Biophysical Reviews
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Protein conformational dynamics and phenotypic switching
Biophysical Reviews - Tập 13 - Trang 1127-1138 - 2021
Intrinsically disordered proteins (IDPs) are proteins that lack rigid 3D structure but exist as conformational ensembles. Because of their structural plasticity, they can interact with multiple partners. The protein interactions between IDPs and their partners form scale-free protein interaction networks (PINs) that facilitate information flow in the cell. Because of their plasticity, IDPs typical...... hiện toàn bộ
Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention
Biophysical Reviews - Tập 10 - Trang 1263-1282 - 2018
Autoinhibition is an effective mechanism that guards proteins against spurious activation. Despite its ubiquity, the distinct organizations of the autoinhibited states and their release mechanisms differ. Signaling is most responsive to the cell environment only if a small shift in the equilibrium is required to switch the system from an inactive (occluded) to an active (exposed) state. Ras signal...... hiện toàn bộ
“Bioluminescence and Photonics of Fluorescent Proteins” session at the 9th Congress of the Russian Photobiology Society (Shepsi, Krasnodar region, Russia; September 12–19, 2021)
Biophysical Reviews - Tập 14 - Trang 765-767 - 2022
Here is a brief summary of presentations made by the participants of the “Bioluminescence and Photonics of Fluorescent Proteins” session at the 9th Congress of the Russian Photobiological Society which were dedicated to basic studies on bioluminescence systems of different organisms as well as to various analytical applications of bioluminescent proteins. Many questions to the speakers and in-dept...... hiện toàn bộ
The present and future of the Japan Society for the Promotion of Science Alumni Association in Australia (JSPSAAA)
Biophysical Reviews - Tập 10 - Trang 97-99 - 2017
New direct dynamic models of protein interactions coupled to photosynthetic electron transport reactions
Biophysical Reviews - Tập 2 - Trang 101-110 - 2010
This review covers the methods of computer simulation of protein interactions taking part in photosynthetic electron transport reactions. A direct multiparticle simulation method that simulates reactions describing interactions of ensembles of molecules in the heterogeneous interior of a cell is developed. In the models, protein molecules move according to the laws of Brownian dynamics, mutually o...... hiện toàn bộ
Polymer-based nanoparticles: fabrication to applications—the many faces of DC8,9PC and albumin
Biophysical Reviews - Tập 13 - Trang 925-930 - 2021
This review is directed to researchers interested in a new point of view with relevance to nano-biomedicine. The first part covers the uses and potential of diacetylene lipid, 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine (DC8,9PC) in facilitating biological target recognition. The second part concentrates on the use of albumin as a “soft” coating for nanoparticles. This review makes c...... hiện toàn bộ
Non-sarcomeric causes of heart failure: a Sydney Heart Bank perspective
Biophysical Reviews - Tập 10 - Trang 949-954 - 2018
Mechanobiology of cells and cell systems, such as organoids
Biophysical Reviews - Tập 11 - Trang 721-728 - 2019
Organoids are in vitro 3D self-organizing tissues that mimic embryogenesis. Organoid research is advancing at a tremendous pace, since it offers great opportunities for disease modeling, drug development and screening, personalized medicine, as well as understanding organogenesis. Mechanobiology of organoids is an unexplored area, which can shed light to several unexplained aspects of self-organiz...... hiện toàn bộ
Molecular interactions of IRF4 in B cell development and malignancies
Biophysical Reviews - Tập 13 - Trang 1219-1227 - 2021
Interferon regulatory factor 4 (IRF4) is a lymphoid transcription factor and a key regulator in the development of various immune cells, including T and B cells. It is well-known that IRF4 controls numerous decision-making processes relating to B cell development, including differentiation, maturation, and signalling. Consequently, genetic alterations that affect the functional aspects of IRF4 can...... hiện toàn bộ
Bayesian statistical learning for big data biology
Biophysical Reviews - Tập 11 - Trang 95-102 - 2019
Bayesian statistical learning provides a coherent probabilistic framework for modelling uncertainty in systems. This review describes the theoretical foundations underlying Bayesian statistics and outlines the computational frameworks for implementing Bayesian inference in practice. We then describe the use of Bayesian learning in single-cell biology for the analysis of high-dimensional, large dat...... hiện toàn bộ
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