Brain Pathology

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TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post‐Mortem Temporal Cortices
Brain Pathology - Tập 25 Số 4 - Trang 469-480 - 2015
Lih‐Fen Lue, Christopher T. Schmitz, Geidy E. Serrano, Lucia I. Sue, Thomas G. Beach, Douglas G. Walker
AbstractTriggering receptor expressed by myeloid cells 2 (TREM2), a member of the immunoglobulin superfamily, has anti‐inflammatory phagocytic function in myeloid cells. Several studies have shown that TREM... hiện toàn bộ
PDGF, Pericytes and the Pathogenesis of Idiopathic Basal Ganglia Calcification (IBGC)
Brain Pathology - Tập 24 Số 4 - Trang 387-395 - 2014
Christer Betsholtz, Annika Keller
AbstractPlatelet‐derived growth factors (PDGFs) are important mitogens for various types of mesenchymal cells, and as such, they exert critical functions during organogenesis in mammalian embryonic and early postnatal development. Increased or ectopic PDGF... hiện toàn bộ
Molecular Mechanisms of Developmental and Tumor Angiogenesis
Brain Pathology - Tập 4 Số 3 - Trang 207-218 - 1994
Karl H. Plate, Georg Breier, Werner Risau
Angiogenesis, the sprouting of capillaries from preexisting vessels, is of fundamental importance during embryonic development and is the principal process by which the brain and certain other organs become vascularized. Angiogenesis occurs during embryonic development but is almost absent in adult tissues. Transient and tightly controlled (physiological) angiogenesis in adult tissues occu...... hiện toàn bộ
Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer's Disease
Brain Pathology - Tập 26 Số 4 - Trang 533-541 - 2016
J. Scott Miners, Jennifer C Palmer, Seth Love
AbstractThe earliest decline in cerebral perfusion in Alzheimer's disease (AD) is in the medial parietal cortex (precuneus). We have analyzed precuneus in post‐mortem tissue from 70 AD and 37 control brains to explore the pathophysiology of the hypoperfusion: the contribution of arteriolosclerotic small vessel disease (SVD) and cerebral amyloid angiopathy (CAA), an...... hiện toàn bộ
Transgenic and Knockout Mice in Research on Prion Diseases
Brain Pathology - Tập 8 Số 4 - Trang 715-733 - 1998
Alex J. Raeber, Sebastian Brandner, Michael A. Klein, Yves Benninger, Christine Musahl, Rico Frigg, Christiane Roeckl, Michael B. Fischer, Charles Weissmann, Adriano Aguzzi
Since the discovery of the prion protein (PrP) gene more than a decade ago, transgenetic investigations on the PrP gene have shaped the field of prion biology in an unprecedented way. Many questions regarding the role of PrP in susceptibility of an organism exposed to prions have been elucidated. For example mice with a targeted disruption of the PrP gene have allowed the demonstration tha...... hiện toàn bộ
Inflammatory Cell Migration into the Central Nervous System: A Few New Twists on an Old Tale
Brain Pathology - Tập 17 Số 2 - Trang 243-250 - 2007
Shumei Man, Eroboghene E. Ubogu, Richard M. Ransohoff
Understanding the mechanisms of leukocyte trafficking into the brain might provide insights into how to modulate pathologic immune responses or enhance host protective mechanisms in neuroinflammatory diseases such as multiple sclerosis. This review summarized our knowledge about the sites for leukocyte entry into the central nervous system, highlighting the routes from blood into the periv...... hiện toàn bộ
A2B5 Cells from Human Glioblastoma have Cancer Stem Cell Properties
Brain Pathology - Tập 20 Số 1 - Trang 211-221 - 2010
Aurélie Tchoghandjian, Nathalie Baeza, Carole Colin, Myriam Cayre, Philippe Métellus, Christophe Béclin, L’Houcine Ouafik, Dominique Figarella‐Branger
AbstractGlioblastomas, like other cancers, harbor small cell populations with the capability of sustaining tumor formation. These cells are referred to as cancer stem cells. We isolated cells expressing the surface marker A2B5 from three human glioblastomas (GBM) and showed that after grafting into nude mice, they generated dense and high...... hiện toàn bộ
Role of Microglia in Neuronal Cell Death in Prion Disease
Brain Pathology - Tập 8 Số 3 - Trang 449-457 - 1998
Armin Giese, David R. Brown, Martin H. Groschup, Claudia Feldmann, Ingrid Haist, Hans A. Kretzschmar
To elucidate the role played by the prion protein in scrapie pathogenesis, we performed experiments with PrP27–30 isolated from scrapie‐infected hamster brains in cell culture and studied in vivo the temporal and spatial correlation between deposition of the disease‐associated isoform of the prion protein (PrPSc), microglial activation and ne...... hiện toàn bộ
Neuronal Apoptosis in Fatal Familial Insomnia
Brain Pathology - Tập 8 Số 3 - Trang 531-537 - 1998
Anne Dorandeu, José Carlos Fernández Fernández, Claire Leconte, Marie‐Bernadette Delisle, C Vital, Piero Parchi, Pasquale Montagna, E Lugaresi, James Ironside, Herbert Budka, Pierluigi Gambetti, Françoise Gray
The possibility that neuronal loss in prion diseases occurs through an apoptotic process has been postulated and is consistent with the lack of inflammation in these disorders. In order to test this hypothesis in FFI, in which neuronal loss is the predominant neuropathological feature, we examined samples of thalamus, basal ganglia, cerebral cortex, cerebellum and medulla from 10 subjects ...... hiện toàn bộ
Mitochondrial Respiratory Chain Diseases and Mutations in Nuclear DNA: A Promising Start?
Brain Pathology - Tập 10 Số 3 - Trang 442-450 - 2000
Carolyn M. Sue, Eric A. Schon
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