Biopolymers
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One hundred‐fold acceleration of DNA renaturation rates in solution
Biopolymers - Tập 20 Số 7 - Trang 1537-1547 - 1981
AbstractSolvents which accelerate DNA renaturation rates have been investigated.
Addition of NaCl or LiCl to DNA in 2.4M Et4NCl initially increases renaturation
rates at 45°C and then leads to a loss of second‐order behavior. The greatest
accelerations are seen with LiCl and dilute DNA. Volume exclusion by dextran
sulfate is the most effective method of accelerating DNA renaturation with
concentra...
Excluded volume as a determinant of macromolecular structure and reactivity
Biopolymers - Tập 20 Số 10 - Trang 2093-2120 - 1981
AbstractThe effect of excluded volume on the thermodynamic activity of globular
macromolecules and macromolecular complexes in solution is studied in the
hard‐particle approximation. Activity coefficients are calculated as a function
of the fraction of total volume occupied by macromolecules using relations
obtained from scaled particle and lattice models. Significant and readily
observable effect...
The influence of macromolecular crowding on thermodynamic activity: Solubility and dimerization constants for spherical and dumbbell‐shaped molecules in a hard‐sphere mixture
Biopolymers - Tập 30 Số 11-12 - Trang 1027-1037 - 1990
AbstractMacromolecules in solution can have large effects on the properties of
other solutes through nonideal excluded‐volume (crowding) interactions. Minton
[(1983) Mol. Cell. Biochem. 55, 119–140] has calculated such effects by treating
the macromolecules as a hard‐sphere fluid in a background of an inert
structureless solvent. In the present paper these calculations are extended by
including th...
Bioencapsulation of apomyoglobin in nanoporous organosilica sol–gel glasses: Influence of the siloxane network on the conformation and stability of a model protein
Biopolymers - Tập 91 Số 11 - Trang 895-906 - 2009
AbstractNanoporous sol–gel glasses were used as host materials for the
encapsulation of apomyoglobin, a model protein employed to probe in a rational
manner the important factors that influence the protein conformation and
stability in silica‐based materials. The transparent glasses were prepared from
tetramethoxysilane (TMOS) and modified with a series of mono‐, di‐ and
tri‐substituted alkoxysila...
Synthesis of some amino acids, sugars, and peptides in cold plasma abiotic synthesis of some high‐molecular‐weight proteid‐like structures (V)
Biopolymers - Tập 13 Số 5 - Trang 943-954 - 1974
AbstractThe synthesis of some high‐molecular‐weight protenoid structures in
radiofrequency cold plasma conditions are discussed. The fractionation results
of the raw product and the spectrum of free and protenoid‐bound amino acids are
given. The uv analysis of these compounds is presented.A protein‐forming
mechanism that might have existed on the primitive earth is proposed.
Poly(L ‐lysyl‐L ‐alanyl‐α‐L ‐glutamic acid). II. Conformational studies
Biopolymers - Tập 16 Số 7 - Trang 1527-1540 - 1977
AbstractThe solution characterization of poly(Lys‐Ala‐Glu) is described. This
polytripeptide is zwitterionic at neutral pH and is shown to take on a
conformation which is dictated by the state of ionization, molecular weight,
temperature, and solvent. The polypeptide is almost entirely α‐helical at low pH
and temperature for polymers of greater than 25,000 molecular weight. Melting
profiles for th...
Gaussian docking functions
Biopolymers - Tập 68 Số 1 - Trang 76-90 - 2003
AbstractA shape‐based Gaussian docking function is constructed which uses
Gaussian functions to represent the shapes of individual atoms. A set of 20
trypsin ligand–protein complexes are drawn from the Protein Data Bank (PDB), the
ligands are separated from the proteins, and then are docked back into the
active sites using numerical optimization of this function. It is found that by
employing this...
Surface plasmon resonance spectroscopy: An emerging tool for the study of peptide–membrane interactions
Biopolymers - Tập 66 Số 1 - Trang 3-18 - 2002
AbstractThe interactions between peptides and membranes mediate a wide variety
of biological processes, and characterization of the molecular details of these
interactions is central to our understanding of cellular events such as protein
trafficking, cellular signaling and ion‐channel formation. A wide variety of
biophysical techniques have been combined with the use of model membrane systems
to ...
Conformational transitions of a dipeptide in water: Effects of imposed pathways using umbrella sampling techniques
Biopolymers - Tập 34 Số 3 - Trang 347-355 - 1994
AbstractThe free energy difference between two states of a molecular system
separated by an energy barrier can generally be computed using the technique of
umbrella sampling along a chosen reaction coordinate or pathway. The effect of a
particular choice of pathway upon the obtained free energy difference is
investigated by molecular dynamics simulation of a model system consisting of a
glycine di...
Các mô hình nguyên tử chiếm chỗ chính xác Dịch bởi AI
Biopolymers - Tập 3 Số 6 - Trang 665-679 - 1965
Tóm tắtNói ngắn gọn, các mô hình nguyên tử chiếm chỗ nhẹ, giá rẻ, chính xác và
phù hợp đặc biệt cho việc xây dựng các đại phân tử có liên quan đến sinh học sẽ
được cung cấp đến cộng đồng khoa học. Việc cung cấp các mô hình này, các Mô hình
Corey‐Pauling‐Koltun, hay còn gọi là Mô hình C‐P‐K, sẽ kết thúc một chương trình
kéo dài năm năm, trong đó có sự hợp tác của các cơ quan Liên bang, các hội khoa...
Tổng số: 160
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