Clinical Diabetes and Endocrinology

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The cost-effectiveness of diabetes prevention: results from the Diabetes Prevention Program and the Diabetes Prevention Program Outcomes Study
Clinical Diabetes and Endocrinology - Tập 1 - Trang 1-10 - 2015
William H. Herman
The Diabetes Prevention Program (DPP) was a randomized, controlled clinical trial. It demonstrated that among high-risk individuals with impaired glucose tolerance, diabetes incidence was reduced by 58 % with lifestyle intervention and 31 % with metformin compared to placebo. During the Diabetes Prevention Program Outcomes Study (DPPOS), all DPP participants were unmasked to their treatment assign...... hiện toàn bộ
A new model for diabetes-focused capacity building – lessons from Sri Lanka
Clinical Diabetes and Endocrinology - Tập 4 - Trang 1-5 - 2018
Anjan K. Saha, Naresh Gunaratnam, Rashmi Patil, Monica Choo, Devika P. Bagchi, Ekta Jhaveri, Jennifer Wyckoff, Ganeika Bahu, Ulysses Balis, Paul Clyde, William H. Herman
Sri Lanka is experiencing a rapid increase in the number of people with diabetes mellitus (DM) due to population growth and aging. Physician shortages, outdated technology, and insufficient health education have contributed to the difficulties associated with managing the burden of disease. New models of chronic disease management are needed to address the increasing prevalence of DM. Medical stud...... hiện toàn bộ
A clinician’s guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoforms
Clinical Diabetes and Endocrinology - Tập 3 Số 1 - 2017
Brijesh Kumar Singh, Paul M. Yen
SGLT2 inhibitors as potentially helpful drugs in PI3K inhibitor-induced diabetes: a case report
Clinical Diabetes and Endocrinology - Tập 7 - Trang 1-4 - 2021
Nicolas Sahakian, Lauranne Cattieuw, Clotilde Ramillon-Cury, Audrey Bégu-Le Corroller, Pascale Silvestre-Aillaud, Sophie Béliard, René Valéro
Hyperglycemia is the most common side-effect of phosphatidylinositol 3-kinase (PI3K) inhibitors that are approved for the treatment of some advanced or metastatic breast cancers. This side-effect is likely due to the central role of PI3K in insulin signalling. Here we report the use of a sodium-glucose cotransporter 2 (SGLT2) inhibitor to manage severe hyperglycemia. We describe a 74-year-old woma...... hiện toàn bộ
Reasons for discontinuing insulin and factors associated with insulin discontinuation in patients with type 2 diabetes mellitus: a real-world evidence study
Clinical Diabetes and Endocrinology - Tập 7 - Trang 1-10 - 2021
Jianmin Wu, Fritha Morrison, Zhenxiang Zhao, Ginger Haynes, Xuanyao He, Ayad K. Ali, Maria Shubina, Shervin Malmasi, Wendong Ge, Xiaomei Peng, Alexander Turchin
Evidence suggests that insulin therapy of patients with type 2 diabetes mellitus (T2DM) is frequently discontinued. However, the reasons for discontinuing insulin and factors associated with insulin discontinuation in this patient population are not well understood. We conducted a retrospective cohort study of adults with T2DM prescribed insulin between 2010 and 2017 at Partners HealthCare. Reason...... hiện toàn bộ
Acromegaly and thyroid cancer: analysis of evolution in a series of patients
Clinical Diabetes and Endocrinology - - 2020
Karina Danilowicz, Soledad Sosa, Mariana Soledad Gonzalez Pernas, Elizabeth Bamberger, Sabrina Mara Diez, Patricia Fainstein-Day, Alejandra Furioso, Mariela Glerean, Mirtha Guitelman, Débora Katz, Nicole Lemaitre, Alicia Lowenstein, Mariela del Valle Luna, María Paz Martínez, Karina Miragaya, Daniel Moncet, María Victoria Ortuño, Analía Pignatta, Constanza Fernanda Ramacciotti, Adriana Reyes, Amelia Susana Rogozinski, Patricia Slavinsky, Julieta Tkatch, Fabián Pitoia
Acromegaly is associated with higher morbidity and mortality mainly due to cardiovascular disease. Data on the incidence and evolution of thyroid cancer in acromegaly are controversial. Our objective was to describe the characteristics of a group of acromegalic patients with differentiated thyroid carcinoma (DTC) and analyze their evolution. This is a retrospective multicenter study of 24 acromega...... hiện toàn bộ
Diabetes and other endocrine-metabolic abnormalities in the long-term follow-up of pancreas transplantation
Clinical Diabetes and Endocrinology - Tập 2 - Trang 1-9 - 2016
Marcio W Lauria, Antonio Ribeiro-Oliveira
Pancreas transplantation (PTX) has been demonstrated to restore long-term glucose homeostasis beyond what can be achieved by intensive insulin therapy or islet transplants. Moreover, PTX has been shown to decrease the progression of the chronic complications of diabetes. However, PTX patients require chronic use of immunosuppressive drugs with potential side effects. The long-term follow-up of PTX...... hiện toàn bộ
Level of adherence to dietary recommendations and barriers among type 2 diabetic patients: a cross-sectional study in an Ethiopian hospital
Clinical Diabetes and Endocrinology - - 2018
Asnakew Achaw Ayele, Yohannes Kelifa Emiru, Sofonyas Abebaw Tiruneh, Belete Achamyelew Ayele, Alemayehu Digssie Gebremariam, Henok Getachew Tegegn
Limited data are available regarding the level of adherence and barriers to dietary recommendations in individuals with type 2 diabetes in Africa including Ethiopia. Therefore, this study aimed at assessing the level of dietary adherence and its barriers among patients with type 2 diabetes in northwest Ethiopia. A prospective hospital-based cross-sectional study was conducted from August to Octobe...... hiện toàn bộ
Classic cardiovascular risk factors improve in very elderly hypopituitary patients treated on standard hormone replacement in long term follow- up
Clinical Diabetes and Endocrinology - Tập 7 - Trang 1-11 - 2021
Isabella Naves Rosa, Alexandre Anderson de Sousa Munhoz Soares, Marcelo Palmeira Rodrigues, Luciana Ansaneli Naves
Hypopituitarism in the elderly population is an underdiagnosed condition and may increase comorbidities related to glucose metabolism, dyslipidemia, and cardiovascular risk factors. Optimization of hormone replacement that considers alterations in clearance rates of hormones, interaction with other medications, and evaluation of the risk-benefit ratio of treatment is a big challenge for clinical p...... hiện toàn bộ
Potential association of LMNA-associated generalized lipodystrophy with juvenile dermatomyositis
Clinical Diabetes and Endocrinology - Tập 4 - Trang 1-6 - 2018
Melis Sahinoz, Shafaq Khairi, Ashley Cuttitta, Graham F. Brady, Amit Rupani, Rasimcan Meral, Marwan K. Tayeh, Peedikayil Thomas, Meredith Riebschleger, Sandra Camelo-Piragua, Jeffrey W. Innis, M. Bishr Omary, Daniel E. Michele, Elif A. Oral
Juvenile dermatomyositis (JDM) is an auto-immune muscle disease which presents with skin manifestations and muscle weakness. At least 10% of the patients with JDM present with acquired lipodystrophy. Laminopathies are caused by mutations in the lamin genes and cover a wide spectrum of diseases including muscular dystrophies and lipodystrophy. The p.T10I LMNA variant is associated with a phenotype ...... hiện toàn bộ
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