Chronic Diseases and Translational Medicine
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Plasma RANTES level is correlated with cardio‐cerebral atherosclerosis burden in patients with ischemic cerebrovascular disease
Chronic Diseases and Translational Medicine - Tập 6 - Trang 46-54 - 2020
AbstractBackgroundRegulated upon activation, normal T‐cell expressed, and
secreted (RANTES) is a chemokine actively involved in the initiation and
progression of atherosclerosis (AS), which is the major cause of ischemic
cerebrovascular disease (ICVD). This study aimed to determine the associations
between circulating RANTES level and overall AS conditions of cardiac and
cerebral vessel beds in pa...
The era of clinical application of gene diagnosis in cardiovascular diseases is coming
Chronic Diseases and Translational Medicine - Tập 5 - Trang 214-220 - 2019
AbstractGene diagnosis refers to the use of genetic testing in the diagnosis of
inheritable conditions, which has gradually been applied in clinical practice
with the completion of the gene sequencing efforts of the Human Genome Project
and the advancement of gene detection technology. In the specialty field of
cardiology, monogenic cardiovascular diseases are defined as monogenic inherited
diseas...
Lifestyle intervention for gestational diabetes mellitus prevention: A cluster‐randomized controlled study
Chronic Diseases and Translational Medicine - Tập 1 - Trang 169-174 - 2015
AbstractObjectiveThe study was to examine whether gestational diabetes mellitus
(GDM) can be prevented by early trimester lifestyle counseling in a high‐risk
population.MethodsFrom September 2012 to January 2013, 1664 pregnancies in the
Department of Obstetrics and Gynecology of First Hospital of Peking University
were enrolled in the study during their first prenatal care visit before the 8
gesta...
Cultural adaptation of the Michigan Hand Outcomes Questionnaire in patients with Carpal Tunnel Syndrome: A Turkish version study
Chronic Diseases and Translational Medicine - Tập 1 - Trang 42-47 - 2015
AbstractObjectiveCultural adaptations of the questionnaires are important for
easy use. We aimed to assess the reliability and validity of the Turkish Version
of the Michigan Hand Outcomes Questionnaire in patients with Carpal Tunnel
Syndrome.MethodsTo assess test‐retest reliability, the Turkish “Michigan Hand
Outcomes Questionnaire” and “Disabilities of Arm, Shoulder and Hand”
questionnaires were...
Novel findings in relation to multiple anti‐atherosclerotic effects of XueZhiKang in humans
Chronic Diseases and Translational Medicine - Tập 4 - Trang 117-126 - 2018
AbstractBackgroundPrevious studies have clearly demonstrated that XueZhiKang
(XZK), an extract of cholestin, can decrease low‐density lipoprotein cholesterol
(LDL‐C) and cardiovascular events. However, the mechanism of the effects of XZK
on atherosclerosis (AS) in humans has been reported less frequently. In the
present study, we investigated the impact of XZK on lipoprotein subfractions,
oxidized...
Identification of key genes and pathways in mild and severe nonalcoholic fatty liver disease by integrative analysis
Chronic Diseases and Translational Medicine - Tập 7 - Trang 276-286 - 2021
AbstractBackgroundThe global prevalence of nonalcoholic fatty liver disease
(NAFLD) is increasing. The pathogenesis of NAFLD is multifaceted, and the
underlying mechanisms are elusive. We conducted data mining analysis to gain a
better insight into the disease and to identify the hub genes associated with
the progression of NAFLD.MethodsThe dataset GSE49541, containing the profile of
40 samples re...
A questionnaire survey on the management of Graves' orbitopathy in China: A comparison with Europe and Latin‐America
Chronic Diseases and Translational Medicine - Tập 1 - Trang 117-123 - 2015
AbstractObjectiveManagement of Graves' orbitopathy (GO) continues to be a
challenge to clinical endocrinologists. In the last few years, surveys on GO
management have succeeded in elucidating trends in Europe and Latin America. To
determine how endocrinologists in China assess and treat patients with GO and
gain insight into how to make the management of this disease more uniform and
standardized....
Thirdhand smoke: Genotoxicity and carcinogenic potential
Chronic Diseases and Translational Medicine - Tập 6 - Trang 27-34 - 2020
AbstractThirdhand smoke (THS), the residual tobacco smoke remaining in the
environment after tobacco has been smoked, represents a hidden and
underestimated public health hazard. Evidence supports its widespread presence
in indoor environments. Exposure to secondhand smoke (SHS), a precursor of THS,
has been well documented as a risk factor for human cancers, especially lung
cancer. However, the c...
Circulating free DNA in the era of precision oncology: Pre‐ and post‐analytical concerns
Chronic Diseases and Translational Medicine - Tập 2 - Trang 223-230 - 2016
AbstractCancer treatment has entered the era of precision medicine, where
knowledge of a patient's genetic profile is used to facilitate early diagnosis,
drug selection, prognosis, prediction of drug responsiveness, the onset of
secondary resistance, and relapse. Circulating free DNA (cfDNA) has emerged as
an ideal source of genetic information for cancer patients, and numerous studies
have explor...
Trend of non‐communicable disease mortality for three common conditions in the elderly population from 2002 to 2010: A population‐based study in China
Chronic Diseases and Translational Medicine - Tập 1 - Trang 152-157 - 2015
AbstractObjectiveThere is a lack of data focusing on non‐communicable disease
(NCD) mortality in the Chinese elderly population over the past
decade.MethodsUsing mortality data from the Chinese Health Statistics, we
explored the crude and age‐standardized mortality trend of three major NCDs in
the Chinese population ≥65 years of age from 2002 to 2010, namely, malignant
neoplasms, heart diseases, a...
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