One hundred‐fold acceleration of DNA renaturation rates in solutionBiopolymers - Tập 20 Số 7 - Trang 1537-1547 - 1981
Robert Wieder, James G. Wetmur
AbstractSolvents which accelerate DNA renaturation rates have been investigated. Addition of NaCl or LiCl to DNA in 2.4M Et4NCl initially increases renaturation rates at 45°C and then leads to a loss of second‐order behavior. The greatest accelerations are seen with LiCl and dilute DNA. Volume exclusion by dextran sul...... hiện toàn bộ
Excluded volume as a determinant of macromolecular structure and reactivityBiopolymers - Tập 20 Số 10 - Trang 2093-2120 - 1981
Allen P. Minton
AbstractThe effect of excluded volume on the thermodynamic activity of globular macromolecules and macromolecular complexes in solution is studied in the hard‐particle approximation. Activity coefficients are calculated as a function of the fraction of total volume occupied by macromolecules using relations obtained from scaled particle and lattice models. Signific...... hiện toàn bộ
Poly(L‐lysyl‐L‐alanyl‐α‐L‐glutamic acid). II. Conformational studiesBiopolymers - Tập 16 Số 7 - Trang 1527-1540 - 1977
H. Joseph Goren, Carl R. McMillin, A. G. Walton
AbstractThe solution characterization of poly(Lys‐Ala‐Glu) is described. This polytripeptide is zwitterionic at neutral pH and is shown to take on a conformation which is dictated by the state of ionization, molecular weight, temperature, and solvent. The polypeptide is almost entirely α‐helical at low pH and temperature for polymers of greater than 25,000 molecula...... hiện toàn bộ
Gaussian docking functionsBiopolymers - Tập 68 Số 1 - Trang 76-90 - 2003
Mark McGann, Harold R. Almond, Anthony Nicholls, Jennifer Grant, Frank J. Schoenen
AbstractA shape‐based Gaussian docking function is constructed which uses Gaussian functions to represent the shapes of individual atoms. A set of 20 trypsin ligand–protein complexes are drawn from the Protein Data Bank (PDB), the ligands are separated from the proteins, and then are docked back into the active sites using numerical optimization of this function. I...... hiện toàn bộ
Surface plasmon resonance spectroscopy: An emerging tool for the study of peptide–membrane interactionsBiopolymers - Tập 66 Số 1 - Trang 3-18 - 2002
Henriette Mozsolits, Marie‐Isabel Aguilar
AbstractThe interactions between peptides and membranes mediate a wide variety of biological processes, and characterization of the molecular details of these interactions is central to our understanding of cellular events such as protein trafficking, cellular signaling and ion‐channel formation. A wide variety of biophysical techniques have been combined with the ...... hiện toàn bộ
Conformational transitions of a dipeptide in water: Effects of imposed pathways using umbrella sampling techniquesBiopolymers - Tập 34 Số 3 - Trang 347-355 - 1994
Franca Fraternali, Wilfred F. van Gunsteren
AbstractThe free energy difference between two states of a molecular system separated by an energy barrier can generally be computed using the technique of umbrella sampling along a chosen reaction coordinate or pathway. The effect of a particular choice of pathway upon the obtained free energy difference is investigated by molecular dynamics simulation of a model ...... hiện toàn bộ
Các mô hình nguyên tử chiếm chỗ chính xác Dịch bởi AI Biopolymers - Tập 3 Số 6 - Trang 665-679 - 1965
Walter L. Koltun
Tóm tắtNói ngắn gọn, các mô hình nguyên tử chiếm chỗ nhẹ, giá rẻ, chính xác và phù hợp đặc biệt cho việc xây dựng các đại phân tử có liên quan đến sinh học sẽ được cung cấp đến cộng đồng khoa học. Việc cung cấp các mô hình này, các Mô hình Corey‐Pauling‐Koltun, hay còn gọi là Mô hình C‐P‐K, sẽ kết thúc một chương trình kéo dài năm năm, trong đó có sự hợp tác của cá...... hiện toàn bộ