Biophysical Reviews
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Finding cancer driver mutations in the era of big data research
Biophysical Reviews - Tập 11 - Trang 21-29 - 2018
In the last decade, the costs of genome sequencing have decreased considerably. The commencement of large-scale cancer sequencing projects has enabled cancer genomics to join the big data revolution. One of the challenges still facing cancer genomics research is determining which are the driver mutations in an individual cancer, as these contribute only a small subset of the overall mutation profi......
Constructing a structural model of troponin using site-directed spin labeling: EPR and PRE-NMR
Biophysical Reviews - Tập 11 - Trang 621-639 - 2019
The relative ease of introducing a paramagnetic species onto a protein, and advances in electron paramagnetic resonance (EPR) over the past two decades, have established spin labeling as a vital structural biology technique for revealing the functional workings of the troponin muscle regulatory complex—an ~80 kDa heterotrimeric protein switch for turning on striated muscle contraction. Through the......
Rate of solute incorporation to liposomes evaluated from encapsulated enzymes activities
Biophysical Reviews - Tập 6 Số 1 - Trang 161-167 - 2014
Diversity and features of proteins with structural repeats
Biophysical Reviews - Tập 15 - Trang 1159-1169 - 2023
The review provides information on proteins with structural repeats, including their classification, characteristics, functions, and relevance in disease development. It explores methods for identifying structural repeats and specialized databases. The review also highlights the potential use of repeat proteins as drug design scaffolds and discusses their evolutionary mechanisms.
Respiratory system dynamical mechanical properties: modeling in time and frequency domain
Biophysical Reviews - - 2011
The mechanical properties of the respiratory system are important determinants of its function and can be severely compromised in disease. The assessment of respiratory system mechanical properties is thus essential in the management of some disorders as well as in the evaluation of respiratory system adaptations in response to an acute or chronic process. Most often, lungs and chest wall are trea......
Hiểu biết về sự thích nghi chuyển hóa thông qua tiến hóa vi khuẩn trong phòng thí nghiệm và phân tích chuyển đổi - ômics Dịch bởi AI
Biophysical Reviews - - 2020
Nhiều bệnh như hội chứng chuyển hóa, ung thư, các bệnh viêm nhiễm và các hiện tượng bệnh lý có thể hiểu như một sự tái cấu trúc thích nghi của trạng thái chuyển hóa (thích nghi chuyển hóa). Một trong những phương pháp hiệu quả để tiết lộ tính chất của các mạng lưới chuyển hóa là sử dụng các sinh vật mô hình như vi sinh vật, mà dễ dàng thí nghiệm hơn so với các sinh vật bậc cao. Bằng cách sử dụng p......
#thích nghi chuyển hóa #tiến hóa vi khuẩn #phân tích ômics #dữ liệu hình thái #mạng lưới chuyển đổi
Cris never left you wondering about where you stood! His motto was: Just do it!
Biophysical Reviews - Tập 12 - Trang 761-762 - 2020
In this commentary, we reflect on our experiences being PhD students of Prof. Cris dos Remedios in the Muscle Research Unit at The University of Sydney at the turn of the new millennium. Cris was/is an example of a fine scientist and a great academic mentor for us and so many others (scientists, academics, surgeons, medical doctors and health professionals) who carry the legacy and traditions of C......
Bayesian statistical learning for big data biology
Biophysical Reviews - Tập 11 - Trang 95-102 - 2019
Bayesian statistical learning provides a coherent probabilistic framework for modelling uncertainty in systems. This review describes the theoretical foundations underlying Bayesian statistics and outlines the computational frameworks for implementing Bayesian inference in practice. We then describe the use of Bayesian learning in single-cell biology for the analysis of high-dimensional, large dat......
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