Circulation Research

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Effects of gonadectomy and hormonal replacement on rat hearts.
Circulation Research - Tập 61 Số 1 - Trang 12-19 - 1987
James Scheuer, Ashwani Malhotra, T Schaible, J. M. Capasso
To evaluate the effects of sex hormones on heart function and biochemistry, gonadectomy (GX) was performed in postpubertal male (M) and female (F) rats and compared with sham-operated controls (SH). The groups were MSH; MGX; MGX replaced with testosterone 3 mg/day s.c. (MGX + T), FSH, and FGX replaced with estrogen 2 mg/day (FGX + E), progesterone 0.4 mg/day (FGX + P), estrogen and progest...... hiện toàn bộ
Properties of single outwardly rectifying Cl- channels in heart.
Circulation Research - Tập 75 Số 4 - Trang 789-795 - 1994
Dayue Darrel Duan, Stanley Nattel
A variety of potentially important macroscopic Cl- currents have been described in the heart. Although the single-channel properties of the cAMP-dependent current (ICl.cAMP) have been well described, the single-channel equivalents of the other forms of cardiac Cl- current remain unknown. Unlike ICl.cAMP, many of these currents show prominent outward rectification in the presence of symmetr...... hiện toàn bộ
Regulation of Angiopoietin-2 mRNA Levels in Bovine Microvascular Endothelial Cells by Cytokines and Hypoxia
Circulation Research - Tập 83 Số 8 - Trang 852-859 - 1998
Stefano J. Mandriota, Michael S. Pepper
Abstract —Angiopoietin-2 (Ang2) is a ligand for the endothelial cell tyrosine kinase receptor Tie2 and counteracts blood vessel maturation/stability mediated by angiopoietin-1 (Ang1), the other known ligand of Tie2. Using degenerate oligonucleotides and reverse transcriptase–polymerase chain reaction, we have screened bovine microvascular...... hiện toàn bộ
Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis
Circulation Research - Tập 122 Số 2 - Trang 337-351 - 2018
Milka Koupenova, Lauren Clancy, Heather A. Corkrey, Jane E. Freedman
Platelets, non-nucleated blood components first described over 130 years ago, are recognized as the primary cell regulating hemostasis and thrombosis. The vascular importance of platelets has been attributed to their essential role in thrombosis, mediating myocardial infarction, stroke, and venous thromboembolism. Increasing knowledge on the platelets’ role in the vasculature has led to ma...... hiện toàn bộ
Calcitonin gene-related peptide mediates nitroglycerin and sodium nitroprusside-induced vasodilation in feline cerebral arterioles.
Circulation Research - Tập 70 Số 6 - Trang 1313-1319 - 1992
E. P. Wei, Mark A. Moskowitz, Pia Boccalini, Hermes A. Kontos
The cerebral vasodilator response induced by topical nitroglycerin and nitroprusside was examined in cats equipped with cranial windows for the observation of the cerebral microcirculation. In cats subjected to chronic unilateral trigeminal ganglionectomy, the vasodilator responses to nitroprusside and nitroglycerin were markedly depressed on the denervated side. Application of a selective...... hiện toàn bộ
Differential Role of G Protein–Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy
Circulation Research - Tập 117 Số 12 - Trang 1001-1012 - 2015
Christopher J. Traynham, Alessandro Cannavò, Yan Zhou, Alexandre G. Vouga, Benjamin P. Woodall, Jonathan Hullmann, Jessica Ibetti, Jessica I. Gold, J. Kurt Chuprun, Erhe Gao, Walter J. Koch
Rationale : G protein–coupled receptor kinases (GRKs) are dynamic regulators of cellular signaling. GRK5 is highly expressed within myocardium and is upregulated in heart failure. Although GRK5 is a critical regulator of cardiac G protein–coupled receptor s...... hiện toàn bộ
BAG3 and Hsc70 Interact With Actin Capping Protein CapZ to Maintain Myofibrillar Integrity Under Mechanical Stress
Circulation Research - Tập 107 Số 10 - Trang 1220-1231 - 2010
Akinori Hishiya, Toshio Kitazawa, Shinichi Takayama
Rationale: A homozygous disruption or genetic mutation of the bag 3 gene, a member of the Bcl-2–associated athanogene (BAG) family proteins, causes cardiomyopathy and myofibrillar myopathy that is char...... hiện toàn bộ
Pressure-Mediated Hypertrophy and Mechanical Stretch Induces IL-1 Release and Subsequent IGF-1 Generation to Maintain Compensative Hypertrophy by Affecting Akt and JNK Pathways
Circulation Research - Tập 105 Số 11 - Trang 1149-1158 - 2009
Shoken Honsho, Susumu Nishikawa, Katsuya Amano, Kan Zen, Yasushi Adachi, Eigo Kishita, Akihiro Matsui, Asako Katsume, Shinichiro Yamaguchi, Kenichiro Nishikawa, Kikuo Isoda, David W. H. Riches, Satoaki Matoba, Mitsuhiko Okigaki, Hiroaki Matsubara
Rationale : It has been reported that interleukin (IL)-1 is associated with pathological cardiac remodeling and LV dilatation, whereas IL-1β has also been shown to induce cardiomyocyte hypertrophy. Thus, the ...... hiện toàn bộ
Metabolic Coordination of Physiological and Pathological Cardiac Remodeling
Circulation Research - Tập 123 Số 1 - Trang 107-128 - 2018
Andrew Gibb, Bradford G. Hill
Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell phenotype. In particular, the heart consumes relatively large amounts of substrate not only to regenerate ATP for contraction but also to sustain biosynthetic reactions for replacement of cellular building blocks. Metabolic pathways also control intracellular redox state, and metabolic intermediates an...... hiện toàn bộ
ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb
Circulation Research - Tập 124 Số 1 - Trang 79-93 - 2019
Erik A. Blackwood, Christoph P. Hofmann, Michelle Santo Domingo, Alina S. Bilal, Anup Sarakki, Winston T Stauffer, Adrian Arrieta, Donna J. Thuerauf, Fred W. Kolkhorst, Oliver Müller, Tobias Jakobi, Christoph Dieterich, Hugo A. Katus, Shirin Doroudgar, Christopher C. Glembotski
Rationale: Endoplasmic reticulum (ER) stress dysregulates ER proteostasis, which activates the transcription factor, ATF6 (activating transcription factor 6α), an inducer of genes that enhance protein folding and restore ER proteostasis. Because of increased protein synt...... hiện toàn bộ
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