Clinical Chemistry

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Influence of Statistical Method Used on the Resulting Estimate of Normal Range
Clinical Chemistry - Tập 17 Số 4 - Trang 275-284 - 1971
Allen H. Reed, Richard J. Henry, William B. Mason
Abstract The choice of statistical method can greatly influence the calculated normal range apart from any biological or chemical considerations. Nonparametric normal range estimates are, for practical purposes, as accurate as estimates that assume the distribution of data to be gaussian or loggaussian when the distribution assumed is true. When data are not distributed as assumed, nonparametric e... hiện toàn bộ
Serum CrossLaps One Step ELISA. First application of monoclonal antibodies for measurement in serum of bone-related degradation products from C-terminal telopeptides of type I collagen
Clinical Chemistry - Tập 44 Số 11 - Trang 2281-2289 - 1998
Christian Rosenquist, Christian Fledelius, Stephan Christgau, B.J. Pedersen, M. Bonde, Per Qvist, Claus Christiansen
AbstractWe have developed a two-site ELISA for measurement in serum of bone-related degradation products derived from C-terminal telopeptides of type I collagen. The assay is based on the application of two highly specific monoclonal antibodies against the amino acid sequence of AHD-β-GGR, where the aspartic acid residue (D) is β-isomerized. In a one-step incubation procedure, the degradation prod... hiện toàn bộ
Rapid Determination of Transferrin Isoforms by Immunoaffinity Liquid Chromatography and Electrospray Mass Spectrometry
Clinical Chemistry - Tập 47 Số 3 - Trang 513-518 - 2001
Jean M. Lacey, H. Robert Bergen, Mark J. Magera, Jake Y. Chen, John F. O’Brien
AbstractBackground: Congenital disorders of glycosylation (CDG) are autosomal recessive disorders that produce increased serum carbohydrate-deficient transferrin (CDT) isoforms. Methods to resolve CDT from fully glycosylated transferrin (Trf) have been based on a neutral shift in the isoelectric focusing (IEF) pattern or on a reduction in the negative charge, allowing resolution by anion-exchange ... hiện toàn bộ
High-Resolution DNA Melting Analysis for Simultaneous Mutation Scanning and Genotyping in Solution
Clinical Chemistry - Tập 51 Số 10 - Trang 1770-1777 - 2005
Luming Zhou, Lesi Wang, Robert Palais, Robert J. Pryor, Carl T. Wittwer
Abstract Background: High-resolution DNA melting analysis with saturation dyes for either mutation scanning of PCR products or genotyping with unlabeled probes has been reported. However, simultaneous PCR product scanning and probe genotyping in the same reaction has not been described. Methods: Asymmetric PCR was performed in the presence of unlabeled oligonucleotide probes and a saturating fluor... hiện toàn bộ
Genotyping of Single-Nucleotide Polymorphisms by High-Resolution Melting of Small Amplicons
Clinical Chemistry - Tập 50 Số 7 - Trang 1156-1164 - 2004
Michael Liew, Robert J. Pryor, Robert Palais, Cindy Meadows, Maria Erali, Elaine Lyon, Carl T. Wittwer
AbstractBackground: High-resolution melting of PCR amplicons with the DNA dye LCGreen™ I was recently introduced as a homogeneous, closed-tube method of genotyping that does not require probes or real-time PCR. We adapted this system to genotype single-nucleotide polymorphisms (SNPs) after rapid-cycle PCR (12 min) of small amplicons (≤50 bp).Methods: Engineered plasmids were used to study all poss... hiện toàn bộ
Sensitivity and Specificity of Single-Nucleotide Polymorphism Scanning by High-Resolution Melting Analysis
Clinical Chemistry - Tập 50 Số 10 - Trang 1748-1754 - 2004
G. H. Reed, Carl T. Wittwer
Abstract Background: Screening for heterozygous sequence changes in PCR products, also known as “mutation scanning”, is an important tool for genetic research and clinical applications. Conventional methods require a separation step. Methods: We evaluated the sensitivity and specificity of homogeneous scanning, using a saturating DNA dye and high-resolution melting. Heterozygous single-nucleotide ... hiện toàn bộ
Validating a Rapid Method for Detecting Common Polymorphisms in the APOA5 Gene by Melting Curve Analysis Using LightTyper
Clinical Chemistry - Tập 51 Số 7 - Trang 1279-1282 - 2005
Francesc Francès, Dolores Corella, José V. Sorlí, Marisa Guillén, José I. González, Olga Portolés
Carboxyhemoglobin as measured by gas chromatography and with the IL 282 and 482 CO-Oximeters.
Clinical Chemistry - Tập 34 Số 12 - Trang 2562-2566 - 1988
H J Vreman, John J. Mahoney, A L Van Kessel, David K. Stevenson
Abstract We measured the concentration of carboxyhemoglobin (HbCO) in original and CO-tonometered blood samples from 53 intensive-care patients with IL 282 and IL 482 CO-Oximeters and by gas chromatography (GC), finding very strong correlations among the three methods for HbCO concentrations greater than 2.5%. For concentrations within the normal reference interval (less than or equal to 2.5%), ho... hiện toàn bộ
Clinical Utility of Zinc Protoporphyrin
Clinical Chemistry - Tập 38 Số 11 - Trang 2167-2168 - 1992
Robert F. Labbé
Identification of 19 New Metabolites Induced by Abnormal Amino Acid Conjugation in Isovaleric Acidemia
Clinical Chemistry - Tập 51 Số 8 - Trang 1510-1512 - 2005
Du Toit Loots, Elardus Erasmus, Lodewyk J. Mienie
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