Clinical Diabetes and Endocrinology
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The cost-effectiveness of diabetes prevention: results from the Diabetes Prevention Program and the Diabetes Prevention Program Outcomes Study
Clinical Diabetes and Endocrinology - Tập 1 - Trang 1-10 - 2015
The Diabetes Prevention Program (DPP) was a randomized, controlled clinical
trial. It demonstrated that among high-risk individuals with impaired glucose
tolerance, diabetes incidence was reduced by 58 % with lifestyle intervention
and 31 % with metformin compared to placebo. During the Diabetes Prevention
Program Outcomes Study (DPPOS), all DPP participants were unmasked to their
treatment assign...
A new model for diabetes-focused capacity building – lessons from Sri Lanka
Clinical Diabetes and Endocrinology - Tập 4 - Trang 1-5 - 2018
Sri Lanka is experiencing a rapid increase in the number of people with diabetes
mellitus (DM) due to population growth and aging. Physician shortages, outdated
technology, and insufficient health education have contributed to the
difficulties associated with managing the burden of disease. New models of
chronic disease management are needed to address the increasing prevalence of
DM. Medical stud...
Clinical management of patients with Cushing syndrome treated with mifepristone: consensus recommendations
Clinical Diabetes and Endocrinology - Tập 6 - Trang 1-13 - 2020
While surgery is the first-line treatment for patients with endogenous
hypercortisolism (Cushing syndrome [CS]), mifepristone has been shown to be a
beneficial medical treatment option, as demonstrated in the SEISMIC (Study of
the Efficacy and Safety of Mifepristone in the Treatment of Endogenous Cushing
Syndrome) trial. Mifepristone is a competitive glucocorticoid receptor
antagonist and progeste...
A clinician’s guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoforms
Clinical Diabetes and Endocrinology - Tập 3 Số 1 - 2017
SGLT2 inhibitors as potentially helpful drugs in PI3K inhibitor-induced diabetes: a case report
Clinical Diabetes and Endocrinology - Tập 7 - Trang 1-4 - 2021
Hyperglycemia is the most common side-effect of phosphatidylinositol 3-kinase
(PI3K) inhibitors that are approved for the treatment of some advanced or
metastatic breast cancers. This side-effect is likely due to the central role of
PI3K in insulin signalling. Here we report the use of a sodium-glucose
cotransporter 2 (SGLT2) inhibitor to manage severe hyperglycemia. We describe a
74-year-old woma...
Reasons for discontinuing insulin and factors associated with insulin discontinuation in patients with type 2 diabetes mellitus: a real-world evidence study
Clinical Diabetes and Endocrinology - Tập 7 - Trang 1-10 - 2021
Evidence suggests that insulin therapy of patients with type 2 diabetes mellitus
(T2DM) is frequently discontinued. However, the reasons for discontinuing
insulin and factors associated with insulin discontinuation in this patient
population are not well understood. We conducted a retrospective cohort study of
adults with T2DM prescribed insulin between 2010 and 2017 at Partners
HealthCare. Reason...
Safety, tolerability, pharmacokinetics and pharmacodynamics of single oral doses of BI 187004, an inhibitor of 11beta-hydroxysteroid dehydrogenase-1, in healthy male volunteers with overweight or obesity
Clinical Diabetes and Endocrinology - Tập 7 - Trang 1-11 - 2021
The study characterizes safety, tolerability, pharmacokinetic and
pharmacodynamic profiles of single rising doses of the 11beta-hydroxysteroid
dehydrogenase-1 (11beta-HSD1) inhibitor BI 187004 in healthy men with overweight
or obesity. This was a randomized, double-blind, parallel group,
placebo-controlled study with administration of 2.5–360 mg BI 187004 or placebo
once daily as single dose in 72...
Predictors of lack of glycemic control in persons with type 2 diabetes
Clinical Diabetes and Endocrinology - Tập 10 - Trang 1-8 - 2024
Professional guidelines recommend an HbA1c < 7% for most people with diabetes
and < 8.5% for those with relaxed glycemic goals. However, many people with type
2 diabetes mellitus (T2DM) are unable to achieve the desired HbA1c goal. This
study evaluated factors associated with lack of improvement in HbA1c over
3 years. All patients with T2DM treated within a major academic healthcare
system during ...
Acromegaly and thyroid cancer: analysis of evolution in a series of patients
Clinical Diabetes and Endocrinology - - 2020
Acromegaly is associated with higher morbidity and mortality mainly due to
cardiovascular disease. Data on the incidence and evolution of thyroid cancer in
acromegaly are controversial. Our objective was to describe the characteristics
of a group of acromegalic patients with differentiated thyroid carcinoma (DTC)
and analyze their evolution. This is a retrospective multicenter study of 24
acromega...
Lipoprotein (a), an independent cardiovascular risk marker
Clinical Diabetes and Endocrinology - Tập 2 - Trang 1-6 - 2016
Epidemiological and genetic studies have identified elevated levels of
lipoprotein (a) ((Lp(a)) as a causal and independent risk factor for
cardiovascular diseases (CVD). The Lp(a)-induced increased risk of CVD may be
mediated by both its proatherogenic and prothrombotic mechanisms. Several
guidelines recommend screening of Lp(a) level; however, there are few treatment
options for the management o...
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