British Journal of Pharmacology

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Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord
British Journal of Pharmacology - Tập 130 Số 8 - Trang 1731-1734 - 2000
Manoj K. Patel, M I Gonzalez, S. Bramwell, R D Pinnock, K Lee
In the present study we tested the effects of the antihyperalgesic compound gabapentin on dorsal horn neurones in adult spinal cord. Slices were taken from control and hyperalgesic animals suffering from streptozocin‐induced diabetic neuropathy. At concentrations up to 100 μM, bath application failed to affect the resting membrane properties of dorsal horn neurones taken from both groups of animal... hiện toàn bộ
Noradrenaline modulates smooth muscle activity of the isolated intravesical ureter of the pig through different types of adrenoceptors
British Journal of Pharmacology - Tập 107 Số 4 - Trang 924-931 - 1992
Medardo Hernández, Dolores Prieto, Ulf Simonsen, Luis Rivera, María Victoria Barahona, Albino García‐Sacristán
We have studied the effects of α‐ and β‐adrenoceptor agonists and antagonists on both phasic peristaltic activity and basal tone of the isolated intravesical ureter of the pig by means of isometric techniques in vitro. Spontaneous phasic activity was exhibited by 21% of pig intravesical ureter preparations manifested as rhythmic contractions with average frequency and amplitude of 2.54 ± 0.18 min−... hiện toàn bộ
The importance of determining circadian parameters in pharmacological studies
British Journal of Pharmacology - Tập 176 Số 16 - Trang 2827-2847 - 2019
Laetitia S. Gaspar, Ana Rita Álvaro, Sara Carmo‐Silva, A.F. Mendes, Angela Relόgio, Cláudia Cavadas
In mammals, most molecular and cellular processes show circadian changes, leading to daily variations in physiology and ultimately in behaviour. Such daily variations induce a temporal coordination of processes that is essential to ensure homeostasis and health. Thus, it is of no surprise that pharmacokinetics (PK) and pharmacodynamics (PD) of many drugs are also subject to circadian variations, p... hiện toàn bộ
β‐Adrenoceptor agonist mediated relaxation of rat isolated resistance arteries: a role for the endothelium and nitric oxide
British Journal of Pharmacology - Tập 108 Số 3 - Trang 631-637 - 1993
J. E. Graves, Lucilla Poston
A comparison of the effect of nitroparacetamol and paracetamol on liver injury
British Journal of Pharmacology - Tập 132 Số 1 - Trang 10-12 - 2001
L E Futter, O A Al‐Swayeh, Philip K. Moore
Paracetamol (5 mmol kg−1, i.p.) caused liver damage in rats as indicated by increased plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and glutamate dehydrogenase (GDH) activities. No change in plasma bilirubin or creatinine was noted. An equimolar dose of nitroparacetamol (a nitric oxide (NO)‐releasing derivative of paracetamol) did not alter plasma levels of any of the mar... hiện toàn bộ
Liver delivery of NO by NCX‐1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice THIS ARTICLE HAS BEEN RETRACTED
British Journal of Pharmacology - Tập 143 Số 1 - Trang 33-42 - 2004
Stefano Fiorucci, Elisabetta Antonelli, Eleonora Distrutti, Andrea Mencarelli, Silvana Farneti, Piero Del Soldato, Antonio Morelli
NCX‐1000, (3α, 5β, 7β)‐3,7‐dihydroxycholan‐24oic acid[2‐methoxy‐4‐[3‐[4‐(nitroxy)butoxy]‐3‐oxo‐1‐propenyl]phenyl ester, is a nitric oxide (NO)‐derivative of ursodeoxyxholic acid (UDCA) that selectively release NO in the liver. Here, we demonstrated that administering mice with 40 μmol kg−1 NCX‐1000, but not UDCA, improves liver histopathology and reduces mortality caused by 330 μmol kg−1 APAP from... hiện toàn bộ
Acetaminophen hepatotoxicity: NO to the rescue
British Journal of Pharmacology - Tập 143 Số 1 - Trang 1-2 - 2004
John L. Wallace
Severe liver injury as a result of overdose or chronic use of acetaminophen (paracetamol) remains a significant clinical problem, accounting for as much as 40% of cases of acute liver failure. The mechanisms underlying the liver injury caused by acetaminophen have become much better understood in recent years. In this issue, Fiorucci et al. report that delivery of nitric oxide (NO) in small amount... hiện toàn bộ
Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin‐resistant rats
British Journal of Pharmacology - Tập 169 Số 5 - Trang 1048-1057 - 2013
Nattayaporn Apaijai, Hiranya Pintana, Nipon Chattipakorn
Background and PurposeLong‐term high‐fat diet (HFD) consumption has been shown to cause insulin resistance, which is characterized by hyperinsulinaemia with metabolic inflexibility. Insulin resistance is associated with cardiac sympathovagal imbalance, cardiac dysfunction and cardiac mitochondrial dysfunction. Dipeptidyl peptidase‐4 (DPP‐4) inhibitors, vildagliptin and sitagliptin, are oral anti‐d... hiện toàn bộ
Doxycycline and its derivative, COL‐3, decrease dyskinesia induced by l‐DOPA in hemiparkinsonian rats
British Journal of Pharmacology - Tập 178 Số 13 - Trang 2595-2616 - 2021
Mariza Bortolanza, Glauce Crivelaro Nascimento, Rita Raisman‐Vozari, Elaine Del‐Bel
Background and Purposel‐DOPA‐induced dyskinesia is a debilitating effect of treating Parkinson's disease with this drug. New therapeutic approaches that prevent or attenuate this side effect are needed.Experimental ApproachWistar adult male rats submitted to 6‐hydroxydopamine‐induced unilateral medial forebrain bundle lesion were treated with l‐DOPA (p.o. 20 mg·kg−1 or s.c. 10 mg·kg−1) once a day ... hiện toàn bộ
Meso‐dihydroguaiaretic acid and licarin A of Machilus thunbergii protect against glutamate‐induced toxicity in primary cultures of a rat cortical cells
British Journal of Pharmacology - Tập 146 Số 5 - Trang 752-759 - 2005
Choong Je, So Ra Kim, Jinwoong Kim, Young Choong Kim
We previously reported that four lignans isolated from the bark of Machilus thunbergii Sieb. et Zucc. (Lauraceae) protected primary cultures of rat cortical neurons from neurotoxicity induced by glutamate. Among the lignans, meso‐dihydroguaiarectic acid (MDGA) and licarin A significantly attenuated glutamate‐induced neurotoxicity when added prior to or right after the excitotoxic glutamate challen... hiện toàn bộ
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