British Journal of Pharmacology

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β‐Adrenoceptor agonist mediated relaxation of rat isolated resistance arteries: a role for the endothelium and nitric oxide
British Journal of Pharmacology - Tập 108 Số 3 - Trang 631-637 - 1993
J. E. Graves, Lucilla Poston
Liver delivery of NO by NCX‐1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice THIS ARTICLE HAS BEEN RETRACTED
British Journal of Pharmacology - Tập 143 Số 1 - Trang 33-42 - 2004
Stefano Fiorucci, Elisabetta Antonelli, Eleonora Distrutti, Andrea Mencarelli, Silvana Farneti, Piero Del Soldato, Antonio Morelli
NCX‐1000, (3α, 5β, 7β)‐3,7‐dihydroxycholan‐24oic acid[2‐methoxy‐4‐[3‐[4‐(nitroxy)butoxy]‐3‐oxo‐1‐propenyl]phenyl ester, is a nitric oxide (NO)‐derivative of ursodeoxyxholic acid (UDCA) that selectively release NO in the liver.... hiện toàn bộ
Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin‐resistant rats
British Journal of Pharmacology - Tập 169 Số 5 - Trang 1048-1057 - 2013
Nattayaporn Apaijai, Hiranya Pintana, Nipon Chattipakorn
Background and PurposeLong‐term high‐fat diet (HFD) consumption has been shown to cause insulin resistance, which is characterized by hyperinsulinaemia with metabolic inflexibility. Insulin resistance is associated with cardiac sympathovagal imbalance, cardiac dysfunction and cardiac mitochondr...... hiện toàn bộ
Stress‐induced anhedonia is associated with an increase in Alzheimer's disease‐related markers
British Journal of Pharmacology - Tập 165 Số 4 - Trang 897-907 - 2012
Alejandro Fernández Briones, Sara Gagno, Eva Martišová, Marta Dobarro, Bárbara Aisa, Maite Solas, Rosa M. Tordera, Marı́a J. Ramı́rez
BACKGROUND AND PURPOSE Stress is believed to be associated with the development of neuropsychiatric disorders, including Alzheimer's disease (AD). We have studied mechanisms implicated in vulnerability to stress and the relationship with changes in AD‐related markers.EXPERIMENTAL APPROACH Anhedonia induced by a chronic mild str...... hiện toàn bộ
The actions of capsaicin applied topically to the skin of the rat on C‐fibre afferents, antidromic vasodilatation and substance P levels
British Journal of Pharmacology - Tập 107 Số 2 - Trang 400-406 - 1992
Lynn Bry, W. Ye, B. Cotsell
Single applications of solutions of capsaicin were made to the intact skin of anaesthetized rats and the effects on cutaneous blood flow and the firing of C‐nociceptor afferents determined. Blood flow was measured by laser‐Doppler flowmetry. C‐fibre activity was recorded from filaments dissected from the saphenous nerve.... hiện toàn bộ
Effect of a calcitonin gene‐related peptide antagonist (CGRP8–37) on skin vasodilatation and oedema induced by stimulation of the rat saphenous nerve
British Journal of Pharmacology - Tập 110 Số 2 - Trang 772-776 - 1993
Katherine J. Escott, Susan D. Brain
The effect of the calcitonin gene‐related peptide antagonist (CGRP8–37, 400 nmol kg−1, i.v.) on the increased blood flow induced by calcitonin gene related peptide (CGRP), vasodilator prostaglandins, and topical capsaicin was measured with a laser Doppler blood flow meter in rat abdomin...... hiện toàn bộ
A pharmacological profile of the novel, peripherally‐selective k‐opioid receptor agonist, EMD 61753
British Journal of Pharmacology - Tập 113 Số 4 - Trang 1317-1327 - 1994
Andrew Barber, Gerd D. Bartoszyk, H.M. Bender, Rudolf Gottschlich, Hartmut E. Greiner, J. Harting, Frank Mauler, Klaus-Otto Minck, Robert Murray, Maxime Simon, Christoph A. Seyfried
The pharmacological properties of the novel diarylacetamide k‐opioid receptor agonist, EMD 61753, have been compared with those of ICI 197067 (a centrally‐acting k agonist) and ICI204448 (a peripherally‐selective k agonist).... hiện toàn bộ
Adenosine A1 receptor activation attenuates cardiac hypertrophy and fibrosis in response to α1‐adrenoceptor stimulation in vivo
British Journal of Pharmacology - Tập 173 Số 1 - Trang 88-102 - 2016
S‐L Puhl, Andrey Kazakov, Andreas Müller, Peter Fries, Daniel R. Wagner, Michael Böhm, Christoph Maack, Yvan Devaux
Background and PurposeAdenosine has been proposed to exert anti‐hypertrophic effects. However, the precise regulation and the role of the different adenosine receptor subtypes in the heart and their effects on hypertrophic signalling are largely unknown. We aimed to characterize expression and function of adenosine A1 receptors follow...... hiện toàn bộ
Effect of prostaglandins E1 and E2 on intestinal motility in the guinea‐pig and rat
British Journal of Pharmacology - Tập 34 Số 3 - Trang 639-647 - 1968
A. B. Bennett, K. G. Eley, G. Scholes
. Prostaglandins E1 and E2 affected intestinal activity both in vitro and in vivo. . Serosal application of prostaglandin to guinea‐pig isolated ileum stimulated the longitudinal musc...... hiện toàn bộ
Neural KCNQ (Kv7) channels
British Journal of Pharmacology - Tập 156 Số 8 - Trang 1185-1195 - 2009
David A. Brown, Gayle M. Passmore
KCNQ genes encode five Kv7 K+ channel subunits (Kv7.1–Kv7.5). Four of these (Kv7.2–Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage‐gated M‐channel, which widely regulates neuronal excitability, although other subunits may contribute to M‐like currents in some locations. M...... hiện toàn bộ
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