Clinical Endocrinology
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The impact of ageing and menopause in women with polycystic ovary syndromeAbstract Polycystic ovary syndrome (PCOS) is a common hormonal, metabolic and reproductive disorder. Women with PCOS at reproductive age have increased risk and prevalence of prediabetes and diabetes and have multiple risk factors for cardiometabolic disease and other comorbidities such as obstructive sleep apnoea, endometrial cancer and mood disorders, which contri... ...
Clinical Endocrinology - Tập 97 Số 3 - Trang 371-382 - 2022
Endocrine and metabolic disorders in young adult survivors of childhood acute lymphoblastic leukaemia (ALL) or non‐Hodgkin lymphoma (NHL)Summary Background Treatments of acute lymphoblastic leukaemia (ALL) and non‐Hodgkin lymphoma (NHL), involving various combinations of chemotherapy (chemo), cranial irradiation (CI) and/or bone marrow transplantation after total body irradiation (BMT/TBI), are often successful but may have several long‐term harmful effects....
Clinical Endocrinology - Tập 69 Số 5 - Trang 819-827 - 2008
HORMONE BINDING GLOBULIN LEVELS IN PATIENTS WITH HEREDITARY ANGIOOEDEMA DURING TREATMENT WITH DANAZOL *SUMMARY Five patients with hereditary angiooedema were treated with Danazol for periods up to 10 months. This therapy resulted in normalization of serum levels of the inhibitor of the first complement component and disappearance of clinical disease symptoms in all patients. Although a variety of hormones were measured, only those of the pituitary‐gonadal axis altere... ...
Clinical Endocrinology - Tập 14 Số 6 - Trang 563-570 - 1981
A systematic review of the gonadal effects of therapeutic radioactive iodine in male thyroid cancer survivorsSummary Background For patients with well‐differentiated thyroid carcinoma (WDTC), the gonadal effects of radioactive iodine (RAI) therapy is an important consideration.Objective and methods We systematically reviewed the controlled studies examining the gonadal effects of RAI therapy in male WDTC surv...
Clinical Endocrinology - Tập 68 Số 4 - Trang 610-617 - 2008
The use of berberine for women with polycystic ovary syndrome undergoing IVF treatmentSummary Objective Previous studies have indicated that berberine is an effective insulin sensitizer with comparable activity to metformin (Diabetes 2006, 55, 2256). Reduced insulin sensitivity is reportedly a factor adversely affecting the outcome of IVF in patients with polycystic ovary syndrome (PCOS) (<...
Clinical Endocrinology - Tập 80 Số 3 - Trang 425-431 - 2014
Novel mutations in the calcium‐sensing receptor gene associated with biochemical and functional differences in familial hypocalciuric hypercalcaemiaSummary Objective Heterozygous inactivating mutations of the calcium‐sensing receptor (CaR) gene cause familial hypocalciuric hypercalcaemia (FHH), a generally benign disorder characterized by mild to moderate PTH‐dependent hypercalcaemia. We aimed to identify the causative CaR mutations in three families with FHH and examine the correlation ...
Clinical Endocrinology - Tập 64 Số 5 - Trang 580-587 - 2006
Discriminative power of three indices of renal calcium excretion for the distinction between familial hypocalciuric hypercalcaemia and primary hyperparathyroidism: a follow‐up study on methodsSummary Background Familial hypocalciuric hypercalcaemia (FHH) must be differentiated from primary hyperparathyroidism (PHPT) because prognosis and treatment differ. In daily practice this discrimination is often based on the renal calcium excretion or the calcium/creatinine clearance ratio (CCCR). However, the diagnostic performance of these...
Clinical Endocrinology - Tập 69 Số 5 - Trang 713-720 - 2008
An adult patient with severe hypercalcaemia and hypocalciuria due to a novel homozygous inactivating mutation of calcium‐sensing receptorInactivating mutations in the calcium‐sensing receptor (CaSR) cause familial hypocalciuric hypercalcaemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Earlier investigations showed patients with FHH are heterozygous, and NSHPT are homozygous for inactivating mutations. However, one adult patient with severe hypercalcaemia and hypocalciuria has been reported to have a homozygous i... ...
Clinical Endocrinology - Tập 50 Số 4 - Trang 537-543 - 1999
Functional characterization of calcium sensing receptor polymorphisms and absence of association with indices of calcium homeostasis and bone mineral densitySummary Objectives Associations between calcium‐sensing receptor (CaSR) polymorphisms and serum calcium, PTH and bone mineral density (BMD) have been reported by six studies. However, three other studies have failed to detect such associations. We therefore further investigated three CaSR coding region polymorphisms (Ala986Ser, Arg990Gly and ...
Clinical Endocrinology - Tập 65 Số 5 - Trang 598-605 - 2006
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