Chimia

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Improving Sensitivity of Solid-state NMR Spectroscopy by Rational Design of Polarizing Agents for Dynamic Nuclear Polarization
Chimia - Tập 71 Số 4 - Trang 190
Dominik J. Kubicki, Lyndon Emsley
We review our recent efforts to optimize the efficiency of polarizing agents for Dynamic Nuclear Polarization (DNP) in solid-state MAS NMR spectroscopy. We elucidate the links between DNP performance, molecular structure and electronic relaxation properties of dinitroxide biradicals. We show that deuteration and increased bulkiness lead to slower electronic relaxation and in turn...... hiện toàn bộ
Development of [18F]-PSS223 as a PET Tracer for Imaging of Metabotropic Glutamate Receptor Subtype 5 (mGluR5)
Chimia - Tập 66 Số 4 - Trang 201
Selena Milicevic Sephton, Patrick Dennler, Dominique S. Leutwiler, Linjing Mu, Roger Schibli, Stefanie D. Krämer, Simon M. Ametamey
Involvement of metabotropic glutamate receptor subtype 5 (mGluR5) in physiological and pathophysiological processes in the brain has been demonstrated, and hence mGluR5 has emerged as an important drug target. [11C]-ABP688 is clinically the most successful mGluR5 positron emission tomography (PET) tracer to date and it allows visualization and quantification of mGluR5. Due to the...... hiện toàn bộ
Hydrogen Activation by Benzene-Ruthenium Complexes in Aqueous Solution: Synthesis, Molecular Structure, and Intercalation of the Cluster Cation [{C₆H₆)₄Ru₄H₄]²⁺
Chimia - Tập 47 Số 6 - Trang 189
Ulf Bodensieck, Annette Meister, Götz Meister, G. Rheinwald, H. Stoeckli‐Evans, Georg Süß‐Fink
The hydrogenation of the aqua complex [(C6H6)Ru(H2O)3]2+, prepared in situ by hydrolysis of (C6H6)2Ru2Cl4 in water, was found to lead to the tetranuclear cluster dication [(C6H6)4Ru4H4]2+ (1) which crystallizes as the dichloride from the aqueous solution. In the presence of acetate ions, however, the reaction yields the dinuclear cations [(C6H6)2Ru2H(OOCCH3)X]+ (X=OH: 2, X=Cl: 3) which cry...... hiện toàn bộ
Probing Colloidal Particle Aggregation by Light Scattering
Chimia - Tập 67 Số 11 - Trang 772
Gregor Trefalt, István Szilágyi, Tamas Oncsik, Amin Sadeghpour, Michal Borkovec
The present article reviews recent progress in the measurement of aggregation rates in colloidal suspensions by light scattering. Time-resolved light scattering offers the possibility to measure absolute aggregation rate constants for homoaggregation as well as heteroaggregation processes. We further discuss the typical concentration dependencies of the aggregation rate constants...... hiện toàn bộ
iMatrixSpray: A Free and Open Source Sample Preparation Device for Mass Spectrometric Imaging
Chimia - Tập 68 Số 3 - Trang 146
Markus Stoeckli, Dieter Staab, Michael Wetzel, Matthias Brechbuehl
A device was built for matrix deposition in mass spectrometric imaging. This spray-type instrument requires no user interaction other than providing the spray solution and selecting the pre-defined or custom-built method. Robustness was achieved by utilizing a delta-robotics design in combination with a simple liquid system. All the information describing the systems is provided ...... hiện toàn bộ
The Synthetic Development of the Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu®): A Challenge for Synthesis & Process Research
Chimia - Tập 58 Số 9 - Trang 621
Stefan Abrecht, Peter J. Harrington, Hans Iding, Martin Karpf, René Trussardi, Beat Wirz, Ulrich Zutter
The evolution of the synthesis of oseltamivir phosphate (Tamiflu®), used for the oral treatment and prevention of influenza virus infections (viral flu) is described. Oseltamivir phosphate is the ethyl ester prodrug of the corresponding acid, a potent and selective inhibitor of influenza neuraminidase. The discovery chemistry route and scalable routes used for kilo laboratory pro...... hiện toàn bộ
Applications of Click Chemistry in Radiopharmaceutical Development
Chimia - Tập 64 Số 1-2 - Trang 29
Joseph C. Walsh, Hartmuth C. Kolb
Click chemistry, a concept that employs only practical and reliable transformations for compound synthesis, has made a significant impact in several areas of chemistry, including material sciences and drug discovery. The present article describes the use of click chemistry for the development of radiopharmaceuticals. Target templated in situ click chemistry was used for lead gene...... hiện toàn bộ
Molecular-Based Magnetism in High-Spin Molecular Clusters and Three-Dimensional Networks Based on Cyanometalate Building Blocks
Chimia - Tập 54 Số 10 - Trang 593
Melanie Pilkington, Silvio Decurtins
The field of molecule-based magnets is a relatively new branch of chemistry, which involves the design and study of molecular compounds that exhibit a spontaneous magnetic ordering below a critical temperature, Tc. One major goal involves the design of materials with tuneable Tc's for specific applications in memory storage devices. Molecule-based magnets with high magnetic ordering temper...... hiện toàn bộ
The Application of Electrospun Titania Nanofibers in Dye-sensitized Solar Cells
Chimia - Tập 67 Số 3 - Trang 149
Hana Krýsová, Arnošt Zukal, Jana Trckova-Barakova, Aravind Kumar Chandiran, Mohammad Khaja Nazeeruddin, Michaël Grätzel, Ladislav Kavan
Titania nanofibers were fabricated using the industrial NanospiderTM technology. The preparative protocol was optimized by screening various precursor materials to get pure anatase nanofibers. Composite films were prepared by mixing a commercial paste of nanocrystalline anatase particles with the electrospun nanofibers, which were shortened by milling. The composite films were se...... hiện toàn bộ
Porous Coordination Polymers as Novel Sorption Materials for Heat Transformation Processes
Chimia - Tập 67 Số 6 - Trang 419
Christoph Janiak, Stefan K. Henninger
Porous coordination polymers (PCPs)/metal-organic frameworks (MOFs) are inorganic–organic hybrid materials with a permanent three-dimensional porous metal–ligand network. PCPs or MOFs are inorganic–organic analogs of zeolites in terms of porosity and reversible guest exchange properties. Microporous water-stable PCPs with high water uptake capacity are gaining attention for low t...... hiện toàn bộ
Tổng số: 10   
  • 1