Brain Structure and Function
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Deletion of aquaporin-4 increases extracellular K+ concentration during synaptic stimulation in mouse hippocampus
Brain Structure and Function - Tập 220 - Trang 2469-2474 - 2014
The coupling between the water channel aquaporin-4 (AQP4) and K+ transport has attracted much interest. In this study, we assessed the effect of Aqp4 deletion on activity-induced [K+]o changes in acute slices from hippocampus and corpus callosum of adult mice. We show that Aqp4 deletion has a layer-specific effect on [K+]o that precisely mirrors the known effect on extracellular volume dynamics. I......
Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer’s disease
Brain Structure and Function - Tập 216 - Trang 227-237 - 2011
Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by amyloid plaque accumulation, intracellular tangles and neuronal loss in selective brain regions. The frontal cortex, important for executive functioning, is one of the regions that are affected. Here, we investigated the neurodegenerative effects of mutant human amyloid precursor protein (APP) and presenilin 1 (PS1) on fron......
Hypothalamic volume and asymmetry in the pediatric population: a retrospective MRI study
Brain Structure and Function - Tập 227 - Trang 2489-2501 - 2022
This study investigated age- and sex-related changes in the volumetric development and asymmetry of the normal hypothalamus from birth to 18. Individuals aged 0–18 with MRI from 2012 to 2020 were selected for this retrospective study. Seven hundred individuals (369 [52.7%] Males) who had 3D-T1 sequences and were radiologically normal were included in the study. Hypothalamus volume was calculated u......
The effects of vibration on the neuronal activity of lateral vestibular nuclei in unilaterally labyrinthectomized rats
Brain Structure and Function - Tập 228 - Trang 463-473 - 2022
Unilateral labyrinthectomy causes distinct oculomotor and postural disorder syndromes that gradually deteriorate. Simultaneously, compensatory mechanisms for the suppression of pathological disorders were activated. The current study aimed to investigate the characteristics of impulse activity in the ipsilateral and contralateral neurons of the lateral vestibular nucleus of unilaterally labyrinthe......
Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system
Brain Structure and Function - Tập 224 - Trang 1647-1658 - 2019
The protein doublecortin is mainly expressed in migrating neuroblasts and immature neurons. The X-linked gene MECP2, associated to several neurodevelopmental disorders such as Rett syndrome, encodes the protein methyl-CpG-binding protein 2 (MeCP2), a regulatory protein that has been implicated in neuronal maturation and refinement of olfactory circuits. Here, we explored doublecortin immunoreactiv......
Vai trò của cơn gyrus góc trong nhận thức ngữ nghĩa: tổng hợp năm nghiên cứu hình ảnh thần kinh chức năng Dịch bởi AI
Brain Structure and Function - Tập 228 - Trang 273-291 - 2022
Kiến thức ngữ nghĩa là trung tâm của nhận thức con người. Gyrus góc (AG) thường được coi là một khu vực não quan trọng cho nhận thức ngữ nghĩa. Tuy nhiên, vai trò của AG trong xử lý ngữ nghĩa vẫn còn gây tranh cãi. Những tranh cãi chính liên quan đến độ cực của phản ứng (kích hoạt so với giảm hoạt động) và mối quan hệ của nó với độ khó của nhiệm vụ, sự phân bố hai bên (AG trái so với AG phải), và ......
#Gyrus góc #nhận thức ngữ nghĩa #fMRI #xử lý ngữ nghĩa #nghiên cứu thần kinh học
Influence of ontogenetic age on the role of dentate granule neurons
Brain Structure and Function - Tập 220 - Trang 645-661 - 2014
New neurons are continuously produced in the adult dentate gyrus of the hippocampus, a key structure in learning and memory. It has been shown that adult neurogenesis is crucial for normal memory processing. However, it is not known whether neurons born during the developmental period and during adulthood support the same functions. Here, we demonstrate that neurons born in neonates (first postnat......
Investigating the ventral-lexical, dorsal-sublexical model of basic reading processes using diffusion tensor imaging
Brain Structure and Function - Tập 220 - Trang 445-455 - 2013
Recent results from diffusion tensor imaging (DTI) studies provide evidence of a ventral-lexical stream and a dorsal-sublexical stream associated with reading processing. We investigated the relationship between behavioural reading speed for stimuli thought to rely on either the ventral-lexical, dorsal-sublexical, or both streams and white matter via fractional anisotropy (FA) and mean diffusivity......
Receptor density pattern confirms and enhances the anatomic-functional features of the macaque superior parietal lobule areas
Brain Structure and Function - - 2019
[18F]AV-1451 binding to neuromelanin in the substantia nigra in PD and PSP
Brain Structure and Function - Tập 223 - Trang 589-595 - 2017
This study investigated binding of [18F]AV-1451 to neuromelanin in the substantia nigra of patients with Parkinson’s disease (PD) and progressive supranuclear palsy (PSP). [18F]AV-1451 is a positron emission tomography radiotracer designed to bind pathological tau. A post-mortem study using [18F]AV-1451 discovered off-target binding properties to neuromelanin in the substantia nigra. A subsequent ......
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