British Journal of Pharmacology

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β‐Adrenoceptor agonist mediated relaxation of rat isolated resistance arteries: a role for the endothelium and nitric oxide
British Journal of Pharmacology - Tập 108 Số 3 - Trang 631-637 - 1993
J. E. Graves, Lucilla Poston
Liver delivery of NO by NCX‐1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice THIS ARTICLE HAS BEEN RETRACTED
British Journal of Pharmacology - Tập 143 Số 1 - Trang 33-42 - 2004
Stefano Fiorucci, Elisabetta Antonelli, Eleonora Distrutti, Andrea Mencarelli, Silvana Farneti, Piero Del Soldato, Antonio Morelli
NCX‐1000, (3α, 5β, 7β)‐3,7‐dihydroxycholan‐24oic acid[2‐methoxy‐4‐[3‐[4‐(nitroxy)butoxy]‐3‐oxo‐1‐propenyl]phenyl ester, is a nitric oxide (NO)‐derivative of ursodeoxyxholic acid (UDCA) that selectively release NO in the liver.... hiện toàn bộ
Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin‐resistant rats
British Journal of Pharmacology - Tập 169 Số 5 - Trang 1048-1057 - 2013
Nattayaporn Apaijai, Hiranya Pintana, Nipon Chattipakorn
Background and PurposeLong‐term high‐fat diet (HFD) consumption has been shown to cause insulin resistance, which is characterized by hyperinsulinaemia with metabolic inflexibility. Insulin resistance is associated with cardiac sympathovagal imbalance, cardiac dysfunction and cardiac mitochondr...... hiện toàn bộ
Stress‐induced anhedonia is associated with an increase in Alzheimer's disease‐related markers
British Journal of Pharmacology - Tập 165 Số 4 - Trang 897-907 - 2012
Alejandro Fernández Briones, Sara Gagno, Eva Martišová, Marta Dobarro, Bárbara Aisa, Maite Solas, Rosa M. Tordera, Marı́a J. Ramı́rez
BACKGROUND AND PURPOSE Stress is believed to be associated with the development of neuropsychiatric disorders, including Alzheimer's disease (AD). We have studied mechanisms implicated in vulnerability to stress and the relationship with changes in AD‐related markers.EXPERIMENTAL APPROACH Anhedonia induced by a chronic mild str...... hiện toàn bộ
The actions of capsaicin applied topically to the skin of the rat on C‐fibre afferents, antidromic vasodilatation and substance P levels
British Journal of Pharmacology - Tập 107 Số 2 - Trang 400-406 - 1992
Lynn Bry, W. Ye, B. Cotsell
Single applications of solutions of capsaicin were made to the intact skin of anaesthetized rats and the effects on cutaneous blood flow and the firing of C‐nociceptor afferents determined. Blood flow was measured by laser‐Doppler flowmetry. C‐fibre activity was recorded from filaments dissected from the saphenous nerve.... hiện toàn bộ
A pharmacological profile of the novel, peripherally‐selective k‐opioid receptor agonist, EMD 61753
British Journal of Pharmacology - Tập 113 Số 4 - Trang 1317-1327 - 1994
Andrew Barber, Gerd D. Bartoszyk, H.M. Bender, Rudolf Gottschlich, Hartmut E. Greiner, J. Harting, Frank Mauler, Klaus-Otto Minck, Robert Murray, Maxime Simon, Christoph A. Seyfried
The pharmacological properties of the novel diarylacetamide k‐opioid receptor agonist, EMD 61753, have been compared with those of ICI 197067 (a centrally‐acting k agonist) and ICI204448 (a peripherally‐selective k agonist).... hiện toàn bộ
Effect of prostaglandins E1 and E2 on intestinal motility in the guinea‐pig and rat
British Journal of Pharmacology - Tập 34 Số 3 - Trang 639-647 - 1968
A. B. Bennett, K. G. Eley, G. Scholes
. Prostaglandins E1 and E2 affected intestinal activity both in vitro and in vivo. . Serosal application of prostaglandin to guinea‐pig isolated ileum stimulated the longitudinal musc...... hiện toàn bộ
Double‐transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations
British Journal of Pharmacology - Tập 163 Số 3 - Trang 546-555 - 2011
Jörg König, Oliver Zolk, Katrin Singer, Christiane Hoffmann, Martin F. Fromm
BACKGROUND AND PURPOSE The organic cation transporters 1 (OCT1) and 2 (OCT2) mediate drug uptake into hepatocytes and renal proximal tubular cells, respectively. Multidrug and toxin extrusion protein 1 (MATE1) is a major component of subsequent export into bile and urine. However, the functional interaction of OCTs and MATE1 for uptake and transcellular transport of ...... hiện toàn bộ
Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics
British Journal of Pharmacology - Tập 164 Số 7 - Trang 1817-1825 - 2011
Atsushi Yonezawa, Ken‐ichi Inui
The renal organic cation transport system mediates the tubular secretion of cationic compounds including drugs, toxins and endogenous metabolites into urine. It consists of a membrane potential‐dependent organic cation transporter at the basolateral membrane and an H+/organic cation antiporter at the brush‐border membrane. In 2005, human multidrug and toxin extrusion M...... hiện toàn bộ
The adenosine receptor‐mediated inhibition of noradrenaline release possibly involves a N‐protein and is increased by α2‐autoreceptor blockade
British Journal of Pharmacology - Tập 90 Số 2 - Trang 403-412 - 1987
Clemens Allgaier, Georg Hertting, Oda Von Kügelgen
The stimulation‐evoked overflow of [3H]‐noradrenaline from slices of the rabbit hippocampus is inhibited by α2‐autoreceptors as well as by adenosine (A1)‐receptors. Slices of rabbit hippocampus were labelled with [3H]‐noradrenaline, superfused c...... hiện toàn bộ
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