Circulation Research

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Effects of gonadectomy and hormonal replacement on rat hearts.
Circulation Research - Tập 61 Số 1 - Trang 12-19 - 1987
James Scheuer, Ashwani Malhotra, T Schaible, J. M. Capasso
To evaluate the effects of sex hormones on heart function and biochemistry, gonadectomy (GX) was performed in postpubertal male (M) and female (F) rats and compared with sham-operated controls (SH). The groups were MSH; MGX; MGX replaced with testosterone 3 mg/day s.c. (MGX + T), FSH, and FGX replaced with estrogen 2 mg/day (FGX + E), progesterone 0.4 mg/day (FGX + P), estrogen and progest...... hiện toàn bộ
Properties of single outwardly rectifying Cl- channels in heart.
Circulation Research - Tập 75 Số 4 - Trang 789-795 - 1994
Dayue Darrel Duan, Stanley Nattel
A variety of potentially important macroscopic Cl- currents have been described in the heart. Although the single-channel properties of the cAMP-dependent current (ICl.cAMP) have been well described, the single-channel equivalents of the other forms of cardiac Cl- current remain unknown. Unlike ICl.cAMP, many of these currents show prominent outward rectification in the presence of symmetr...... hiện toàn bộ
Calcitonin gene-related peptide mediates nitroglycerin and sodium nitroprusside-induced vasodilation in feline cerebral arterioles.
Circulation Research - Tập 70 Số 6 - Trang 1313-1319 - 1992
E. P. Wei, Mark A. Moskowitz, Pia Boccalini, Hermes A. Kontos
The cerebral vasodilator response induced by topical nitroglycerin and nitroprusside was examined in cats equipped with cranial windows for the observation of the cerebral microcirculation. In cats subjected to chronic unilateral trigeminal ganglionectomy, the vasodilator responses to nitroprusside and nitroglycerin were markedly depressed on the denervated side. Application of a selective...... hiện toàn bộ
Differential Role of G Protein–Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy
Circulation Research - Tập 117 Số 12 - Trang 1001-1012 - 2015
Christopher J. Traynham, Alessandro Cannavò, Yan Zhou, Alexandre G. Vouga, Benjamin P. Woodall, Jonathan Hullmann, Jessica Ibetti, Jessica I. Gold, J. Kurt Chuprun, Erhe Gao, Walter J. Koch
Rationale : G protein–coupled receptor kinases (GRKs) are dynamic regulators of cellular signaling. GRK5 is highly expressed within myocardium and is upregulated in heart failure. Although GRK5 is a critical regulator of cardiac G protein–coupled receptor s...... hiện toàn bộ
BAG3 and Hsc70 Interact With Actin Capping Protein CapZ to Maintain Myofibrillar Integrity Under Mechanical Stress
Circulation Research - Tập 107 Số 10 - Trang 1220-1231 - 2010
Akinori Hishiya, Toshio Kitazawa, Shinichi Takayama
Rationale: A homozygous disruption or genetic mutation of the bag 3 gene, a member of the Bcl-2–associated athanogene (BAG) family proteins, causes cardiomyopathy and myofibrillar myopathy that is char...... hiện toàn bộ
ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb
Circulation Research - Tập 124 Số 1 - Trang 79-93 - 2019
Erik A. Blackwood, Christoph P. Hofmann, Michelle Santo Domingo, Alina S. Bilal, Anup Sarakki, Winston T Stauffer, Adrian Arrieta, Donna J. Thuerauf, Fred W. Kolkhorst, Oliver Müller, Tobias Jakobi, Christoph Dieterich, Hugo A. Katus, Shirin Doroudgar, Christopher C. Glembotski
Rationale: Endoplasmic reticulum (ER) stress dysregulates ER proteostasis, which activates the transcription factor, ATF6 (activating transcription factor 6α), an inducer of genes that enhance protein folding and restore ER proteostasis. Because of increased protein synt...... hiện toàn bộ
Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy
Circulation Research - Tập 94 Số 1 - Trang 110-118 - 2004
Benjamin J. Wilkins, Yan‐Shan Dai, Orlando F. Bueno, Stephanie A. Parsons, Jian Xu, David M. Plank, Fred Jones, Thomas R. Kimball, Jeffery D. Molkentin
Calcineurin (PP2B) is a calcium/calmodulin-activated, serine-threonine phosphatase that transmits signals to the nucleus through the dephosphorylation and translocation of nuclear factor of activated T cell (NFAT) transcription factors. Whereas calcineurin-NFAT signaling has been implicated in regulating the hypertrophic growth of the myocardium, considerable controversy persi...... hiện toàn bộ
RANKL Increases Vascular Smooth Muscle Cell Calcification Through a RANK-BMP4–Dependent Pathway
Circulation Research - Tập 104 Số 9 - Trang 1041-1048 - 2009
Sara Panizo, Anna Cardús, Mario Encinas, Eva Parisi, Petya Valcheva, Susana López‐Ongil, Blai Coll, Elvira Fernández, José Manuel Valdivielso
Vascular calcification commonly associated with several pathologies and it has been suggested to be similar to bone mineralization. The axis RANKL-OPG (receptor activator of nuclear factor κB ligand–osteoprotegerin) finely controls bone turnover. RANKL has been suggested to increase vascular calcification, but direct evidence is missing. Thus, in the present work, we assess the effect of R...... hiện toàn bộ
Statins Protect Human Aortic Smooth Muscle Cells From Inorganic Phosphate-Induced Calcification by Restoring Gas6-Axl Survival Pathway
Circulation Research - Tập 98 Số 8 - Trang 1024-1031 - 2006
Bo‐Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Taro Kojima, Hidetaka Ota, Y. Senda, Koji Maemura, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouchi
Vascular calcification is clinically important in the development of cardiovascular disease. It is reported that hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) inhibited vascular calcification in several clinical trials. However, the mechanism is poorly understood. Recently, it has been suggested that apoptosis is one of the important processes regulating vasc...... hiện toàn bộ
Phosphate Regulation of Vascular Smooth Muscle Cell Calcification
Circulation Research - Tập 87 Số 7 - 2000
Shuichi Jono, Marc D. McKee, Charles E. Murry, Atsushi Shioi, Yoshiki Nishizawà, Katsuhito Mori, Hirotoshi Morii, Cecilia M. Giachelli
Abstract —Vascular calcification is a common finding in atherosclerosis and a serious problem in diabetic and uremic patients. Because of the correlation of hyperphosphatemia and vascular calcification, the ability of extracellular inorganic phosphate levels to regulate human aortic smooth muscle cell (HSMC) culture mineralization in vitr...... hiện toàn bộ
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