Clinical Chemistry

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Laboratory Automation: Smart Strategies and Practical Applications
Clinical Chemistry - Tập 46 Số 5 - Trang 740-745 - 2000
Donald S. Young
Biclonal IgA and IgM gammopathy in lymphocytic lymphoma.
Clinical Chemistry - Tập 30 Số 10 - Trang 1710-1712 - 1984
Stuart A. Weinstein, Ankur Jain, N.V. Bhagavan, A G Scottolini
Abstract We report the case of a 76-year-old white man with a diffuse, well-differentiated lymphocytic lymphoma at the base of his tongue. Although serum electrophoresis, immunoelectrophoresis, and immunofixation showed he had a biclonal IgA kappa and IgM kappa gammopathy, biopsy of the tumor showed a positive immunoperoxidase response only for IgM k...... hiện toàn bộ
Lack of Concordance between the 75-g and 100-g Glucose Load Tests for the Diagnosis of Gestational Diabetes Mellitus
Clinical Chemistry - Tập 52 Số 9 - Trang 1679-1684 - 2006
Giorgio Mello, Elena Parretti, Agostino Ognibene, Riccardo Cioni, Tondi Filippo, Paola Pezzati, Monica Pratesi, Gianfranco Scarselli, Gianni Messeri
Abstract Background: Gestational diabetes mellitus (GDM) is common and can have a substantial impact on fetal growth, birth weight, and morbidity. The American Diabetes Association recommends GDM testing with either a 3-h, 100-g glucose load (100g) (criteria according to Am J Obstet Gynecol 1982;144:768–73) or a 2-h, 75-g glucose load (75g). We inves...... hiện toàn bộ
Multi-laboratory comparison of three heparin-Mn2+ precipitation procedures for estimating cholesterol in high-density lipoprotein.
Clinical Chemistry - Tập 24 Số 6 - Trang 853-856 - 1978
J J Albers, G. Russell Warnick, Donald A. Wiebe, P.J. King, P M Steiner, L. Smith, Carl Breckenridge, A. Chow, K Kuba, S W Weidman, H Arnett, P D Wood, A Shlagenhaft
Abstract Plasma high-density lipoprotein is commonly estimated by measuring the cholesterol remaining in plasma supernatant solutions after other lipoproteins, which contain apolipoprotein B, are precipitated with heparin and Mn2+. The method (method I) now in use by the Lipid Research Clinics, in which Mn2+ is at 46 mmol/liter final concentration, i...... hiện toàn bộ
Improved Determination of Total Serum Lipids by the Sulfo-Phospho-Vanillin Reaction
Clinical Chemistry - Tập 18 Số 7 - Trang 673-674 - 1972
Christopher S Frings, Ted W Fendley, Ralph T Dunn, Cecelia A Queen
Abstract We have modified and improved a colorimetric method for determining total serum lipids [Amer. J. Clin. Pathol. 53, 89 (1970)]. The improved procedure requires only 20 µl of serum, and the entire determination is done in one tube, thus eliminating the tedious pipetting of a concentrated sulfuric acid-serum digest. The phospho-vanillin reagent...... hiện toàn bộ
Interferences in current methods for measurements of creatinine
Clinical Chemistry - Tập 37 Số 5 - Trang 695-700 - 1991
Julien Weber, Anton P. van Zanten
Abstract We measured the interference of carbonyl compounds, drugs, and other substances in human serum on the determination of creatinine by the two-point, fixed-time kinetic modification of the Jaffé reaction as well as by four enzymatic methods. We added known concentrations of the interfering substances to a solution of creatinine in water. For b...... hiện toàn bộ
Multilayer film elements for clinical analysis: applications to representative chemical determinations.
Clinical Chemistry - Tập 24 Số 8 - Trang 1343-1350 - 1978
R W Spayd, B Bruschi, Bruce A. Burdick, G M Dappen, Jon N. Eikenberry, Theodore W. Esders, John Figueras, C. T. Goodhue, D D LaRossa, Randall W. Nelson, R N Rand, T W Wu
Abstract Using the general concept of a dry multilayer analytical element, we can change chemical procedures and configurations to assay several blood components. In the assay of serum urea nitrogen, urease in the reagent layer catalyzes the hydrolysis of urea. A semipermeable membrane excludes aqueous base, but allows ammonia to diffuse to an underl...... hiện toàn bộ
Carnitine measurements in liver, muscle tissue, and blood in normal subjects
Clinical Chemistry - Tập 39 Số 4 - Trang 592-599 - 1993
Pauline Harper, C Wadström, G. Cederblad
Abstract We determined carnitine concentrations in blood and in liver and abdominal muscle biopsy specimens in 13 men and 16 women undergoing elective surgery (mostly gallbladder removal). The data suggest that the carnitine pools of plasma and erythrocytes are different. The erythrocytes show a higher acylcarnitine concentration than does plasma (P ...... hiện toàn bộ
Growth Differentiation Factor 15: A Canary in a Coal Mine?
Clinical Chemistry - Tập 58 Số 1 - Trang 3-5 - 2012
Jennifer E. Ho, Thomas J. Wang
The role of organic volatile profiles in clinical diagnosis.
Clinical Chemistry - Tập 27 Số 6 - Trang 789-797 - 1981
A. Zlatkis, R.S. Brazell, Colin F. Poole
Abstract The organic volatile constituents of biological fluids contain clinically useful diagnostic information for the recognition of metabolic disorders in man. To gain access to this information, it was necessary to develop the methodology for reproducibly stripping the trace concentrations of volatiles from biological fluids (dynamic headspace, ...... hiện toàn bộ
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