostate cancer
Clinical and Translational Oncology - Tập 16 - Trang 906-913 - 2014
L. Zhou, D. Xia, J. Zhu, Y. Chen, G. Chen, R. Mo, Y. Zeng, Q. Dai, H. He, Y. Liang, F. Jiang, W. Zhong
Our previous study showed the upregulation of inosine 5′-monophosphate dehydrogenase type II (IMPDH2) protein in human prostate cancer (PCa) tissues and sera compared to non-cancerous controls by proteomics and ELISA analyses. However, the clinical significance of IMPDH2 in PCa has not been fully elucidated. Thus, the aim of the current study was to investigate the associations of IMPDH2 upregulat...... hiện toàn bộ
Extreme liver surgery as treatment of liver tumors involving the hepatocaval confluence
Clinical and Translational Oncology - Tập 18 - Trang 1131-1139 - 2016
C. Codony, S. López-Ben, M. Albiol, L. Falgueras, E. Castro, A. Codina-Barreras, M. Casellas, J. Gil, A. Codina-Cazador, J. Figueras
Analyze the characteristics, surgical technique, morbidity and survival of patients treated with extreme liver surgery. We present a series of consecutive patients with malignant liver tumors in hepatocaval confluence treated in a single center with extreme liver surgery (April 2008–March 2015). Data were collected prospectively and analyzed with SPSS 21.0. 12 patients were included. 50 % were mal...... hiện toàn bộ
Wnt signalling and cancer stem cells
Clinical and Translational Oncology - Tập 11 - Trang 411-427 - 2009
Jesús Espada, Moisés B. Calvo, Silvia Díaz-Prado, Vanessa Medina
Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and stem cell function in adult tissues. Aberrant activation of Wnt signalling pathways has been directly linked to the genesis of different tumours. Here, the components and molecular mechani...... hiện toàn bộ
The importance of adjuvant treatment and primary anatomical site in head and neck basaloid squamous cell carcinoma survival: an analysis of the National Cancer Database
Clinical and Translational Oncology - - 2020
J. Gootee, M. Patel, S. Aurit, P. Silberstein
Basaloid squamous cell carcinoma (BSCC) of the head and neck is an aggressive and highly malignant variant of squamous cell carcinoma that accounts for 2% of head and neck cancers. Previous studies have not analyzed the significance of adjuvant chemoradiation and anatomical site within BSCC subtype and its impact on survival. A cohort of 1999 patients with BSCC of the head and neck was formed from...... hiện toàn bộ
Shorter hemodialysis duration is a risk factor for the recurrence of urothelial carcinoma of the bladder in patients on maintenance hemodialysis
Clinical and Translational Oncology - Tập 18 - Trang 304-309 - 2015
S.-L. Liu, L. Qi, W.-Q. Han, B.-S. Zhu, X. Zhou, S.-S. Jiang, M.-F. Chen, Y. Li, W. He, L.-F. Liu, X.-H. Hu, Y. Xie, F.-H. Zeng, X.-B. Zu
To investigate the association of hemodialysis duration with the recurrence of urothelial carcinoma (UC) of the bladder and overall survival in patients undergoing maintenance hemodialysis (MHD). 52 bladder cancer patients who underwent MHD at the Xiangya Hospital of The Central South University between 2001 and 2011 were enrolled in the study. The patients were divided into three groups according...... hiện toàn bộ
The effects of human sera conditioned by high-intensity exercise sessions and training on the tumorigenic potential of cancer cells
Clinical and Translational Oncology - Tập 23 - Trang 22-34 - 2020
G. Baldelli, M. De Santi, M. Gervasi, G. Annibalini, D. Sisti, P. Højman, P. Sestili, V. Stocchi, E. Barbieri, G. Brandi
There is growing evidence of an association between physical activity and a reduced risk of cancer and cancer recurrence. The aim of this study was to assess the effects of exercise-conditioned human serum (HS) effects on the proliferative and tumorigenic potential of triple-negative breast cancer (TNBC) and prostate cancer (PC) cells. Moreover, modulated mechanisms and several physiological facto...... hiện toàn bộ
Daily schedule for high-dose-rate brachytherapy in postoperative treatment of endometrial carcinoma
Clinical and Translational Oncology - Tập 15 - Trang 111-116 - 2012
Angeles Rovirosa, Izaskun Valduvieco, Carlos Ascaso, Antonio Herreros, Carlos Bautista, Ingrid Romera, Meritxell Arenas, Jaume Pahisa, Albert Biete
To analyze the results of daily high-dose-rate brachytherapy (HDRBT) on local control and toxicity in the postoperative treatment of endometrial carcinoma (EC). From January 2007 to September 2010, 112 patients were treated with HDRBT after surgery for EC. FIGO staging: 24-IA, 48-IB, 14-II, 12-IIIA, 2-IIIB, 8-IIIC1 and 4-IIIC2. Pathology 99/112 endometrioid and 23/112 other types. Radiotherapy pat...... hiện toàn bộ
Methylation detection of circulating tumor cell miR-486-5p/miR-34c-5p in the progression of colorectal cancer
Clinical and Translational Oncology - - 2022
Guolei Li, Xuhua Hu, Guiying Wang, Cuizhi Geng
This study set out to examine the expression and methylation levels of miR-486-5p/miR-34c-5p and its mechanism of action based on the microRNA methylation level of circulating tumor cells (CTCs) in colorectal cancer (CRC) through clinical data and tissue detection. EGFR and EpCAM immunophospholipid magnetic spheres (EpCAM-IML/EGFR-IML) were synthesized by the thin film method to capture CTCs in pe...... hiện toàn bộ
Intimal–medial thickness and carotid arteries lumen in irradiated patients for head and neck cancer: preliminary data of an observational study
Clinical and Translational Oncology - Tập 15 - Trang 861-864 - 2013
M. Faruolo, A. Fiorentino, G. Gallucci, L. Lapadula, V. Fusco
To investigate the effect of external beam radiotherapy (EBRT) for head and neck cancer (HNC) the intimal–medial thickness (IMT) and the lumen of the carotid artery. Patients with HNC and an indication for EBRT were enrolled. A carotid artery color Doppler examination was performed before and 6 and 12 months after EBRT. From 2008 to 2011, 50 patients were enrolled. The mean carotid IMT was 0.9 vs....... hiện toàn bộ
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