Clinical Endocrinology
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The cardiovascular risk profile of middle‐aged women with polycystic ovary syndromeAbstract Objectives Contradictory results have been reported regarding the association between polycystic ovary syndrome (PCOS) and cardiovascular disease (CVD). We assessed the cardiometabolic phenotype and prevalence of CVD in middle‐aged women with PCOS, compared with age‐matched controls from the general population, and estimate...
Clinical Endocrinology - Tập 92 Số 2 - Trang 150-158 - 2020
The impact of ageing and menopause in women with polycystic ovary syndromeAbstract Polycystic ovary syndrome (PCOS) is a common hormonal, metabolic and reproductive disorder. Women with PCOS at reproductive age have increased risk and prevalence of prediabetes and diabetes and have multiple risk factors for cardiometabolic disease and other comorbidities such as obstructive sleep apnoea, endometrial cancer and mood disorders, which contri... ...
Clinical Endocrinology - Tập 97 Số 3 - Trang 371-382 - 2022
Oral contraceptive plus antiandrogen therapy and cardiometabolic risk in polycystic ovary syndromeAbstract Objective Oral contraceptives alone or in combination with antiandrogens are commonly used in the treatment for polycystic ovary syndrome (PCOS ). We aimed to determine the effects of ethinyl estradiol/drospirenone (EE...
Clinical Endocrinology - Tập 78 Số 1 - Trang 120-125 - 2013
Endocrine and metabolic disorders in young adult survivors of childhood acute lymphoblastic leukaemia (ALL) or non‐Hodgkin lymphoma (NHL)Summary Background Treatments of acute lymphoblastic leukaemia (ALL) and non‐Hodgkin lymphoma (NHL), involving various combinations of chemotherapy (chemo), cranial irradiation (CI) and/or bone marrow transplantation after total body irradiation (BMT/TBI), are often successful but may have several long‐term harmful effects....
Clinical Endocrinology - Tập 69 Số 5 - Trang 819-827 - 2008
THE INTERACTION OF HUMAN ENDOMETRIAL AND MYOMETRIAL STEROID RECEPTORS WITH DANAZOLSUMMARY The affinity of danazol for oestrogen, androgen and progesterone receptors in human endometrium and myometrium was determined, to study the mechanism of action of this drug in the treatment of endometriosis. The ability of danazol to combine with each of the three types of receptor was similar in both endometrium and myometrium. The capacity ... ...
Clinical Endocrinology - Tập 19 Số 3 - Trang 377-388 - 1983
HORMONE BINDING GLOBULIN LEVELS IN PATIENTS WITH HEREDITARY ANGIOOEDEMA DURING TREATMENT WITH DANAZOL *SUMMARY Five patients with hereditary angiooedema were treated with Danazol for periods up to 10 months. This therapy resulted in normalization of serum levels of the inhibitor of the first complement component and disappearance of clinical disease symptoms in all patients. Although a variety of hormones were measured, only those of the pituitary‐gonadal axis altere... ...
Clinical Endocrinology - Tập 14 Số 6 - Trang 563-570 - 1981
Testicular dose and fertility in men following I131 therapy for thyroid cancerSummary objective Young adults with differentiated thyroid cancer are treated with high doses of radioiodine and have an excellent long‐term prognosis. However, there is limited information on the effects of this treatment on the gonads and fertility in male patients. We have reviewed the outcome of treatment in our centre with respect to male...
Clinical Endocrinology - Tập 56 Số 6 - Trang 755-758 - 2002
A systematic review of the gonadal effects of therapeutic radioactive iodine in male thyroid cancer survivorsSummary Background For patients with well‐differentiated thyroid carcinoma (WDTC), the gonadal effects of radioactive iodine (RAI) therapy is an important consideration.Objective and methods We systematically reviewed the controlled studies examining the gonadal effects of RAI therapy in male WDTC surv...
Clinical Endocrinology - Tập 68 Số 4 - Trang 610-617 - 2008
Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetesSummary Objective Resistin, secreted from adipocytes, causes insulin resistance in rodents. We reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at −420 increases type 2 diabetes (T2DM) susceptibility by enhancing promoter activity. We also showed that serum resistin was positively correlated with...
Clinical Endocrinology - Tập 69 Số 1 - Trang 74-80 - 2008
IDENTIFICATION AND CHARACTERIZATION OF THE HUMAN HEPATIC ANDROGEN RECEPTORSUMMARY Human liver contains components in both cytosol and nucleosol which bind the synthetic testosterone derivative, mibolerone, with a high affinity, moderate capacity and a high specificity for androgens. Gel filtration chromatography shows two binding components, a high molecular weight component (mol wt. 250 000) present in cytosol alone and a low molecular w... ...
Clinical Endocrinology - Tập 23 Số 5 - Trang 495-502 - 1985
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