Biophysical Reviews
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Gliadin proteolytical resistant peptides: the interplay between structure and self-assembly in gluten-related disorders
Biophysical Reviews - Tập 13 - Trang 1147-1154 - 2021
In recent years, the evaluation of the structural properties of food has become of crucial importance in the understanding of food-related disorders. One of the most exciting systems is gliadin, a protein in wheat gluten, that plays a protagonist role in gluten-related disorders with a worldwide prevalence of 5%, including autoimmune celiac disease (CeD) (1%) and non-celiac wheat sensitivity (0.5–......
Biophysical Reviews: A goodbye to 2023
Biophysical Reviews - - Trang 1-4 - 2023
This Editorial for the IUPAB Biophysical Reviews journal (2023 volume 15 issue 6) first provides an overview of the contents of this “Regular Issue featuring an Issue Focus on the Computational Biophysics of Atomic Force Microscopy” before going on to highlight some of the notable work published in the journal throughout 2023. Highlights of the current Issue include the contributed review article ......
The critical role of mitochondrial lipid peroxidation in ferroptosis: insights from recent studies
Biophysical Reviews - Tập 15 - Trang 875-885 - 2023
Ferroptosis is a regulated form of necrotic cell death reliant on iron-catalyzed lipid peroxidation. Although the precise involvement of mitochondria in ferroptosis remains incompletely elucidated, recent research indicates that mitochondrial oxidative events wield a pivotal influence in this mechanism. This article centers on the most recent discoveries, spotlighting the significance of mitochond......
Finding cancer driver mutations in the era of big data research
Biophysical Reviews - Tập 11 - Trang 21-29 - 2018
In the last decade, the costs of genome sequencing have decreased considerably. The commencement of large-scale cancer sequencing projects has enabled cancer genomics to join the big data revolution. One of the challenges still facing cancer genomics research is determining which are the driver mutations in an individual cancer, as these contribute only a small subset of the overall mutation profi......
Constructing a structural model of troponin using site-directed spin labeling: EPR and PRE-NMR
Biophysical Reviews - Tập 11 - Trang 621-639 - 2019
The relative ease of introducing a paramagnetic species onto a protein, and advances in electron paramagnetic resonance (EPR) over the past two decades, have established spin labeling as a vital structural biology technique for revealing the functional workings of the troponin muscle regulatory complex—an ~80 kDa heterotrimeric protein switch for turning on striated muscle contraction. Through the......
Ratchets, red cells, and metastability
Biophysical Reviews - Tập 5 - Trang 217-224 - 2013
Sickle cell disease is a genetic disorder in which a negatively charged glutamic acid is replaced by a hydrophobic valine on the surface of the hemoglobin molecule, leading to polymerization of the deoxygenated form, and resulting in microvascular obstruction. Because of the high volume occupancy under which polymerization occurs physiologically, this process has been an exemplar in the study of e......
Metal ion-dependent anti-termination of transcriptional regulation of ribonucleoprotein complexes
Biophysical Reviews - Tập 6 - Trang 215-226 - 2014
Anti-terminator proteins are frequently used by bacteria to sense a specific metabolite signal and direct RNA polymerase to either terminate or continue transcription of the genes downstream of an operon. One such protein is HutP, which binds to upstream cis-regulatory sequences to regulate expression of the histidine utilization (hut) operon in Bacillus subtilis. HutP must be activated by L-histi......
Structure and functions of profilins
Biophysical Reviews - Tập 1 - Trang 71-81 - 2009
Profilins are small actin-binding proteins found in eukaryotes and certain viruses that are involved in cell development, cytokinesis, membrane trafficking, and cell motility. Originally identified as an actin sequestering/binding protein, profilin has been involved in actin polymerization dynamics. It catalyzes the exchange of ADP/ATP in actin and increases the rate of polymerization. Profilins a......
Application of direct electrometry in studies of microbial rhodopsins reconstituted in proteoliposomes
Biophysical Reviews - Tập 14 - Trang 771-778 - 2022
Microbial rhodopsins are the family of retinal-containing proteins that perform primarily the light-driven transmembrane ion transport and sensory functions. They are widely distributed in nature and can be used for optogenetic control of the cellular activities by light. Functioning of microbial rhodopsins results in generation of the transmembrane electric potential in response to a flash that c......
The emerging role of DNA supercoiling as a dynamic player in genomic structure and function
Biophysical Reviews - Tập 8 - Trang 1-3 - 2016
This editorial highlights the pervasive role of DNA supercoiling in genomic structure and function and introduces the main themes of the reviews in this Special Issue.
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