Brain Structure and Function
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Extracellular signal-regulated kinase1/2-dependent changes in tight junctions after ischemic preconditioning contributes to tolerance induction after ischemic stroke
Brain Structure and Function - Tập 220 - Trang 13-26 - 2013
Less disruption of the blood–brain barrier (BBB) after severe ischemic stroke is one of the beneficial outcomes of ischemic preconditioning (IP). However, the effect of IP on tight junctions (TJs), which regulate paracellular permeability of the BBB, is not well understood. In the present study, we examined IP-induced changes in TJs before and after middle cerebral artery occlusion (MCAO) in mice,...... hiện toàn bộ
Faster scaling of visual neurons in cortical areas relative to subcortical structures in non-human primate brains
Brain Structure and Function - Tập 218 - Trang 805-816 - 2012
Cortical expansion, both in absolute terms and in relation to subcortical structures, is considered a major trend in mammalian brain evolution with important functional implications, given that cortical computations should add complexity and flexibility to information processing. Here, we investigate the numbers of neurons that compose 4 structures in the visual pathway across 11 non-human primate...... hiện toàn bộ
Contralateral cerebello-thalamo-cortical pathways with prominent involvement of associative areas in humans in vivo
Brain Structure and Function - Tập 220 - Trang 3369-3384 - 2014
In addition to motor functions, it has become clear that in humans the cerebellum plays a significant role in cognition too, through connections with associative areas in the cerebral cortex. Classical anatomy indicates that neo-cerebellar regions are connected with the contralateral cerebral cortex through the dentate nucleus, superior cerebellar peduncle, red nucleus and ventrolateral anterior n...... hiện toàn bộ
Hippocampal 5-HT1A receptor binding is related to object–location memory in humans
Brain Structure and Function - Tập 220 - Trang 559-570 - 2014
Animal studies suggest that serotonin, mediated by the 5-HT1A receptor, plays a key role in spatial learning and memory. The role of serotonin in spatial memory in humans has, however, been less well studied. This study examined the relationship between serotonin receptor density in the human brain and spatial learning and memory using the 5-HT1A receptor ligand 18F-4-(2′-methoxyphenyl)-1-[2′-(N-2...... hiện toàn bộ
Khía cạnh học tập phản hồi bị suy giảm và được bảo tồn ở aMCI: sự đóng góp của tính kết nối cấu trúc Dịch bởi AI
Brain Structure and Function - Tập 221 - Trang 2831-2846 - 2015
Nhiều nghiên cứu đã chỉ ra rằng bệnh nhân mắc chứng suy giảm nhận thức nhẹ mất trí nhớ (aMCI), một tiền đề tiềm năng của bệnh Alzheimer (AD), đặc biệt gặp khó khăn trong việc nhớ các mối quan hệ giữa các đối tượng và việc sử dụng các mục tiêu cảm xúc có thể hỗ trợ trí nhớ ở bệnh nhân mắc AD. Chúng tôi liên kết những phát hiện này bằng cách kiểm tra việc học thông qua phản hồi tích cực và tiêu cực ...... hiện toàn bộ
#Suy giảm nhận thức nhẹ mất trí nhớ #bệnh Alzheimer #học từ phản hồi #kết nối giải phẫu #chất trắng.
A new perspective of the hippocampus in the origin of exercise–brain interactions
Brain Structure and Function - Tập 223 - Trang 2527-2545 - 2018
Exercising regularly is a highly effective strategy for maintaining cognitive health throughout the lifespan. Over the last 20 years, many molecular, physiological and structural changes have been documented in response to aerobic exercise training in humans and animals, particularly in the hippocampus. However, how exercise produces such neurological changes remains elusive. A recent line of inve...... hiện toàn bộ
Rostral intralaminar thalamic deep brain stimulation ameliorates memory deficits and dendritic regression in β-amyloid-infused rats
Brain Structure and Function - - 2020
Rostral intralaminar thalamic deep brain stimulation (ILN-DBS) has been shown to enhance attention and cognition through neuronal activation and brain plasticity. We examined whether rostral ILN-DBS can also attenuate memory deficits and impaired synaptic plasticity and protect glutamatergic transmission in the rat intraventricular β-amyloid (Aβ) infusion model of Alzheimer’s disease (AD). Spatial...... hiện toàn bộ
Bimanual motor deficits in older adults predicted by diffusion tensor imaging metrics of corpus callosum subregions
Brain Structure and Function - Tập 220 - Trang 273-290 - 2013
Age-related changes in the microstructural organization of the corpus callosum (CC) may explain declines in bimanual motor performance associated with normal aging. We used diffusion tensor imaging in young (n = 33) and older (n = 33) adults to investigate the microstructural organization of seven specific CC subregions (prefrontal, premotor, primary motor, primary sensory, parietal, temporal and ...... hiện toàn bộ
Erratum to: Age differences in arterial and venous extra-cerebral blood flow in healthy adults: contributions of vascular risk factors and genetic variants
Brain Structure and Function - - 2017
Factors determining the density of AQP4 water channel molecules at the brain–blood interface
Brain Structure and Function - Tập 222 - Trang 1753-1766 - 2016
Perivascular endfeet of astrocytes are enriched with aquaporin-4 (AQP4)—a water channel that is critically involved in water transport at the brain–blood interface and that recently was identified as a key molecule in a system for waste clearance. The factors that determine the size of the perivascular AQP4 pool remain to be identified. Here we show that the size of this pool differs considerably ...... hiện toàn bộ
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