Circulation Research
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Acid-Evoked Currents in Cardiac Sensory Neurons
Circulation Research - Tập 84 Số 8 - Trang 921-928 - 1999
Abstract —Sensory neurons that innervate the heart sense ischemia and mediate
angina. To use patch-clamp methods to study ion channels on these cells, we
fluorescently labeled cardiac sensory neurons (CSNs) in rats so that they could
later be identified in dissociated primary culture of either nodose or dorsal
root ganglia (DRG). Currents evoked by a variety of different agonists imply the
importa...
Measurement of Local Blood Flow with Hydrogen Gas
Circulation Research - Tập 14 Số 2 - Trang 164-187 - 1964
When a platinized platinum electrode is polarized at the potential of the
standard calomel electrode, the current generated is proportional to the
concentration of dissolved hydrogen gas. The effects of physiological variations
in oxygen tension, pH, temperature, and ascorbic acid concentration were found
to be negligible. Although absolute calibration in vivo is not possible, the
rate of tissue h...
Progress in the Reprogramming of Somatic Cells
Circulation Research - Tập 112 Số 3 - Trang 562-574 - 2013
Pluripotent stem cells can differentiate into nearly all types of cells in the
body. This unique potential provides significant promise for cell-based
therapies to restore tissues or organs destroyed by injuries, degenerative
diseases, aging, or cancer. The discovery of induced pluripotent stem cell
(iPSC) technology offers a possible strategy to generate patient-specific
pluripotent stem cells. H...
Effects of gonadectomy and hormonal replacement on rat hearts.
Circulation Research - Tập 61 Số 1 - Trang 12-19 - 1987
To evaluate the effects of sex hormones on heart function and biochemistry,
gonadectomy (GX) was performed in postpubertal male (M) and female (F) rats and
compared with sham-operated controls (SH). The groups were MSH; MGX; MGX
replaced with testosterone 3 mg/day s.c. (MGX + T), FSH, and FGX replaced with
estrogen 2 mg/day (FGX + E), progesterone 0.4 mg/day (FGX + P), estrogen and
progesterone (F...
Expression of cGMP-Dependent Protein Kinase I and Phosphorylation of Its Substrate, Vasodilator-Stimulated Phosphoprotein, in Human Endothelial Cells of Different Origin
Circulation Research - Tập 77 Số 5 - Trang 897-905 - 1995
Abstract Previous studies demonstrated that the thrombin-induced permeability of
endothelial cell monolayers is reduced by the elevation of cGMP. In the present
study, the presence of cGMP-dependent protein kinase (cGMP-PK) immunoreactivity
and activity in various types of human endothelial cells (ECs) and the role of
cGMP-PK in the reduction of thrombin-induced endothelial permeability was
invest...
Properties of single outwardly rectifying Cl- channels in heart.
Circulation Research - Tập 75 Số 4 - Trang 789-795 - 1994
A variety of potentially important macroscopic Cl- currents have been described
in the heart. Although the single-channel properties of the cAMP-dependent
current (ICl.cAMP) have been well described, the single-channel equivalents of
the other forms of cardiac Cl- current remain unknown. Unlike ICl.cAMP, many of
these currents show prominent outward rectification in the presence of
symmetrical tra...
Coronary pressure-function and steady-state pressure-flow relations during autoregulation in the unanesthetized dog.
Circulation Research - Tập 63 Số 4 - Trang 821-836 - 1988
The present study was intended to define the interrelation among endocardial
flow, endocardial function, and coronary arterial pressure during spontaneous
autoregulation in the left ventricle of chronically instrumented unanesthetized
dogs. Steady-state sonomicrometric measurements of regional function and
epicardial coronary artery pressure were used to determine the lower pressure
limit of endoc...
Regulation of Angiopoietin-2 mRNA Levels in Bovine Microvascular Endothelial Cells by Cytokines and Hypoxia
Circulation Research - Tập 83 Số 8 - Trang 852-859 - 1998
Abstract —Angiopoietin-2 (Ang2) is a ligand for the endothelial cell tyrosine
kinase receptor Tie2 and counteracts blood vessel maturation/stability mediated
by angiopoietin-1 (Ang1), the other known ligand of Tie2. Using degenerate
oligonucleotides and reverse transcriptase–polymerase chain reaction, we have
screened bovine microvascular endothelial (BME), aortic, lymphatic, pulmonary
artery, and...
Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis
Circulation Research - Tập 122 Số 2 - Trang 337-351 - 2018
Platelets, non-nucleated blood components first described over 130 years ago,
are recognized as the primary cell regulating hemostasis and thrombosis. The
vascular importance of platelets has been attributed to their essential role in
thrombosis, mediating myocardial infarction, stroke, and venous thromboembolism.
Increasing knowledge on the platelets’ role in the vasculature has led to many
advan...
Calcitonin gene-related peptide mediates nitroglycerin and sodium nitroprusside-induced vasodilation in feline cerebral arterioles.
Circulation Research - Tập 70 Số 6 - Trang 1313-1319 - 1992
The cerebral vasodilator response induced by topical nitroglycerin and
nitroprusside was examined in cats equipped with cranial windows for the
observation of the cerebral microcirculation. In cats subjected to chronic
unilateral trigeminal ganglionectomy, the vasodilator responses to nitroprusside
and nitroglycerin were markedly depressed on the denervated side. Application of
a selective calcito...
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