Clinical Science

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Rofecoxib decreases renal injury in obese Zucker rats
Clinical Science - Tập 107 Số 6 - Trang 561-570 - 2004
Aparajita Dey, Christine Maric, Wayne Kaesemeyer, Constantine Z. Zaharis, J. Philip Stewart, Jennifer S. Pollock, John D. Imig
The present study tested the hypothesis that altered vascular regulation of arachidonic acid enzymes in obese Zucker rats contributes to renal damage. Protein expression of CYP450 (cytochrome P450) and COX (cyclo-oxygenase) enzymes in renal microvessels was studied in obese and lean Zucker rats at 20–21 weeks of age. Body weight and blood glucose averaged 649±13 g and 142±10 mg/dl in obese...... hiện toàn bộ
Post-transcriptional effects of extracellular pH on tumour necrosis factor-α production in RAW 246.7 and J774 A.1 cells
Clinical Science - Tập 100 Số 3 - Trang 259 - 2001
Thomas A. Heming, Divina Tuazon, Sanat K. DAVÉ, Ashok K. Chopra, Johnny W. Peterson, A. Bidani
The inflammatory macrophage: a story of Jekyll and Hyde
Clinical Science - Tập 104 Số 1 - Trang 27 - 2003
Jeremy S. Duffield
Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes
Clinical Science - Tập 83 Số 6 - Trang 639-648 - 1992
Christopher Haslett
Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase
Clinical Science - Tập 120 Số 8 - Trang 321-333 - 2011
R López-Sepúlveda, Manuel Gómez‐Guzmán, María José Zarzuelo Romero, Miguel Romero, Manuel Sánchez, Ana María Quintela, Pilar Galindo, Francisco O’Valle, Juan Tamargo, Francisco Pérez‐Vizcaíno, Juan Duarte, Rosario Jiménez
RWPs (red wine polyphenols) exert antihypertensive effects and improve endothelial function by reducing the plasma levels of ET-1 (endothelin-1) and the subsequent vascular production of O2•− (superoxide anion). Our present study was designed to evaluate whether RWPs act directly in the vascular wall improving endothelial dysfunction and O2•− production induced by ET-1 and to analyse the c...... hiện toàn bộ
Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases
Clinical Science - Tập 129 Số 1 - Trang 1-25 - 2015
Karl‐Heinz Wagner, Marlies Wallner, Christine Mölzer, Silvia Gazzin, Andrew C. Bulmer, Claudio Tiribelli, Libor Vı́tek
Bilirubin, the principal tetrapyrrole, bile pigment and catabolite of haem, is an emerging biomarker of disease resistance, which may be related to several recently documented biological functions. Initially believed to be toxic in infants, the perception of bilirubin has undergone a transformation: it is now considered to be a molecule that may promote health in adults. Data from the last...... hiện toàn bộ
Non-esterified fatty acids may regulate human leucocyte sodium pump activity
Clinical Science - Tập 71 Số 6 - Trang 737-742 - 1986
Leong L. Ng, T. D. R. Hockaday
1. Human leucocyte sodium pump activity was studied in normal fasting subjects by measuring the ouabain-sensitive 22Na+ efflux rate constants. 2. This 22Na+ efflux rate constant was inversely related to the fasting plasma non-esterified fatty acid level (rs = −0.73, P < 0.0001). 3. An oral glucose load (40 g/m2 surface ...... hiện toàn bộ
The renin–angiotensin–aldosterone system in pre-eclampsia: the delicate balance between good and bad
Clinical Science - Tập 126 Số 8 - Trang 537-544 - 2014
Koen Verdonk, W. Edward Visser, Anton H. van den Meiracker, A.H. Jan Danser
Pregnancy demands major changes of the cardiovascular system, and this involves, among others, activation of the RAAS (renin–angiotensin–aldosterone system), allowing an aldosterone-dependent increase in volume. Remarkably, a relative resistance to the pressor response of AngII (angiotensin II) develops simultaneously to prevent the increase in blood pressure that would normally accompany ...... hiện toàn bộ
Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet
Clinical Science - Tập 119 Số 6 - Trang 239-250 - 2010
Vanessa Souza‐Mello, Bianca Martins Gregório, Fernando S. Cardoso-de-Lemos, Laı́s de Carvalho, Márcia Barbosa Águila, Carlos Alberto Mandarim‐de‐Lacerda
The aim of the present study was to evaluate the effects of monotherapies and combinations of drugs on insulin sensitivity, adipose tissue morphology, and pancreatic and hepatic remodelling in C57BL/6 mice fed on a very HF (high-fat) diet. Male C57BL/6 mice were fed on an HF (60% lipids) diet or SC (standard chow; 10% lipids) diet for 10 weeks, after which time the following drug treatment...... hiện toàn bộ
Increased urinary excretion of prostaglandin E in patients with idiopathic hypercalciuria
Clinical Science - Tập 75 Số 6 - Trang 581-587 - 1988
Carlos Henríquez-La Roche, Bernardo Rodrı́guez-Iturbe, José Herrera, Gustavo Parra
1. Because urinary prostaglandin excretion could play a role in idiopathic hypercalciuria (IH), we studied the excretion of prostaglandin E (PGE), calcium and sodium at various urine flows in 21 patients (14 males) with urolithiasis and IH, seven stone formers (five males) with normal calciuria and 20 controls (11 males). Dietary composition was comparable and sodium intake was restricted ...... hiện toàn bộ
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