Circulation Research

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Acid-Evoked Currents in Cardiac Sensory Neurons
Circulation Research - Tập 84 Số 8 - Trang 921-928 - 1999
Christopher J. Benson, S P Eckert, Edwin W. McCleskey
Abstract —Sensory neurons that innervate the heart sense ischemia and mediate angina. To use patch-clamp methods to study ion channels on these cells, we fluorescently labeled cardiac sensory neurons (CSNs) in rats so that they could later be identified in dissociated primary culture of either nodose or dorsal root ganglia (DRG). Currents...... hiện toàn bộ
Measurement of Local Blood Flow with Hydrogen Gas
Circulation Research - Tập 14 Số 2 - Trang 164-187 - 1964
KNUR AUKLAND, Bruce Bower, Robert W. Berliner
When a platinized platinum electrode is polarized at the potential of the standard calomel electrode, the current generated is proportional to the concentration of dissolved hydrogen gas. The effects of physiological variations in oxygen tension, pH, temperature, and ascorbic acid concentration were found to be negligible. Although absolute calibration in vivo is not possible, the rate of ...... hiện toàn bộ
Progress in the Reprogramming of Somatic Cells
Circulation Research - Tập 112 Số 3 - Trang 562-574 - 2013
Tianhua Ma, Min Xie, Timothy Laurent, Sheng Ding
Pluripotent stem cells can differentiate into nearly all types of cells in the body. This unique potential provides significant promise for cell-based therapies to restore tissues or organs destroyed by injuries, degenerative diseases, aging, or cancer. The discovery of induced pluripotent stem cell (iPSC) technology offers a possible strategy to generate patient-specific pluripotent stem ...... hiện toàn bộ
Effects of gonadectomy and hormonal replacement on rat hearts.
Circulation Research - Tập 61 Số 1 - Trang 12-19 - 1987
James Scheuer, Ashwani Malhotra, T Schaible, J. M. Capasso
To evaluate the effects of sex hormones on heart function and biochemistry, gonadectomy (GX) was performed in postpubertal male (M) and female (F) rats and compared with sham-operated controls (SH). The groups were MSH; MGX; MGX replaced with testosterone 3 mg/day s.c. (MGX + T), FSH, and FGX replaced with estrogen 2 mg/day (FGX + E), progesterone 0.4 mg/day (FGX + P), estrogen and progest...... hiện toàn bộ
Expression of cGMP-Dependent Protein Kinase I and Phosphorylation of Its Substrate, Vasodilator-Stimulated Phosphoprotein, in Human Endothelial Cells of Different Origin
Circulation Research - Tập 77 Số 5 - Trang 897-905 - 1995
Richard Draijer, Arie B. Vaandrager, Christine Nolte, Hugo R. de Jonge, Ulrich Walter, Victor W.M. van Hinsbergh
Abstract Previous studies demonstrated that the thrombin-induced permeability of endothelial cell monolayers is reduced by the elevation of cGMP. In the present study, the presence of cGMP-dependent protein kinase (cGMP-PK) immunoreactivity and activity in various types of human endothelial cells (ECs) and the role of cGMP-PK in the reduc...... hiện toàn bộ
Properties of single outwardly rectifying Cl- channels in heart.
Circulation Research - Tập 75 Số 4 - Trang 789-795 - 1994
Dayue Darrel Duan, Stanley Nattel
A variety of potentially important macroscopic Cl- currents have been described in the heart. Although the single-channel properties of the cAMP-dependent current (ICl.cAMP) have been well described, the single-channel equivalents of the other forms of cardiac Cl- current remain unknown. Unlike ICl.cAMP, many of these currents show prominent outward rectification in the presence of symmetr...... hiện toàn bộ
Coronary pressure-function and steady-state pressure-flow relations during autoregulation in the unanesthetized dog.
Circulation Research - Tập 63 Số 4 - Trang 821-836 - 1988
John M. Canty
The present study was intended to define the interrelation among endocardial flow, endocardial function, and coronary arterial pressure during spontaneous autoregulation in the left ventricle of chronically instrumented unanesthetized dogs. Steady-state sonomicrometric measurements of regional function and epicardial coronary artery pressure were used to determine the lower pressure limit ...... hiện toàn bộ
Regulation of Angiopoietin-2 mRNA Levels in Bovine Microvascular Endothelial Cells by Cytokines and Hypoxia
Circulation Research - Tập 83 Số 8 - Trang 852-859 - 1998
Stefano J. Mandriota, Michael S. Pepper
Abstract —Angiopoietin-2 (Ang2) is a ligand for the endothelial cell tyrosine kinase receptor Tie2 and counteracts blood vessel maturation/stability mediated by angiopoietin-1 (Ang1), the other known ligand of Tie2. Using degenerate oligonucleotides and reverse transcriptase–polymerase chain reaction, we have screened bovine microvascular...... hiện toàn bộ
Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis
Circulation Research - Tập 122 Số 2 - Trang 337-351 - 2018
Milka Koupenova, Lauren Clancy, Heather A. Corkrey, Jane E. Freedman
Platelets, non-nucleated blood components first described over 130 years ago, are recognized as the primary cell regulating hemostasis and thrombosis. The vascular importance of platelets has been attributed to their essential role in thrombosis, mediating myocardial infarction, stroke, and venous thromboembolism. Increasing knowledge on the platelets’ role in the vasculature has led to ma...... hiện toàn bộ
Calcitonin gene-related peptide mediates nitroglycerin and sodium nitroprusside-induced vasodilation in feline cerebral arterioles.
Circulation Research - Tập 70 Số 6 - Trang 1313-1319 - 1992
E. P. Wei, Mark A. Moskowitz, Pia Boccalini, Hermes A. Kontos
The cerebral vasodilator response induced by topical nitroglycerin and nitroprusside was examined in cats equipped with cranial windows for the observation of the cerebral microcirculation. In cats subjected to chronic unilateral trigeminal ganglionectomy, the vasodilator responses to nitroprusside and nitroglycerin were markedly depressed on the denervated side. Application of a selective...... hiện toàn bộ
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