Circulation: Heart Failure
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The Natural History of Preclinical Diastolic Dysfunction
Circulation: Heart Failure - Tập 5 Số 2 - Trang 144-151 - 2012
Background— Preclinical diastolic dysfunction (PDD) has been broadly defined as
subjects with left ventricular diastolic dysfunction, without the diagnosis of
congestive heart failure (HF) and with normal systolic function. Our objective
was to determine the risk factors associated with the progression from PDD
(stage B) HF to symptomatic (stage C) HF. Methods and Results— Using the
resources of t...
Cardiac Structure and Function and Prognosis in Heart Failure With Preserved Ejection Fraction
Circulation: Heart Failure - Tập 7 Số 5 - Trang 740-751 - 2014
Background— Abnormalities in cardiac structure and function in heart failure
with preserved ejection fraction may help identify patients at particularly high
risk for cardiovascular morbidity and mortality. Methods and Results— Cardiac
structure and function were assessed by echocardiography in a blinded core
laboratory at baseline in 935 patients with heart failure with preserved
ejection fractio...
A New Direction for Cardiac Regeneration Therapy
Circulation: Heart Failure - Tập 2 Số 6 - Trang 643-653 - 2009
Background— Adult human epicardium-derived cells (EPDCs), transplanted into the
infarcted heart, are known to improve cardiac function, mainly through paracrine
protection of the surrounding tissue. We hypothesized that this effect might be
further improved if these supportive EPDCs were combined with cells that could
possibly supply the ischemic heart with new cardiomyocytes. Therefore, we
transp...
Diagnosis, Treatment, and Outcome of Giant-Cell Myocarditis in the Era of Combined Immunosuppression
Circulation: Heart Failure - Tập 6 Số 1 - Trang 15-22 - 2013
Background— Giant-cell myocarditis often escapes diagnosis until autopsy or
transplantation and has defied proper treatment trials for its rarity and deadly
behavior. Current therapy rests on multiple-drug immunosuppression but its
prognostic influence remains poorly known. We set out to analyze (1) our
experience in diagnosing giant-cell myocarditis and (2) the outcome of patients
on combined imm...
Outcomes of Patients With Peripartum Cardiomyopathy Who Received Mechanical Circulatory Support
Circulation: Heart Failure - Tập 7 Số 2 - Trang 300-309 - 2014
Background— We describe the characteristics and outcomes of peripartum
cardiomyopathy (PPCMP) patients who received durable mechanical circulatory
support and compared it with other etiologies of advanced heart failure. Methods
and Results— We analyzed 1258 women who were registered in Interagency Registry
for Mechanically Assisted Circulatory Support between June 2006 and March 2012.
Baseline cha...
Physical Function, Frailty, Cognition, Depression, and Quality of Life in Hospitalized Adults ≥60 Years With Acute Decompensated Heart Failure With Preserved Versus Reduced Ejection Fraction
Circulation: Heart Failure - Tập 11 Số 11 - 2018
Background: Older hospitalized acute decompensated heart failure (HF) patients
have persistently poor outcomes and delayed recovery regardless of ejection
fraction (EF). We hypothesized that impairments in physical function, frailty,
cognition, mood, and quality of life (QoL) potentially contributing to poor
clinical outcomes would be similarly severe in acute decompensated HF patients
≥60 years o...
Analysis of Metabolic Remodeling in Compensated Left Ventricular Hypertrophy and Heart Failure
Circulation: Heart Failure - Tập 3 Số 3 - Trang 420-430 - 2010
Background— Congestive heart failure (CHF) is associated with a change in
cardiac energy metabolism. However, the mechanism by which this change is
induced and causes the progression of CHF is unclear. Methods and Results— We
analyzed the cardiac energy metabolism of Dahl salt-sensitive rats fed a
high-salt diet, which showed a distinct transition from compensated left
ventricular hypertrophy to C...
Percutaneous Left-Ventricular Support With the Impella-2.5–Assist Device in Acute Cardiogenic Shock
Circulation: Heart Failure - Tập 6 Số 1 - Trang 23-30 - 2013
Background— Acute cardiogenic shock after myocardial infarction is associated
with high in-hospital mortality attributable to persisting low-cardiac output.
The Impella–EUROSHOCK-registry evaluates the safety and efficacy of the
Impella-2.5–percutaneous left-ventricular assist device in patients with
cardiogenic shock after acute myocardial infarction. Methods and Results— This
multicenter registr...
Exercise Training in Patients With Heart Failure and Preserved Ejection Fraction
Circulation: Heart Failure - Tập 8 Số 1 - Trang 33-40 - 2015
Background— Heart failure with preserved ejection fraction (HFPEF) is common and
characterized by exercise intolerance and lack of proven effective therapies.
Exercise training has been shown to be effective in improving cardiorespiratory
fitness (CRF) in patients with systolic heart failure. In this meta-analysis, we
aim to evaluate the effects of exercise training on CRF, quality of life, and
di...
Physical Fitness and Risk for Heart Failure and Coronary Artery Disease
Circulation: Heart Failure - Tập 6 Số 4 - Trang 627-634 - 2013
Background— Multiple studies have demonstrated strong associations between
cardiorespiratory fitness and lower cardiovascular disease mortality. In
contrast, little is known about associations of fitness with nonfatal
cardiovascular events. Methods and Results— Linking individual participant data
from the Cooper Center Longitudinal Study with Medicare claims files, we studied
20 642 participants (...
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