Liver delivery of NO by NCX‐1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice THIS ARTICLE HAS BEEN RETRACTEDBritish Journal of Pharmacology - Tập 143 Số 1 - Trang 33-42 - 2004
Stefano Fiorucci, Elisabetta Antonelli, Eleonora Distrutti, Andrea Mencarelli, Silvana Farneti, Piero Del Soldato, Antonio Morelli
NCX‐1000, (3α, 5β, 7β)‐3,7‐dihydroxycholan‐24oic acid[2‐methoxy‐4‐[3‐[4‐(nitroxy)butoxy]‐3‐oxo‐1‐propenyl]phenyl ester, is a nitric oxide (NO)‐derivative of ursodeoxyxholic acid (UDCA) that selectively release NO in the liver.... hiện toàn bộ
Stress‐induced anhedonia is associated with an increase in Alzheimer's disease‐related markersBritish Journal of Pharmacology - Tập 165 Số 4 - Trang 897-907 - 2012
Alejandro Fernández Briones, Sara Gagno, Eva Martišová, Marta Dobarro, Bárbara Aisa, Maite Solas, Rosa M. Tordera, Marı́a J. Ramı́rez
BACKGROUND AND PURPOSE Stress is believed to be associated with the development of neuropsychiatric disorders, including Alzheimer's disease (AD). We have studied mechanisms implicated in vulnerability to stress and the relationship with changes in AD‐related markers.EXPERIMENTAL APPROACH Anhedonia induced by a chronic mild str...... hiện toàn bộ
A pharmacological profile of the novel, peripherally‐selective k‐opioid receptor agonist, EMD 61753British Journal of Pharmacology - Tập 113 Số 4 - Trang 1317-1327 - 1994
Andrew Barber, Gerd D. Bartoszyk, H.M. Bender, Rudolf Gottschlich, Hartmut E. Greiner, J. Harting, Frank Mauler, Klaus-Otto Minck, Robert Murray, Maxime Simon, Christoph A. Seyfried
The pharmacological properties of the novel diarylacetamide k‐opioid receptor agonist, EMD 61753, have been compared with those of ICI 197067 (a centrally‐acting k agonist) and ICI204448 (a peripherally‐selective k agonist).... hiện toàn bộ
Adenosine A1 receptor activation attenuates cardiac hypertrophy and fibrosis in response to α1‐adrenoceptor stimulation in vivoBritish Journal of Pharmacology - Tập 173 Số 1 - Trang 88-102 - 2016
S‐L Puhl, Andrey Kazakov, Andreas Müller, Peter Fries, Daniel R. Wagner, Michael Böhm, Christoph Maack, Yvan Devaux
Background and PurposeAdenosine has been proposed to exert anti‐hypertrophic effects. However, the precise regulation and the role of the different adenosine receptor subtypes in the heart and their effects on hypertrophic signalling are largely unknown. We aimed to characterize expression and function of adenosine A1 receptors follow...... hiện toàn bộ
Neural KCNQ (Kv7) channelsBritish Journal of Pharmacology - Tập 156 Số 8 - Trang 1185-1195 - 2009
David A. Brown, Gayle M. Passmore
KCNQ genes encode five Kv7 K+ channel subunits (Kv7.1–Kv7.5). Four of these (Kv7.2–Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage‐gated M‐channel, which widely regulates neuronal excitability, although other subunits may contribute to M‐like currents in some locations. M...... hiện toàn bộ