Cancer Microenvironment

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Macrophage Infiltration in Tumor Stroma is Related to Tumor Cell Expression of CD163 in Colorectal Cancer
Cancer Microenvironment - Tập 7 - Trang 61-69 - 2014
Ivan Shabo, Hans Olsson, Rihab Elkarim, Xiao-Feng Sun, Joar Svanvik
The scavenger receptor, CD163, is a macrophage-specific marker. Recent studies have shown that CD163 expression in breast and rectal cancer cells is associated with poor prognosis. This study was conducted to evaluate the relationship between CD163 expression as a macrophage trait in cancer cells, and macrophage infiltration and its clinical significance in colorectal cancer. Immunostaining of CD1... hiện toàn bộ
Small But Mighty: Microparticles as Mediators of Tumor Progression
Cancer Microenvironment - Tập 7 - Trang 11-21 - 2014
Tali Voloshin, Ella Fremder, Yuval Shaked
A wide spectrum of both normal and diseased cell types shed extracellular vesicles that facilitate intercellular communication without direct cell-to-cell contact. Microparticles (MPs) are a subtype of extracellular vesicles that participate in multiple biological processes. They carry abundant bioactive molecules including different forms of nucleic acids and proteins that can markedly modulate c... hiện toàn bộ
The Liver Prometastatic Reaction of Cancer Patients: Implications for Microenvironment-Dependent Colon Cancer Gene Regulation
Cancer Microenvironment - Tập 4 Số 2 - Trang 163-180 - 2011
Fernando Vidal‐Vanaclocha
Anakoinosis: Communicative Reprogramming of Tumor Systems - for Rescuing from Chemorefractory Neoplasia
Cancer Microenvironment - Tập 8 - Trang 75-92 - 2015
Christina Hart, Martin Vogelhuber, Daniel Wolff, Sebastian Klobuch, Lina Ghibelli, Jürgen Foell, Selim Corbacioglu, Klaus Rehe, Guy Haegeman, Simone Thomas, Wolfgang Herr, Albrecht Reichle
Disruptive technologies, such as communicative reprogramming (anakoinosis) with cellular therapies in situ for treating refractory metastatic cancer allow patient care to accelerate along a totally new trajectory and highlight what may well become the next sea change in the care of patients with many types of advanced neoplasia. Cellular therapy in situ consisted of repurposed drugs, pioglitazone ... hiện toàn bộ
Stromal Myofibroblasts Accompany Modifications in the Epithelial Phenotype of Tongue Dysplastic and Malignant Lesions
Cancer Microenvironment - Tập 2 - Trang 49-57 - 2009
Marilena Vered, Irit Allon, Amos Buchner, Dan Dayan
Stromal myofibroblasts (SMF) associated with various types of carcinomas are believed to emerge under the influence of the tumor cells. Recent studies have shown that SMF may originate from fibroblasts within the tumor stroma or even from carcinoma cells by the process of epithelial-mesenchymal transition. The aim of this study was to investigate the concomitant expression of epithelial membrane a... hiện toàn bộ
Clinical and Biological Implications of the Tumor Microenvironment
Cancer Microenvironment - Tập 5 Số 2 - Trang 95-112 - 2012
David Tarin
Shaping of NK Cell Responses by the Tumor Microenvironment
Cancer Microenvironment - Tập 6 - Trang 135-146 - 2012
Ana Stojanovic, Margareta P. Correia, Adelheid Cerwenka
Natural killer (NK) cells belong to the innate immune system and are potent cytolytic and cytokine-producing effector cells in response to tumor targets. NK cell based anti-tumor immunotherapy was so far mainly successful in patients with different types of leukemia. For instance, acute myeloid leukemia (AML) patients displayed a prolonged survival if transplanted with haploidentical stem cells gi... hiện toàn bộ
Clinical Implications of Marker Expression of Carcinoma-Associated Fibroblasts (CAFs) in Patients with Epithelial Ovarian Carcinoma After Treatment with Neoadjuvant Chemotherapy
Cancer Microenvironment - - 2013
Paulette Mhawech-Fauceglia, Dan Wang, Damanzoopinder Samrao, Grace Kim, Kate Lawrenson, Teodulo Meneses, Song Liu, Annie Yessaian, Tanja Pejovic
Cancer-associated fibroblasts (CAFs) play an important role in tumor initiation and progression. The aim of this study is to explore the role of 2 CAF markers, fibroblast activated protein (FAP) and α-smooth muscle actin (αSMA), in patients with epithelial ovarian cancer (EOC) post-neoadjuvant chemotherapy. Sixty-six patients with the diagnosis of EOC treated with debulking surgery after neoadjuva... hiện toàn bộ
Tumor-Associated T-Lymphocytes and Macrophages are Decreased in Endometrioid Endometrial Carcinoma with MELF-Pattern Stromal Changes
Cancer Microenvironment - Tập 11 - Trang 107-114 - 2018
Dmitry Aleksandrovich Zinovkin, Md Zahidul Islam Pranjol, Il’ya Andreevich Bilsky, Valeriya Alexandrovna Zmushko
Microcystic, elongated, fragmented (MELF)-pattern is an unusual morphology of myometrial invasive front in endometrioid endometrial carcinoma (EA). The aim of the study was to investigate potential correlation between MELF-pattern and peritumoral inflammatory immune response. A total of 96 out of 368 patients were included in this study. CD3, CD20, CD57. CD68 and S100 markers were used for the det... hiện toàn bộ
Mammographic Density and Matrix Metalloproteinases in Breast Tissue
Cancer Microenvironment - Tập 3 - Trang 57-65 - 2009
Jana S. Steude, Gertraud Maskarinec, Eva Erber, Martijn Verheus, Brenda Y. Hernandez, Jeffrey Killeen, J. Mark Cline
Mammographic density is a strong risk factor for breast cancer, yet the underlying histopathologic correlates are not clear. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) play important roles in multiple stages of tumorigenesis. This study examined the association between mammographic density and expression of MMPs 1, 3, 9, and 12 and TIMP3 in benign and malignant breast tissue of ... hiện toàn bộ
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