Clinical Endocrinology

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THE ROLE OF MODERN BIOASSAYS IN CLINICAL ENDOCRINOLOGY
Clinical Endocrinology - Tập 27 Số 2 - Trang 259-278 - 1987
W. R. Robertson, Ann Lambert, N. Loveridge
The cardiovascular risk profile of middle‐aged women with polycystic ovary syndrome
Clinical Endocrinology - Tập 92 Số 2 - Trang 150-158 - 2020
Cindy Meun, Marlise N. Gunning, Yvonne V. Louwers, Henrike E. Peters, Jolien W. Roos‐Hesselink, Antoinette MaassenVanDenBrink, Oscar L. Rueda‐Ochoa, Christianne J.M. de Groot, Cornelis B. Lambalk, Eric Boersma, Maryam Kavousi, Bart C.J.M. Fauser, Joop S.E. Laven
AbstractObjectivesContradictory results have been reported regarding the association between polycystic ovary syndrome (PCOS) and cardiovascular disease (CVD). We assessed the cardiometabolic phenotype and prevalence of CVD in middle‐aged women with PCOS, compared with age‐matched controls from the general population, and estimated 10‐year CVD risk and cardiovascular health score.DesignA cross‐sec... hiện toàn bộ
The impact of ageing and menopause in women with polycystic ovary syndrome
Clinical Endocrinology - Tập 97 Số 3 - Trang 371-382 - 2022
Nafiye Helvacı, Bülent O. Yildiz
AbstractPolycystic ovary syndrome (PCOS) is a common hormonal, metabolic and reproductive disorder. Women with PCOS at reproductive age have increased risk and prevalence of prediabetes and diabetes and have multiple risk factors for cardiometabolic disease and other comorbidities such as obstructive sleep apnoea, endometrial cancer and mood disorders, which contribute to the overall health burden... hiện toàn bộ
PCOS Forum: research in polycystic ovary syndrome today and tomorrow
Clinical Endocrinology - Tập 74 Số 4 - Trang 424-433 - 2011
Renato Pasquali, Elisabet Stener‐Victorin, Bülent O. Yildiz, Antoni J. Dulęba, Kathleen M. Hoeger, Helen Mason, Roy Homburg, Theresa E. Hickey, Steve Franks, Juha S. Tapanainen, Adam Balen, David H. Abbott, Evanthia Diamanti‐Kandarakis, Richard S. Legro
Oral contraceptive plus antiandrogen therapy and cardiometabolic risk in polycystic ovary syndrome
Clinical Endocrinology - Tập 78 Số 1 - Trang 120-125 - 2013
Ayla Harmancı, Neşe Çınar, Miyase Bayraktar, Bülent O. Yildiz
AbstractObjectiveOral contraceptives alone or in combination with antiandrogens are commonly used in the treatment for polycystic ovary syndrome (PCOS). We aimed to determine the effects of ethinyl estradiol/drospirenone (EE‐DRSP) plus spironolactone therapy on inflammation and cardiometabolic risk in PCOS.DesignProspective cohort study.PatientsTwenty‐three lean, normal glucose‐tolerant patients w... hiện toàn bộ
Replacement therapy with levothyroxine plus triiodothyronine (bioavailable molar ratio 14 : 1) is not superior to thyroxine alone to improve well‐being and cognitive performance in hypothyroidism
Clinical Endocrinology - Tập 60 Số 6 - Trang 750-757 - 2004
Werner Siegmund, K. Spieker, A. I. Weike, Thomas Gießmann, Christiane Modeß, Thomas Dabers, G Kirsch, E. Sänger, George L. Engel, A Hamm, Matthias Nauck, Weihua Meng
Summaryobjectives  There is evidence from recent controlled clinical studies that replacement therapy of hypothyroidism with T4 in combination with a small amount of T3 may improve the well‐being of the patients. As the issue is still the subject of controversial discussion, our study was assigned to confirm the superiority of a physiological combination of thyroid hormones (absorbed molar ratio 1... hiện toàn bộ
Endocrine and metabolic disorders in young adult survivors of childhood acute lymphoblastic leukaemia (ALL) or non‐Hodgkin lymphoma (NHL)
Clinical Endocrinology - Tập 69 Số 5 - Trang 819-827 - 2008
Mélanie Steffens, Véronique Beauloye, Bénédicte Brichard, Annie Robert, Orsalia Alexopoulou, Ch. Vermylen, Dominique Maiter
SummaryBackground  Treatments of acute lymphoblastic leukaemia (ALL) and non‐Hodgkin lymphoma (NHL), involving various combinations of chemotherapy (chemo), cranial irradiation (CI) and/or bone marrow transplantation after total body irradiation (BMT/TBI), are often successful but may have several long‐term harmful effects.Objective  To evaluate late endocrine and metabolic complications in adult ... hiện toàn bộ
THE INTERACTION OF HUMAN ENDOMETRIAL AND MYOMETRIAL STEROID RECEPTORS WITH DANAZOL
Clinical Endocrinology - Tập 19 Số 3 - Trang 377-388 - 1983
Graham Jenkin, C. I. Cookson, G. D. Thorburn
SUMMARYThe affinity of danazol for oestrogen, androgen and progesterone receptors in human endometrium and myometrium was determined, to study the mechanism of action of this drug in the treatment of endometriosis.The ability of danazol to combine with each of the three types of receptor was similar in both endometrium and myometrium. The capacity of danazol to compete with oestradiol‐17β for the ... hiện toàn bộ
HORMONE BINDING GLOBULIN LEVELS IN PATIENTS WITH HEREDITARY ANGIOOEDEMA DURING TREATMENT WITH DANAZOL *
Clinical Endocrinology - Tập 14 Số 6 - Trang 563-570 - 1981
S. Schwarz, G Tappeiner, Helmut Hintner
SUMMARYFive patients with hereditary angiooedema were treated with Danazol for periods up to 10 months. This therapy resulted in normalization of serum levels of the inhibitor of the first complement component and disappearance of clinical disease symptoms in all patients. Although a variety of hormones were measured, only those of the pituitary‐gonadal axis altered during treatment: a moderate de... hiện toàn bộ
Testicular dose and fertility in men following I131 therapy for thyroid cancer
Clinical Endocrinology - Tập 56 Số 6 - Trang 755-758 - 2002
Stephen Hyer, L. Vini, Mary E. O'Connell, B. Pratt, Clive Harmer
Summaryobjective Young adults with differentiated thyroid cancer are treated with high doses of radioiodine and have an excellent long‐term prognosis. However, there is limited information on the effects of this treatment on the gonads and fertility in male patients. We have reviewed the outcome of treatment in our centre with respect to male fertility. We have also assessed directly the radiation... hiện toàn bộ
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