Tumour-stromal interactions: Integrins and cell adhesions as modulators of mammary cell survival and transformationBreast Cancer Research - Tập 3 - Trang 1-6 - 2001
Micah A Chrenek, Paul Wong, Valerie M Weaver
Stromal–epithelial interactions modulate mammary epithelial cell (MEC) growth and apoptosis by influencing cell adhesion and tissue organization. Perturbations in the mammary stroma and cell adhesion characterize breast tumors and underlie the altered tissue organization, disrupted tissue homeostasis and enhanced survival phenotype of the disease. Apoptosis resistance likely arises during malignan...... hiện toàn bộ
In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffnessBreast Cancer Research - Tập 22 - Trang 1-12 - 2020
Clarissa Wormsbaecher, Andrea R. Hindman, Alex Avendano, Marcos Cortes-Medina, Caitlin E. Jones, Andrew Bushman, Lotanna Onua, Claire E. Kovalchin, Alina R. Murphy, Hannah L. Helber, Ali Shapiro, Kyle Voytovitch, Xingyan Kuang, Renan Aguilar-Valenzuela, Jennifer L. Leight, Jonathan W. Song, Craig J. Burd
In utero endocrine disruption is linked to increased risk of breast cancer later in life. Despite numerous studies establishing this linkage, the long-term molecular changes that predispose mammary cells to carcinogenic transformation are unknown. Herein, we investigated how endocrine disrupting compounds (EDCs) drive changes within the stroma that can contribute to breast cancer susceptibility. W...... hiện toàn bộ
Mutations in normal breast tissue and breast tumoursBreast Cancer Research - Tập 3 - Trang 1-5 - 2001
Ian PM Tomlinson
The accumulation of mutations is a feature of all normal cells. The probability of any individual gene in any cell acquiring a mutation is, however, low. Cancer is therefore a rare disease in comparison with the number of susceptible cells. Mutations in normal tissue are stochastic, vary widely among cells and are therefore difficult to detect using standard methods because each change is so rare....... hiện toàn bộ
25th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, 10–14 December 2002 Update on clinical researchBreast Cancer Research - Tập 5 - Trang 1-4 - 2003
Alistair Ring, Julia Head
The Annual San Antonio Breast Cancer Symposium has become a key forum for the presentation and discussion of both translational scientific aspects as well as clinical aspects of breast cancer care. In this report of the 25th Annual Meeting, an update of the salient clinical data is presented. The findings of the CALGB 9741 trial, an updated analysis of the Arimidex, Tamoxifen, Alone or in Combinat...... hiện toàn bộ
Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor developmentBreast Cancer Research - Tập 12 - Trang 1-12 - 2010
Arusha Oloumi, Mykola Maidan, Frances E Lock, Howard Tearle, Steven McKinney, William J Muller, Samuel AJR Aparicio, Shoukat Dedhar
Breast cancer is genetically and clinically a heterogeneous disease. However, the exact contribution of different cell types and oncogenic mutations to this heterogeneity are not well understood. Recently, we discovered an interaction between Wnt and integrin-linked kinase (ILK) within the signaling cascade that regulates cell growth and survival. Interestingly, mammary-specific expression of eith...... hiện toàn bộ
Loss of Brca1 and Trp53 in adult mouse mammary ductal epithelium results in development of hormone receptor-positive or hormone receptor-negative tumors, depending on inactivation of Rb family proteinsBreast Cancer Research -
Ludmila Szabova, Melanie B. Gordon, Lucy Lu, Nathan Pate, Laura Bassel, Anthony J. Iacovelli, Baktiar Karim, Philip J. Homan, Deborah B. Householder, Theresa M. Guerin, Sandra Burkett, Amanda Day, Wendi Custer, Zoë Weaver Ohler
Abstract
Background
Breast cancer is a heterogenous disease with several histological and molecular subtypes. Models that represent these subtypes are essential for translational research aimed at improving clinical strategy for targeted therapeutics.
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