Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunitBiology of the Cell - Tập 96 - Trang 509-517 - 2004
Christine Dozier, Mortaza Bonyadi, Laurent Baricault, Laure Tonasso, Jean-Marie Darbon
Summry— Chk2 is a key player of the DNA damage signalling pathway. To identify new regulators of this kinase, we performed a yeast two‐hybrid screen and found that Chk2 associated with the B' regulatory subunit of protein phosphatase PP2A. In vitro GST‐Chk2 pulldowns demonstrated that B'γ isoforms bound to Chk2 with the strongest apparent a...... hiện toàn bộ
In vitro studies on Itm2a reveal its involvement in early stages of the chondrogenic differentiation pathwayBiology of the Cell - Tập 96 - Trang 463-470 - 2004
Dave Van den Plas, Joseph Merregaert
Summry— The Integral membrane protein 2A (Itm2A) is a transmembrane protein belonging to a family composed of at least two other members, Itm2B and Itm2C, all of them having a different expression pattern. The Itm2a gene serves as a marker for early stages in endochondral ossification. In order to understand the role of Itm2A in this proces...... hiện toàn bộ