Clinical and Molecular Hepatology
SCIE-ISI SCOPUS (2012-2025)
2287-2728
2287-285X
Hàn Quốc
Cơ quản chủ quản: KOREAN ASSOC STUDY LIVER , Korean Association for the Study of the Liver
Lĩnh vực:
Molecular BiologyMedicine (miscellaneous)Hepatology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase
Tập 21 Số 4 - Trang 319 - 2015
Autophagy and liver cancer
Tập 26 Số 4 - Trang 606-617 - 2020
Autophagy is a highly conserved catabolic process that degrades cytosolic
proteins and organelles via formation of autophagosomes that fuse with lysosomes
to form autolysosomes, whereby autophagic cargos are degraded. Numerous studies
have demonstrated that autophagy plays a critical role in the regulation of
liver physiology and homeostasis, and impaired autophagy leads to the
pathogenesis of var...
Substantial risk of recurrence even after 5 recurrence-free years in early-stage hepatocellular carcinoma patients
Tập 26 Số 4 - Trang 516-528 - 2020
Background/Aims: Although hepatocellular carcinoma (HCC) is notorious for its
high recurrence rate, some patients do not experience recurrence for more than 5
years after resection or radiofrequency ablation for early-stage HCC. For those
with five recurrence-free period, the risk of HCC recurrence within the next 5
years remains unknown.Methods: A total of 1,451 consecutive patients (median, 55
y...
Hepatic Hippo signaling inhibits development of hepatocellular carcinoma
Tập 26 Số 4 - Trang 742-750 - 2020
Primary liver cancer is one of the most common cancer worldwide. Hepatocellular
carcinoma (HCC) in particular, is the second leading cause of cancer deaths in
the world. The Hippo signaling pathway has emerged as a major oncosuppressive
pathway that plays critical roles inhibiting hepatocyte proliferation, survival,
and HCC formation. A key component of the Hippo pathway is the inhibition of
yes-a...
Comparison of LI-RADS 2018 and KLCA-NCC 2018 for noninvasive diagnosis of hepatocellular carcinoma using magnetic resonance imaging
Tập 26 Số 3 - Trang 340-351 - 2020
Background/Aims: This study aimed to compare the diagnostic performances of
Liver Imaging Reporting and Data System (LI-RADS) 2018 and Korean Liver Cancer
Association-National Cancer Center (KLCA-NCC) 2018 criteria on magnetic
resonance imaging (MRI) for the noninvasive diagnosis of hepatocellular
carcinoma (HCC) in high-risk patients.Methods: This retrospective study included
273 treatment-naïve ...
Effectiveness of nivolumab versus regorafenib in hepatocellular carcinoma patients who failed sorafenib treatment
Tập 26 Số 3 - Trang 328-339 - 2020
Background/Aims: Several treatment options are currently available for patients
with hepatocellular carcinoma (HCC) failing previous sorafenib treatment. We
aimed to compare the effectiveness of regorafenib and nivolumab in these
patients.Methods: Consecutive HCC patients who received regorafenib or nivolumab
after failure of sorafenib treatment were included. Primary endpoint was overall
survival...
A survey on transarterial chemoembolization refractoriness and a real-world treatment pattern for hepatocellular carcinoma in Korea
Tập 26 Số 1 - Trang 24-32 - 2020
Inhibition of PI3K/Akt signaling suppresses epithelial-to-mesenchymal transition in hepatocellular carcinoma through the Snail/GSK-3/beta-catenin pathway
Tập 26 Số 4 - Trang 529-539 - 2020
Background/Aims: Patients with advanced hepatocellular carcinoma (HCC) have a
poor prognosis due to the lack of effective systemic therapies.
Epithelial-to-mesenchymal transition (EMT) is a pivotal event in tumor
progression, during which cancer cells acquire invasive properties. In this
study, we investigated the effects of phosphatidylinositol 3-kinase (PI3K)
inhibitors, including LY294002 and i...
Endoplasmic reticulum stress and autophagy dysregulation in alcoholic and non-alcoholic liver diseases
Tập 26 Số 4 - Trang 715-727 - 2020
Alcoholic and non-alcoholic liver diseases begin from an imbalance in lipid
metabolism in hepatocytes as the earliest response. Both liver diseases share
common disease features and stages (i.e., steatosis, hepatitis, cirrhosis, and
hepatocellular carcinoma). However, the two diseases have differential
pathogenesis and clinical symptoms. Studies have elucidated the molecular basis
underlying simil...