Cancer Microenvironment
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Extracellular ATP is Differentially Metabolized on Papillary Thyroid Carcinoma Cells Surface in Comparison to Normal Cells
Cancer Microenvironment - Tập 11 - Trang 61-70 - 2018
The incidence of differentiated thyroid cancer has been increasing. Nevertheless, its molecular mechanisms are not well understood. In recent years, extracellular nucleotides and nucleosides have emerged as important modulators of tumor microenvironment. Extracellular ATP is mainly hydrolyzed by NTPDase1/CD39 and NTPDase2/CD39L1, generating AMP, which is hydrolyzed by ecto-5′-nucleotidase (CD73) t...... hiện toàn bộ
Skewed Signaling through the Receptor for Advanced Glycation End-Products Alters the Proinflammatory Profile of Tumor-Associated Macrophages
Cancer Microenvironment - Tập 11 - Trang 97-105 - 2018
Tumors are complex tissues composed of variable amounts of both non-cellular components (matrix proteins) and a multitude of stromal cell types, which are under an active cross-talk with tumor cells. Tumor-associated macrophages (TAMs) are the major leukocyte population among the tumor-infiltrating immune cells. Once they are infiltrated into tumor stroma they undergo a polarized activation, where...... hiện toàn bộ
Recovery of Immunoglobulin VJ Recombinations from Pancreatic Cancer Exome Files Strongly Correlates with Reduced Survival
Cancer Microenvironment - Tập 11 - Trang 51-59 - 2018
We assessed pancreatic cancer, lymphocyte infiltrates with a computational genomics approach. We took advantage of tumor-specimen exome files available from the cancer genome atlas to mine T- and B-cell immune receptor recombinations, using highly efficient, scripted algorithms established in several previous reports. Surprisingly, the results indicated that pancreatic cancer exomes represent one ...... hiện toàn bộ
The Involvement of RCAS1 in Creating a Suppressive Tumor Microenvironment in Patients with Salivary Gland Adenocarcinoma
Cancer Microenvironment - Tập 4 - Trang 13-21 - 2010
The tumor microenvironment is the tissue that determines the growth and progression of the tumor as well as its ability to initiate metastases. The aim of the present study has been to evaluate the role of RCAS1 in creating the suppressive tumor microenvironment in cases of parotid adenocarcinoma. The tissue samples of salivary gland adenocarcinomas and their stroma and the palatine tonsils which ...... hiện toàn bộ
Microparticles mediated cross-talk between tumoral and endothelial cells promote the constitution of a pro-metastatic vascular niche through Arf6 up regulation
Cancer Microenvironment - Tập 7 - Trang 41-59 - 2014
The tumor stroma plays an essential role in tumor growth, resistance to therapy and occurrence of metastatic phenotype. Tumor vessels have been considered as passive conducts for nutrients but several studies have demonstrated secretion of pro-tumoral factors by endothelial cells. The failure of anti-angiogenic therapies to meet expectations raised by pre-clinical studies prompt us to better study...... hiện toàn bộ
Identification of Molecular Distinctions Between Normal Breast-Associated Fibroblasts and Breast Cancer-Associated Fibroblasts
Cancer Microenvironment - Tập 2 Số 1 - 2009
Angiotropism, Pericytic Mimicry and Extravascular Migratory Metastasis in Melanoma: An Alternative to Intravascular Cancer Dissemination Dịch bởi AI
Cancer Microenvironment - Tập 7 - Trang 139-152 - 2014
Trong hơn 15 năm qua, hiện tượng angiotropism ở u hắc tố đã được nhấn mạnh như một dấu hiệu của sự di cư ngoài mạch của tế bào khối u dọc theo bề mặt mạch máu ngoại vi, mở ra một cơ chế thay thế cho sự lan rộng của khối u khác với sự phát tán trong lòng mạch. Cơ chế này đã được gọi là sự di căn ngoài mạch (EVMM). Trong quá trình EVMM, các tế bào khối u angiotropic di chuyển theo cách giống như ‘pe...... hiện toàn bộ
#angiotropism #di căn ngoài mạch #u hắc tố #pericytic mimicry #di cư tế bào #di căn.
Erratum to: Clinical and Biological Implications of the Tumor Microenvironment
Cancer Microenvironment - - 2012
Stiffened Extracellular Matrix and Signaling from Stromal Fibroblasts via Osteoprotegerin Regulate Tumor Cell Invasion in a 3-D Tumor in Situ Model
Cancer Microenvironment - Tập 9 - Trang 127-139 - 2016
Several changes have been described in the stroma surrounding a tumor, including changes in cellular composition, altered extracellular matrix composition and organization, and increases in stiffness. Tumor cells are influenced by the composition, organization, and mechanical properties of the microenvironment, and by signals from stromal cells. Here we sought to test whether signaling from stroma...... hiện toàn bộ
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