Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cordBritish Journal of Pharmacology - Tập 130 Số 8 - Trang 1731-1734 - 2000
Manoj K. Patel, M I Gonzalez, S. Bramwell, R D Pinnock, K Lee
In the present study we tested the effects of the antihyperalgesic compound gabapentin on dorsal horn neurones in adult spinal cord. Slices were taken from control and hyperalgesic animals suffering from streptozocin‐induced diabetic neuropathy. At concentrations up to 100 μM, bath application failed to affect the resting membrane properties of dorsal horn neurones taken...... hiện toàn bộ
The importance of determining circadian parameters in pharmacological studiesBritish Journal of Pharmacology - Tập 176 Số 16 - Trang 2827-2847 - 2019
Laetitia S. Gaspar, Ana Rita Álvaro, Sara Carmo‐Silva, A.F. Mendes, Angela Relόgio, Cláudia Cavadas
In mammals, most molecular and cellular processes show circadian changes, leading to daily variations in physiology and ultimately in behaviour. Such daily variations induce a temporal coordination of processes that is essential to ensure homeostasis and health. Thus, it is of no surprise that pharmacokinetics (PK) and pharmacodynamics (PD) of many drugs are also subject to circadian varia...... hiện toàn bộ
A comparison of the effect of nitroparacetamol and paracetamol on liver injuryBritish Journal of Pharmacology - Tập 132 Số 1 - Trang 10-12 - 2001
L E Futter, O A Al‐Swayeh, Philip K. Moore
Paracetamol (5 mmol kg−1, i.p.) caused liver damage in rats as indicated by increased plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and glutamate dehydrogenase (GDH) activities. No change in plasma bilirubin or creatinine was noted. An equimolar dose of nitroparacetamol (a nitric oxide (NO)‐releasing derivative of paracetamol) did not alter pl...... hiện toàn bộ
Liver delivery of NO by NCX‐1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice THIS ARTICLE HAS BEEN RETRACTEDBritish Journal of Pharmacology - Tập 143 Số 1 - Trang 33-42 - 2004
Stefano Fiorucci, Elisabetta Antonelli, Eleonora Distrutti, Andrea Mencarelli, Silvana Farneti, Piero Del Soldato, Antonio Morelli
NCX‐1000, (3α, 5β, 7β)‐3,7‐dihydroxycholan‐24oic acid[2‐methoxy‐4‐[3‐[4‐(nitroxy)butoxy]‐3‐oxo‐1‐propenyl]phenyl ester, is a nitric oxide (NO)‐derivative of ursodeoxyxholic acid (UDCA) that selectively release NO in the liver.... hiện toàn bộ
Acetaminophen hepatotoxicity: NO to the rescueBritish Journal of Pharmacology - Tập 143 Số 1 - Trang 1-2 - 2004
John L. Wallace
Severe liver injury as a result of overdose or chronic use of acetaminophen (paracetamol) remains a significant clinical problem, accounting for as much as 40% of cases of acute liver failure. The mechanisms underlying the liver injury caused by acetaminophen have become much better understood in recent years. In this issue, Fiorucci et al. report that delivery o...... hiện toàn bộ
Doxycycline and its derivative, COL‐3, decrease dyskinesia induced by l‐DOPA in hemiparkinsonian ratsBritish Journal of Pharmacology - Tập 178 Số 13 - Trang 2595-2616 - 2021
Mariza Bortolanza, Glauce Crivelaro Nascimento, Rita Raisman‐Vozari, Elaine Del‐Bel
Background and Purposel‐DOPA‐induced dyskinesia is a debilitating effect of treating Parkinson's disease with this drug. New therapeutic approaches that prevent or attenuate this side effect are needed.Experimental ApproachWistar adult male rats su...... hiện toàn bộ