Cancer Convergence
2366-6196
Cơ quản chủ quản: N/A
Các bài báo tiêu biểu
Cancer dormancy and criticality from a game theory perspective
Tập 2 - Trang 1-8 - 2018
The physics of cancer dormancy, the time between initial cancer treatment and
re-emergence after a protracted period, is a puzzle. Cancer cells interact with
host cells via complex, non-linear population dynamics, which can lead to very
non-intuitive but perhaps deterministic and understandable progression dynamics
of cancer and dormancy. We explore here the dynamics of host-cancer cell
population...
A network modeling approach to elucidate drug resistance mechanisms and predict combinatorial drug treatments in breast cancer
Tập 1 - Trang 1-25 - 2017
Mechanistic models of within-cell signal transduction networks can explain how
these networks integrate internal and external inputs to give rise to the
appropriate cellular response. These models can be fruitfully used in cancer
cells, whose aberrant decision-making regarding their survival or death,
proliferation or quiescence can be connected to errors in the state of nodes or
edges of the sign...
Probing three-dimensional collective cancer invasion with DIGME
Tập 1 - Trang 1-12 - 2017
Multicellular pattern formation plays an important role in developmental
biology, cancer metastasis and wound healing. While many physical factors have
been shown to regulate these multicellular processes, the role of ECM
micro-to-meso scale geometry has been poorly understood in 3D collective cancer
invasion. We have developed a mechanical-based strategy, Diskoid In
Geometrically Micropatterned E...
Distinguishing mechanisms underlying EMT tristability
Tập 1 - Trang 1-19 - 2017
The Epithelial-Mesenchymal Transition (EMT) endows epithelial-looking cells with
enhanced migratory ability during embryonic development and tissue repair. EMT
can also be co-opted by cancer cells to acquire metastatic potential and
drug-resistance. Recent research has argued that epithelial (E) cells can
undergo either a partial EMT to attain a hybrid epithelial/mesenchymal (E/M)
phenotype that t...