Cancer Convergence
2366-6196
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Các bài báo tiêu biểu
Probing three-dimensional collective cancer invasion with DIGME
Tập 1 - Trang 1-12 - 2017
Multicellular pattern formation plays an important role in developmental biology, cancer metastasis and wound healing. While many physical factors have been shown to regulate these multicellular processes, the role of ECM micro-to-meso scale geometry has been poorly understood in 3D collective cancer invasion. We have developed a mechanical-based strategy, Diskoid In Geometrically Micropatterned E......
Distinguishing mechanisms underlying EMT tristability
Tập 1 - Trang 1-19 - 2017
The Epithelial-Mesenchymal Transition (EMT) endows epithelial-looking cells with enhanced migratory ability during embryonic development and tissue repair. EMT can also be co-opted by cancer cells to acquire metastatic potential and drug-resistance. Recent research has argued that epithelial (E) cells can undergo either a partial EMT to attain a hybrid epithelial/mesenchymal (E/M) phenotype that t......
Cancer dormancy and criticality from a game theory perspective
Tập 2 - Trang 1-8 - 2018
The physics of cancer dormancy, the time between initial cancer treatment and re-emergence after a protracted period, is a puzzle. Cancer cells interact with host cells via complex, non-linear population dynamics, which can lead to very non-intuitive but perhaps deterministic and understandable progression dynamics of cancer and dormancy. We explore here the dynamics of host-cancer cell population......
A network modeling approach to elucidate drug resistance mechanisms and predict combinatorial drug treatments in breast cancer
Tập 1 - Trang 1-25 - 2017
Mechanistic models of within-cell signal transduction networks can explain how these networks integrate internal and external inputs to give rise to the appropriate cellular response. These models can be fruitfully used in cancer cells, whose aberrant decision-making regarding their survival or death, proliferation or quiescence can be connected to errors in the state of nodes or edges of the sign......